Scientific Program

11th International Conference on Cachexia, Sarcopenia & Muscle Wasting

The 11th International SCWD Conference on Cachexia, Sarcopenia and Muscle Wasting,
Maastricht, Netherlands, 07/12/2018-09/12/2018 has been accredited by the European
Accreditation Council for Continuing Medical Education (EACCME®) with 17 European CME credits
(ECMEC®s).
Each medical specialist should claim only those hours of credit that he/she actually spent
in the educational activity.”

Friday, 7 December 2018

 

10:00-11:30     A. Clinical and societal impact of cachexia & sarcopenia
                        Chairs: Annemie Schols (The Netherlands) & John Morley (USA)

Recent facts & figures
Stephan von Haehling (Germany)

Clinicians quest: geriatrician
Francesco Landi (Italy)

Clinicians quest: medical oncologist
Florian Strasser (Switzerland)

Clinicians quest: surgeon
Steven Olde Damink (The Netherlands)

Patients quest
TBD


11:30-12:00     Appetizer: Highlights of afternoon workshops

                         Annemie Schols & Workshop Chairs


12:00-13:00     Lunch


13:00-17:00     B. Workshops: Innovation & implementation

Due to limited capacity, registration is required

Workshop 1: Novel methodologies in basic cachexia research (50 seats)
Biomaterial production platforms
Lab on a chip
Radio-nucleotide lab
Human xenografts
Organoid culture facility

Workshop 2: Innovative approaches in human metabolic research and fMRI research (50 seats)
Whole body & tissue metabolism: respiration chambers, MS imaging, PET-MRI, Flusomics
Imaging: Brain fMRI, Radiomics

Workshop 3: Metabolic risk & outcome assessment (50 seats)
Body composition
Biomarkers
Physical performance & mobility
Physical activity
Cognitive performance
Patient reported outcomes (+ hands on training)

Workshop 4: Rehabilitation and advanced care planning (45-50 seats)
Visit the CIRO Centre of Expertise Chronic Organ Diseases
Tailored intervention modules: different exercise training modalities, NMES

 Workshop 5: Where science meets art: preserving and authenticating old master paintings (25 seats)

 

18:00-20:00    Welcome reception

 

Saturday, 8 December 2018

 

7:15-8:15     Ken Fearon Career Café – Meet the Mentor
                     Coordinated by Mitja Lainscak (Slovenia)

 

8:30-10:00     C. Multi-layered triggers of chronic disease associated wasting
                       Chairs: Annemie Schols (The Netherlands) & Wolfram Doehner (Germany)

Acute events upon chronic wasting in COPD

Clinical perspective
Frits Franssen (The Netherlands)

Basic research insights
Ramon Langen (The Netherlands)

Striated muscle pathology in cardiac cachexia

Clinical perspective
Mitja Lainscak (Slovenia)

Basic research insights
Jochen Springer (Germany)

Chronic kidney disease + accelerated aging

Clinical perspective
Kamyar Kalantar-Zadeh (USA)

Basic research insights
Xiaonan H. Wang (USA)


10:00-11:00     Break & Poster session



11:00-12:30     D. Late breaking clinical science & clinial trial update
                        Chairs: Stefan Anker (Germany) & Andrew Coats (UK)

Resistance training to build muscle mass in stage II and III colorectal cancer patients
Bette Caan (USA)

The effect of a six-month intensive strength training and strength-endurance training on muscle strength and body composition in older adults: A randomized controlled trial (1-21)
Keliane Liberman (Belgium)

Αcute effects of essential amino acid gel-based and whey protein supplements on appetite and energy intake in older women (5-04)
Theocharis Ispoglou (UK)

BIO101 accelerates differentiation and enhances mitochondrial function in skeletal muscle cells (4-11)
Maria Serova (France)

Short-term creatine supplementation reduces the malnutrition-inflammation score and attenuates lean body mass loss in hemodialysis patients (6-06)
Gustavo Pimentel (Brazil)

Update on ACTA agents for cancer cachexia
Andrew Coats (UK)

Development of botanical drug from purified ginseng extract for the treatment of cancer cachexia
Jin Kyung Lee (Korea)

 

11:00-12:30     E. Clinical track: emerging fields in critical illness wasting
                        Chairs: Kamyar Kalantar-Zadeh (USA) & Maurizio Muscaritoli (Italy)

Muscle metabolism and physiology in chronic critical illness
Zudin Puthucheary (UK)

Linking critical illness, chronic inflammation, and long-term muscle dysfunction
David Griffith (UK)

Persistent inflammation immunosuppression catabolic syndrome
Scott Brakenridge (USA)

Circadian rhythm in skeletal muscle homeostasis
Karyn Esser (USA)

Novel approaches to skeletal muscle loss in alcohol use and alcoholic liver disease
Srinivasan Dasarathy (USA)

