Reframing Cardiometabolic Risk and Frailty Through Sarcopenic Obesity.
🗓️ 2026-07-01
📰 Publication: Journal Of The American College Of Cardiology
Read MoreReframing Cardiometabolic Risk and Frailty Through Sarcopenic Obesity.Heart_failure
Imaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology.
BACKGROUND
The prognostic value of obesity in cardiovascular disease is complex. Measures such as body mass index and waist-to-height ratio show differing associations with outcomes, especially in heart failure. Assessing sarcopenic obesity, the coexistence of excess fat and low muscle mass,...
🗓️ 2026-07-01
📰 Publication: Journal Of The American College Of Cardiology
Read MoreImaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology.Combined GLIM-defined malnutrition and sarcopenia and the risk of 2-year mortality in adults with heart failure: A FRAGILE-HF study post hoc analysis.
BACKGROUND
Malnutrition is common in older patients with heart failure and predicts poor outcomes. However, the prognostic value of assessing muscle function and fat stores alongside GLIM remains unclear. We therefore tested whether assessing handgrip strength and fat mass index alongside...
🗓️ 2026-06-03
📰 Publication: Journal Of Parenteral And Enteral Nutrition
Read MoreCombined GLIM-defined malnutrition and sarcopenia and the risk of 2-year mortality in adults with heart failure: A FRAGILE-HF study post hoc analysis.Associations Between Gut Microbiota and Mitochondrial Metabolites, with Growth Differentiation Factor-15 as a Marker of Oxidative Stress in Heart Failure vs. Healthy Ageing.
Growth differentiation factor-15 (GDF-15) is an established marker of oxidative stress and a general stress-response mitokines. In this study, we aim to investigate the association of GDF-15 with the metabolic signature of gut and mitochondrial activity in HF and ageing...
🗓️ 2026-02-27
Read MoreAssociations Between Gut Microbiota and Mitochondrial Metabolites, with Growth Differentiation Factor-15 as a Marker of Oxidative Stress in Heart Failure vs. Healthy Ageing.Skeletal muscle morphology and metabolism in heart failure compared to healthy controls: a systematic review and meta-analysis.
Background: Heart failure (HF) is characterised by altered skeletal muscle morphology. The aim of this systematic review and meta-analysis was to explore cross-sectional differences in muscle morphology and metabolism between patients with HF and healthy controls. Methods: A literature search...
🗓️ 2026-02-10
📰 Publication: Journal Of Applied Physiology
Read MoreSkeletal muscle morphology and metabolism in heart failure compared to healthy controls: a systematic review and meta-analysis.Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.
BACKGROUND
Dyslipidaemia is among the major risk factors for atherosclerotic cardiovascular disease. Paradoxically, higher cholesterol levels are associated with better survival in heart failure (HF) of any aetiology. Because cholesterol is an integral component of skeletal muscle structure, one possible explanation...
🗓️ 2026-01-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.Prognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.
AIM
Respiratory sarcopenia, characterised by reduced respiratory muscle mass and function, can impair ventilatory reserve and physical capacity, potentially worsening outcomes. However, its prevalence and prognostic significance in older patients with heart failure remain unclear. This study aimed to investigate the...
🗓️ 2026-01-07
📰 Publication: European Journal Of Preventive Cardiology
Read MorePrognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.Sex-specific differences between C-reactive protein and appendicular lean soft tissue index in heart failure: findings from the National Health and Nutrition Examination Survey.
INTRODUCTION
Heart failure (HF) is often accompanied by muscle wasting and elevated C-reactive protein (CRP). This study aimed to examine the association between CRP and appendicular lean soft tissue index (ALSTI) in patients with HF, focusing on potential sex differences.
METHODS
Using data...
🗓️ 2025-12-05
📰 Publication: Acta Cardiologica
Read MoreSex-specific differences between C-reactive protein and appendicular lean soft tissue index in heart failure: findings from the National Health and Nutrition Examination Survey.Air pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study.
BACKGROUND
Ambient air pollution aggravates cardiovascular-kidney-metabolic (CKM) disorders and sarcopenia, yet the shared genetic and epigenetic mechanisms that underlie their frequent co-occurrence remain poorly understood.
METHODS
We integrated genome-wide association study (GWAS) data for CKM components (cardiovascular disease [CVD], chronic kidney disease [CKD],...
🗓️ 2025-11-22
📰 Publication: Metabolism-Clinical And Experimental
Read MoreAir pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study.Sarcopenia in Heart Failure: Insights from the Global Leadership Initiative on Sarcopenia Framework.
🗓️ 2025-11-19
📰 Publication: European Journal Of Preventive Cardiology
Read MoreSarcopenia in Heart Failure: Insights from the Global Leadership Initiative on Sarcopenia Framework.Differences in peak oxygen uptake in heart failure patients with and without cachexia: A systematic review and meta-analysis.
Chronic heart failure (CHF) is characterized by reduced peak oxygen consumption (VO 2peak). Cachexia may exacerbate the decline in VO 2peak from reductions in muscle mass and strength. We sought to assess differences in VO 2peak between patients with CHF...
🗓️ 2025-11-17
Read MoreDifferences in peak oxygen uptake in heart failure patients with and without cachexia: A systematic review and meta-analysis.Different Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.
Sarcopenia, characterized by decreased skeletal muscle mass and strength, is classified as "primary" (due to aging) or "secondary" (due to diseases). MicroRNA-22-3p (miR-22) regulates muscle differentiation and function. We assessed the diagnostic value of circulating miR-22 levels in patients with...
🗓️ 2025-11-15
📰 Publication: Aging Cell
Read MoreDifferent Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.Prognostic role of sarcopenia in heart failure patients.
AIM
Sarcopenia is common in heart failure (HF) patients; however, there are no data regarding the possible long-term prognostic role of sarcopenia in younger adults with chronic HF without malnutrition. The aim of this study was to examine the long-term prognostic...
🗓️ 2025-10-29
📰 Publication: Cardiovascular Diabetology
Read MorePrognostic role of sarcopenia in heart failure patients.Body composition in patients with obesity-related heart failure with preserved ejection fraction: A comparison study.
Appendicular lean mass index is a major determinant of cardiorespiratory fitness in patients with obesity-related heart failure with preserved ejection fraction (HFpEF). Moreover, appendicular lean mass index can be used to diagnose sarcopenia and sarcopenic obesity in this population. We...
🗓️ 2025-09-20
📰 Publication: Journal Of Parenteral And Enteral Nutrition
Read MoreBody composition in patients with obesity-related heart failure with preserved ejection fraction: A comparison study.Sarcopenia Assessment Using Fully Automated Deep Learning Predicts Cardiac Allograft Survival in Heart Transplant Recipients.
Sarcopenia is associated with adverse outcomes in patients with end-stage heart failure. Muscle mass can be quantified via manual segmentation of computed tomography images, but this approach is time-consuming and subject to interobserver variability. We sought to determine whether fully...
🗓️ 2025-08-20
Read MoreSarcopenia Assessment Using Fully Automated Deep Learning Predicts Cardiac Allograft Survival in Heart Transplant Recipients.Patient Focus: Understanding Muscle Wasting in Heart Failure. An explanation of "Consolidating Concepts from Recent International Expert Consensus on Sarcopenia: Implications for Heart Failure Management".
🗓️ 2025-07-04
📰 Publication: Journal Of Cardiac Failure
Read MorePatient Focus: Understanding Muscle Wasting in Heart Failure. An explanation of "Consolidating Concepts from Recent International Expert Consensus on Sarcopenia: Implications for Heart Failure Management".