CET time zone
Exploring Sarcopenia and Cachexia: Multidisciplinary Perspectives
Welcome to the first day of our Annual Conference on Sarcopenia, Cachexia, and Wasting Disorders. Discover world-renowned experts to discuss the latest research and advancements in the field.
Opening Session
12:30 - 13:45
A - Opening Session
Chairs: Stefan Anker, Vickie Baracos and Gianluigi Savarese
Welcome
Stefan Anker
“Prometheus” basic science key note lecture:
Central mechanisms in cachexia: bench to bedside
Daniel Marks
“Hippocrates” clinical science key note lecture:
Small non-coding RNA profiling and cachexia in patients with cancer
Maurizio Muscaritoli
JCSM & SCWD – update 2023
Stephan von Haehling & Stefan Anker
Chairs & Speakers
Stefan Anker, Germany
Vickie Baracos, Germany
Lunch Session 1
14:00-15:00
Sarcopenia as a multisystem disorder
Chair: Ivan Aprahamian
Sarcopenia and diabetes
Gustavo Duque
Sarcopenia and stroke/dysphagia
Hidetaka Wakabayashi
Sarcopenia and heart failure
Gianluigi Savarese
Chairs & Speakers
General Sarcopenia
15:00 - 16:15
B - The fat story of sarcopenia – the fat in muscle
Chair: Ivan Aprahamian & Marianne Hjermstad
Intermuscular fat infiltration in sarcopenia
Gustavo Duque
Clinical implications of fat infiltration in sarcopenia
Reshma Merchant
Metabolic role of fat in muscle
James Carson
Targeting ACTIVIN receptors and the effect on muscle and fat tissue
David Glass
Chairs & Speakers
General Cachexia
15:00 - 16:15
C - Novel cancer cachexia biomarkers
Chairs: Nick Hoogenraad & Stephan von Haehling
The MIC-1/GDF15 story – biomarker and therapeutic target
Samuel Breit
Targeted therapy relapse models to study cachexia development in lung cancer
Swarnali Acharya
Tumor genetic mutations and cancer cachexia – clinical findings
Puneeth Iyengar
A geroscience approach to frailty biomarker discovery in cancer patients
Emanuele Marzetti
Chairs & Speakers
Coffee Break
16:15 - 17:15
Coffee Break
Posters
16:20-17:10
Poster Session 1
Rapid Fire Abstracts Session 1
General Sarcopenia
17:15-18:30
D - Sarcopenia in lung disease: interplay with chronic conditions
Chair: Abigail Mackey & Hidetaka Wakabayashi
Definition, diagnostic criteria and treatment of respiratory sarcopenia
Akira Tamaki
Cytokine signaling in adipose tissue browning and muscle wasting in CKD
Robert Mak
COPD and other chronic diseases
Marielle Engelen
Sarcopenia in cardio-respiratory illnesses
Stephan von Haehling
Chairs & Speakers
General Cachexia
17:15-18:30
E - Liver metabolism in cancer and cachexia
Chairs: Maria Rohm & Jochen Springer
Cancer-induced rewiring of metabolism and zonation in the liver
Shinpei Kawaoka
Targeting bile acid metabolism to counteract cancer cachexia
Laure Bindels
Liver mitochondrial function in cancer cachexia
Marilia Seelaender
Liver NAD+ metabolism in cancer- and chemotherapy-induced cachexia
Fabio Penna
Chairs & Speakers
Register Now!
Embrace this opportunity to redefine the field and create lasting impact in the lives of patients worldwide.
