Aging

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice.

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both sexes. Using different mouse models,...

🗓️ 2026-11-05
📰 Publication: Nature Communications
Read MoreNeonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice.

Disruption of the Muscle-Brain Axis in Ageing: Role of Myokines in Sarcopenia and Neurodegeneration.

This narrative review analyzes how myokines act as key links in communication between skeletal muscle and the brain, focusing on the impact of aging on this axis. Although the current literature links defects in this signaling pathway to sarcopenia, neurodegeneration,...

🗓️ 2026-10-26
Read MoreDisruption of the Muscle-Brain Axis in Ageing: Role of Myokines in Sarcopenia and Neurodegeneration.

Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice.

Age-related weakness is strongly associated with disability and mortality in older adults. While muscle atrophy contributes to weakness, strength declines at a faster rate than muscle mass, implicating neural mechanisms such as changes at the spinal cord and neuromuscular junction....

🗓️ 2026-09-23
📰 Publication: Aging Cell
Read MoreMotor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice.

A probiotic Bifidobacterium pseudocatenulatum converts hesperidin to bioactive hesperetin and improves metabolic dysfunction in aging mice.

Dietary flavonoids often require microbial metabolism to generate bioactive metabolites that influence host physiology. Hesperidin, a citrus flavanone glycoside, exhibits limited intestinal absorption and depends on gut microbial biotransformation to yield its active aglycone, hesperetin. Hesperetin activates CDGSH iron-sulfur domain...

🗓️ 2026-09-23
📰 Publication: Gut Microbes
Read MoreA probiotic Bifidobacterium pseudocatenulatum converts hesperidin to bioactive hesperetin and improves metabolic dysfunction in aging mice.

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions.

Skeletal muscle aging is a major cause of frailty, metabolic dysfunction, and loss of independence in later life, yet it cannot be explained by muscle mass loss alone. Recent single-cell, multi-omics, and translational studies show that aged muscle is shaped...

🗓️ 2026-09-22
Read MoreAging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions.

UA-30 mitigates systemic aging and motor decline by inhibiting RalA signaling in naturally aged mice.

Aging, characterized by progressive physiological decline and systemic dysfunction, represents a major risk factor for age-related diseases such as sarcopenia, which involves fibrosis that disrupts muscle regeneration and function. Effective therapeutic strategies remain limited. Here we report UA-30, a novel...

🗓️ 2026-09-16
📰 Publication: Journal Of Experimental Medicine
Read MoreUA-30 mitigates systemic aging and motor decline by inhibiting RalA signaling in naturally aged mice.

NCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice.

Sarcopenia is an age-related pathological syndrome characterized by progressive and generalized loss of skeletal muscle mass and function, with muscle atrophy representing its cardinal pathological hallmark. Ferroptosis, an iron-dependent regulated cell death, has been implicated in the pathogenesis of muscle...

🗓️ 2026-08-26
Read MoreNCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice.

Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.

In mammals, nearly every cell contains an intrinsic circadian clock that functions both as a timekeeping system and an environmental sensor, integrating external cues to maintain alignment between internal physiology and the external environment. While the core clock machinery is...

🗓️ 2026-08-26
Read MoreStable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.

Effects of exercise and nutritional interventions on muscle-specific strength in older adults: A systematic review and meta-analysis.

PURPOSE

Deficient muscle-specific strength has been recognized as a key component of sarcopenia. However, the impact of various interventions on muscle-specific strength has not been systematically reviewed. This study aims to provide a systematic summary of research examining the effects of...

🗓️ 2026-08-09
📰 Publication: Ageing Research Reviews
Read MoreEffects of exercise and nutritional interventions on muscle-specific strength in older adults: A systematic review and meta-analysis.

Do muscle strength cut-offs used to define sarcopenia affect trajectories of disability progression in basic activities of daily living in older adults?

OBJECTIVE

This study aims to analyse trajectories of disability progression in basic activities of daily living (BADLs) as a function of sarcopenia, using different cut-off points for defining low muscle strength (LMS).

METHODS

A longitudinal study included 3,328 participants from the English Longitudinal...

🗓️ 2026-08-06
📰 Publication: Archives Of Gerontology And Geriatrics
Read MoreDo muscle strength cut-offs used to define sarcopenia affect trajectories of disability progression in basic activities of daily living in older adults?

A C. elegans-to-Mouse Discovery Framework for Prioritizing Sarcopenia Interventions.

Sarcopenia is a manifestation of musculoskeletal aging, yet no approved therapy is available. A major challenge is not the lack of potential interventions, but the difficulty of efficiently identifying which candidates should advance to aged-mammal validation. Sarcopenia is driven by...

🗓️ 2026-07-28
📰 Publication: Aging And Disease
Read MoreA C. elegans-to-Mouse Discovery Framework for Prioritizing Sarcopenia Interventions.

Prevalence of sarcopenia and individual- and country-level risk factors in 36 countries: pooled analysis of nationally representative individual data.

BACKGROUND

Sarcopenia is an age-related condition that contributes to disability and healthcare burden worldwide. Yet cross-national evidence on prevalence and multi-level risk factors is limited.

METHODS

We pooled data from 10 nationally representative or population-based ageing studies, including 144 226 adults aged ≥50 years...

🗓️ 2026-07-23
📰 Publication: Age And Ageing
Read MorePrevalence of sarcopenia and individual- and country-level risk factors in 36 countries: pooled analysis of nationally representative individual data.

CXCL2 is a modifiable driver of sarcopenic inflammation attenuated by exercise in older women: Integrated transcriptomic and experimental evidence.

BACKGROUND

Sarcopenia is a progressive muscle-wasting condition driven in part by chronic inflammation; however, the specific inflammatory mediators that contribute to functional decline in humans and their responses to exercise remain poorly defined.

METHODS

We analyzed public ribonucleic acid (RNA) datasets to identify...

🗓️ 2026-07-23
📰 Publication: Journal Of Sport And Health Science
Read MoreCXCL2 is a modifiable driver of sarcopenic inflammation attenuated by exercise in older women: Integrated transcriptomic and experimental evidence.

Plasma Extracellular Vesicles-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts.

BACKGROUND

Sarcopenia is characterized by progressive loss of muscle mass, strength and physical performance, yet current diagnostic tools are limited for practical and longitudinal monitoring. Extracellular vesicles (EVs) encapsulate various biomolecules, including proteins, nucleic acids, lipids and metabolites and have emerged...

🗓️ 2026-07-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePlasma Extracellular Vesicles-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts.

Biological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study.

INTRODUCTION

Sarcopenia, the accelerated loss of muscle mass, strength and function with age, is associated with adverse health outcomes. DNA methylation accumulates across life and methylation clocks (which provide a measure of biological age) could potentially be used to predict individuals...

🗓️ 2026-07-19
📰 Publication: Aging Clinical And Experimental Research
Read MoreBiological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study.

Metabolic Syndrome as a Determinant of Bidirectional Transitions Between Frailty States: Evidence From the Whitehall II Study.

BACKGROUND

Understanding interactions between geriatric syndromes is central for promoting healthy aging. Frailty is among the most relevant, as it predicts disability, falls, hospitalization and mortality. In addition, emerging evidence also indicates that metabolic factors play a key role in the...

🗓️ 2026-07-08
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMetabolic Syndrome as a Determinant of Bidirectional Transitions Between Frailty States: Evidence From the Whitehall II Study.

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