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Obesity

Muscle

Exploring opportunities to better characterize the effects of dietary protein on health across the lifespan.

Remarkable advances have been made over the last thirty years in understanding the role of dietary protein in optimizing muscle health across the lifespan. That is, acute (<24h) stable isotope-derived measures of muscle protein synthesis have led to established recommendations...

🗓️ 2024-11-26

Cardiovascular_diseases / Diabetes_mellitus / Diabetes_mellitus,_type_2 / Dietary_proteins / muscles / Obesity / Research / Sarcopenia / Sleep

Muscle

Lactobacillus paragasseri SBT2055 attenuates obesity via the adipose tissue-muscle-gut axis in obese mice.

The anti-obesity effects of Lactobacillus paragasseri (L. paragasseri) have been reported, but the exact mechanisms have not been elucidated. There are also no reports on the impact of L. paragasseri on the gut microbiota environment. Recently, the incidence of sarcopenia...

🗓️ 2024-11-14

📰 Publication: Microbiological Research

Adipose_tissue / Adipose_tissue,_white / Biotechnology / Fatty_acid-binding_proteins / Fatty_acids / Gastrointestinal_microbiome / Hand_strength / Lactobacillus / Microbiota / muscles / Obesity / PLASMA / Sarcopenia / tissues

Sarcopenia

Exploring the Association between Sarcopenic Obesity and Cardiovascular Risk: A Summary of Findings from Longitudinal Studies and Potential Mechanisms.

It is estimated that more than one-tenth of adults aged ≥60 years are now classified as having sarcopenic obesity (SO), a clinical condition characterized by the concurrent presence of sarcopenia (low muscle mass and weakness) and obesity (excessive fat mass)....

🗓️ 2024-11-18

📰 Publication: Proceedings Of The Nutrition Society

Longitudinal_studies / Obesity

Muscle

Body Composition and Progression of Biopsy-Proven Non-Alcoholic Fatty Liver Disease in Patients With Obesity.

Obesity is a significant risk factor for the progression of non-alcoholic fatty liver disease (NAFLD). However, a convenient and efficacious non-invasive test for monitoring NAFLD progression in patients with obesity is currently lacking. This study aims to investigate the associations...

🗓️ 2024-10-10

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Alcoholics / Biopsy / Body_composition / cachexia / Fatty_liver / Fatty_liver,_alcoholic / Liver_diseases / Muscle,_skeletal / muscles / Non-alcoholic_fatty_liver_disease / Obesity / Sarcopenia

Muscle

Muscle Mass and Glucagon-Like Peptide-1 Receptor Agonists: Adaptive or Maladaptive Response to Weight Loss?

Recent studies have shown that pharmacologic weight loss with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and combination therapies is approaching magnitudes achieved with surgery. However, as more weight loss is achieved, there is concern for potential adverse effects on muscle...

🗓️ 2024-10-14

📰 Publication: Circulation

Adaptation,_physiological / Glucagon-like_peptide-1_receptor / Glucagon-like_peptide-1_receptor_agonists / Muscle,_skeletal / Obesity / Sarcopenia / Weight_loss

Muscle

Sarcopenic obesity in patients with head and neck cancer is predictive of critical weight loss during radiotherapy.

The impact of computed tomography-defined sarcopenia on outcomes in head and neck cancer has been well described. Sarcopenic obesity (SO) (depleted muscle mass combined with obesity) may pose a more serious risk than either condition alone. We investigated SO and...

🗓️ 2024-09-30

📰 Publication: British Journal Of Nutrition

Head_and_neck_neoplasms / muscles / neoplasms / Nutritional_physiological_phenomena / Obesity / radiotherapy / Sarcopenia / therapeutics / Tomography / Weight_loss

Cachexia

Sarcopenic obesity and health outcomes: An umbrella review of systematic reviews with meta-analysis.

Many studies support the idea that sarcopenic obesity (SO) could be considered a potential risk factor for negative health outcomes. These results have been inconsistent, and no umbrella reviews exist regarding this topic. Several databases until November 2023 were searched...

🗓️ 2024-06-19

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Case-controlstudies / muscles / Obesity / Riskfactors / Sarcopenia

Cachexia

The maternal lifestyle in pregnancy: Implications for foetal skeletal muscle development.

The world is facing a global nutrition crisis, as evidenced by the rising incidence of metabolic disorders such as obesity, insulin resistance and chronic inflammation. Skeletal muscle is the largest tissue in humans and plays an important role in movement...

