Cancer Cachexia
Navigating Cancer Cachexia : Innovations in Understanding and Treatment. Journey through the latest breakthroughs in cancer research. From the role of sarcopenia in hepatocellular carcinoma to the nutritional challenges in nasopharyngeal carcinoma, explore how these insights shape patient care and treatment strategies.
The role of body composition in the development of diabetes mellitus among childhood cancer survivors, and novel intervention strategies to mitigate diabetes risk.
The growing population of childhood cancer survivors (CCSs) experiences a large burden of comorbidities, including a markedly increased risk of diabetes mellitus. Among CCSs, prediabetes and diabetes are important risk factors for subsequent cardiovascular disease, which is a leading cause...
Dose-dependent effect of megestrol acetate supplementation in cancer patients with anorexia-cachexia syndrome: A meta-analysis.
There is inconsistent evidence relating to the effects of megestrol acetate (MA) supplementation on cancer patients suffering from anorexia-cachexia syndrome. This review aimed to examine the dose-response effect of MA supplementation in patients with cancer-associated anorexia/cachexia. Relevant keywords were searched...
Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi-centre factorial randomized trial.
Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations. This hypothesis-generating analysis used biospecimens collected from a multi-centre 2ย รย 2 factorial...
The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia.
With limited treatment options, cachexia remains a major challenge for patients with cancer. Characterizing the interplay between tumor cells and the immune microenvironment may help identify potential therapeutic targets for cancer cachexia. Herein, we investigate the critical role of macrophages...
Polymorphism (rs1143634) and IL-1ฮฒ Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients.
Multiple myeloma (MM) is a hematological neoplasm of the early precursor of B-cells. The most characteristic symptoms observed during MM include hypocalcemia, anemia, bacterial infections, and renal damage. Nutritional disorders, especially malnutrition, are noted in about 35-71% of MM patients....
Cancer cachexia: biomarkers and the influence of age.
Cancer cachexia (Ccx) is a complex metabolic condition characterized by pronounced muscle and fat wasting, systemic inflammation, weakness and fatigue. Up to 30% of cancer patients succumb directly to Ccx, yet therapies that effectively address this perturbed metabolic state are...
Factors associated with multimodal care practices for cancer cachexia among registered dietitians.
This study aimed to determine factors associated with multimodal care practices for cancer cachexia among registered dietitians (RDs) working in cancer care. A secondary analysis was performed using RDs' data. Data on knowledge, skills, and confidence in multimodal care were...
Cachexia: A systemic consequence of progressive, unresolved disease
Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away...
Assessing the Clinical Relevance of the C-Reactive Protein-Triglyceride-Glucose Index in Cancer Cachexia
This research uncovers the clinical significance of the C-reactive protein-triglyceride-glucose index (CTI) in predicting survival outcomes in cancer cachexia (CC). Demonstrating superior predictive accuracy over CRP or TyG indices alone, the study reveals CTI's correlation with increased mortality risks and its potential to refine patient management strategies in CC. Published in 'Cancer and Metabolism', January 2024, by Ruan GT, Deng L, Xie HL, et al., this work highlights CTI's pivotal role in enhancing prognosis and guiding treatment in CC.
Cancer Cachexia: Molecular Mechanisms and Therapeutic Strategies
This comprehensive review sheds light on cancer cachexia (CC), a significant condition marked by muscle wasting in cancer patients, emphasizing its molecular mechanisms and potential treatments. Highlighting the challenge CC presents, especially in older individuals, the article discusses the multifaceted approach needed to combat this syndrome.
The Path to Holistic Multimodal Care for Cancer Cachexia Patients
Holistic multimodal care for cancer cachexia emphasizes integrating medical, nutritional, and emotional support, aiming to improve life quality for patients and caregivers.
Interplay Between Multidimensional Frailty and Chronic Diseases: A Review
Discover the intricate relationship between frailty and chronic diseases in ageing. Dive into our analysis for insights and prevention strategies.
The roles of P-selectin in cancer cachexia
Cancer cachexia is a systemic inflammation disorder associated with muscle wasting. P-selectin is a cell adhesion molecule that can beโฆ
Hepatocellular carcinoma and sarcopenia: a narrative review
Sarcopenia (muscle wasting) is common in people with hepatocellular carcinoma (HCC). Sarcopenia is associated with poor clinical outcomes in HCCโฆ
Sarcopenia and its Prognostic Value in Advanced Gastroesophageal Cancer
This study reveals the prognostic value of sarcopenia measurements in patients with advanced metastatic gastroesophageal cancer, showing its association with poor overall and progression-free survival. The findings highlight the importance of considering sarcopenia status alongside clinical variables for better prognostication.