Sarcopenia

Hepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH.

A bidirectional relationship exists between metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), and sarcopenia, with each worsening the prevalence and prognosis of the other. Hepatokines have recently been shown to affect skeletal...

🗓️ 2026-06-11
📰 Publication: Molecular Metabolism
Read MoreHepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH.

Endocannabinoid system and skeletal muscle health: insights from cannabidiol.

The endocannabinoid (EC) system is a complex network comprising endogenous ligands, enzymes responsible for their synthesis and degradation, and various receptors (including CB1 and CB2). Present in many peripheral tissues, including skeletal muscle, EC system is now recognized to influence...

🗓️ 2026-06-10
📰 Publication: Molecular Metabolism
Read MoreEndocannabinoid system and skeletal muscle health: insights from cannabidiol.

Lowered Abundance of Gut Bacteriophage Species Is Associated With Human Cancer Cachexia.

BACKGROUND

Cancer cachexia exemplifies a high medical need condition without effective treatment. Recent studies implicated bacterial gut microbiome alterations to cancer cachexia. Whether the gut bacteriophage profile, an important microbiome component for health and disease, is also related to cancer cachexia...

🗓️ 2026-06-08
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLowered Abundance of Gut Bacteriophage Species Is Associated With Human Cancer Cachexia.

Sarcopenic obesity and dementia risk: Primary associations and landmark analyses of muscle strength and body composition trajectories.

BACKGROUND AND AIMS

Sarcopenic obesity (SO) has been proposed as a risk factor for cognitive impairment. Yet evidence is inconsistent and often limited by heterogeneous definitions and lack of longitudinal assessments. This study aimed to examine associations of SO with all-cause...

🗓️ 2026-06-07
📰 Publication: Clinical Nutrition
Read MoreSarcopenic obesity and dementia risk: Primary associations and landmark analyses of muscle strength and body composition trajectories.

Muscle-Adipose Aging Dynamics and Inflammaging Patterns Across Ethnically Diverse Populations: Exploring Potential Roles of Lipolysis.

BACKGROUND

Muscle-adipose aging reflects interactions between body composition changes and chronic inflammatory processes, but age-related patterns in these measures across ethnically diverse populations remain incompletely described. Understanding population-specific patterns is crucial for developing tailored prevention and intervention strategies. We aimed to...

🗓️ 2026-06-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle-Adipose Aging Dynamics and Inflammaging Patterns Across Ethnically Diverse Populations: Exploring Potential Roles of Lipolysis.

Positive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor.

The muscle nicotinic acetylcholine receptor (AChR) is the key mediator of neuromuscular signal transmission and is essential for all voluntary movement in our body. In this study, we present DC-98-LC74, a positive allosteric modulator (PAM) for the adult skeletal muscle-type...

🗓️ 2026-06-02
📰 Publication: Proceedings Of The National Academy Of Sciences Of The United States Of America
Read MorePositive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor.

Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice.

BACKGROUND

Cancer cachexia is a debilitating syndrome marked by involuntary weight loss resulting from reduced food intake and intricate metabolic reprogramming. Despite its high prevalence, cancer cachexia remains undertreated, with a lack of effective and approved pharmacotherapies. Ghrelin has emerged as...

🗓️ 2026-06-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNovel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice.

Longitudinal Assessment of Muscle Involvement in Late-Onset Pompe Disease Using Quantitative MRI: A Prospective Cohort Study.

BACKGROUND

Late-onset Pompe disease (LOPD) is a progressive metabolic myopathy characterised by lysosomal glycogen accumulation and leading to secondary disruptions in autophagy and cellular energy metabolism. While enzyme replacement therapy (ERT) has improved outcomes, early detection remains critical, because irreversible muscle...

🗓️ 2026-06-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLongitudinal Assessment of Muscle Involvement in Late-Onset Pompe Disease Using Quantitative MRI: A Prospective Cohort Study.

Sema4A Protects Against Muscle Atrophy and Promotes Repair by Regulating Intracellular Metabolic Signalling.

