Ceramides

Liver-derived ceramides link metabolism to tissue wasting in cancer cachexia.

Cancer cachexia, characterized by weight loss, muscle wasting, and anorexia, complicates cancer treatment and adversely affects patient outcomes. Both tumor-derived and host inflammatory factors are implicated in aspects of cachexia. The search for circulating mediators of cancer cachexia has focused...

🗓️ 2026-05-15
📰 Publication: Journal Of Clinical Investigation
Read MoreLiver-derived ceramides link metabolism to tissue wasting in cancer cachexia.

Inhibition of ceramide synthesis ameliorates body wasting in a cancer cachexia model.

Cachexia is a metabolic wasting syndrome affecting many patients with cancer, with poor survival outcomes. Disturbed lipid metabolism is a hallmark of cachexia, and our previous work has identified increased levels of circulating ceramides, which are bioactive lipids with adverse...

🗓️ 2026-05-15
📰 Publication: Journal Of Clinical Investigation
Read MoreInhibition of ceramide synthesis ameliorates body wasting in a cancer cachexia model.

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence.

BACKGROUND

Ceramides have garnered considerable attention as pro-aging bioactive lipids implicated in both metabolic dysfunction and musculoskeletal decline. Among these, C18:0 and C24:1 ceramides may play a role in the pathophysiology of sarcopenia, a key manifestation of age-related deterioration. However, their...

🗓️ 2026-05-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreElevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence.

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