EXERCISE

Defining Healthy Weight Loss and Target Weight in the Era of Highly Effective Treatment of Patients With Obesity.

BACKGROUND

Highly effective anti-obesity medications (AOMs) induce substantial weight loss and have renewed debate on appropriate treatment targets. Weight loss comprises reductions in fat mass (FM) and fat-free mass (FFM), with skeletal muscle (SM) as the major component of FFM. Clinical...

🗓️ 2026-07-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDefining Healthy Weight Loss and Target Weight in the Era of Highly Effective Treatment of Patients With Obesity.

Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.

BACKGROUND

Frailty and sarcopenia contribute to functional decline in older people with HIV (PWH), yet intervention data remain limited. We evaluated changes in frailty phenotype status, sarcopenia-related outcomes and functional performance during a supervised exercise trial and assessed associations between baseline...

🗓️ 2026-07-06
📰 Publication: Age And Ageing
Read MoreFrailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.

Myovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

Skeletal muscle health and regeneration are highly orchestrated processes governed by a complex interplay of muscle stem cells, fibro-adipogenic progenitors, immune cells, and endothelial cells. Among these cell types, endothelial cells play a central role not only by regulating blood...

🗓️ 2026-07-02
📰 Publication: Circulation Research
Read MoreMyovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

Deletion of Tgf-β1 From CD206 + M2 Macrophages Ameliorates Obesity-Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle.

BACKGROUNDS

Obesity and diabetes impair the ability of the muscle to regenerate, repair and remodel, resulting in a gradual decrease in muscle mass and function. However, the underlying mechanisms and effective therapeutic strategies remain poorly understood. M2 macrophages within skeletal muscle...

🗓️ 2026-06-19
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeletion of Tgf-β1 From CD206 + M2 Macrophages Ameliorates Obesity-Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle.

Evaluating the Impact of a One-Year Exercise Program on Probable Sarcopenia in Older Adults.

OBJECTIVES

The present study was conducted to examine the effects of a 1-year multicomponent exercise training (MCET) program on the physical function and sarcopenia status of community-dwelling older adults with probable sarcopenia.

METHODS

Data of 132 Brazilian community-dwelling older adults with probable sarcopenia...

🗓️ 2026-06-17
Read MoreEvaluating the Impact of a One-Year Exercise Program on Probable Sarcopenia in Older Adults.

Association of Airway Mucus Plugs and Physical Activity, Exercise Tolerance, Sarcopenia, and Frailty in Patients With COPD and Pre-COPD.

BACKGROUND AND OBJECTIVE

Airway mucus plugs on computed tomography (CT) are an imaging biomarker of chronic obstructive pulmonary disease (COPD) associated with airflow limitation, respiratory symptoms, and poor prognosis. However, clinical phenotypes relevant to mucus plugs, including sarcopenia and frailty, are...

🗓️ 2026-06-12
📰 Publication: Respirology
Read MoreAssociation of Airway Mucus Plugs and Physical Activity, Exercise Tolerance, Sarcopenia, and Frailty in Patients With COPD and Pre-COPD.

Autophagy in cancer cachexia: From mechanisms to therapeutic opportunities.

Cancer cachexia is a multifactorial syndrome characterized by body weight loss, muscle wasting, and systemic metabolic alterations, significantly contributing to patient morbidity and mortality. A key feature of cachexia is the excessive degradation of muscle proteins and mitochondria, largely mediated...

🗓️ 2026-06-11
Read MoreAutophagy in cancer cachexia: From mechanisms to therapeutic opportunities.

Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia.

We investigated the prophylactic effects of exercise before and during cancer cachexia (CC) using a model designed to mimic endurance and resistance (i.e., concurrent) adaptations. Male and female Balb/c mice were randomly assigned to exercise or control groups whereby exercise...

🗓️ 2026-06-04
📰 Publication: Journal Of Physiology-London
Read MoreExercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia.

The Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.

