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Programme

Join us for the Annual Conference on Sarcopenia, Cachexia, and Wasting Disorders, taking place from December 6th to 8th, 2024. Engage with leading experts and delve into a comprehensive program that spans from revolutionary basic science to transformative clinical trials. This event is a critical platform for showcasing the latest research and advancements, offering multidisciplinary insights into these complex conditions. Register today to contribute to groundbreaking discussions and network with peers.

EDT Time zone (UTC -4)

Exploring Sarcopenia and Cachexia: Multidisciplinary Perspectives

Welcome to the first day of our Annual Conference on Sarcopenia, Cachexia, and Wasting Disorders. Discover world-renowned experts to discuss the latest research and advancements in the field. 

CANCER CACHEXIA

9:30-10:30

HALL A

Session A: Abnormal metabolism in cachexia

Role of PRPS1 in age- and cancer-induced skeletal muscle atrophy

Metabolic crosstalk mechanisms in cancer cachexia

cAMP/CREB1-derived mitochondrial dysfunctions in cachexia

Altered energy metabolism contributes to impaired muscle function in cachexia

Chairs & Speakers

Stefan Anker, Germany

Vickie Baracos, Germany

Gianluigi Savarese, Sweden
Daniel Marks, MD, PhD
Daniel Marks, USA
Maurizio Muscaritoli, Italy
Maurizio Muscaritoli, Italy
Stephan von Haehling, Germany

GENERAL SARCOPENIA

10:45-11:45

HALL A

Session B: New findings on muscle wasting

Identifying Mytho as a new regulator of muscle autophagy

EDA2R-NIK signaling promotes muscle atrophy linked to cancer cachexia

Regulation of muscle sarcomere assembly and bioenergetics by an unsuspected E3 ligase: Implications for the diagnostics of myopathies

GLP-2 treatment improves muscle recovery following starvation in rats: a clinical opportunity to reverse muscle wasting?

Chairs & Speakers

Ivan Aprahamian, Brazil
Ivan Aprahamian, Brazil
Gustavo Duque, Canada
Hidetaka Wakabayashi, Japan
Gianluigi Savarese, Sweden

BREAK

12:00-12:50

Lunch Break

Ivan Aprahamian, Brazil
Ivan Aprahamian, Brazil
Gustavo Duque, Canada
Hidetaka Wakabayashi, Japan
Gianluigi Savarese, Sweden

Opening Session

13:00-14:10

HALL A

Session C: Opening Session

Welcome

“Prometheus” basic science key note lecture: Evolution of Cachexia – Adaptive to Maladaptive
Teresa Zimmers, USA

“Hippocrates” clinical science key note lecture

JCSM & SCWD lecture

Chairs & Speakers

Teresa Zimmers, USA
Teresa Zimmers, USA

Coffee Break

14:10-14:30

MECHANISMS, DIAGNOSTICS

Session D

14:30-15:45

Advances on the roles of cancer-released extracellular vesicles in cachexia

Cancer-cell-secreted extracellular vesicles target p53 in impair mitochondrial function in muscle

Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells

Lipolysis by pancreatic cancer-derived extracellular vesicles in cancer-associated cachexia via specific integrins

Chemotherapy drugs 5-FU and cisplatin promote cachexia by stimulating extracellular vesicle release from cancer

Chairs & Speakers

Ivan Aprahamian, Brazil
Ivan Aprahamian, Brazil
Marianne Hjermstad, Norway
Marianne Hjermstad, Norway
Gustavo Duque, Canada 
Reshma Merchant, Singapore
James Carson, USA
David Glass, USA
CANCER CACHEXIA

Session E

14:30-15:45

Understanding Dysregulated Metabolic Homeostasis in Cancer Cachexia

Tumor-induced physiological changes in the host in cachexia

Sustained tissue glucose consumption despite reduced food intake in cancer cachexia

Imaging metabolic adaptions in cancer cachexia using positron emission tomography (PET)

Improving insulin sensitivity to treat cancer cachexia in humans

Chairs & Speakers

Nick Hoogenraad, Australia
Nick Hoogenraad, Australia
Stephan von Haehling, Germany
Samuel Breit, Australia
Swarnali Acharyya, USA
Puneeth Iyengar, USA 
Emanuele Marzetti, Italy

