Scientific Program

12th International Conference on Cachexia, Sarcopenia & Muscle Wasting

Berlin, 06-08 Dec 2019 

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                                                                               Friday, 6 December 2019
9:00-10:30
A) Opening Session

“Prometheus” basic science key note lecture:
Proteolysis in muscle wasting: past, present and future
Didier Attaix (France)

“Hippocrates” clinical science key note lecture
Why skeletal muscle matters in chronic heart failure

Andrew Coats (UK)

Recent facts & figures: Cachexia & SCWD
Stefan Anker (Germany)

Recent facts & figures: sarcopenia & frailty (the JCSM lecture)
Stephan von Haehling (Germany)

 

10:30-11:00
Coffee Break

11:00-13:00
B) Novel targets parade

State of the art lecture: Therapeutic interventions targeting mitochondria – rationale & clinical results
Michelangelo Mancuso (Italy)

Novel tumor-derived mediators of cachexia
Mauricio Berriel Diaz (Germany)

Metastasis and cancer cachexia
Swarnali Acharyya (USA)

Epi-genomics landscapes in cancer cachexia
Søren Fisker-Schmidt (Germany)

Mechanism of p300 activation and mediation of muscle wasting in cancer cachexia
Yi-Ping Li (USA)

Targeting the ubiquitin-proteasome system to counteract cancer cachexia – update 2019
Volker Adams (Germany)

Intervention strategies targeting Critical Illness Myopathy (CIM) and Ventilator Induced Diaphragm Dysfunction (VIDD)
Lars Larsson (Sweden)

Activating Mas receptor to reduce cachexia
Gordon Lynch (Australia)

C) Bone and muscle interactions in cachexia and sarcopenia

Musculoskeletal complications of cancer and its treatments
Andrea Bonetto (USA)

Muscle-bone crosstalk – results from the experimental studies
Robert Kob (Germany)

Bone-muscle crosstalk in bone metastatic cancer
David Waning (USA)

Role of muscle and bone factors in energetics and metabolism
Gustavo Duque (Australia)

 The role of microRNAs in osteosarcopenia
Hanna Taipaleenmäki (Germany)

Does testosterone play a key role in osteosarcopenia?
Giuseppe Rosano (UK)

Low muscle mass and strength as a risk factor for fracture – clinical studies
Jürgen Bauer(Germany)

Impact of the fracture on muscle strength and physical performance
Pawel Szulc (France)

Receptor-modified approach on anorexia-cachexia syndrome with an emphasis of ghrelin-neuropeptide Y-orexin hunger system
Yasuhito Uezono (Japan)

13:15-14:15
Lunch Seminar

14:30-16:00
D) Cachexia, sarcopenia and frailty in acute illness: clinical discussion

Assessing muscle and fat mass using imaging and biomarker tests in the critical ill: practical approach
Emanuele Marzetti (Italy)

Critical-illness induced wasting of muscular fat tissue
Werner Z’Graggen (Switzerland)

Critical-illness acquired weakness (ICU-AW)
Tobias Wollersheim (Germany)

Outlook: additional critical illness induced neuromuscular dysfunctions
Joerg Schefold (Switzerland)

Nutritional interventions in the ICU: an overview
Arthur van Zanten(The Netherlands)

E) Myogenesis for cachexia / sarcopenia

Mesoangioblast-driven muscle regeneration in aging
Maurilio Sampaolesi (Belgium)

Twist1, myogenesis and cancer cachexia
Azeddine Atfi (USA)

The S100B/RAGE pathway in myogenesis impairment
GuglielmoSorci (Italy)

Myoparr, a novel mediator of muscle wasting
Kunihiro Tsuchida (Japan)

The relevance of studying old vs. young animals
Connie Jackaman (Australia)

 16:00-17:00
Coffee Break

16:05-16:55
Poster Session 1

16:10-16:50
Rapid Fire Abstracts Session 1
(8 abstracts / 5 min)

17:00-18:30
F) Cachexia in chronic illness: update 2019

Cachexia in chronic obstructive pulmonary disease
Annemie Schols (The Netherlands)

Cachexia and protein-energy wasting liver disease
Srinivasan Dasarathy(USA)

Diagnosis, treatment and prevention of cardiac cachexia in heart failure
Stephan von Haehling (Germany)

Liver cachexia
Matthias Plauth (Germany)

Anorexia and cachexia
Maurizio Muscaritoli (Italy)

G) Muscle stem cells and regeneration in sarcopenia and cachexia

Regulation of muscle stem cells and regeneration during aging in humans
Abigail Mackey (Denmark)

Cross-talk between muscle stem cells, inflammation and fibrosis during muscle regeneration in aging
Alessandra Sacco (USA)

Therapeutic interventions targeting cellular communication in the aged stem cell niche
Jerome Feige (Switzerland)