🗓️ 2024-08-18

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

EXERCISE / Gastrointestinalmicrobiome / Lifestyle / Muscle,Skeletal / Muscledevelopment / muscles / Obesity / PREGNANCY / Sarcopenia

Cachexia

Effect of liraglutide on thigh muscle fat and muscle composition in adults with overweight or obesity: Results from a randomized clinical trial.

Excess muscle fat is observed in obesity and associated with greater burden of cardiovascular risk factors and higher risk of mortality. Liraglutide reduces total body weight and visceral fat but its effect on muscle fat and adverse muscle composition is...

🗓️ 2024-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

bodyweight / Liraglutide / muscles / Obesity / Overweight / RISK / Sarcopenia

Cachexia

Sarcopenia is independently associated with poor preoperative physical fitness in patients undergoing colorectal cancer surgery.

Accurate preoperative risk assessment for major colorectal cancer (CRC) surgery remains challenging. Body composition (BC) and cardiopulmonary exercise testing (CPET) can be used to evaluate risk. The relationship between BC and CPET in patients undergoing curative CRC surgery is unclear....

🗓️ 2024-06-26

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Colorectalneoplasms / EXERCISE / neoplasms / Obesity / Physicalfitness / Regressionanalysis / Sarcopenia / Sex

Sarcopenia

Diagnosis of sarcopenic obesity in Japan: Consensus statement of the Japanese Working Group on Sarcopenic Obesity.

Sarcopenic obesity is the co-existence of obesity and sarcopenia in individuals aged 40-75 years. The Japanese Working Group on Sarcopenic Obesity has developed diagnostic criteria tailored for the Japanese population, considering their unique characteristics compared with European populations. Our algorithm consists...

🗓️ 2024-09-10

📰 Publication: Geriatrics & Gerontology International

Algorithms / DIAGNOSIS / Geriatrics / muscles / Obesity

Sarcopenia

Difference in Body Composition Patterns between Age Groups in Italian Individuals with Overweight and Obesity: When BMI Becomes a Misleading Tool in Nutritional Settings.

Little is known about the changes in body composition (BC) in people with overweight or obesity. The aim of this study was to assess the differences in BC patterns in this population based on gender and age. A total of...

🗓️ 2024-07-25

Absorptiometry,photon / Adiposity / Aged / Aged,80andover / Agefactors / bodycomposition / Bodymassindex / Obesity / Overweight / Sexfactors

Cachexia

Assessing cachexia in obesity: contradiction or perfectly possible?

Existing definitions of clinically important weight loss in patients with cancer do not specifically address weight loss in patients who are obese at presentation. This review explores the clinical impact of weight loss and depletion of the skeletal muscle mass...

🗓️ 2024-07-04

📰 Publication: Current Opinion In Clinical Nutrition And Metabolic Care

Bodymassindex / Muscle,Skeletal / neoplasms / Obesity / Sarcopenia / Weightloss

Sarcopenia Muscle

The BET inhibitor JQ1 targets fat metabolism and counteracts obesity.

Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other disorders such as type II diabetes, cardiovascular disorders, physical...

🗓️ 2024-02-15

📰 Publication: Journal Of Advanced Research

Adiposetissue / Adiposetissue,white / Aging / Diet / Diet,high-fat / Muscle,Skeletal / muscles / Obesity / tissues

Sarcopenia

Body composition is associated with postoperative complications in perihilar cholangiocarcinoma.

Perihilar cholangiocarcinoma (pCCA) is a malignant tumor of the hepatobiliary system which is still associated with a challenging prognosis. Postoperative complications play a crucial role in determining the overall prognosis of patients with pCCA. Changes in body composition (BC) have...

🗓️ 2024-01-01

📰 Publication: Cancer Medicine

bodycomposition / Cholangiocarcinoma / Kaplan-meierestimate / neoplasms / Obesity / Postoperativecomplications / Prognosis

Sarcopenia

Association between Sarcopenia and Reduced Bone Mass: Is Osteosarcopenic Obesity a New Phenotype to Consider in Weight Management Settings?

Sarcopenic obesity (SO) is a frequent phenotype in people with obesity; however, it is unclear whether this links with an impaired bone status. In this study, we aimed to investigate the association between SO and low bone mass, and to...

🗓️ 2023-12-21

muscles / Obesity / Phenotype / PREVALENCE

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