While the gradually aggravated motor and non-motor disorders of Parkinson's disease (PD) lead to progressive disability and frequent falling, skeletal muscle impairment may contribute to this condition. The leucine-rich repeat kinase2 (LRRK2) is a common disease-causing gene in PD. Little...
๐๏ธ 2024-09-23
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is the accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility as...
In 2023, the concept of metabolic dysfunction-associated steatotic liver disease (MASLD) was introduced as an alternative to non-alcoholic fatty liver disease (NAFLD). We aimed to assess the quantity and quality of skeletal muscle using each of these diagnostic classifications. This...
๐๏ธ 2024-07-16
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is associated with unfavourable long-term survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). However, the impact of myosteatosis and muscle loss on patient prognosis has not been investigated. Seven hundred fifty-six HCC patients who received LT...
๐๏ธ 2024-08-27
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development of diabetes and obesity. The tumour suppressor...
๐๏ธ 2024-07-15
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is an important indicator of ill health and is linked to increased mortality and a reduced quality of life. Age-associated muscle mass indices provide a critical tool to help understand the development of sarcopenia. This study aimed to develop...
๐๏ธ 2024-07-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The world is facing a global nutrition crisis, as evidenced by the rising incidence of metabolic disorders such as obesity, insulin resistance and chronic inflammation. Skeletal muscle is the largest tissue in humans and plays an important role in movement...
๐๏ธ 2024-08-18
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Intensive care unit-acquired weakness (ICU-AW) is a syndrome characterized by a long-term muscle weakness often observed in sepsis-surviving patients during the chronic phase. Although ICU-AW is independently associated with increased mortality, effective therapies have yet to be established. Programmed death-1...
๐๏ธ 2024-07-17
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Increasing interest surrounds the utility of blood-based biomarkers for diagnosing sarcopenia. C-terminal agrin fragment (CAF), a marker of neuromuscular junction stability, is amongst the most promising candidates; however, a dearth of reference data impedes the incorporation of its use in...
๐๏ธ 2024-06-07
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Mitochondria represent key organelles influencing cellular homeostasis and have been implicated in the signalling events regulating protein synthesis. We examined whether mitochondrial bioenergetics (oxidative phosphorylation and reactive oxygen species (HO) emission, ROS) measured in vitro in permeabilized muscle fibres represent...
๐๏ธ 2024-07-15
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Alzheimer's disease (AD) impairs cognitive functions and peripheral systems, including skeletal muscles. The PS19 mouse, expressing the human tau P301S mutation, shows cognitive and muscular pathologies, reflecting the central and peripheral atrophy seen in AD. We analysed skeletal muscle morphology...
๐๏ธ 2024-04-22
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Muscle atrophy can cause muscle dysfunction and weakness. Krรผppel-like factor 13 (KLF13), a central regulator of cellular energy metabolism, is highly expressed in skeletal muscles and implicated in the pathogenesis of several diseases. This study investigated the role of KLF13...
๐๏ธ 2024-07-08
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Low skeletal muscle mass (LSMM) and/or, function associated with an increased risk of treatment-related toxicities and inferior overall survival (OS) among adults with solid malignancies. However, the association between LSMM and treatment-related toxicities among adults with haematologic malignancies remains unclear....
๐๏ธ 2024-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Glycative stress, characterized by the formation and accumulation of advanced glycation end products (AGEs) associated with protein glycation reactions, has been implicated in inducing a decline of muscle function. Although the inverse correlation between glycative stress and muscle mass and...
๐๏ธ 2024-04-04
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Hydrogen sulfide (HS), the third gasotransmitter discovered, regulates a variety of physiological functions. Whether HS alleviates skeletal muscle ageing by regulating autophagy has not been reported. Mice were administered 150ย mg/kg/day of D-galactose ( D-gal), and C2C12 myotubes were cultured in...
๐๏ธ 2024-08-27
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
In the context of cardiovascular surgery, the foremost concern lies in delayed functional recovery, as typified by the acquisition of independent walking after surgery, among older patients with decline in skeletal muscle mass and quality. Computed tomography (CT), which is...
๐๏ธ 2024-06-19
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Stay Informed with the Latest Updates and Exclusive Insights!
Manage Cookie Consent
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
