Transcriptional intermediary factor 1ฮณ (TIF1ฮณ) is a negative regulator of TGF-ฮฒ1 signalling and has been associated with patient survival in renal cell carcinoma. However, its role in diabetes mellitus (DM), particularly in diabetic nephropathy (DN), remains unclear. DN is the...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Although sarcopenia and insulin resistance are closely related, there is limited evidence regarding how they interact to influence mortality across different population groups. The purpose of this study was to examine the relationship between skeletal muscle mass and insulin resistance...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
G protein-coupled receptor 40 (GPR40) acts as a modulator of various physiological functions, including glycaemic lowering, anti-inflammation and antioxidative stress, in several tissues. However, the role of GPR40 in skeletal muscles remains unclear. To investigate the roles of muscle GPR40,...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The prevalence of obesity is rising around the world, as the number of subjects dieting and experiencing weight loss followed by unintentional weight regain, the so-called weight cycling (WC). In this narrative review we sought to reveal the effects of...
๐๏ธ 2025-04-15
๐ฐ Publication: Reviews In Endocrine & Metabolic Disorders
Skeletal muscle function and mass continuously decrease during aging. Most studies target limb muscles owing to their direct impact on mobility and falls risk. The diaphragm (DIA), also a type of skeletal muscle with different phenotype, has received less attention....
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Hospitalization in older adults often worsens sarcopenia due to prolonged bed rest, poor nutrition, and inactivity. This study examined how hospitalization impacts muscle mass, focusing on oxidative stress and gut-derived endotoxemia. Thirty-one hospitalized older adults were compared with 31 outpatients....
The interrelation between non-alcoholic fatty liver disease (NAFLD) and sarcopenia has emerged as a significant concern due to its systemic impact on metabolic health. However, therapeutic approaches targeting the liver-muscle axis remain underdeveloped. Oxidative stress and inflammatory pathways are key...
Sarcopenia is the age-related loss of skeletal muscle mass and function. Recently, research has focused on defining diagnostic criteria for this condition, now recognized as a muscle disease with a specific identifying code (ICD-10: M62.84). The diagnostic process for sarcopenia...
Non-steroidal anti-inflammatory drugs (NSAIDs) may influence musculoskeletal health. The purpose of this study was to compare the effects of three different NSAIDS: naproxen sodium, ibuprofen, flurbiprofen or a placebo on musculoskeletal adaptations in rodents with or without 6โweeks of aerobic...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Fasting shows promise for public health, but concerns about muscle loss hinder its acceptance, particularly among the elderly. We explored the impact of long-term fasting (12โdays, 250โkcal/day) on muscle structure, metabolism and performance. We prospectively assessed muscle volume, composition, relaxometry...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Programmed cell death plays a critical role in skeletal muscle atrophy. Ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy remains unclear. Ferroptosis in...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Hypothalamic inflammation plays a pivotal role in appetite dysregulation across various pathological conditions, including cancer cachexia. However, delivering anti-inflammatory agents to microglia, key mediators of hypothalamic inflammation, remains challenging due to the unsurmountable blood-brain barrier (BBB). To overcome this challenge,...
Around 80% of patients with advanced cancer have cancer cachexia (CC), a serious complication for which there are currently no FDA-approved treatments. Nuciferine (NF) is the main active ingredient of lotus leaf, which has anti-inflammatory, anti-tumour and other effects. The...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Additional tools are needed to assess mortality risk among patients with cancer. Patients with chronic graft vs. host disease (cGVHD) after allogeneic haematopoietic cell transplantation (HCT) represent a high-risk cancer population with mortality risk explained by cGVHD severity, but also...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
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