Coffee Break

15:45-16:45

POSTER SESSION

Poster Session 1

15:50-16:40

Chairs

Denis Guttridge, USA
Jochen Springer, Germany
Joanne Reid, UK
Florian Strasser, Switzerland
Stuart Phillips, Canada
Stuart Phillips, Canada
Adrian Slee
Adrian Slee, UK
Swarnali Acharyya, USA
Philip Atherton, UK
ABSTRACT SESSION

Rapid Fire Abstracts Session 1

15:50-16:40

Chairs

Elke Dworatzek, Germany
Maria Rohm, PhD
Maria Rohm, Germany
Erin Talbert, USA

16:45-18:00

NUTRITION

Session F

Nutrition and translational cachexia research

Nutritional treatment options in cancer care

Microbiota and nutrition in oncology: new player?

Balanced nutrition to prevent proetin-energy wasting and preseve renal function in chronic kidney diesease

Uncoupling chronic cardiac wasting-associated cardiomyopathy from tumor and skeletal muscle wasting in cancer cachexia

Chairs & Speakers

Abigail Mackey, Denmark
Abigail Mackey, Denmark
Hidetaka Wakabayashi, Japan
Akira Tamaki, Japan 
Robert Mak, USA
Marielle Engelen, USA
Stephan von Haehling, Germany
GENERAL SARCOPENIA

Session G

Body composition changes induced by GLP1-RA in obesity therapy

The GLP1-RA evidence base for clinical benefits in obesity

How do GLP1-RA cause weight loss?

TBN

Body composition changes when giving GLP1-RA

Anabolic co-treatment in obesity therapy: rationale and early data

Panel discussion

Chairs & Speakers

Maria Rohm, PhD
Maria Rohm, Germany
Jochen Springer, Germany
Shinpei Kawaoka, Japan
Laure Bindels, Belgium
Marilia Seelaender, Brazil
Fabio Penna, Italy

18:30 – 19:30: Welcome Reception - Poster Area

Register Now!

Embrace this opportunity to redefine the field and create lasting impact in the lives of patients worldwide.

Day 2: Saturday, 7 December 2024

Comprehensive Exploration of Cancer Cachexia and Aging-Related Sarcopenia

Discover the second day of our programme, dedicated to exploring the complexities of cancer cachexia and aging-related sarcopenia. With a stellar lineup of international experts presenting their latest research and engaging in insightful panel discussions

CAREER CAFÉ

08:00-08:50

Ken Fearon Career Café

09:00-10:15

GENERAL CACHEXIA

Session H

Multimodal interventions for cachexia

Multimodal interventions in cancer and heart failure cachexia

Findings from Cochrane review – multimodal therapies for cachexia management – where are we at?

Update on nutrition and exercise interventions in cachexia

The clinical provision of a multi-disciplinary clinic for cancer cachexia  

Chairs & Speakers

Florian Strasser, Switzerland
Joanne Reid, UK
Alessio Molfino
Alessio Molfino, Italy 
Laure Bindels, Belgium
Adrian Slee
Adrian Slee, UK
Nicholas P. Greene, USA
CANCER CACHEXIA

Session I

Treatment-induced muscle deficits in cachexia

Mechanisms of radiation-induced muscle fibrosis

Immune cell signature in chemotherapy-induced cachexia

Sex dependent effects in chemotherapy-induced cachexia

Musculoskeletal consequences of pediatric radiotherapy

Chairs & Speakers

Andrea Bonetto Ph.D.
Andrea Bonetto, USA
Paola Costelli, Italy
Selma Masri Ph.D.
Selma Masri, USA
Erin E Talbert, USA
Luca Delfinis, Canada
Fabrizio Pin, USA
Fabrizio Pin, USA

Coffee Break

10:15-11:15

POSTER SESSION

Poster Session 2

10:20-11:10

Chairs

Denis Guttridge, USA
Jochen Springer, Germany
Joanne Reid, UK
Florian Strasser, Switzerland
Marielle Engelen, USA
Olav Rooyackers, Sweden
Olav Rooyackers, Sweden
ABSTRACT SESSION

Rapid Fire Abstracts Session 2

10:20-11:10

Chairs

Laurence Genton, Switzerland
Laurence Genton, Switzerland
Marianne Hjermstad, Norway
Marianne Hjermstad, Norway

11:15-12:30

CANCER CACHEXIA

Session J

Cancer (cachexia/sarcopenia) related fatigue

Will lifestyle interventions be effective in primary prevention work in wasting diseases?