BACKGROUND

Skeletal muscle atrophy is a debilitating condition associated with diverse diseases and clinical interventions. Although triggers such as glucocorticoid excess or direct muscle injury disrupt the balance between protein homeostasis and tissue repair, the upstream molecular signals that actively preserve...

🗓️ 2026-05-30
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSema4A Protects Against Muscle Atrophy and Promotes Repair by Regulating Intracellular Metabolic Signalling.

Handgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.

BACKGROUND

Muscular fitness, particularly handgrip strength, is increasingly recognized as a robust marker of cardiometabolic risk (CMR) in children and adolescents. However, evidence-based diagnostic thresholds for identifying at-risk individuals remain scarce, particularly in children. This study aimed to (1) establish sex-specific...

🗓️ 2026-05-28
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHandgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.

Combined Bisoprolol and Megestrol Acetate Improves Survival and Preserves Cardiac Performance in a Rat Model of Cancer Cachexia.

BACKGROUND

Cancer cachexia is associated with rapid body wasting and cardiac dysfunction. Bisoprolol (BIS) and megestrol acetate (MA) improve selected cachexia phenotypes in the Yoshida AH-130 model, but their combined effects are not defined. We tested reduced-dose combined treatment of BIS...

🗓️ 2026-05-23
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCombined Bisoprolol and Megestrol Acetate Improves Survival and Preserves Cardiac Performance in a Rat Model of Cancer Cachexia.

Food-derived bioactive peptides in gut-muscle Axis regulation: Potential and challenges from microbiota homeostasis to muscle metabolism remodeling.

The global population is aging at an accelerating pace, and sarcopenia has emerged as a central challenge to elderly health. Food-derived bioactive peptides, as natural functional compounds, can interact significantly with the gut microbiota, thereby indirectly influencing muscle metabolism and...

🗓️ 2026-05-22
📰 Publication: Food Research International
Read MoreFood-derived bioactive peptides in gut-muscle Axis regulation: Potential and challenges from microbiota homeostasis to muscle metabolism remodeling.

Automated abdominal aortic calcification, muscle health and incident falls: the UK Biobank Imaging Study.

Emerging evidence suggests that vascular disease is linked with poorer muscle strength and higher falls risk. We evaluated the association between abdominal aortic calcification (AAC), scored using a well-established and validated 24-point machine learning algorithm (ML-AAC24), with magnetic resonance imaging-derived...

🗓️ 2026-05-21
📰 Publication: Journal Of Bone And Mineral Research
Read MoreAutomated abdominal aortic calcification, muscle health and incident falls: the UK Biobank Imaging Study.

From Pixels to Prediction: Reviewing the Role of Artificial Intelligence in Body Composition Analysis.

Evaluation of body composition (BC) is a set of biomarkers, including fat, muscle and bone, that allows the quantification of an individual's composition at different levels of complexity (whole body, tissues, macroscopic and microscopic). Recently, BC has gained medical interest...

🗓️ 2026-05-18
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreFrom Pixels to Prediction: Reviewing the Role of Artificial Intelligence in Body Composition Analysis.

Heme Metabolism-Derived Carbon Monoxide Regulates Skeletal Muscle Function.

BACKGROUND

Heme oxygenases, HO-1 (Hmox1) and HO-2 (Hmox2), regulate skeletal muscle homeostasis by degrading heme and generating carbon monoxide (CO), a bioactive signalling molecule. Although HO-1 is known to influence muscle fibre composition and mitochondrial function, the role of HO-2 in...

🗓️ 2026-05-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHeme Metabolism-Derived Carbon Monoxide Regulates Skeletal Muscle Function.

Frailty Transforms Care Continuity-Mortality Relationships Across Age Groups: Evidence From Taiwan and South Korea.

BACKGROUND

Healthcare fragmentation typically predicts poor outcomes, yet its relationship with frailty across different age groups remains unexplored. We examined how frailty modifies the association between care patterns and mortality in middle-aged and older adults from two rapidly ageing Asian societies.

METHODS

We...

🗓️ 2026-05-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreFrailty Transforms Care Continuity-Mortality Relationships Across Age Groups: Evidence From Taiwan and South Korea.

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