Iron_overload

NCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice.

Sarcopenia is an age-related pathological syndrome characterized by progressive and generalized loss of skeletal muscle mass and function, with muscle atrophy representing its cardinal pathological hallmark. Ferroptosis, an iron-dependent regulated cell death, has been implicated in the pathogenesis of muscle...

🗓️ 2026-08-26
Read MoreNCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice.

Interplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in maintaining skeletal muscle homeostasis by regulating cell growth, protein degradation, and nutrient sensing. Beyond its role in muscle growth and atrophy, recent findings suggest that mTORC1 also...

🗓️ 2025-10-12
📰 Publication: Free Radical Biology And Medicine
Read MoreInterplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

Subscribe to the SCWD Newsletter

Stay Informed with the Latest Updates and Exclusive Insights!