Day 2: 18 June 2023
Comprehensive Exploration of Cancer Cachexia and Aging-Related Sarcopenia
Doscover the second day of our programme, dedicated to exploring the complexities of cancer cachexia and aging-related sarcopenia. With a stellar lineup of international experts presenting their latest research and engaging in insightful panel discussions
café
08:00-08:50
Ken Fearon Career Café
Nutrition
09:00-10:15
F - Nutritional issues in cachexia
Chairs: Florian Strasser & Joanne Reid
Appetite, food quantity and quality in cancer cachexia
Alessio Molfino
Gut barrier, nutrient absorption and cachexia
Laure Bindels
Exercise, nutrition and omega-3 PUFA Interventions for kidney cachexia
Adrian Slee
Examining biological sex variability in cancer-induced cachexia
Nicholas P. Greene
Chairs & Speakers
Mechanisms, Diagnostics (Basic / Translational)
09:00-10:15
G - New mechanisms of cancer cachexia
Chairs: Andrea Bonetto & Paola Costelli
Tissue crosstalk during cancer cachexia: consequences of altered metabolic networks
Selma Masri
Inflammation as target in cancer cachexia
Erin E Talbert
Examining the relationship between mitochondrial function and muscle force in cancer cachexia
Luca Delfinis
Deletion of FNDC5/Irisin protects against cancer induced cachexia syndrome
Fabrizio Pin
Chairs & Speakers
Coffee Break
10:15-11:15
Coffee Break
Posters
10:20-11:10
Poster Session 2
Rapid Fire Abstracts Session 2
GENERAL SARCOPENIA
11:15-12:30
H - Update on aging and immobilisation related sarcopenia
Chair: Philip Atherton, UK & Robert Mankowski
Effects of aging on human muscle atrophy with immobilization
Stuart Phillips
The human neuromuscular junction in ageing and exercise
Abigail Mackey
The role of nutrition in aging: appetite loss
Ivan Aprahamian
Brain muscle cross talk
Reshma Merchant
Chairs & Speakers
Robert Mankowski, USA
GENERAL CACHEXIA
11:15-12:30
I - The role of extracellular vesicles in wasting
Chairs: Samuel Breit & Adrian Slee
Tumour-derived exosomes
Joanna Lima
Intracellular peptides: potential biomarkers and therapeutic targets
Patrícia Reckziegel
Extracellular vesicles and inflammation: from cachexia to COVID-19
Marilia Seelaender
Tumor-host cross-talk: focus on the extracellular vesicles
Paola Costelli
Chairs & Speakers
Lunch Break
12:30-13:30
Lunch Break
Cancer Cachexia Therapeutics
13:30-14:45
J - Endpoints in cancer cachexia clinical trials
Panel: Jeffrey Crawford, Jose Garcia, Frank Misselwitz, Maurizio Muscaritoli, Richard Skipworth
Physical function endpoints
Barry Laird
Appetite and dietary intake endpoints in cancer cachexia trials
Tora Solheim
Quality of life endpoints
Marianne Hjermstad
Approvable endpoints for cancer cachexia – an evolving field
Stefan Anker
Panel & Speakers
Maurizio Muscaritoli, Italy
Stefan Anker, Germany
Cancer Cachexia Therapeutics
13:30-14:45
K - New cachexia treatment approaches on the horizon
Chairs: Mauricio Berriel Diaz & Nicolaas Deutz
Anti-Fn14 therapy for cancer cachexia
Nick Hoogenraad
Peptide-based therapeutic approaches in cancer cachexia
Stephan Herzig
Targeting the TGFbeta pathway
Marcus D. Goncalves
Modulating metabolic pathways – impact on cachexia and malnutrition
Bei B. Zhang
Chairs & Speakers
Nicolaas Deutz, USA
Coffee Break
14:45-15:45
Coffee Break
Posters
14:50-15:40
Poster Session 3
Rapid Fire Abstracts Session 3
Cancer Cachexia Therapeutics
15:45-17:00
L - Emerging trials in cancer cachexia
Chairs & Panelists: Stefan Anker, Maurizio Muscaritoli
Update on ponsegromab early clinical trial
Jeffrey Crawford
Multimodal intervention for cancer cachexia – MENAC study
Barry Laird
Pilot study of macimorelin for cancer cachexia
Jose Garcia
Chairs, Panel & Speakers
Stefan Anker, Germany
Maurizio Muscaritoli, Italy
Mechanisms, Diagnostics (Basic / Translational)
15:45-17:00
M - Tissue crosstalk in cancer cachexia
Chair: Stephan Herzig & Fabrizio Pin
Adipocytokines in patients with cancer cachexia
Richard Skipworth
Crosstalk of lipid metabolism and inflammation drives cachexia
Maria Rohm
Liver-derived factors contributing to cancer cachexia
Mauricio Berriel Diaz
Mechanisms of bioamplification in cancer cachexia
Daniel Marks
Chairs & Speakers
Break
17:00-17:15
Break
Late Breaking Trials Session
17:15-18:30
N - Emerging trails and late breaking results in cancer cachexia
Mechanisms, Diagnostics (Basic / Translational)
17:15-18:30
O - New insights into the mechanisms of cancer-associated muscle wasting
Chair: James Carson & Julien Gondin
Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of activin
Teresa Zimmers
FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness
Andrew Judge
Liver metastases enhance the pro-cachectic signaling in colorectal cancer hosts
Andrea Bonetto
Cancer preferentially causes fast muscle mass loss through UBR2-mediated ubiquitylation of myosin heavy chain IIb and IIx
Yi-Ping Li
Chairs & Speakers
Julien Gondin, France
Register Now!