Myogenic commitment in cancer cachexia
Denis Guttridge (USA)

Cell therapy of muscle injuries: basic principles and new insights in mechanisms
Sven Geißler (Germany)

18:30-19.30
Wine & Cheese Welcome Reception in Poster Area

Saturday, 7 December 2019

7:00-7:50
SCWD Board Meeting

 8:00-8:45
Breakfast Seminar
Ken Fearon Career Café – Meet the Mentor
Coordinated by Mitja Lainscak, Slovenia

Statistical Seminar
Jennifer Le-Rademacher
Ruta Brazauskas

9:00-10:30
H) Symptoms of patients with cachexia and their therapy

Shortness of breath
Markus Anker

Swallowing problems
Hidetaka Wakabayashi (Japan)

Pain
Florian Strasser (Switzerland)

Depression
Joanne Reid (Ireland)

Muscle weakness and fatigue: how to assess objectivity
Richard Dunne (USA)

I) Mitochondria: a nexus for muscle wasting and impaired metabolism

Mitochondrial dynamics in the regulation of muscle mass
Antonio Zorzano (Spain)

Oxidative stress impact on muscle mass and function
Maria Carmen Gomez-Cabrera (Spain)

Feeding mitochondria to counteract cachexia
Klaske van Norren (The Netherlands)

Exercise and oxidative metabolism in muscle wasting
James Carson (USA)

Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation
Joseph Gordon (Canada)

10:30-11:30
Break

10:35-11:25
Poster session 2

10:40-11:20
Rapid Fire Abstracts Session 2
(8 abstracts / 5 min)

 

11:30-13:00
J) Sarcopenia and frailty in chronic illness

Sarcopenia in chronic kidney disease and its therapy
Kamyar Kalantar-Zadeh (USA)

Sarcopenia in COPD and its therapy
Ramon Langen (The Netherlands)

Heart failure sarcopenia and adiposity paradox
Mitja Lainscak (Slovenia)

Heart Failure Association/European Society of Cardiology position paper on frailty in patients with heart failure
Cristiana Vitale (Italy)

K) Cachexia, sarcopenia and frailty in acute illness: from mechanisms to therapy

Satellite cells, inflammation and senescence
Stephen Harridge (UK

The inflammatory “genomic storm” post trauma and sepsis – a driver of rapid muscle wasting
Scott Brakenridge (USA)

Age-related signaling and expression changes that may contribute to sarcopenia
David Glass (USA)

Post-sepsis microenvironment alterations in wasting muscle and adipose tissue
Jason Doles (USA)

Electrical stimulation as an intervention in the critically ill
Steffen Weber-Carstens (Germany)

Potential nutritional interventions to prevent acute muscle wasting
Alessandro Laviano (Italy)

13:15-14:15
Lunch Seminar Session on Cachexia Research sponsored by
Chairs: Dr. Bei Zhang and Prof. Stefan Anker

Introduction: Cachexia Unmet Needs, Opportunities and Challenges
Bei Zhang, USA

  • Overview of Research in Cachexia
    – Cancer Cachexia focus : HT1080 tumor cachexia model for preclinical research
    Danna Breen, USA
    – Non-Cancer Cachexia Focus: Preclinical models for non-cancer related cachectic and wasting condition
    Zhidan Wu, USA
  • Wrap up: Where do we go from here
    Stefan Anker, Germany

 

14:30-16:00
L) Late breaking clinical science and clinical trial update

The EFFORT study – effective to preserve muscle mass and functional outcomes in critically ill patients
Christian Stoppe (Germany)

The HIPGEN Study – Allogeneic cell therapy for muscle injury in phase III
Tobias Winkler(Germany)

Endocrine manipulation of cachexia in mice with lung cancer
Marcus DaSilva Goncalves (USATBD

Beyond ROMANA: moving forward with the anamorelin phase 3 SCALA program
Ruben Giorgino (Switzerland)

Iodide reduces cachexia in a BALB/c CT26 mouse tumor model
Michael Insko (USA)

 Effect of Elamipretide on exercise, muscle strength, and heart function in patients with Barth Syndrome after 48 weeks of therapy
Jim Carr (USA)

 M) Sarcopenia and aging – diagnosis, exercise, nutrition

The SCWD consensus on sarcopenia
John Morley (USA)

Screening for sarcopenia
Angela Sanford (USA)

Exercise as a treatment of frailty in hospital care
Mikel Izquierdo (Spain)

Treating sarcopenia in a rural community
Janice Lundy (USA)

Herbal medicine based nutrition
Akio Inui (Japan)

 16:00-17:00
Coffee Break

16:05-16:55
Poster session 3

16:10-16:50
Rapid Fire Abstracts Session 3
(8 abstracts / 5 min)

 

17:00-19:00
N) Hot topic in muscle wasting

Molecular mechanisms and promising therapies in Muscle wasting
Amanda Vest (USA)

