Cancer-associated_cachexia

Interprofessional selection and integration of multimodal cachexia interventions into cancer care: an interpretive description study.

PURPOSE

Cancer cachexia negatively impacts health, quality of life and prognosis. Although clinical guidelines and evidence support multimodal management to improve patient outcomes, challenges remain in translating recommendations into clinical practice. This study describes how an interprofessional (IP) team selects and...

🗓️ 2026-11-03
📰 Publication: Supportive Care In Cancer
Read MoreInterprofessional selection and integration of multimodal cachexia interventions into cancer care: an interpretive description study.

NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway.

Cancer-associated cachexia (CAC) is a devastating multifactorial syndrome characterized by progressive skeletal muscle atrophy. Its mechanisms remain incompletely clarified, with limited effective therapeutic targets. NUB1, a negative regulator of ubiquitin-like proteins mediating protein degradation, has not been fully elucidated in...

🗓️ 2026-11-01
Read MoreNUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway.

Induced-fit anti-GFRAL antibody ameliorates cancer cachexia and attenuates sympathetic outflow in tumor-bearing mice.

The GDF15-GFRAL-RET neuroendocrine axis is a key regulator of body-weight homeostasis and metabolic control. GFRAL, a hindbrain-restricted receptor for the stress-responsive cytokine GDF15, signals by assembling a ternary complex with GDF15 and the tyrosine kinase RET. Pathological hyperactivation of this...

🗓️ 2026-10-28
📰 Publication: Science Advances
Read MoreInduced-fit anti-GFRAL antibody ameliorates cancer cachexia and attenuates sympathetic outflow in tumor-bearing mice.

Adaptive Mitochondrial Specialization in Lung Adenocarcinoma: Redox Homeostasis, Hypoxia Adaptation, and Therapeutic Resistance.

Lung adenocarcinoma (LUAD) exhibits metabolic flexibility that transcends the classical interpretation of the Warburg effect. This review proposes the concept of "adaptive mitochondrial specialization (AMS)", an integrative framework in which mitochondria undergo coordinated, context-dependent remodeling of bioenergetic metabolism, redox homeostasis,...

🗓️ 2026-10-27
Read MoreAdaptive Mitochondrial Specialization in Lung Adenocarcinoma: Redox Homeostasis, Hypoxia Adaptation, and Therapeutic Resistance.

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.

Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning in both physiological...

🗓️ 2026-09-23
📰 Publication: Nature Cancer
Read MoreAn iron-regulated methionine redox axis governs adipose browning and cancer cachexia.

Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.

BACKGROUND

Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. However, circadian dysregulation in...

🗓️ 2026-09-23
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.

UNLABELLED

Cancer cachexia is a devastating wasting syndrome with no approved therapies. In this study, we identify the tumor-derived glycoprotein ADAMTSL4 as a circulating factor associated with body weight loss in preclinical cachexia models and patients with colorectal and lung cancers....

🗓️ 2026-09-01
📰 Publication: Cancer Discovery
Read MoreTumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.

Systemic Inflammatory Biomarkers and Cancer-Associated Cachexia: A Narrative Review.

Cancer-associated cachexia (CAC) is a multifactorial syndrome characterized by systemic inflammation, muscle wasting, and progressive functional decline, affecting up to 80% of patients with advanced cancer. The inconsistent diagnostic criteria limit comparability across studies and hinder translation into clinical practice....

🗓️ 2026-08-26
📰 Publication: Current Oncology
Read MoreSystemic Inflammatory Biomarkers and Cancer-Associated Cachexia: A Narrative Review.

Antisense oligonucleotides against Il6ra ameliorate cancer cachexia in mice.

Mounting evidence indicates that interleukin-6 (IL-6) plays an essential role in the development of cancer cachexia. Particularly, recent work showed that IL-6 drives cancer cachexia through neurons in the area postrema of the brainstem. However, there are currently no approved...

🗓️ 2026-08-20
📰 Publication: Molecular Therapy
Read MoreAntisense oligonucleotides against Il6ra ameliorate cancer cachexia in mice.

Circulating granulocyte colony-stimulating factor as a sex-unbiased global marker of lung and colorectal cancer cachexia pre-clinical models.

Cancer cachexia, affecting up to 80% of patients with advanced cancer, is characterized by metabolic and inflammatory dysregulation driven by tumour- and host-derived factors. Although cytokines are central to cachexia pathogenesis, their circulating profiles and transcriptional relevance across models and...

🗓️ 2026-08-13
📰 Publication: Experimental Physiology
Read MoreCirculating granulocyte colony-stimulating factor as a sex-unbiased global marker of lung and colorectal cancer cachexia pre-clinical models.

Therapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice.

Cancer cachexia is a life-threatening wasting syndrome that can be driven by tumor-derived GDF15 signaling through the brainstem-restricted receptor GFRAL. Despite its clinical importance, central genetic interventions targeting this axis remain limited. Here, we develop a potent antisense oligonucleotide (Gfral-ASO,...

🗓️ 2026-07-28
📰 Publication: Cell Reports Medicine
Read MoreTherapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice.

Pre-clinical cancer cachexia causes glucose hypermetabolism prior to overt weight loss.

PURPOSE

Cancer cachexia is a life-threatening complication of advanced malignancies, driven by profound systemic metabolic reprogramming and anorexia. Insulin action is markedly impaired in patients with cancer and may contribute directly to cachexia pathogenesis. However, the interplay between weight loss, food...

🗓️ 2026-07-18
📰 Publication: Molecular Metabolism
Read MorePre-clinical cancer cachexia causes glucose hypermetabolism prior to overt weight loss.

Sex-divergent skeletal muscle remodeling emerges early in cancer cachexia.

Cancer cachexia is characterised by progressive skeletal muscle wasting and dysfunction, yet the early events that precede overt muscle wasting remain poorly defined. Here, we utilised a time-coursed C26 carcinoma model in male and female mice to define the pre-cachectic...

🗓️ 2026-07-17
📰 Publication: American Journal Of Physiology-Cell Physiology
Read MoreSex-divergent skeletal muscle remodeling emerges early in cancer cachexia.

Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart.

Cancer cachexia is a metabolic syndrome commonly observed in patients with pancreatic ductal adenocarcinoma (PDAC), characterized by wasting of skeletal and cardiac muscle. This condition is associated with the neurohormonal stress response and activation of the sympathetic nervous system. However...

🗓️ 2026-07-17
📰 Publication: Journal Of Physiology-London
Read MorePancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart.

Subscribe to the SCWD Newsletter

Stay Informed with the Latest Updates and Exclusive Insights!