Genome

Cachexia

Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.

BACKGROUND

Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood. We performed this...

🗓️ 2026-04-24

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Genes / Genome / Genomics / Pulmonary_disease,_chronic_obstructive / Sarcopenia / Sequence_analysis / Weight_loss

Sarcopenia

Genome-wide association and epidemiological evidence linking air pollution to aging mechanisms.

This study aimed to investigate the effects of air pollution on aging and aging-related diseases, focusing on potential causal relationships and molecular mechanisms. The first part involved a comprehensive analysis of global studies, examining the associations among PM 2.5 exposure,...

🗓️ 2025-07-16

📰 Publication: Journal Of Hazardous Materials

Aging / Air / Air_pollution / Environmental_pollution / Genome / Hazardous_substances / Incidence / Telomere

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

2,2'-dipyridyl / 3-iodobenzylguanidine / 3,3'-diaminobenzidine / 3'_untranslated_regions / 5-methylcytosine / 5'_untranslated_regions / Abattoirs / Abdominal_muscles / Abdominal_neoplasms / Abdominal_pain / Abdominoplasty / Abortion,_spontaneous / Absenteeism / Absorption / Academic_medical_centers / Academic_performance / Accidental_falls / Accidents / Accounting / Acepromazine / Acetaldehyde / Acetals / Acetates / Acetylcholine / Acetylcholinesterase / Acetylcysteine / Acetylene / Acetylglucosamine / Acetyltransferases / Achievement / Acid_ceramidase / Acid_sensing_ion_channels / Acid-base_equilibrium / Acidosis / Acinetobacter / Acinetobacter_baumannii / Acne_vulgaris / Acoustics / Acquired_immunodeficiency_syndrome / Acromegaly / Acrylamide / Actins / Action_potentials / Activities_of_daily_living / Acute_care_surgery / Acute_coronary_syndrome / Acute_kidney_injury / Acute_lung_injury / Acyltransferases / Adaptation,_physiological / Adenocarcinoma_of_lung / Adenoma / Adenoma,_pleomorphic / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipocytes,_brown / Adipocytes,_white / Adipogenesis / Adiponectin / Adipose_tissue / Adiposity / Administration,_intranasal / Administration,_oral / Adolescent / Adrenal_cortex_hormones / Adrenocorticotropic_hormone / Adult_stem_cells / Advance_care_planning / Adverse_childhood_experiences / Advertising / Aeromonas_veronii / Aerosols / Aflatoxin_m1 / Aflatoxins / African_swine_fever / Aftercare / Agar / Agaricales / Age_distribution / Aged / Agent_orange / Aggregatibacter / Aggregatibacter_aphrophilus / Aggression / Aging,_premature / Agranulocytosis / Agricultural_irrigation / Agriculture / Agrochemicals / Aids-related_complex / Air_pollution / Alanine / Alcohol_drinking / Alcoholics / Aldehydes / Aldosterone / Alendronate / Alginates / Algorithms / Alkaline_phosphatase / Alkalosis / Alkanesulfonates / Alkynes / Alleles / Allergens / Allografts / Allopurinol / Alloys / Alopecia / Alopecia_areata / Alpha_1-antitrypsin / Alpha_1-antitrypsin_deficiency / Alpha-glucosidases / Alpha-linolenic_acid / Alpha-synuclein / Alphapapillomavirus / Altitude / Alzheimer_disease / Amanita / Ambulances / Ambulatory_care / Ambulatory_care_facilities / Amikacin / Amine_oxidase_(copper-containing) / Amines / Amino_acid_sequence / Amino_acid_substitution / Amino_acids / Amino_acids,_branched-chain / Amino_acids,_sulfur / Amino_alcohols / Aminolevulinic_acid / Amlodipine / Amoxicillin / Amphetamines / Amphotericin_b / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyloidosis / Amylopectin / Amyotrophic_lateral_sclerosis / Analgesia / Analgesics / Analysis_of_variance / Anaphylaxis / Anastomotic_leak / Anemia / Anemia,_aplastic / Anemia,_iron-deficiency / Anemia,_sickle_cell / Anesthesia / Anesthesia,_conduction / Anesthesia,_epidural / Anesthesia,_intravenous / Anesthesia,_local / Anesthesia,_obstetrical / Anesthesiologists / Anesthesiology / Anesthetics / 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Bronchogenic_cyst / Bronchopulmonary_sequestration / Bronchoscopy / Brucella / Brucellosis / Brugada_syndrome / Budesonide / Buffers / Bulimia / Bundle-branch_block / Bupropion / Burning_mouth_syndrome / Burnout,_psychological / Burns / Butter / Butyrylcholinesterase / C-peptide / C-reactive_protein / Ca-19-9_antigen / cachexia / Caco-2_cells / Cadherins / Caffeine / Calcitonin_gene-related_peptide / Calcium / Calcium_channel_blockers / Calcium_channels / Calcium_signaling / Cancer_vaccines / Cancer-associated_cachexia / Cancer-associated_fibroblasts / Candidemia / Candidiasis / Candidiasis,_invasive / Candidiasis,_vulvovaginal / Cannabidiol / Cannula / Capacity_building / Capillaries / Capsaicin / Capsid / Capsules / Car-t_cell / Carbamazepine / Carbapenems / Carbidopa / Carbohydrates / Carboxylic_acids / Carcinogenesis / Carcinogens / Carcinoid_tumor / Carcinoma_in_situ / Carcinoma,_basal_cell / Carcinoma,_hepatocellular / Carcinoma,_intraductal,_noninfiltrating / Carcinoma,_non-small-cell_lung / Carcinoma,_ovarian_epithelial / Carcinoma,_renal_cell / Carcinoma,_squamous_cell / Cardiac_catheters / Cardiac_output / Cardiac_rehabilitation / Cardiac_resynchronization_therapy / Cardiac_volume / Cardiology / Cardiomyopathy,_restrictive / Cardiopulmonary_bypass / Cardiopulmonary_resuscitation / Cardiotoxicity / Cardiovascular_diseases / Cardiovascular_system / Caregivers / Carotenoids / Carotid_arteries / Carotid_artery,_internal / Carrier_proteins / Case-control_studies / Caseins / Caspase_3 / Caspase_9 / Caspases / Castleman_disease / Castration / Catalase / Cataract / Catastrophization / Catechin / Catechol_o-methyltransferase / Catecholamines / Catenins / Catheter_ablation / Catheterization / Causality / Caveolins / Cecum / Cefazolin / Cefoperazone / Cefotaxime / Ceftazidime / Ceftriaxone / Celiac_disease / Cell_aggregation / Cell_biology / Cell_body / Cell_communication / Cell_count / Cell_culture_techniques / Cell_cycle / Cell_death / 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Cold_temperature / Colectomy / Colic / Colistin / Colitis / Colitis,_ulcerative / Collagen / Collagen_type_i / Collagen_type_ii / Collagenases / Collectins / Colletotrichum / Collodion / COLON / Colon,_ascending / Colon,_sigmoid / Colon,_transverse / Colonic_neoplasms / Colonoscopy / Colony-stimulating_factors / Colorectal_neoplasms / Colorectal_surgery / Colostomy / Colposcopy / Coma,_post-head_injury / Commerce / Common_variable_immunodeficiency / Communicable_diseases / Communicable_diseases,_emerging / Communication / Community_health_workers / Community_participation / Comorbidity / Compartment_syndromes / Complement_activation / Complement_c1_inhibitor_protein / Complement_c1q / Complement_c3a / Complement_inactivating_agents / Complement_system_proteins / Complementary_therapies / Complex_regional_pain_syndromes / Composite_resins / Composting / Computational_chemistry / Computed_tomography_angiography / Computers / Conditioning,_psychological / Confidence_intervals / 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Epilepsies,_partial / Epilepsy / Epilepsy,_absence / Epilepsy,_temporal_lobe / Episiotomy / Epithelial_cells / Epithelial-mesenchymal_transition / Epithelium,_corneal / Erythrocyte_transfusion / Erythrocytes / Erythropoietin / Escherichia_coli / Esophageal_fistula / Esophageal_neoplasms / Esophageal_sphincter,_lower / Esophageal_squamous_cell_carcinoma / Esophagectomy / Esophagogastric_junction / Esophagus / Estrus_detection / Ether / Ethics / Ethics,_medical / Ethmoid_sinus / Ethylene_glycol / Ethylene_oxide / Etomidate / European_union / Evolution,_molecular / Exanthema / Excitation_contraction_coupling / Executive_function / Exercise_test / Exercise_therapy / Exome / Exome_sequencing / Exons / Exosomes / Explosive_agents / External_fixators / Extracellular_matrix / Extracellular_vesicles / Extracorporeal_membrane_oxygenation / Extreme_weather / Eye / Eye_diseases / Eye_movements / Eyeglasses / Eyelids / Facial_expression / Facial_paralysis / Facial_recognition / Factor_viii / Factor_xi_deficiency / Failure_to_thrive / Fallopian_tubes / Famciclovir / Family_practice / Family_relations / Family_structure / Fanconi_syndrome / Farms / Fasciitis,_plantar / Fasting / Fathers / FATIGUE / Fatigue_syndrome,_chronic / Fatty_acid-binding_proteins / Fatty_acids / Fatty_acids,_omega-3 / Fatty_acids,_volatile / Fatty_liver / Fear / Feasibility_studies / Febuxostat / Fecal_incontinence / Feedback / Feedback,_sensory / Feeding_behavior / Femoracetabular_impingement / Femoral_fractures,_distal / Fentanyl / Ferritins / Ferroptosis / Fertility / Fertilization / Fertilization_in_vitro / Fertilizers / Fetal_hemoglobin / Fetuins / Fetus / Fibrin / Fibrinogen / Fibrinolysin / Fibroblast_growth_factors / Fibrocartilage / Fibroins / Fibronectins / Fibrosis / Fires / Fish_oils / Fistula / Flank_pain / Flavivirus / Flavonoids / Flowmeters / Flucytosine / Fluid_therapy / Fluorescent_dyes / Fluoroquinolones / Fluoroscopy / Fluorouracil / Focus_groups / Folliculitis / Follow-up_studies 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Exercise

