Sex

Integrative Muscle-Adipose Score (IMAS): A Novel Unified, Sex-Sensitive Body Composition-Based Survival Predictor Enhancing Risk Stratification After Liver Transplantation.

OBJECTIVE

To investigate the potential of integrating muscle and fat compartments into a novel and unified score for outcome prediction in a bicentric European cohort of LT recipients.

BACKGROUND

Body composition (BC) reflects nutritional status and metabolic reserves and influences outcomes after orthotopic...

🗓️ 2026-09-02
📰 Publication: Annals Of Surgery
Read MoreIntegrative Muscle-Adipose Score (IMAS): A Novel Unified, Sex-Sensitive Body Composition-Based Survival Predictor Enhancing Risk Stratification After Liver Transplantation.

Circulating granulocyte colony-stimulating factor as a sex-unbiased global marker of lung and colorectal cancer cachexia pre-clinical models.

Cancer cachexia, affecting up to 80% of patients with advanced cancer, is characterized by metabolic and inflammatory dysregulation driven by tumour- and host-derived factors. Although cytokines are central to cachexia pathogenesis, their circulating profiles and transcriptional relevance across models and...

🗓️ 2026-08-13
📰 Publication: Experimental Physiology
Read MoreCirculating granulocyte colony-stimulating factor as a sex-unbiased global marker of lung and colorectal cancer cachexia pre-clinical models.

Body Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.

BACKGROUND

Metabolic and musculoskeletal abnormalities in patients with heart failure (HF) may not be fully captured by body mass index.

OBJECTIVES

Body composition was studied in participants with HF and matched control subjects in the UK Biobank Imaging Study, and findings were compared...

🗓️ 2026-08-05
📰 Publication: Jacc-Heart Failure
Read MoreBody Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.

Sex-divergent skeletal muscle remodeling emerges early in cancer cachexia.

Cancer cachexia is characterised by progressive skeletal muscle wasting and dysfunction, yet the early events that precede overt muscle wasting remain poorly defined. Here, we utilised a time-coursed C26 carcinoma model in male and female mice to define the pre-cachectic...

🗓️ 2026-07-17
📰 Publication: American Journal Of Physiology-Cell Physiology
Read MoreSex-divergent skeletal muscle remodeling emerges early in cancer cachexia.

Improving Hip Fracture Prediction by Using Sarcopenia-Specific Cut-Offs of T-Scores for Osteosarcopenia: A Prospective Cohort Study.

BACKGROUND

Older adults with osteosarcopenia, defined as the coexistence of osteopenia/osteoporosis and sarcopenia, have been associated with an increased risk of fractures compared with those with normal bone mineral density (BMD) and without sarcopenia. However, the conventional definition of osteosarcopenia has...

🗓️ 2026-07-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImproving Hip Fracture Prediction by Using Sarcopenia-Specific Cut-Offs of T-Scores for Osteosarcopenia: A Prospective Cohort Study.

Differential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a pre-clinical model of colorectal cancer by biological sex.

Cancer cachexia is a wasting condition characterized by muscle loss and reduced quality of life in cancer patients. Although biological sex differences in the progression of cancer cachexia have been increasingly recognized, their role during chemotherapy-treated cancer cachexia remains largely...

🗓️ 2026-07-15
📰 Publication: American Journal Of Physiology-Endocrinology And Metabolism
Read MoreDifferential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a pre-clinical model of colorectal cancer by biological sex.

DXA-Measured Total and Regional Fat-to-Lean Mass Ratio and Mortality Risk in Chinese Older Adults: A 20-Year Prospective Study.

BACKGROUND

The association of fat-to-lean mass ratio (FLR) with mortality remains unclear in older adults. This study aimed to investigate the sex-specific associations of total and regional FLR with mortality in older Chinese adults.

METHODS

This analysis included 2000 men (mean age: 72.4 ± 5.0 years)...

🗓️ 2026-07-14
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDXA-Measured Total and Regional Fat-to-Lean Mass Ratio and Mortality Risk in Chinese Older Adults: A 20-Year Prospective Study.

Prognostic performance of Asian Working Group for Sarcopenia 2025 Constructs for activities of daily living at discharge after stroke: a head-to-head validation.

PURPOSE

To compare the prognostic performance of the Asian Working Group for Sarcopenia (AWGS) 2025 diagnostic constructs-specifically height- versus body mass index (BMI)-indexed muscle mass-for discriminating functional outcomes in patients with stroke.