NT-proBNP levels predict worse long-term physical function and muscle strength in sepsis survivors (1-28)
Robert Mankowski (USA)

 


12:30-13:30     Lunch break & Seminar

 


13:30-15:00     F. Basic track: tumor- and host-derived triggers of cachexia
                        Chairs: Stephan Herzig (Germany) & Denis Guttridge (USA)

Inflammation and control of muscle mass
James Carson (USA)

Muscle-derived growth factors and muscle atrophy
Vanina Romanello (Italy)

Tumor-derived Hsp-70/90 in cancer cachexia
Yi-Ping Li (USA)

Transfer of enzymatic activity of tumor-borne extracellular vesicles
Mauricio Berriel Diaz (Germany)

Tumor gp130 ligands expression and release in cancer cachexia
Teresa Zimmers (USA)


13:30-15:00     G. Clinical track: challenges of cancer induced wasting in the older patient
                         Chairs: Paola Costelli (Italy) & Florian Strasser (Switzerland)

Update on treatment options for cancer cachexia
Maurizio Muscaritoli (Italy)

When cancer cachexia occurs with sarcopenia
Aminah Jatoi (USA)

Proteomics and sarcopenia/frailty
Luigi Ferrucci (USA)

Controversies of comprehensive geriatric assessment in weight losing cancer patients
Paula Ravasco (Portugal)

Complex decision making in the older, weight-losing cancer patient
Alessandro Laviano (Italy)

Towards a more comprehensive understanding of the barriers to implementing nutritional advice in patients with cancer cachexia (6-02)
R. Thomas Jagoe (Canada)


15:00-16:00     Break & Poster session


16:00-17:30     H. Basic track: experimental models
                        Chairs: Fabio Penna (Italy) & Jochen Springer (Germany)

In vitro muscle culture: Muscling in on the third dimension
Lieven Thorrez (Belgium)

Mouse avatars in cancer cachexia
Andrew Judge (USA)

Natural (large animal) models of sarcopenia and cachexia
Lisa Freeman (USA)

An innovative experimental setup for characterizing in vivo muscle weakness in mouse models of cancer cachexia (3-30)
Julien Gondin (France)

Novel models of human pancreatic cancer cachexia heterogeneity by tumor organoids transplantation into mice (4-05)
Merel Aberle (The Netherlands)

Characterization of the endotoxin induced cachexia preclinical model (2-30)
Olivier Bezy (USA)


16:00-17:30     I. Clinical track: management guidelines for sarcopenia
                        Chair: Stephan von Haehling (Germany) & Luigi Ferrucci (Italy)

Rapid screening for sarcopenia
John Morley (USA)

The added value of the concepts of frailty and sarcopenia in the development of a proactive elderly care
Jos Schols (The Netherlands)

Screening for sarcopenia, frailty and anorexia in the community
Theodore Malmstrom (USA)

Guidelines for management of sarcopenia
Jürgen Bauer (Germany)

The natural course of body composition in hemodialysis patients (1-55)
Wesley J. Visser (The Netherlands)

Sex differences in the relationship of concurrent change in knee extension peak torque and body composition with change in gait speed (1-14)
Yusuke Osawa (USA)


17:30-18:30     J. Novel nutritional and pharmacological targets in cachexia and sarcopenia

                          Chairs: Samuel Breit (Australia) & Alessandro Laviano (Italy)

Epigenetic targeting of bromodomain protein BRD4
Giuseppina Caretti (Italy)

Non-classical targets in cancer cachexia: liver metabolism
Stephan Herzig (Germany)

GDF11/15 in skeletal muscle wasting
David Glass (USA)

PDK4 drives metabolic alterations and skeletal muscle atrophy in cancer cachexia
Andrea Bonetto (USA)

Multi-organ nutritional targets
Josep Argiles (Spain)


17:30-18:30     K. Rapid fire abstract session
                        Chairs/Judges: Bette Caan (USA), James Carson (USA), Wolfram Doehner (Germany), Mitja Lainscak (Slovenia) & Maurizio Muscaritoli (Italy)

Cross-sectional associations of n-6 plasma phospholipid fatty acids with circulating C-reactive protein and skeletal muscle mass in the EPIC-Norfolk cohort (1-01)
Richard P.G. Hayhoe (UK)

Longitudinal muscle and myocellular changes in community-dwelling men over two decades of successful aging – The ULSAM cohort revisited (1-30)
Elisabeth Skoglund (Sweden)

Prognostic role of muscle, fat, and bone mass in heart failure (1-39)
Masaaki Konishi (Japan)

Effects of mitochondrial targeting with SS-31 in cancer-induced muscle wasting (2-03)
Riccardo Ballarò (Italy)

Integrative transcriptome and miRNAome analysis reveals extracellular matrix remodeling during muscle atrophy in cancer cachexia (2-12)
Geysson Javier Fernandez (Brazil)

