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Day 1
24 Jun 2022
Day 2
25 Jun 2022
Day 3
26 Jun 2022

10:00 - 11:00 CEST

OPENING SESSION

10:00 - 10:15 CEST

“Prometheus” basic science key note lecture – Targeting the ubiquitin proteasome system to fight muscle atrophy: update 2022

Volker Adams, Dresden, Germany

Adams, Volker

10:15 - 10:30 CEST

“Hippocrates” clinical science key note lecture

John Morley, Saint Louis, MO, USA

Morley, John E.

10:30 - 10:45 CEST

JCSM & SCWD lecture

Stephan von Haehling, Göttingen, Germany

von Haehling, Stephan

10:45 - 11:00 CEST

Discussion

All faculty

11:15 - 12:00 CEST

NOVEL ASPECTS OF ADIPOSE TISSUE FUNCTION IN WASTING (Clinical Session B)

11:15 - 11:23 CEST

Immune-sympathetic neuron communication guides adipose tissue browning in cancer-associated cachexia

Martina Schweiger, Graz, Austria

11:23 - 11:31 CEST

Angiocrine signals promote adipose tissue wasting in cancer cachexia

Andreas Fischer, Heidelberg, Germany

11:31 - 11:39 CEST

Brown adipose tissue activation is not related to hypermetabolism in emphysematous COPD patients

Annemie Schols, Maastricht, The Netherlands

Schols, Annemie

11:39 - 47 CEST

MRI-determined psoas muscle fat infiltration correlates with severity of weight loss during cancer cachexia

Dimitrios Karampinos, Munich, Germany

11:47 - 12:00 CEST

Discussion

All faculty

12:10 - 12:55 CEST

Lunchtime Sessions

13:00 - 13:45 CEST

Mechanisms of muscle loss due to cancer and chemotherapy and early interventions to help counteract negative effects (Clinical Session D)

13:00 - 13:08 CEST

Doxorubicin-induced skeletal muscle atrophy, underlying molecular pathways and potential protective effects of exercise: Evidence from pre- clinical and clinical data

Anouk E. Hiensch, Utrecht, The Netherlands

13:08 - 13:16 CEST

Exercise and Nutrition-based Rehabilitation programme (EneRgy) in people with cancer

TBD

13:16 - 13:24 CEST

Resistance training during chemotherapy for non-metastatic colon cancer: The FORCE study: Effects on body composition and physical function

Bette J. Caan, Oakland, CA, USA

Caan, Bette J.

13:24 - 13:32 CEST

Effects of exercise in patients after curative treatment for esophageal cancer: body composition and adequacy of energy and protein intake (the PERFECT study)

Anne M. May, Utrecht, The Netherlands

May, Ann M.

13:32 - 13:45 CEST

Discussion

All faculty

13:50 - 14:40 CEST

Poster and Rapid Fire Abstracts Sessions

14:45 - 15:30 CEST

New Basic Findings in Muscle Wasting
Basic Science Session E

14:45 - 14:53 CEST

Activation of Akt-mTORC1 signaling reverts cancer-dependent muscle wasting

Bert Blaauw, Padova, Italy

Blaauw, Bert

14:53 - 15:01 CEST

New insights into the role of GCN2-eIF2alpha signaling in the regulation of autophagy

Anne-Catherine Maurin, Clermont-Ferrand, France

15:01 - 15:09 CEST

Interventions for improving mitochondrial function to counteract cancer and chemotherapy-induced cachexia

Fabio Penna, Turin, Italy

Penna, Fabio

15:09 - 15:17 CEST

Fighting muscle loss: lessons from hibernation in brown bear

Etienne Lefai, Clermont-Ferrand, France

Lefai, Etienne
15:35 - 16:25 CEST

Poster and Rapid Fire Abstracts Sessions

16:30 - 17:15 CEST

Ammonia and the muscle- multiple diseases, one mechanism
Basic Science Session G

16:30 - 16:38 CEST

Mechanisms of ammonia induced sarcopenia – a common mediator in multiple diseases

Srinivasan Dasarathy, Cleveland, OH, USA

Dasarathy, Srinivasan

16:38 - 16:46 CEST

Multiomics based approaches to identify novel cellular and tissue responses

TBD

16:46 - 16:54 CEST

Hyperammonemia in disease – metabolic responses in the skeletal muscle

Steven W. M. Olde Damink, Maastricht, The Netherlands

Olde Damink, Steven W. M.

