Esophageal_squamous_cell_carcinoma

Cachexia

PBK-Loaded secretory autophagosomes drive radiotherapy-induced systemic adipose depletion via MAPK/ERK-PRKA/PKA-LIPE/HSL signaling: a therapeutic target for esophageal cancer cachexia.

Radiotherapy, while a cornerstone treatment for esophageal squamous cell carcinoma (ESCC), is paradoxically associated with significant weight loss that portends poor patient outcomes. The mechanisms driving this metabolic complication remain elusive. Here, we identified adipose depletion - rather than muscle...

🗓️ 2026-04-16

📰 Publication: Autophagy

Autophagosomes / Autophagy / Cancer-associated_cachexia / Cell_death / Esophageal_neoplasms / Esophageal_squamous_cell_carcinoma / neoplasms / radiotherapy / therapeutics / Weight_loss

Cachexia

High expression of the cachexia-related protein Fn14 in esophageal squamous cell carcinoma correlates with poor chemotherapy response and anti-Fn14 therapy decreases chemotherapeutic resistance.

In cancer cachexia, cytokine release by tumours causes weight loss, decreased therapeutic efficacy, and worsened prognosis. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and fibroblast inducible factor 14 (Fn14) are cancer cachexia-related proteins; however, their expression in oesophageal squamous...

🗓️ 2025-07-15

📰 Publication: British Journal Of Cancer

Cancer-associated_cachexia / Carcinoma,_squamous_cell / CELLS / chemotherapy / Drug_therapy / Esophageal_squamous_cell_carcinoma / neoplasms / Prognosis / therapeutics