METHODS

From a cohort of 1246 consecutive post-acute stroke admissions, we...

🗓️ 2026-07-07
📰 Publication: European Geriatric Medicine
Read MorePrognostic performance of Asian Working Group for Sarcopenia 2025 Constructs for activities of daily living at discharge after stroke: a head-to-head validation.

Associations of length of stay with sarcopenia parameters in geriatric patients: age and sex differences in the oldest old.

BACKGROUND

Hospital-associated deconditioning is a contributor to secondary sarcopenia, which may be driven by prolonged hospital length of stay (LoS). This study investigated the bidirectional association of LoS and sarcopenia indices (lean soft tissue, muscle strength, physical function) in older inpatients,...

🗓️ 2026-06-25
📰 Publication: Aging Clinical And Experimental Research
Read MoreAssociations of length of stay with sarcopenia parameters in geriatric patients: age and sex differences in the oldest old.

Association of Airway Mucus Plugs and Physical Activity, Exercise Tolerance, Sarcopenia, and Frailty in Patients With COPD and Pre-COPD.

BACKGROUND AND OBJECTIVE

Airway mucus plugs on computed tomography (CT) are an imaging biomarker of chronic obstructive pulmonary disease (COPD) associated with airflow limitation, respiratory symptoms, and poor prognosis. However, clinical phenotypes relevant to mucus plugs, including sarcopenia and frailty, are...

🗓️ 2026-06-12
📰 Publication: Respirology
Read MoreAssociation of Airway Mucus Plugs and Physical Activity, Exercise Tolerance, Sarcopenia, and Frailty in Patients With COPD and Pre-COPD.

Increased epicardial adipose tissue area and radiodensity in sarcopenic obesity.

BACKGROUND

Sarcopenic obesity (SO) confers substantially greater cardiometabolic risk than either sarcopenia or obesity alone, but the tissue-level structural alterations underlying this risk remain unclear. Epicardial adipose tissue (EAT) characteristics, including both area and radiodensity, may provide clinically relevant insight into...

🗓️ 2026-06-11
📰 Publication: Cardiovascular Diabetology
Read MoreIncreased epicardial adipose tissue area and radiodensity in sarcopenic obesity.

Sarcopenic obesity and dementia risk: Primary associations and landmark analyses of muscle strength and body composition trajectories.

BACKGROUND AND AIMS

Sarcopenic obesity (SO) has been proposed as a risk factor for cognitive impairment. Yet evidence is inconsistent and often limited by heterogeneous definitions and lack of longitudinal assessments. This study aimed to examine associations of SO with all-cause...

🗓️ 2026-06-07
📰 Publication: Clinical Nutrition
Read MoreSarcopenic obesity and dementia risk: Primary associations and landmark analyses of muscle strength and body composition trajectories.

Handgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.

BACKGROUND

Muscular fitness, particularly handgrip strength, is increasingly recognized as a robust marker of cardiometabolic risk (CMR) in children and adolescents. However, evidence-based diagnostic thresholds for identifying at-risk individuals remain scarce, particularly in children. This study aimed to (1) establish sex-specific...

🗓️ 2026-05-28
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHandgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.

Automated abdominal aortic calcification, muscle health and incident falls: the UK Biobank Imaging Study.

Emerging evidence suggests that vascular disease is linked with poorer muscle strength and higher falls risk. We evaluated the association between abdominal aortic calcification (AAC), scored using a well-established and validated 24-point machine learning algorithm (ML-AAC24), with magnetic resonance imaging-derived...

🗓️ 2026-05-21
📰 Publication: Journal Of Bone And Mineral Research
Read MoreAutomated abdominal aortic calcification, muscle health and incident falls: the UK Biobank Imaging Study.

A Novel Mouse Model to Identify Antigen-Specific Immune Responses in Pancreatic Cancer Cachexia.

BACKGROUND

Pancreatic Ductal Adenocarcinoma (PDAC) has a dismal five-year survival rate of 13% and is closely associated with cachexia. Cancer cachexia is a multifactorial syndrome characterized by irreversible wasting of skeletal muscles, fat loss and systemic inflammation. While cachexia is known...

🗓️ 2026-02-27
Read MoreA Novel Mouse Model to Identify Antigen-Specific Immune Responses in Pancreatic Cancer Cachexia.

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