Sarcopenia

Remodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

BACKGROUND

The global prevalence of iron deficiency anaemia (IDA) is about 25% and even higher in women of reproductive age and children. IDA can impair skeletal muscle by disrupting oxygen utilization, energy production and contractile function. Haematological effects of intravenous (IV)...

🗓️ 2026-11-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRemodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

Baseline Physical Frailty Predicts Clinical Outcomes During Lecanemab Therapy in Early Alzheimer's Disease: A Prospective Real-World Cohort Study.

BACKGROUND

Physical frailty and sarcopenia are recognized as determinants of Alzheimer's disease (AD) progression, but their implications during anti-amyloid therapy remain unclear. We investigated their associations with longitudinal cognitive outcomes, treatment safety, tolerability, and plasma p-tau217 trajectories in patients with early...

🗓️ 2026-11-02
📰 Publication: Aging And Disease
Read MoreBaseline Physical Frailty Predicts Clinical Outcomes During Lecanemab Therapy in Early Alzheimer's Disease: A Prospective Real-World Cohort Study.

Aquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline.

BACKGROUND

Impaired muscle regeneration is a key contributor to age-related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin-4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that...

🗓️ 2026-10-27
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline.

Frailty Rather Than Sonographic Muscle Measurement Predicts Outcome in Liver Cirrhosis.

BACKGROUND

Sarcopenia and frailty are frequent in patients with liver cirrhosis and are associated with morbidity and mortality. Given the limitations of computed tomography (CT) for routine assessment of muscle loss and the need for practical bedside assessment, we aimed to...

🗓️ 2026-10-27
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreFrailty Rather Than Sonographic Muscle Measurement Predicts Outcome in Liver Cirrhosis.

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes.

BACKGROUND

Urolithin A (UA) and urolithin B (UB) are gut microbiota-derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined. We characterized UA- and UB-induced molecular responses...

🗓️ 2026-09-23
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreExploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes.

Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.

BACKGROUND

Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. However, circadian dysregulation in...

🗓️ 2026-09-23
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions.

Skeletal muscle aging is a major cause of frailty, metabolic dysfunction, and loss of independence in later life, yet it cannot be explained by muscle mass loss alone. Recent single-cell, multi-omics, and translational studies show that aged muscle is shaped...

🗓️ 2026-09-22
Read MoreAging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions.

Integrating Leg-Press Strength and Nutritional Status Improves 16-Year Mortality Risk Stratification in General Older Adults.

BACKGROUND

Malnutrition and muscle weakness are critical prognostic factors for mortality in older adults. While indices like the Geriatric Nutritional Risk Index (GNRI) are well-established, the long-term prognostic value of integrating nutrition with muscle strength (MS) remains insufficiently established in community-dwelling...

🗓️ 2026-09-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreIntegrating Leg-Press Strength and Nutritional Status Improves 16-Year Mortality Risk Stratification in General Older Adults.

Quantitative Muscle MRI Fat Fraction as a Biomarker of Disease Severity in Mitochondrial Myopathies.

BACKGROUND

Quantitative muscle MRI is increasingly used to assess structural muscle damage in inherited myopathies, but its application in primary mitochondrial myopathies (PMM) has not been systematically evaluated in large cohorts. Because PMM are clinically and genetically heterogeneous, objective imaging biomarkers...

🗓️ 2026-09-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreQuantitative Muscle MRI Fat Fraction as a Biomarker of Disease Severity in Mitochondrial Myopathies.

Integrative Muscle-Adipose Score (IMAS): A Novel Unified, Sex-Sensitive Body Composition-Based Survival Predictor Enhancing Risk Stratification After Liver Transplantation.

OBJECTIVE

To investigate the potential of integrating muscle and fat compartments into a novel and unified score for outcome prediction in a bicentric European cohort of LT recipients.

BACKGROUND

Body composition (BC) reflects nutritional status and metabolic reserves and influences outcomes after orthotopic...

🗓️ 2026-09-02
📰 Publication: Annals Of Surgery
Read MoreIntegrative Muscle-Adipose Score (IMAS): A Novel Unified, Sex-Sensitive Body Composition-Based Survival Predictor Enhancing Risk Stratification After Liver Transplantation.

Skeletal Muscle-Derived Extracellular Vesicles During Eccentric and Concentric Exercise Promote Muscle Regeneration After Injury.

BACKGROUND

Skeletal muscle injuries significantly impair mobility and function, yet effective therapeutic interventions remain limited. Both eccentric exercise (EE) and concentric exercise (CE) promote muscle repair, but the underlying mechanisms are not fully understood. Muscle-derived extracellular vesicles (mEVs) have emerged as...

🗓️ 2026-08-29
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal Muscle-Derived Extracellular Vesicles During Eccentric and Concentric Exercise Promote Muscle Regeneration After Injury.

Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.

In mammals, nearly every cell contains an intrinsic circadian clock that functions both as a timekeeping system and an environmental sensor, integrating external cues to maintain alignment between internal physiology and the external environment. While the core clock machinery is...

🗓️ 2026-08-26
Read MoreStable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.

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