Frailty
Assessing the relationships between frailty, sarcopenia and Alzheimer's disease biomarkers: a scoping review.
INTRODUCTION
While both frailty and sarcopenia have been linked with the Alzheimer's disease (AD) clinical phenotype, their association with AD pathophysiology is unclear. This review aimed to identify current evidence of relationships between frailty, sarcopenia and AD biomarkers.
METHODS
Four databases (Ovid MEDLINE,...
Association of Airway Mucus Plugs and Physical Activity, Exercise Tolerance, Sarcopenia, and Frailty in Patients With COPD and Pre-COPD.
BACKGROUND AND OBJECTIVE
Airway mucus plugs on computed tomography (CT) are an imaging biomarker of chronic obstructive pulmonary disease (COPD) associated with airflow limitation, respiratory symptoms, and poor prognosis. However, clinical phenotypes relevant to mucus plugs, including sarcopenia and frailty, are...
Artificial intelligence analysis of temporalis muscle thickness for monitoring sarcopenia and clinical outcomes in individuals with paediatric brain tumours: a retrospective cohort study.
BACKGROUND
People with and who have survived paediatric brain tumour (PBT) have a poor quality of life due to physiological frailty, a primary component of which is sarcopenia (ie, low lean muscle mass) and the associated condition, sarcopenic overweight. MRI-based temporalis...
Why Osteosarcopenia Matters: Clinical and Investigative Implications.
BACKGROUND
Osteosarcopenia, the combination of osteoporosis and sarcopenia, is a geriatric syndrome linked to functional decline, falls, and fragility fractures. The interaction among bone, muscle, and their shared pathophysiology is driven by mechanical, metabolic, and hormonal factors. With global population aging...
Home-Based Intervention to Prevent Functional Decline in (Pre)frail Older Adults: The PromeTheus Randomized Controlled Trial.
BACKGROUND
Older adults with (pre)frailty are vulnerable to deteriorations in physical functioning, mobility and independence. Evidence for frailty interventions utilizing existing services within primary healthcare structure is limited. The PromeTheus trial aimed to evaluate the effectiveness of a home-based, multifactorial, interdisciplinary...