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

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Exercise

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / Antihypertensive_agents / Antimicrobial_stewardship / Antineoplastic_agents / Antioxidants / Antiphospholipid_syndrome / Antipsychotic_agents / Antitubercular_agents / Antiviral_agents / Aorta / Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_dissection / Aortic_valve / Aphasia / Aphasia,_primary_progressive / Apicoplasts / Apolipoproteins / Apoptosis / Apoptosis_regulatory_proteins / Appendiceal_neoplasms / Appendicitis / Appendix / Appetite / Arboviruses / Arenavirus / Arginine / Arrhythmias,_cardiac / Arteriovenous_malformations / Arthralgia / Arthritis / Arthritis,_rheumatoid / Arthroplasty / Arthroplasty,_replacement,_knee / Artificial_intelligence / Artificially_sweetened_beverages / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillosis / Aspergillosis,_allergic_bronchopulmonary / Asthenozoospermia / Astrocytes / Astrocytoma / Astronauts / Ataxia / Ataxia_telangiectasia / Atherectomy / Atherosclerosis / Athletes / Atrasentan / Atrial_fibrillation / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Attitude_to_health / Audiology / Augmented_reality / Authorship / Autism_spectrum_disorder / Autistic_disorder / Autoantibodies / Autoimmune_diseases / Autophagy / Autopsy / Axial_spondyloarthritis / Axons / B-lymphocytes / Back_pain / Bacterial_adhesion / Bacteriocins / Bacteriophages / Balantidiasis / Bariatric_surgery / Bartonella / Base_sequence / Basement_membrane / Basophils / Beds / Begomovirus / Behcet_syndrome / Benzene / Benzimidazoles / Benzocaine / Bevacizumab / Bezafibrate / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bilirubin / Biochemistry / Biocompatible_materials / Biodiversity / Biofilms / Biogenic_amines / Biological_availability / Biological_factors / Biological_monitoring / Biological_oxygen_demand_analysis / Biological_therapy / Biomarkers / Biomass / Biomedical_research / Biomimetics / Biophysics / Biopolymers / Biopsy / Biosimilar_pharmaceuticals / Biostatistics / Biotechnology / Birth_rate / Birth_weight / Blepharoplasty / Blindness / Blister / BLOOD / Blood_circulation / Blood_component_removal / Blood_culture / Blood_glucose / Blood_platelet_disorders / Blood_platelets / Blood_pressure / Blood_urea_nitrogen / Blood_vessels / Blood_volume / Blood-brain_barrier / Bocavirus / Body_composition / Body_mass_index / Body_size / Body_temperature / Body_weight / Bone_conduction / Bone_density / Bone_regeneration / Bone_transplantation / Botulinum_toxins / Brachytherapy / Brain_diseases / Brain_injuries / Brain_injuries,_traumatic / Brain_neoplasms / Bread / Breast_diseases / Breast_feeding / Breast_implants / Breast_neoplasms / Breeding / Bronchiectasis / Bronchiolitis_obliterans_syndrome / Bronchoalveolar_lavage / Bronchopulmonary_dysplasia / Bronchoscopy / Bruxism / Buffers / Burns / Butter / Calcinosis / Calcitonin / Calcium / Calcium_signaling / Camptothecin / Cancer_pain / Candy / Cannabidiol / Cannula / Capillaries / Capsaicin / Capsules / Car-t_cell / Carbohydrates / Carbon_footprint / Carbonic_anhydrase_ix / Carbonic_anhydrases / Carboplatin / Carboxylic_acids / Carboxymethylcellulose_sodium / Carcinogenesis / Carcinoid_tumor / Carcinoma,_adenoid_cystic / Carcinoma,_hepatocellular / Carcinoma,_large_cell / Carcinoma,_lewis_lung / Carcinoma,_neuroendocrine / Carcinoma,_non-small-cell_lung / Carcinoma,_renal_cell / Carcinoma,_squamous_cell / Cardenolides / Cardia / Cardiac_catheterization / Cardiac_output / Cardiac_rehabilitation / Cardiology / Cardiomyopathies / Cardiomyopathy,_hypertrophic / Cardiopulmonary_bypass / Cardiopulmonary_resuscitation / Cardiotoxicity / Cardiovascular_diseases / Caregivers / Carotid_arteries / Carotid_artery,_common / Cartilage / Case-control_studies / Cataract / Catastrophization / Catenins / Cathepsins / Catheter_ablation / Catheters / Causality / Caves / Cd4_lymphocyte_count / Cefazolin / Cefoperazone / Ceftriaxone / Celiac_disease / Cell_adhesion / Cell_adhesion_molecules / Cell_biology / Cell_count / Cell_culture_techniques / Cell_cycle / Cell_death / Cell_line / Cell_membrane / Cell_proliferation / Cell_survival / Cell_transplantation / Cell-free_nucleic_acids / CELLS / Cellulite / Cellulose / Central_amygdaloid_nucleus / Central_nervous_system / Central_nervous_system_stimulants / Ceramics / Cerclage,_cervical / Cerebellum / Cerebral_amyloid_angiopathy / Cerebral_palsy / Cerebrovascular_disorders / Cesarean_section / Chalcone / Chalcones / Chemistry,_pharmaceutical / Chemoprevention / Chemoradiotherapy / Chemotherapy,_adjuvant / Chickenpox / Child_abuse / Child_health / Child,_hospitalized / Child,_preschool / Chitinases / Chitosan / Chlorophyll / Chloroplasts / Choice_behavior / Cholangiocarcinoma / Cholangiography / Cholecystectomy / Cholera / Cholesteatoma / Cholesterol / Cholesterol,_hdl / Cholesterol,_ldl / Cholinergic_agents / Chondrocytes / Choroid / Choroid_plexus / Chromatin / Chromatin_immunoprecipitation_sequencing / Chromogranins / Chromosomes / 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Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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/ PREGNANCY / Pregnancy_outcome / Pregnancy_rate / Pregnancy_trimester,_second / Pregnancy_trimester,_third / Pregnancy,_ectopic / Pregnancy,_interstitial / Pregnancy,_multiple / Pregnancy,_twin / Pregnant_women / Premature_birth / Prenatal_care / Prescription_drugs / PREVALENCE / Preventive_health_services / Preventive_medicine / Primary_myelofibrosis / Primary_ovarian_insufficiency / Prion_diseases / Prions / Prisons / Privacy / Probability / Probiotics / Procollagen / Professional_role / Progesterone / Prognosis / Programmed_cell_death_1_receptor / Progression-free_survival / Prolactin / Promoter_regions,_genetic / Propensity_score / Prophages / Propidium / Propofol / Proportional_hazards_models / Prospective_studies / Prostaglandin-endoperoxide_synthases / Prostate / Prostatectomy / Prostatic_neoplasms / Prostheses_and_implants / Prosthesis_design / Prosthesis_fitting / Prosthodontics / Protective_factors / Protein_biosynthesis / Protein_engineering / Protein_isoforms / 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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Esophageal_squamous_cell_carcinoma

PBK-Loaded secretory autophagosomes drive radiotherapy-induced systemic adipose depletion via MAPK/ERK-PRKA/PKA-LIPE/HSL signaling: a therapeutic target for esophageal cancer cachexia.

High expression of the cachexia-related protein Fn14 in esophageal squamous cell carcinoma correlates with poor chemotherapy response and anti-Fn14 therapy decreases chemotherapeutic resistance.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

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