Osteoporosis

Why Osteosarcopenia Matters: Clinical and Investigative Implications.

BACKGROUND

Osteosarcopenia, the combination of osteoporosis and sarcopenia, is a geriatric syndrome linked to functional decline, falls, and fragility fractures. The interaction among bone, muscle, and their shared pathophysiology is driven by mechanical, metabolic, and hormonal factors. With global population aging...

🗓️ 2026-05-15
📰 Publication: European Journal Of Clinical Investigation
Read MoreWhy Osteosarcopenia Matters: Clinical and Investigative Implications.

Beyond the Lungs: The Role of Extrapulmonary Manifestations in the Quality of Life of Indians with Chronic Airway Diseases.

PURPOSE

Chronic airway diseases (CAD) including Chronic obstructive pulmonary diseases (COPD), persistent asthma (≥2weekly episodes) and bronchiectasis, exhibit overlapping extrapulmonary manifestations potentially affecting health-related quality-of-life (HRQOL). The study objective was to quantify HRQOL of CAD patients and identify impact of associated...

🗓️ 2026-05-09
📰 Publication: Respiratory Medicine
Read MoreBeyond the Lungs: The Role of Extrapulmonary Manifestations in the Quality of Life of Indians with Chronic Airway Diseases.

The Crossroads between Osteosarcopenia and Intrinsic Capacity – A Narrative Review.

Intrinsic Capacity (IC) is defined as the composite of physical and mental abilities an individual possesses, encompassing five domains: cognition, psychological health, sensory function, vitality, and locomotion. This construct is central to the World Health Organization's framework for assessing functional...

🗓️ 2026-04-17
📰 Publication: Journals Of Gerontology Series A-Biological Sciences And Medical Sciences
Read MoreThe Crossroads between Osteosarcopenia and Intrinsic Capacity – A Narrative Review.

The Interplay Between Osteosarcopenia and Intrinsic Capacity: Insights and Associations With All-Cause Mortality in the Toledo Study for Healthy Aging.

BACKGROUND

Osteosarcopenia-the coexistence of osteopenia/osteoporosis and sarcopenia-is associated with numerous adverse health outcomes, but its association with intrinsic capacity (IC) remains unknown. We aimed to explore the associations of osteosarcopenia with IC and all-cause mortality in older adults.

METHODS

We conducted a cross-sectional...

🗓️ 2026-04-09
📰 Publication: Journals Of Gerontology Series A-Biological Sciences And Medical Sciences
Read MoreThe Interplay Between Osteosarcopenia and Intrinsic Capacity: Insights and Associations With All-Cause Mortality in the Toledo Study for Healthy Aging.

Pain characterization in osteosarcopenia: an exploratory study.

OBJECTIVE

To characterize pain in terms of frequency, intensity, and correlation with nutritional status, muscle mass, and physical performance in osteosarcopenic patients.

METHOD

We included patients affected by osteosarcopenia (OSP), according to WHO criteria and EWGSOP2 guidelines. Assessments included Bone Mineral Density, Trabecular...

🗓️ 2026-02-11
Read MorePain characterization in osteosarcopenia: an exploratory study.

Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Gut microbiome plays an important role in several metabolic, immune, and inflammatory pathways; however, there is limited evidence for its role in body composition and musculoskeletal health. Sarcopenia, defined as a loss of skeletal muscle mass and function, and obesity,...

🗓️ 2026-01-09
📰 Publication: Osteoporosis International
Read MoreImpact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 + T cell-secreted CCL5.

BACKGROUND

Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk.

METHODS

A cohort study was conducted to elucidate the associations among circulating IL-33, osteoporosis, and...

🗓️ 2025-11-15
📰 Publication: Ebiomedicine
Read MoreSkeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 + T cell-secreted CCL5.

Emerging basic science concepts in geriatric fracture fixation and patient recovery.

In recent history, human life expectancy has increased significantly, resulting in a high burden of late-life morbidity and geriatric fractures. Changes to the body as a result of aging, such as degeneration of the bone marrow, osteoblast apoptosis, and a...

🗓️ 2025-10-01
Read MoreEmerging basic science concepts in geriatric fracture fixation and patient recovery.

Corrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

🗓️ 2025-07-07
📰 Publication: Metabolism-Clinical And Experimental
Read MoreCorrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

Corrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

🗓️ 2025-07-07
📰 Publication: Metabolism-Clinical And Experimental
Read MoreCorrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

Interactions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77-101 years).

Low bone density and low muscle mass are both independent risk factors for mortality in older men. However, it is unknown if these tissues interact to increase mortality risk. Elucidating this information is important as bone and muscle are modifiable...

🗓️ 2025-07-01
📰 Publication: Age And Ageing
Read MoreInteractions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77-101 years).

Osteosarcopenic obesity: A systematic review and a call for consensus on definitions and diagnostic criteria.

Osteosarcopenic obesity (OSO) is a clinical and functional condition characterized by the coexistence of osteopenia/osteoporosis, sarcopenia, and obesity (excess adiposity). Currently, the lack of consensus on diagnostic criteria and cut-off values complicates prevalence estimates and limits its potential role as...

🗓️ 2025-06-16
📰 Publication: Clinical Nutrition
Read MoreOsteosarcopenic obesity: A systematic review and a call for consensus on definitions and diagnostic criteria.

Association Between Waist-to-Height Ratio Estimated Fat Mass Categories and Incident Fractures.

Although obesity is a well-known risk factor for various metabolic disorders, its impact on fracture risk remains uncertain. The inconsistency in findings may be due to the fact that most studies have relied solely on body mass index (BMI) as...

🗓️ 2025-06-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation Between Waist-to-Height Ratio Estimated Fat Mass Categories and Incident Fractures.

Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice.

The Wnt/β-catenin pathway and its bone-specific inhibitor, sclerostin, play important roles in skeletal development and homeostasis. The humanized sclerostin antibody, romosozumab, can significantly increase bone mineral density (BMD) of patients with osteoporosis, but it may also increase cardiovascular adverse events,...

🗓️ 2025-06-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNovel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice.

Prediction of 10-Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort.

Muscle strength, mass and function have been associated with falls, fractures and mortality, but the results vary between previous studies. We aimed to investigate the predictive ability of muscle strength and mass with 10-year incident fragility fractures. This study included...

🗓️ 2025-06-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePrediction of 10-Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort.

Osteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study.

Osteosarcopenia is suggested to be on the causal pathway to frailty; however, data on this topic is scarce, and it is unclear if osteosarcopenia is associated with frailty risk. To investigate if osteosarcopenia is associated with frailty risk in community-dwelling...

🗓️ 2025-05-02
📰 Publication: Archives Of Gerontology And Geriatrics
Read MoreOsteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study.

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