11th International Conference on Cachexia, Sarcopenia & Muscle Wasting

Friday 7 December 2018
10.00-11.30 A 1. Clinical and societal impact of cachexia & sarcopenia
Chairs
Recent facts & figures Stephan von Haehling Germany
Clinicians quest: geriatrician Francesco Landi Italy
Clinicians quest: medical oncologist Florian Strasser Switzerland
Clinicians quest: surgeon Steven Olde Damink The Netherlands
Patients quest TBD
11.30-12.00 Appetizer: Highlights of afternoon workshops Workshops chairs
12.00-13.00 Lunch
13.00-17.00 B 2. Workshops: Innovation & implementation
WS 1: Novel methodologies in basic cachexia research 
biomaterial production platforms, lab on a chip, radio-nucleotide lab, human xenografts, organoid culture facility
WS 2: Innovative approaches in human metabolic research
Whole body & tissue metabolism (respiration chambers, MS imaging, PET-MRI, Fluxomics) Imaging (Brain-fMRI, Radiomics)
WS 3: Metabolic risk & outcome assessment
body composition, biomarkers, physical performance & mobility, physical activity, cognitive performance, patient reported outcomes (+hands on training)
WS 4: Rehabilitation and advanced care planning
visit to CIRO Centre of Expertise Chronic Organ Diseases
tailored intervention modules: different exercise training modalities, NMES
18.00-20.00 Reception
Saturday 8 December 2018
7.15-8.15 Ken Fearon Career Café – Meet the mentors
8.30-10.00 D 4. Plenary: Multilayered triggers of chronic disease associated wasting
Chairs
Acute events upon chronic wasting in COPD
Clinical perspective Michael Steiner UK
Basic research insights Ramon Langen The Netherlands
Sarcopenia in fatty liver disease progression
Clinical perspective Verena Keitel Germany
Basic research insights Bente Klarlund Pedersen Denmark
Chronic kidney disease + accelerated aging
Clinical perspective Kamyar Kalantar-Zadeh USA
Basic research insights Peter Stenvinkel Sweden
10.00-11.00 Break + Poster session
11.00-12.30 E 5A Basic track: tumor secreted triggers of cachexia
Stephan Herzig Germany
Tumor-derived Hsp-70/90 in cancer cachexia Yi-Ping Li USA
Transfer of enzymatic activity of Tumor-borne extracellular vesicles Mauricio Berriel Diaz Germany
Tumor gp130 ligands expression and release in cancer cachexia Teresa Zimmers USA
3-5 selected orals
F 5B: Clinical track: Emerging fields in critical illness wasting
Chairs
Muscle metabolism and physiology in chronic critical illness Zudin Puthucheary UK
FES-ICU Trial: Functional Electrical Stimulation Sue Berney Australia
Persistent inflammation immunosuppression catabolic syndrome Scott Brakenridge USA
3-5 selected orals
12.30-13.30 Lunch Break + Seminar
13.30-15.00 G 6A: Basic track: Non-tumor derived factors involved in muscle wasting
Chairs
Inflammatory and glucocorticoid signaling in muscle atrophy Rowan Hardy UK
Intermittent glucocorticoid dosing and muscle repair Elizabeth McNally USA
Muscle-derived growth factors and muscle atrophy Vanina Romanello Italy
3-5 selected orals
H 6B: Clinical track: Challenges of cancer induced wasting in the older patient
Chairs
Update on treatment options for cancer cachexia Maurizio Muscaritoli Italy
When cancer cachexia occurs with sarcopenia  Aminah Jatoi USA
  Clinical presentations and outcomes
Controversies of comprehensive geriatric assessment   in weight losing cancer patients Etienne Brain France
Complex decision making in the older, weight-losing cancer patient Matti Aapro Switzerland
3-5 selected orals
15.00-16.00 Break + Poster session
16.00-17.30 I 7A: Basic track: Experimental models
Chairs
In vitro muscle culture: Muscling in on the third dimension Penney Gilbert Canada
Mouse avatars in cancer cachexia Andrew Judge USA
Natural (large animal) models of sarcopenia and cachexia Lisa Freeman USA
3-5 selected orals
J 7B: Clinical track: Management guidelines for sarcopenia Chairs