Effectiveness of self-management in improving hard outcomes in sarcopenia and fatigue cancer research 

How fasting can be implemented in wasting disorders in an effective and safe way?

Potential relevance of blood mitochondrial gene expression in sarcopenia and fatigue

Chairs & Speakers

Philip Atherton, UK
Robert Mankowski, USA

Robert Mankowski, USA

Stuart Phillips, Canada
Stuart Phillips, Canada
Abigail Mackey, Denmark
Abigail Mackey, Denmark
Ivan Aprahamian, Brazil
Ivan Aprahamian, Brazil
Reshma Merchant, Singapore
MECHANISMS, DIAGNOSTICS

Session K

Novel approaches to the diagnosis of sarcopenia: translating research into practice

Sit-to-stand muscle power at the core of sarcopenia assessment

D3Cr muscle mass as a clinically feasible assessment of muscle quantity

Artificial intelligence to diagnose sarcopenia in CT and MRI images

New biomarkers for sarcopenia

Chairs & Speakers

Samuel Breit, Australia
Adrian Slee
Adrian Slee, UK
Joanna Lima, UK
Joanna Lima, UK
Patrícia Reckziegel, Brazil
Patrícia Reckziegel, Brazil
Marilia Seelaender, Brazil
Paola Costelli, Italy

Break

12:30-13:30

Lunch Break

13:30-14:45

MECHANISMS, DIAGNOSTICS

Session L

Biomarkers in muscle wasting: The intersect between cachexia, sarcopenia and frailty

Biomarkers of sarcopenia and cachexia in prostate cancer patients. The ADT Study

Biomarkers of cachexia in cardiovascular disease

Biomarkers of frailty

Functional biomarkers of cancer cachexia

Panel & Speakers

Jeffrey Crawford, USA
Jose Garcia, USA
Frank Misselwitz, Germany
Maurizio Muscaritoli, Italy

Maurizio Muscaritoli, Italy

Richard Skipworth, UK
Barry Laird - Senior Clinical Lecturer in Palliative Medicine
Barry Laird, UK
Tora Solheim, Norway
Tora Solheim, Norway
Marianne Hjermstad, Norway
Marianne Hjermstad, Norway

Stefan Anker, Germany

GENERAL SARCOPENIA

Session M

Muscular disorders in critically ill patients

ICU-acquired weakness (ICU-AW): pathophysiology and clinical diagnostics

Critical illness associated (neuro-) muscular disorders

Innovative treatment approaches for neuromuscular disorders in the ICU: any news?

Experimental research for ICU-AW

Chairs & Speakers

Mauricio Berriel Diaz, Germany
Nicolaas Deutz, USA

Nicolaas Deutz, USA

Nick Hoogenraad, Australia
Nick Hoogenraad, Australia
Stephan Herzig, Germany
Stephan Herzig, Germany
Marcus D. Goncalves, USA
Marcus D. Goncalves, USA
Bei B. Zhang, Ph.D.
Bei B. Zhang, USA

Coffee Break

14:45-15:45

POSTER SESSION

Poster Session 3

14:50-15:40

Chairs

Nick Hoogenraad, Australia
Nick Hoogenraad, Australia
Robert Mak, USA
Paola Costelli, Italy
Sander Rensen, The Netherlands
Swarnali Acharyya, USA
Philip Atherton, UK
ABSTRACT SESSION

Rapid Fire Abstracts Session 3

14:50-15:40

Chairs

Elke Dworatzek, Germany
Lykke Sylow, Denmark
Lykke Sylow, Denmark
Sarah Judge, USA

15:45-17:00

NUTRITION

Session N

Metabolic and nutritional changes in cancer

Body adipose tissue changes in women with advanced cancer

Nutritional status, sociodemographic characteristics and outcomes in breast cancer patients

Time course of body composition changes in pancreatic cancer

Pancreatic cancer cachexia: is it nutrition-sensitive?