Embrace this opportunity to redefine the field and create lasting impact in the lives of patients worldwide.
Day 3: 19 June 2023
Exploring the Intricacies of Muscle Wasting and Microbiome in Cancer Cachexia
Day three of our programme plunges us into the intricacies of muscle wasting and the microbiome’s influence in cancer cachexia. We are pleased to present a distinguished gathering of international experts, eager to share their groundbreaking research and partake in dynamic discussions.
Award Session
8:00-8:50
P - Young Investigators Award Session
Mechanisms, Diagnostics (Basic / Translational)
9:00-10:15
Q - CURRENT LIMITATIONS IN PRESERVING MUSCLE IN CANCER
Chairs: Andrea Bonetto, USA, Erin Talbert, USA
Pathological remodeling of respiratory muscles during cancer: mechanisms and therapeutic targets
Sarah Judge, USA
Molecular basis and clinical relevance of insulin resistance in cancer cachexia
Lykke Sylow, Denmark
Neuromuscular electrical stimulation limits muscle weakness and wasting and modulates satellite cell function and niche during cancer cachexia
Julien Gondin, France
Chemotherapy-specific effects on cardiorespiratory status and body composition
Ashley Smuder, USA
Chairs & Speakers
Sarah Judge, USA
Lykke Sylow, Denmark
Julien Gondin, France
Ashley Smuder, USA
Coffee Break
10:15-11:15
Coffee Break
Posters
10:20-11:20
Poster Session 4
Nutrition
11:15-12:30
R - New concepts in preventing muscle wasting in critically ill patients
Chairs: Maurizio Muscaritoli & Joanne Reid
Anabolic resistance in critically Ill patients
Olav Rooyackers
Ketogenic feeding in the critically ill patients
Zudin Puthucheary
Persistent inflammation, immunosuppression and catabolism syndrome and the role nutrition in the surgical ICU
Robert Mankowski
The metabolic response to critical illness – a therapeutic target?
Nicolaas Deutz
Speakers
Maurizio Muscaritoli, Italy
Olav Rooyackers, Sweden
Zudin Puthucheary, UK
Robert Mankowski, USA
Nicolaas Deutz, USA
Lunch Break
12:30-13:30
Lunch Break
Cancer Cachexia Therapeutics
13:30-14:45
S - The microbiome and other novel therapeutic targets in cancer cachexia
Chairs: Laure Bindels & Denis Guttridge
Gut microbiota alterations in patients with cancer cachexia
Sander Rensen
Gut microbiota and muscle: from proof-of-concept to molecular mechanisms
Camille Lefevre
Fecal microbiota transplantation (FMT) in cancer cachexia
Laurence Genton
Targeting CXCR2 signaling counteracts cancer cachexia
Andrew Judge
Chairs & Speakers
Sander Rensen, The Netherlands
Camille Lefevre, Belgium
Laurence Genton, Switzerland
Andrew Judge, USA
HIGHLIGHTS SESSION
14:45-15:45
T - Highlights Session
Chair: Stephan von Haehling
Basic Science
Jochen Springer
Nutrition
Ivan Aprahamian
Sarcopenia
Vickie Baracos
Cancer Cachexia
Teresa Zimmers
Awards
Chair & Speakers
Vickie Baracos, Germany