Jean Woo  Hong Kong
Rapid screening for sarcopenia John Morley USA
How to pragmatically and meaningfully screen on sarcopenia and physical frailty in community dwelling older people?                                                                    Jos Schols The Netherlands
Targeting muscle quality Bertrand Fougere France
Guidelines for management of Sarcopenia Jürgen Bauer Germany
Recent advance on sarcopenia in Asia Hidenori Arai Japan
3-5 selected orals
17.30-18.30 K 8: Plenary: Novel nutritional and pharmacological targets in cachexia and sarcopenia
Chairs
Epigenetic targeting of bromodomain protein BRD4 Giuseppina Caretti Italy
FGF-19 modulates skeletal muscle mass and wasting Jerome Ruzzin Norway
GDF11/15 in skeletal muscle wasting David Glass USA
Multiorgan nutritional targets Josep Argiles Spain –> Italy
19.30
Sunday 9 December 2018
8.30-10.00 L 9. Plenary session: Multilayered triggers of cancer cachexia Chairs
Andrea Bonetto USA
Tumor-induced local tissue dysfunction contributing to cachexia
Dysphagia in sarcopenia and head and neck cancer Hidetaka Wakabayashi Japan
Cancer associated fibroblasts in pancreatic cancer Daniel Öhlund Sweden
Tumor-host interactions in cachexia
Exercise-dependent regulation of tumour microenvironment Lee Jones USA
Tumor-induced immune- and metabolic reprogramming Thomas Flint UK
Tumor treatment-induced muscle wasting
Influence of the gut microbiota  on anticancer immunosurveillance Bertrand Routy France Canada ?
Mechanisms of chemotherapy-induced muscle wasting Riikka Kivelä Finland
10.00-11.00 Break + Poster session
11.00-12.30 M 10A. Basic track : Intracellular mechanisms of muscle wasting
Chairs
Altered muscle proteostasis in muscle wasting Marco Sandri Italy
Role of microRNAs in muscle wasting Paola Costelli Italy
Muscle progenitor cell function and muscle wasting Denis Guttridge USA
3-5 selected speakers from abstracts
N 10B.Translational track:  Anabolic resistance in sarcopenia and cachexia: Myth or opportunity?
Chairs
Sarcopenic obesity Yves Boirie France
Physical inactivity accelerates sarcopenia and leads to metabolic dysfunction Luc van Loon The Netherlands
Exercise as therapeutic approach in cancer cachexia Fabio Penna Italy
* or focus on ageing and chronic disease?
3-5 selected speakers from abstracts
12.30-13.30 Lunch Break + Seminar
13.30-14.30 O 11A: Omics approaches in cachexia & sarcopenia research Chairs
Alexander Ebhardt Switzerland
Extra-cellular vesicles in tissue crosstalk during exercise Martin Whitham Australia
Multi-omics analysis of serum reveals tissue crosstalk in cancer Christopher Gerner Austria
Transcript-metabolite interactive networks in mouse skeletal muscle Andrew Philp UK
Small RNAome profiling of skeletal muscle in cancer cachexia Sambasivarao Damaraju Canada
1-2 selected speakers from abstracts
P 11B: Translational track: No time to pause: Circadian rhythm and wasting disorders
Chairs: Srinivasan Dasarathy USA
Translational control in response to different exercise training modes in young and old humans TBD someone from NL (Tieland or DeGroot from Wagenigen)
Circadian rhythm in skeletal muscle homeostasis Karyn Esser USA
Intestinal microbiota, body composition & biological clock Lora Hooper USA
1-2 selected speakers from abstracts
14.30-16.00 Q  12. Plenary session: Novel intervention strategies and clinical study designs     
Chairs
Proteomics and sarcopenia/frailty Luigi Ferrucci USA
Evidence versus practice based medicine Stefan Anker Germany
Nutrition & pharma joining forces Annemie Schols The Netherlands
P4 medicine in cachexia & sarcopenia John Morley USA

 

 

During the congress an ‘physical activity’ is stimulated by walking & cycling to different locations at the Campus and to the nearby City Centre Awards Ceremony
Best Poster Award 
Young Investigators Award 
Trainee Poster Award