Scientific Program

12th International Conference on Cachexia, Sarcopenia & Muscle Wasting

Berlin, 06-08 Dec 2019 

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                                                                               Friday, 6 December 2019
9:00-10:30
A) Opening Session

“Prometheus” basic science key note lecture

“Hippocrates” clinical science key note lecture

Recent facts & figures: sarcopenia & frailty (the JCSM lecture)

Recent facts & figures: Cachexia & SCWD

10:30-11:00
Coffee Break

11:00-13:00
B) Novel targets parade

The role of brain CCR2 in cachexia or neuroinflammation and cancer cachexia

Novel tumor-derived mediators of cachexia

Metastasis and cancer cachexia

Epi-genomics landscapes in cancer cachexia

Therapeutic effects of creatine supplementation and exercise in cachexia

Activating Mas receptor to reduce cachexia

Mechanism of p300 activation and mediation of muscle wasting in cancer cachexia
TBD
TBD

C) Bone and muscle interactions in cachexia and sarcopenia

Musculoskeletal complications of cancer and its treatments

Bone-muscle crosstalk in bone metastatic cancer

Wnt pathway in bone-muscle crosstalk

Role of soluble factors in muscle/bone interactions

Role of muscle and bone factors in energetics and metabolism

Muscle-bone crosstalk – results from the experimental studies

Does testosterone play a key role in osteosarcopenia?

Low muscle mass and strength as a risk factor for fracture – clinical studies

Impact of the fracture on muscle strength and physical performance

13:15-14:15
Lunch Seminar

14:30-16:00
D) Cachexia, sarcopenia and frailty in acute illness: clinical discussion

Assessing muscle and fat mass using imaging and biomarker tests in the critical ill: practical approach

Critical-illness induced wasting of muscular fat tissue

Critical-illness acquired weakness (ICU-AW)

Outlook: additional critical illness induced neuromuscular dysfunctions

Nutritional interventions in the ICU: an overview

E) Myogenesis for cachexia / sarcopenia

Mesoangioblast-driven muscle regeneration in aging

Twist1, myogenesis and cancer cachexia

The S100B/RAGE pathway in myogenesis impairment

Myoparr, a novel mediator of muscle wasting

The relevance of studying old vs. young animals

16:00-17:00
Coffee Break

16:05-16:55
Poster Session 1

16:10-16:50
Rapid Fire Abstracts Session 1

(8 abstracts á 5 min)

17:00-18:30
F) Cachexia in chronic illness: update 2019

Cachexia in chronic obstructive pulmonary disease.

Cachexia and protein-energy wasting liver disease

Diagnosis, treatment and prevention of cardiac cachexia in heart failure

Liver cachexia

Anorexia and cachexia

G) Muscle stem cells and regeneration in sarcopenia and cachexia

Regulation of muscle stem cells and regeneration during aging in humans

Cross-talk between muscle stem cells, inflammation and fibrosis during muscle regeneration in aging

Therapeutic interventions targeting cellular communication in the aged stem cell niche

Myogenic commitment in cancer cachexia

Allogeneic cell therapy for muscle injury in phase III

 18:30-19.30
Wine & Cheese Welcome Reception in Poster Area

Saturday, 7 December 2019

 8:00-8:45

Breakfast Seminar
Ken Fearon Career Café – Meet the Mentor
Statistical Seminar

9:00-10:30
H) Symptoms of patients with cachexia and their therapy

Shortness of breath

Swallowing problems

Pain

Depression

Muscle weakness and fatigue: how to assess objectivity

I) Mitochondria: a nexus for muscle wasting and impaired metabolism

Mitochondrial dynamics in the regulation of muscle mass

Oxidative stress impact on muscle mass and function

Feeding mitochondria to counteract cachexia

Exercise and oxidative metabolism in muscle wasting

Therapeutic interventions targeting mitochondria – clinical results

10:30-11:30
Break

 10:35-11:25
Poster session 2

10:40-11:20

Rapid Fire Abstracts Session 2
(8 abstracts á 5 min)

 

11:30-13:00

J) Sarcopenia and frailty in chronic illness

Sarcopenia in chronic kidney disease and its therapy

Sarcopenia in COPD and its therapy

Heart failure sarcopenia and adiposity paradox

Fraility and muscle function in chronic illness

Adipose tissue browning and vitamin D in chronic illness

 