Sarcopenia is an age-related skeletal muscle disorder characterized by reduced muscle mass, strength, and physical performance, as well as increased risk of disability, hospitalization, and mortality. Emerging evidence suggests that gut microbiota alterations may contribute to muscle decline via a...

🗓️ 2026-05-27
Read MoreThe Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.

Heme Metabolism-Derived Carbon Monoxide Regulates Skeletal Muscle Function.

BACKGROUND

Heme oxygenases, HO-1 (Hmox1) and HO-2 (Hmox2), regulate skeletal muscle homeostasis by degrading heme and generating carbon monoxide (CO), a bioactive signalling molecule. Although HO-1 is known to influence muscle fibre composition and mitochondrial function, the role of HO-2 in...

🗓️ 2026-05-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHeme Metabolism-Derived Carbon Monoxide Regulates Skeletal Muscle Function.

Home-Based Intervention to Prevent Functional Decline in (Pre)frail Older Adults: The PromeTheus Randomized Controlled Trial.

BACKGROUND

Older adults with (pre)frailty are vulnerable to deteriorations in physical functioning, mobility and independence. Evidence for frailty interventions utilizing existing services within primary healthcare structure is limited. The PromeTheus trial aimed to evaluate the effectiveness of a home-based, multifactorial, interdisciplinary...

🗓️ 2026-05-14
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHome-Based Intervention to Prevent Functional Decline in (Pre)frail Older Adults: The PromeTheus Randomized Controlled Trial.

Control of muscle mass during growth and aging: Clinical targets and pathways.

Muscle mass is a strong indicator of overall health in older adults. In healthy individuals, an adequate muscle mass is maintained through a balance between anabolic pathways, such as the mTOR pathway (mammalian target of rapamycin), and catabolic pathways, including...

🗓️ 2026-05-14
📰 Publication: Best Practice & Research Clinical Endocrinology & Metabolism
Read MoreControl of muscle mass during growth and aging: Clinical targets and pathways.

Muscle failure and risk of adverse outcomes in older adults: a derivation and multicohort validation study.

BACKGROUND

Sarcopenia is inconsistently defined, and its definition might not adequately capture muscle failure, underlying disability, and other adverse outcomes in older adults. We aimed to develop and validate an evidence-based, outcome-driven model of muscle failure.

METHODS

In this derivation and multicohort validation...

🗓️ 2026-05-13
Read MoreMuscle failure and risk of adverse outcomes in older adults: a derivation and multicohort validation study.

Beyond the Lungs: The Role of Extrapulmonary Manifestations in the Quality of Life of Indians with Chronic Airway Diseases.

PURPOSE

Chronic airway diseases (CAD) including Chronic obstructive pulmonary diseases (COPD), persistent asthma (≥2weekly episodes) and bronchiectasis, exhibit overlapping extrapulmonary manifestations potentially affecting health-related quality-of-life (HRQOL). The study objective was to quantify HRQOL of CAD patients and identify impact of associated...

🗓️ 2026-05-09
📰 Publication: Respiratory Medicine
Read MoreBeyond the Lungs: The Role of Extrapulmonary Manifestations in the Quality of Life of Indians with Chronic Airway Diseases.

Exercise Modalities to Preserve Muscle Mass and Bone Health After Metabolic Bariatric Surgery.

BACKGROUND

Metabolic bariatric surgery (MBS) effectively reduces fat mass (FM), but how to best preserve muscle and bone mass after MBS is unknown.

OBJECTIVE

This study aimed to evaluate the effect of aerobic, resistance and combined exercise regimens on body composition, bone mineral...

🗓️ 2026-04-30
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreExercise Modalities to Preserve Muscle Mass and Bone Health After Metabolic Bariatric Surgery.

A comprehensive review of cancer-induced cardiac wasting.

Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural...

🗓️ 2026-04-23
📰 Publication: British Journal Of Pharmacology
Read MoreA comprehensive review of cancer-induced cardiac wasting.

Subscribe to the SCWD Newsletter

Stay Informed with the Latest Updates and Exclusive Insights!