Mytho a novel player in autophagy and cancer
Marco Sandri (Italy)

Key facilitator proteins that mediate sarcolemma membrane repair have potential as therapeutics for muscle disease and injury
Noah Weisleder (USA)

Role of the microcirculation in muscle wasting and plasticity
Hans Degens (UK)

Tissue sodium accumulation and peripheral insulin sensitivity in maintenance hemodialysis patients
Talat Alp Ikizler (USA)

Apelin and sarcopenia of aging
Cédric Dray (France)

Deacetylase inhibitors to treat muscle wasting
Vered Raz (The Netherlands)  

An update on the role of anabolic steroids in muscle wasting
Jeffrey Crawford (USA)

 O) The fat and appetite session

An update on brown fat
Josep Argiles (ESP)

Brown fat and cancer cachexia: understanding interactive mechanisms
Annemie Schols (The Netherlands)

Measuring brown fat in humans
Jan Nedergaard  (Sweden)

TLR4 involvement in adipose tissue loss in cancer cachexia
Miguel L. Batista (BR)    

A novel cancer variant discovered by identifying tumor-driven changes in fat redistribution
Oliver Bathe (Canada)

The clinical impact and spectrum of obesity and cancer
Aminah Jatoi (USA)

The gap between existing large population data and the need of novel database relevant to cachexia
Melissa Miller (USA)

In-vivo screening platform to identify new pro-cachectic/anorectic tumor factors
Olivier Bezy (USA)

 

Sunday, 8 December 2019

 

7:30-8:20
Breakfast Seminar

Ken Fearon Career Café – Meet the Mentor
Coordinated by Mitja Lainscak, Slovenia

7:30-8:15
Statistical Seminar
Jennifer Le-Rademacher
Ruta Brazauskas

8:30-10:00
P) Neurological impact of sarcopenia

Neurophysiological basis of anorexia-cachexia syndrome
Toshihiko Yada (Japan)

Sarcopenia in neuromuscular diseases
Gabriele Siciliano (Italy)

Stroke and sarcopenia
Wolfram Doehner (GER)

Dementia and sarcopenia. A vicious circle
Rainer Wirth (Germany)

Brain wasting
Matthias Endres (Germany)

Q) Young Investigators Awards Session – Clinical & Basic
(Finalists:  3 abstracts clinical / 3 abstracts basic)

Presentations will be selected from submitted abstracts. Each presenter has 10 min for presentation & 5 min for discussion by the panel of chairs & judges.

 10:00-11:00
Coffee Break

 10:05-10:55
Poster session 4

 11:00-12.30

R) Sex matters in cachexia
(Clinical)

Chairs:
Filippo Rossi-Fanelli (Italy)

Multi-platform omics analyses document distinct phenotypes and mechanisms in cancer cachexia
Vickie Baracos (CAN)

Sex-specific differences in treatment response in cancer cachexia
Jose Garcia (USA)

Sex specific phenotypes, mechanisms, and treatment response in mice and humans with pancreatic cancer
Xiaoling Zhong (USA)

Sex differences in imaging for cachexia
Steven Heymsfield (USA)

The role of estrogen in cachexia-induced metabolic disruptions
James Carson (USA)

S) Cancer- and chemotherapy-induced wasting

Chemotherapy-induced metabolic abnormalities in cancer cachexia
Thomas O’Connell (USA)

Skeletal muscle adaptations to cancer and chemotherapy and the protective effects of exercise
Micheal Toth (USA)

Effects of Activin inhibition on chemotherapy-induced cachexia
Juha Hulmi (Finland)

Chemotherapy to delay/counteract cachexia
Fabio Penna (Italy)

Cancer mediated cardiac wasting – update 2019
Stephan Herzig (Germany)

12:30-13:00
Break

13:00-13:45
T) Frailty and Sarcopenia

Characterisation of the frail geriatric patient
Francesco Landi (Italy)

Exercise to improve muscle health and cancer outcomes
Bette Caan (USA)

Nutritional interventions: what is the evidence?
TBD

 

13:45-15:15
U) Novel ideas to enhance muscle mass and function.

Targeting the GDF15/MIC-1 pathway for anorexia / cachexia
Samuel Breit (AUS)

Satellite cells, muscle regeneration, and cancer cachexia
Jason Doles (USA)

CD8 T cells – a novel player in cachexia during viral infection
Andreas Bergthaler (Austria)

Making patients fat again: good idea? If so, how?
Andrew Coats (UK)

Data-driven identification and optimization of new medicines for cancer cachexia
Ben Zeskind (USA)

 

15:15-16:00
V) Highlights Session

 Highlights Basic Science

Highlights Clinical Science & Nutrition

Highlights Treatment

Poster Awards
Young Investigator Awards
Farewell