16:54 - 17:02 CEST

Amino acid perturbations in hyperammonemia

Milan Holecek, Hradec Kralove, Czech Republic

17:02 - 17:15 CEST

Discussion

All faculty

09:00 - 09:45 CEST

Liver alterations as drivers of cancer cachexia
Clinical Session H

09:00 - 09;15 CEST

Hepatic and intestinal disturbances as targets to counteract cancer cachexia

Laure Bindels, Leuven, Belgium

09:15 - 09:30 CEST

A cachexia score based on liver alterations predicts prognosis of gastrointestinal cancer patients

Achim Krüger, Munich, Germany

09:30 - 09:45 CEST

Discussion

All faculty

10:00 - 10:45 CEST

Hot topics in basic research: role of muscle stem and progenitor cells during aging, disease and regeneration
Basic Science Session K

10:00 - 10:08 CEST

Muscle stem cells in age and disease

Julia von Maltzahn, Leibniz, Germany

10:08 - 10:16 CEST

Neurofibromatosis type 1 associated myopathy is due to metabolic reprogramming of muscle stem cells in a mouse model

Sigmar Stricker, Berlin, Germany

10:16 - 10:24 CEST

Fibro-adipogenic progenitors coordinate muscle regeneration

Georgios Kotsaris, Berlin, Germany

10:24 - 10:32 CEST

Activating stem cells to drive muscle regeneration in cancer

Jason D. Doles, Rochester, MN, USA

Doles, Jason D.

10:32 - 10:45 CEST

Discussion

All faculty

10:50 - 11:40 CEST

Poster and Rapid Fire Abstracts Sessions

11:45 - 12:30 CEST

State of the art nutrition for outcome driven cancer treatments
Clinical Session N

11:45 - 11:53 CEST

Integrated evaluation of body composition in the oncology setting: paradigm change

David da Silva Dias, Faro, Portugal

11:53 - 12:01 CEST

Nutrition Options in 2022: What is on the market?

Paula Ravasco, Lisbon, Portugal

12:01 - 12:09 CEST

Nutrition in ambulatory cytotoxic treatment: new data on the role of the clinical pharmacist

Leila Costa, Portugal

12:09 - 12:17 CEST

Head and neck cancer and cachexia – a high risk cancer and higher risk treatments

TBD

12:17 - 12:30 CEST

Discussion

All faculty

12:40 - 13:40 CEST

Lunchtime sessions

13:50 - 14:35 CEST

Novel cachexia mediators – proteins and beyond
Basic Science Session O

13:50 - 13:58 CEST

Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia

Tobias Janowitz, Cold Spring Harbor, NY, USA

Janowitz, Tobias

13:58 - 14:06 CEST

Tumor-derived cachexia mediators and biomarkers

Mauricio Berriel Diaz, Neuherberg, Germany

Berriel Diaz, Mauricio

14:06 - 14:14 CEST

Tumor-derived extracellular vesicles

Paola Costelli, Turin, Italy

Costelli, Paola

14:08 - 14:22 CEST

Oncometabolites and cachexia

TBD

14:22 - 14:35 CEST

Discussion

All faculty

14:40 - 15:30 CEST

Poster session

15:35 - 16:20 CEST

Mechanisms of energy and anabolic crisis in cancer cachexia – new therapeutic targets?
Basic Science Session Q

15:35 - 15:43 CEST

MyomiRNA, systemic and local inflammation and muscle wasting

Maurizio Muscaritoli, Rome, Italy

Muscaritoli, Maurizio

15:43 - 15:51 CEST

FFA1R agonists in cancer cachexia

TBD

15:51 - 15:59 CEST

The transcriptional repressor FoxP1 in cancer-induced skeletal muscle wasting and weakness

Sarah M. Judge, Gainesville, FL, USA

15:59 - 16:07 CEST

Cancer-derived extracellular vesicles as mediators of lipolysis and adipose tissue browning

TBD

16:07 - 16:20 CEST

Discussion

All faculty

16:35 - 17:20 CEST

Cachexia-associated microenvironment alterations
Basic Science Session S

16:35 - 16:45 CEST

Endothelial dysfunction in cachexia

Young-Mee Kim, Coral Gables, FL, USA

16:45 - 16:55 CEST

Immunity in cachexia

TBD

16:55 - 17:05 CEST

NMJ defects and stem cell defects in wasting muscle

Joe Chakkalakal, Durham, NC, USA

17:05 -17:20 CEST

Discussion

All faculty

17:35 - 18:20 CEST

Host-specific and tumor-specific molecular mechanisms of biological variability in cancer cachexia
Basic Science Session U

17:35 - 17:43 CEST

Host factors: sexual dimorphism in murine models of cancer cachexia

Nicholas P. Greene, Fayetteville, AR, USA

Greene, Nicholas P.