K) Cachexia, sarcopenia and frailty in acute illness: from mechanisms to therapy

Satellite cells and inflammation:

The inflammatory “genomic storm” post trauma and sepsis- a driver of rapid muscle wasting

TBD

Post-sepsis microenviroment alterations in skeletal muscle wasting

Electrical stimulation as an intervention in the critically ill

Potential nutritional interventions to prevent acute muscle wasting

13:15-14:15
Lunch Seminar

 

14:30-16:00

L) Late breaking clinical science and clinical trial update

The EFFORT study – effective to preserve muscle mass and functional outcomes in critically ill patients

TBD

TBD

TBD

TBD

 M) Sarcopenia and aging – diagnosis, exercise, nutrition

The SCWD consensus on sarcopenia

Screening for sarcopenia

Exercise in the acute hospital

Treating sarcopenia in a rural community

Herbal medicine based nutrition

16:00-17:00
Coffee Break

16:05-16:55
Poster session 3

 

16:10-16:50
Rapid Fire Abstracts Session 3
(8 abstracts á 5 min)

 

17:00-19:00

N) Hot topic in muscle wasting

Molecular mechanisms and promising therapies in Muscle wasting

Mytho a novel player in autophagy and cancer

Key facilitator proteins that mediate sarcolemma membrane repair have potential as therapeutics for muscle disease and injury

An epigenetic mechanism suppresses muscle protein synthesis by regulation of ribosomal biogenesis in catabolic conditions

Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation

Tissue sodium accumulation and peripheral insulin sensitivity in maintenance hemodialysis patients

Apelin and sarcopenia of aging

Deacetylase inhibitors to treat muscle wasting

TBD

O) The fat and appetite session

An update on brown fat

Brown fat and cancer cachexia: understanding interactive mechanisms

Measuring brown fat in humans

TLR4 involvement in adipose tissue loss in cancer cachexia

Targeting the GDF15/MIC-1 pathway for anorexia/cachexia

MC3R modulate locomotor activity, energy expenditure, and adiposity in mice

Mining the genetics of obesity in humans for novel opportunities against cachexia

The gap between existing large population data and the need of novel database relevant to cachexia

In-vivo screening platform to identify new pro-cachectic/anorectic tumor factors

 

Sunday, 8 December 2019

 

 

7:30-8:20
Breakfast Seminar
Ken Fearon Career Café – Meet the Mentor
Statistical Seminar

 

8:30-10:00

P) Neurological impact of sarcopenia

Stroke and sarcopenia

Sarcopenia in neuromuscular diseases

Dementia and sarcopenia. A vicious circle.

Mitochondrial impact on sarcopenia

Brain wasting

 

Q) Young Investigators Awards Session – Clinical & Basic
(Finalists:  3 abstracts clinical / 3 abstracts basic)

Presentations will be selected from submitted abstracts. Each presenter has 10 min for presentation & 5 min for discussion by the panel of chairs & judges.

 10:00-11:00
Coffee Break

 10:05-10:55
Poster session 4

 11:00-12.30

R) Sex matters in cachexia

Multi-platform omics analyses document distinct phenotypes and mechanisms in cancer cachexia

Sex differences in imaging for cachexia

The role of estrogen in cachexia-induced metabolic disruptions

Sex-specific differences in treatment response in cancer cachexia

Sex specific phenotypes, mechanisms, and treatment response in mice and humans with pancreatic cancer

TBD

S) Cancer- and chemotherapy-induced wasting

Chemotherapy-induced metabolic abnormalities in cancer cachexia

Skeletal muscle adaptations to cancer and chemotherapy and the protective effects of exercise

Effects of Activin inhibition on chemotherapy-induced cachexia

Chemotherapy to delay/counteract cachexia

TBD
TBD

12:30-13:00
Break

13:00-13:45

T) Frailty in major chronic illnesses

Impact and definition

Screening tools

Management

 

13:45-15:15

U) Mind-bending therapeutic ideas to enhance muscle functionality

Spider dragline silk as a potential component of artificial muscle

Resilience training and results in war veterans who have lost limbs

Muscle satellite cells and their role in regenerative medicine

Making patients fat again: good idea? If so, how?

Data-driven identification and optimization of new medicines for cancer cachexia

 

15:15-16:00

V) Highlights Session

 Highlights Basic Science

Highlights Clinical Science & Nutrition

Highlights Treatment

Poster Awards
Young Investigator Awards
Farewell