Chairs & Panelists

Stefan Anker, Germany

Vickie Baracos, Canada
Frank Misselwitz, Germany
Maurizio Muscaritoli, Italy

Maurizio Muscaritoli, Italy

Stephan von Haehling, Germany
Jose Garcia, USA
MUSCLE WASTING

Session O

Muscle wasting in critical illness and injury

The physiological rationale for cachexia: recovery from organ injury

Burn-induced cachexia.

Immunosuppression therapy and its catabolic consequences

Sepsis-induced muscle weakness and dysfunction

Chairs & Speakers

Stephan Herzig, Germany
Stephan Herzig, Germany
Fabrizio Pin, USA

Fabrizio Pin, USA

Richard Skipworth, UK
Maria Rohm, PhD
Maria Rohm, Germany
Mauricio Berriel Diaz, Germany
Daniel Marks, MD, PhD
Daniel Marks, USA

Break

17:00-17:15

Break

17:15-18:30

GENERAL CACHEXIA

Session P

Artificial Intelligence for cachexia and sarcopenia

Using AI to identify early cachexia; results from national database

AI and sarcopenia

Artificial intelligence for body composition and sarcopenia evaluation on computed tomography: A systematic review and meta-analysis

RNAome Guided Classification of Human Skeletal Muscle Subtypes in Cancer Cachexia (AI-non-negative matrix factorization method)

Chairs & Panelists

Stefan Anker, Germany

Jose Garcia, USA
Barry Laird - Senior Clinical Lecturer in Palliative Medicine
Barry Laurd, UK
Maurizio Muscaritoli, Italy

Maurizio Muscaritoli, Italy

Richard Skipworth, UK
Daniela Domnica Rotaru, Switzerland
Frank Misselwitz, Germany
Jeffrey Crawford, USA
Cendrine Tourette, France
GENERAL SARCOPENIA

Session Q

The association of sarcopenia on organ and system dysfunction

Cardiometabolic effect

Osteosarcopenia

Effect on cognition

Effect of exercise

Chairs & Speakers

James Carson, USA
Julien Gondin, France

Julien Gondin, France

Teresa Zimmers, USA
Teresa Zimmers, USA
Andrew Judge, PhD
Andrew Judge, USA
Andrea Bonetto Ph.D.
Andrea Bonetto, USA
Yi-Ping Li, USA

Register Now!

Embrace this opportunity to redefine the field and create lasting impact in the lives of patients worldwide.

Day 3: Sunday 8 December 2024

Exploring the Intricacies of Muscle Wasting and Microbiome in Cancer Cachexia

Day three of our programme plunges us into the intricacies of muscle wasting and the microbiome’s influence in cancer cachexia. We are pleased to present a distinguished gathering of international experts, eager to share their groundbreaking research and partake in dynamic discussions.

Award Session

8:00-8:50

Young Investigators Award Session

Chairs/Judges

James Carson, USA
Paola Costelli, Italy
Daniel Marks, MD, PhD

Daniel Marks, USA

Maurizio Muscaritoli, Italy

Maurizio Muscaritoli, Italy

Maria Rohm, PhD

Maria Rohm, Germany

Jochen Springer, Germany

Teresa Zimmers, USA

Teresa Zimmers, USA

9:00-10:15

GENERAL CACHEXIA

Session S

Neural control of cachexia - covering appetite control, neuroinflammation to metabolism

Neural control of anorexia

Neuroinflammatory changes in cachexia

Appetite control and metabolic changes in cancer cachexia

Xanthine oxidase in the brain and cancer cachexia

Chairs & Panelists

Stefan Anker, Germany

Jose Garcia, USA
Barry Laird - Senior Clinical Lecturer in Palliative Medicine
Barry Laurd, UK
Maurizio Muscaritoli, Italy