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / Antihypertensive_agents / Antimicrobial_stewardship / Antineoplastic_agents / Antioxidants / Antiphospholipid_syndrome / Antipsychotic_agents / Antitubercular_agents / Antiviral_agents / Aorta / Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_dissection / Aortic_valve / Aphasia / Aphasia,_primary_progressive / Apicoplasts / Apolipoproteins / Apoptosis / Apoptosis_regulatory_proteins / Appendiceal_neoplasms / Appendicitis / Appendix / Appetite / Arboviruses / Arenavirus / Arginine / Arrhythmias,_cardiac / Arteriovenous_malformations / Arthralgia / Arthritis / Arthritis,_rheumatoid / Arthroplasty / Arthroplasty,_replacement,_knee / Artificial_intelligence / Artificially_sweetened_beverages / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillosis / Aspergillosis,_allergic_bronchopulmonary / Asthenozoospermia / Astrocytes / Astrocytoma / Astronauts / Ataxia / Ataxia_telangiectasia / Atherectomy / Atherosclerosis / Athletes / Atrasentan / Atrial_fibrillation / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Attitude_to_health / Audiology / Augmented_reality / Authorship / Autism_spectrum_disorder / Autistic_disorder / Autoantibodies / Autoimmune_diseases / Autophagy / Autopsy / Axial_spondyloarthritis / Axons / B-lymphocytes / Back_pain / Bacterial_adhesion / Bacteriocins / Bacteriophages / Balantidiasis / Bariatric_surgery / Bartonella / Base_sequence / Basement_membrane / Basophils / Beds / Begomovirus / Behcet_syndrome / Benzene / Benzimidazoles / Benzocaine / Bevacizumab / Bezafibrate / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bilirubin / Biochemistry / Biocompatible_materials / Biodiversity / Biofilms / Biogenic_amines / Biological_availability / Biological_factors / Biological_monitoring / Biological_oxygen_demand_analysis / Biological_therapy / Biomarkers / Biomass / Biomedical_research / Biomimetics / Biophysics / Biopolymers / Biopsy / Biosimilar_pharmaceuticals / Biostatistics / Biotechnology / Birth_rate / Birth_weight / Blepharoplasty / Blindness / Blister / BLOOD / Blood_circulation / Blood_component_removal / Blood_culture / Blood_glucose / Blood_platelet_disorders / Blood_platelets / Blood_pressure / Blood_urea_nitrogen / Blood_vessels / Blood_volume / Blood-brain_barrier / Bocavirus / Body_composition / Body_mass_index / Body_size / Body_temperature / Body_weight / Bone_conduction / Bone_density / Bone_regeneration / Bone_transplantation / Botulinum_toxins / Brachytherapy / Brain_diseases / Brain_injuries / Brain_injuries,_traumatic / Brain_neoplasms / Bread / Breast_diseases / Breast_feeding / Breast_implants / Breast_neoplasms / Breeding / Bronchiectasis / Bronchiolitis_obliterans_syndrome / Bronchoalveolar_lavage / Bronchopulmonary_dysplasia / Bronchoscopy / Bruxism / Buffers / Burns / Butter / Calcinosis / Calcitonin / Calcium / Calcium_signaling / Camptothecin / Cancer_pain / Candy / Cannabidiol / Cannula / Capillaries / Capsaicin / Capsules / Car-t_cell / Carbohydrates / Carbon_footprint / Carbonic_anhydrase_ix / Carbonic_anhydrases / Carboplatin / Carboxylic_acids / Carboxymethylcellulose_sodium / Carcinogenesis / Carcinoid_tumor / Carcinoma,_adenoid_cystic / Carcinoma,_hepatocellular / Carcinoma,_large_cell / Carcinoma,_lewis_lung / Carcinoma,_neuroendocrine / Carcinoma,_non-small-cell_lung / Carcinoma,_renal_cell / Carcinoma,_squamous_cell / Cardenolides / Cardia / Cardiac_catheterization / Cardiac_output / Cardiac_rehabilitation / Cardiology / Cardiomyopathies / Cardiomyopathy,_hypertrophic / Cardiopulmonary_bypass / Cardiopulmonary_resuscitation / Cardiotoxicity / Cardiovascular_diseases / Caregivers / Carotid_arteries / Carotid_artery,_common / Cartilage / Case-control_studies / Cataract / Catastrophization / Catenins / Cathepsins / Catheter_ablation / Catheters / Causality / Caves / Cd4_lymphocyte_count / Cefazolin / Cefoperazone / Ceftriaxone / Celiac_disease / Cell_adhesion / Cell_adhesion_molecules / Cell_biology / Cell_count / Cell_culture_techniques / Cell_cycle / Cell_death / Cell_line / Cell_membrane / Cell_proliferation / Cell_survival / Cell_transplantation / Cell-free_nucleic_acids / CELLS / Cellulite / Cellulose / Central_amygdaloid_nucleus / Central_nervous_system / Central_nervous_system_stimulants / Ceramics / Cerclage,_cervical / Cerebellum / Cerebral_amyloid_angiopathy / Cerebral_palsy / Cerebrovascular_disorders / Cesarean_section / Chalcone / Chalcones / Chemistry,_pharmaceutical / Chemoprevention / Chemoradiotherapy / Chemotherapy,_adjuvant / Chickenpox / Child_abuse / Child_health / Child,_hospitalized / Child,_preschool / Chitinases / Chitosan / Chlorophyll / Chloroplasts / Choice_behavior / Cholangiocarcinoma / Cholangiography / Cholecystectomy / Cholera / Cholesteatoma / Cholesterol / Cholesterol,_hdl / Cholesterol,_ldl / Cholinergic_agents / Chondrocytes / Choroid / Choroid_plexus / Chromatin / Chromatin_immunoprecipitation_sequencing / Chromogranins / Chromosomes / 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Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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/ PREGNANCY / Pregnancy_outcome / Pregnancy_rate / Pregnancy_trimester,_second / Pregnancy_trimester,_third / Pregnancy,_ectopic / Pregnancy,_interstitial / Pregnancy,_multiple / Pregnancy,_twin / Pregnant_women / Premature_birth / Prenatal_care / Prescription_drugs / PREVALENCE / Preventive_health_services / Preventive_medicine / Primary_myelofibrosis / Primary_ovarian_insufficiency / Prion_diseases / Prions / Prisons / Privacy / Probability / Probiotics / Procollagen / Professional_role / Progesterone / Prognosis / Programmed_cell_death_1_receptor / Progression-free_survival / Prolactin / Promoter_regions,_genetic / Propensity_score / Prophages / Propidium / Propofol / Proportional_hazards_models / Prospective_studies / Prostaglandin-endoperoxide_synthases / Prostate / Prostatectomy / Prostatic_neoplasms / Prostheses_and_implants / Prosthesis_design / Prosthesis_fitting / Prosthodontics / Protective_factors / Protein_biosynthesis / Protein_engineering / Protein_isoforms / 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Cachexia

Comment on 'Systematic Druggable Genome-Wide Mendelian Randomization Identifies Therapeutic Targets for Sarcopenia' by Yin et al.-The Author's Reply.

🗓️ 2024-11-21

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Genome / Random_allocation / Sarcopenia / therapeutics

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The Journal of Cachexia, Sarcopenia & Muscle ⟶

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Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.

Genome-wide association and epidemiological evidence linking air pollution to aging mechanisms.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Comment on 'Systematic Druggable Genome-Wide Mendelian Randomization Identifies Therapeutic Targets for Sarcopenia' by Yin et al.-The Author's Reply.

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