17:43 - 17:51 CEST

Host factors: aging and host genotype in cancer cachexia

Maria Rohm, Neuherberg, Germany

Rohm, Maria

17:51 - 17:59 CEST

Tumor factors: tumor molecular and cellular heterogeneity mediates cancer cachexia phenotype

Teresa A. Zimmers, Indianapolis, IN, USA

Zimmers, Teresa A.

17:59 - 18:07 CEST

In vivo screening reveals lung cancer tumor-specific mediators of cancer cachexia in mice

Rodney Infante, Dallas, TX, USA

Infante, Rodney

18:07 - 18:20 CEST

Discussion

All faculty

09:00 - 09:50 CEST

Covid-19 and cachexia: common players and perspectives
Session W

09:00 - 09:10 CEST

The role of adipose tissue in Covid-19 cytokine storm: learning from cachexia

Marilia Seelaender, São Paulo, Brazil

Seelaender, Marilia

09:10 - 09:20 CEST

Nutrition: a matter of life or death

Alessandro Laviano, Rome, Italy

Laviano, Alessandro

09:20 - 09:30 CEST

Body composition and muscle quality in Covid-19 patients

Carla Prado, Edmonton, Alberta, Canada

Prado, Carla

09:30 - 09:40 CEST

Frailty and rehabilitation in Covid-19 patients

Francesco Landi, Rome, Italy

Landi, Francesco

09:40 - 09:50 CEST

Discussion

All faculty

10:00 - 10:50 CEST

Multi-modal interventions for cachexia
Session X

10:00 - 10:15 CEST

Evolution and outcomes from a multi-disciplinary cachexia clinic

Peter Martin, Melbourne, Australia

10:15 - 10:30 CEST

The importance of exercise and nutrition in an integrated response to cachexia management

Adrian Slee, London, United Kingdom

Slee, Adrian

10:30 - 10:50 CEST

Discussion

All faculty

11:00 - 11:50 CEST

Mechanisms of cancer cachexia – transition from basic research to clinical investigation
Session Y

11:00 - 11:10 CEST

MEF2c-dependent downregulation of myocilin mediates cancer-induced muscle wasting and associates with cachexia in patients with cancer

Andrew R. Judge, Gainesville, FL, USA

Judge, Andrew

11:10 - 11:20 CEST

Activation of p38β MAPK in skeletal muscle correlates with weight loss in cancer patients

Yi-Ping Li, Houston, TX, USA

Li, Yi-Ping

11:20 - 11:30 CEST

Association between growth differentiation factor-15 (GDF-15) serum levels, anorexia and low muscle mass among cancer patients

Alessio Molfino, Rome, Italy

11:30 - 11:40 CEST

Adipose depot gene expression and intelectin-1 in the metabolic response to cancer and cachexia

Richard J. E. Skipworth, Edinburgh, United Kingdom

Skipworth, Richard J. E.

11:40 - 11:50 CEST

Discussion

All faculty

12:00 - 12:45 CEST

Lunchtime session

14:00 - 14:50 CEST

Targeting cachexia treatment: GDF15 and beyond
Session Z

14:01 14-08 CEST

GDF15 neutralization as a transformative therapeutic approach

Bei Zhang, Cambridge, MA, USA

Zhang, Bei B.

14:08 - 14:16 CEST

GFRAL antibody in cancer cachexia

TBD

14:16 - 14:24 CEST

GDF-15 in the treatment of obesity

TBD

14:24 - 14:32 CEST

Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15

Danna Breen, Cambridge, MA, USA

14:32 - 14:40 CEST

MC4R antagonism for appetite and body weight regulation – from human genetics to aged rat model

Zhidan Wu, Cambridge, MA, USA

Wu, Zhidan

14:40 - 14:50 CEST

Discussion

* CEST, Central European Summer Time (UTC +2)
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