Maurizio Muscaritoli, Italy

Richard Skipworth, UK
Daniela Domnica Rotaru, Switzerland
Frank Misselwitz, Germany
Jeffrey Crawford, USA
Cendrine Tourette, France
GENERAL SARCOPENIA

Session T

Advanced biologic and motion therapies for musculoskeletal diseases

HIPGEN – Lessons learned from a Phase III study on allogeneic cell therapy for muscle regeneration in
hip fracture patients

PROTO – Phase I study tackling inflammation in Osteoarthritis

PROTO – Digital training therapy for correction of movement after ligament surgery in knee patients

The Advanced Therapies in Orthopaedics Alliance (ATiO) – an endeavour to create the medicine of the future for musculoskeletal diseases

Chairs & Speakers

James Carson, USA
Julien Gondin, France

Julien Gondin, France

Teresa Zimmers, USA
Teresa Zimmers, USA
Andrew Judge, PhD
Andrew Judge, USA
Andrea Bonetto Ph.D.
Andrea Bonetto, USA
Yi-Ping Li, USA

Coffee Break

10:15-11:15

POSTER SESSION

10:20-11:10

Poster Session 4

Speakers

Nicholas Greene, USA

Yi-Ping Li, USA
Nick Hoogenraad, Australia

Nick Hoogenraad, Australia

Hidetaka Wakabayashi, Japan

Mauricio Berriel-Diaz, Germany

Marcus D. Goncalves, USA

Marcus Goncalves, USA

LATE BREAKING

11:15-12:30

Session U: Late Breaking Trials/Science

Speakers

Maurizio Muscaritoli, Italy

Maurizio Muscaritoli, Italy

Joanne Reid, UK
Olav Rooyackers, Sweden

Olav Rooyackers, Sweden

Zudin Puthucheary, UK

Robert Mankowski, USA

Robert Mankowski, USA

Nicolaas Deutz, USA

Nicolaas Deutz, USA

Break

12:30-13:30

Lunch Break

Chairs & Speakers

Laure Bindels, Belgium
Denis Guttridge, USA
Sander Rensen, The Netherlands

Sander Rensen, The Netherlands

Camille Lefevre, Belgium

Camille Lefevre, Belgium

Laurence Genton, Switzerland

Laurence Genton, Switzerland

Andrew Judge, PhD

Andrew Judge, USA

13:30-14:45

GENERAL CACHEXIA

Session V

Liver metabolism alterations in cachexia (basic science session)

Liver lipids and mitochondrial dysfunction

Leukemia inhibitory factor impact on hepatic lipid metabolism

Transcriptional reprogramming of the liver in cancer cachexia

Aryl hydrocarbon receptor signaling as a driver of liver disease in cancer cachexia

Chairs & Panelists

Stefan Anker, Germany

Jose Garcia, USA
Barry Laird - Senior Clinical Lecturer in Palliative Medicine
Barry Laurd, UK
Maurizio Muscaritoli, Italy

Maurizio Muscaritoli, Italy

Richard Skipworth, UK
Daniela Domnica Rotaru, Switzerland
Frank Misselwitz, Germany
Jeffrey Crawford, USA
Cendrine Tourette, France
CANCER CACHEXIA

Session W

Ghrelin in cancer cachexia: Exploring Innovative Horizons

Interrogating the Ghrelin-AgRP system in the KPC mouse model

Macimorelin results from a pilot trial and future directions

Anamorelin in Japan

TBN

Chairs & Speakers

James Carson, USA
Julien Gondin, France

Julien Gondin, France

Teresa Zimmers, USA
Teresa Zimmers, USA
Andrew Judge, PhD
Andrew Judge, USA
Andrea Bonetto Ph.D.
Andrea Bonetto, USA
Yi-Ping Li, USA

HIGHLIGHTS

14:45-15:45

Session T: Highlights Session

Basic Science

Nutrition

Sarcopenia

Cancer Cachexia

Awards

Chair & Speakers

Stephan von Haehling, Germany
Jochen Springer, Germany
Ivan Aprahamian, Brazil
Ivan Aprahamian, Brazil

Vickie Baracos, Germany

Teresa Zimmers, USA
Teresa Zimmers, USA

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