Depot specific adipose mRNA transcriptomics in cancer cachexia (2-20)
Janice Miller (UK)

Identification of potential cancer cachexia biomarkers by tumor transcriptome analysis in non-small cell lung cancer patients with low muscularity (2-27)
Sarah Santiloni Cury (Brazil)

Detection of sarcopenia and cachexia during the recording of the routine 12 channel ECG (Combyn™ ECG) (4-01)
Falko Skrabal (Austria)

Muscle microRNAs predict muscle wasting following cardiac surgery (4-02)
Paul Kemp (UK)

Skeletal muscle collagen content is increased in cachectic pancreatic cancer patients and is a significant predictor of survival (5-08)
Sarah M. Judge (USA)

Sunday, 9 December 2018

 

8:30-10:00     L. Multilayered triggers of cancer cachexia
                      Chairs: Andrea Bonetto (Italy) & Aminah Jatoi (USA)

Tumor-induced local tissue dysfunction contributing to cachexia

Dysphagia in sarcopenia and head and neck cancer
Hidetaka Wakabayashi (Japan)

IL-6 trans-signaling among tumor, muscle and fat mediates pancreatic cancer cachexia (2-28)
Joseph Rupert (USA)

Tumor-host interactions in cachexia

Inflammation-adipocyte crosstalk in muscle wasting
Marilia Seelaender (Brazil)

Tumor-induced immune- and metabolic reprogramming
Thomas Flint (UK)

Tumor treatment-induced muscle wasting

Influence of the gut microbiota on anticancer immunosurveillance
Areille Elkrief (France)

Preventing chemotherapy-induced heart and muscle wasting
Riikka Kivelä (Finland)


10:00-11:00     Break & Poster session


11:00-12.30     M. Basic track: (intra)cellular mechanisms of muscle wasting
                        Chairs: Mauricio Berriel Diaz (Germany) & James Carson (USA)

Altered muscle proteostasis in muscle wasting
Marco Sandri (Italy)

Role of microRNAs in muscle wasting
Paola Costelli (Italy)

Muscle progenitor cell function and muscle wasting
Denis Guttridge (USA)

Inflammatory and glucocorticoid signaling in muscle atrophy
Rowan Hardy (UK)

IBloom of Enterobacteriaceae in cancer cachexia: Klebsiella oxytoca as a gut pathobiont contributing to intestinal dysfunction (3-22)
Laure B. Bindels (Belgium)


11:00-12:30     N. Translational track: anabolic resistance in sarcopenia and cachexia: myth or opportunity?
                        Chairs: Jürgen Bauer (Germany) & Francesco Landi (Italy)

Sarcopenic obesity
Yves Boirie (France)

Physical inactivity accelerates sarcopenia and leads to metabolic dysfunction
Luc van Loon (The Netherlands)

Exercise as therapeutic approach in cancer cachexia
Fabio Penna (Italy)

Cell therapy for muscle injury – preclinical model and clinical application
Tobias Winkler (Germany)

Leucine nutritional supplementation modulates the tumour-induced alteration in energy metabolism and production in skeletal muscle activity (6-10)
Maria Cristina Cintra Gomes-Marcondes (Brazil)

Distinct skeletal muscle molecular responses to pulmonary rehabilitation in COPD: a cluster analysis (1-48)
Anita E.M. Kneppers (The Netherlands)

Prolonged exercise training improves acute type II skeletal muscle fiber stem cell response in healthy older men (1-23)
Tim Snijders (Canada)


12:30-13:30     Lunch Break & Seminar


13:30-14:30     O. Translational track: omics approaches in cachexia & sarcopenia research

                         Chairs: Alexander Ebhardt (Switzerland) & Filippo Rossi-Fanelli (Italy)

Extra-cellular vesicles in tissue crosstalk during exercise
Martin Whitham (Australia)

TBD
Iain Gallagher (UK)

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle
Swarnali Acharyya (USA)

Small RNAome profiling of skeletal muscle in cancer cachexia
Sambasivarao Damaraju (Canada)


13:30-14:30     P. Clinical track: novel intervention strategies and clinical study designs
                        Chairs: Jeff Crawford (USA) & John Morley (USA)

Cancer cachexia development update
Stefan Anker (Germany)

Nutrition & pharma joining forces
Annemie Schols (The Netherlands)

P4 medicine in cachexia & sarcopenia
John Morley (USA)

The regulator’s update: EMA, cachexia and sarcopenia
Giuseppe Rosano (UK)


14:30-16:00     Q. Highlights session
                        Chairs: Stefan Anker (Germany) & Annemie Schols (The Netherlands)

Treatment
Andrew Coats (UK)

Imaging
Steven Heymsfield (USA)

Biomarker/Sarcopenia
Stephan von Haehling (Germany)

Basic
Didier Attaix (France)


Best Poster Awards
Farewell