Obesity
Imaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology.
BACKGROUND
The prognostic value of obesity in cardiovascular disease is complex. Measures such as body mass index and waist-to-height ratio show differing associations with outcomes, especially in heart failure. Assessing sarcopenic obesity, the coexistence of excess fat and low muscle mass,...
Deletion of Tgf-β1 From CD206 + M2 Macrophages Ameliorates Obesity-Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle.
BACKGROUNDS
Obesity and diabetes impair the ability of the muscle to regenerate, repair and remodel, resulting in a gradual decrease in muscle mass and function. However, the underlying mechanisms and effective therapeutic strategies remain poorly understood. M2 macrophages within skeletal muscle...
Invited State of the Art Review for MCP Rethinking Obesity Beyond Body Mass Index: A Review of Body Composition and Chronic Disease Risk.
Body mass index (BMI) is widely used to diagnose obesity and assess chronic disease risk, yet it does not reflect true body composition (BC), particularly fat distribution and lean mass. While widely used and valuable for population-level screening, BMI is...
Increased epicardial adipose tissue area and radiodensity in sarcopenic obesity.
BACKGROUND
Sarcopenic obesity (SO) confers substantially greater cardiometabolic risk than either sarcopenia or obesity alone, but the tissue-level structural alterations underlying this risk remain unclear. Epicardial adipose tissue (EAT) characteristics, including both area and radiodensity, may provide clinically relevant insight into...
Diagnostic Utility of Muscle Ultrasound for Sarcopenia in Prader-Willi Syndrome: A Cross-Sectional Study.
BACKGROUND
Prader-Willi syndrome (PWS) is characterized by sarcopenic obesity; however, validated screening tools for muscle mass in clinical settings are lacking. This study aimed to evaluate the diagnostic utility of muscle ultrasound (US) for detecting low muscle mass in individuals with...
Sarcopenic obesity and dementia risk: Primary associations and landmark analyses of muscle strength and body composition trajectories.
BACKGROUND AND AIMS
Sarcopenic obesity (SO) has been proposed as a risk factor for cognitive impairment. Yet evidence is inconsistent and often limited by heterogeneous definitions and lack of longitudinal assessments. This study aimed to examine associations of SO with all-cause...
Body Composition Changes in Patients on GLP-1 Receptor Agonists Undergoing an Intensive Cardiac Rehabilitation Program.
BACKGROUND
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely used for type 2 diabetes and obesity and produce significant weight loss. However, concerns have emerged about potential loss of skeletal muscle mass (SMM) with pharmacologic weight reduction, particularly in older adults...
Triglyceride-Glucose-Waist-to-Weight Index: Novel Biomarker for Mild Cognitive Impairment in Older People With Sarcopenic Obesity.
BACKGROUND
Sarcopenic obesity (SO) is closely associated with mild cognitive impairment (MCI). However, traditional body composition-based diagnostic criteria for SO fail to adequately incorporate insulin resistance, a key pathophysiological mechanism. This study aimed to investigate the association between SO, defined using...
The diagnostic accuracy of blood biomarkers for sarcopenia, sarcopenic obesity, and osteosarcopenia: a meta-analysis.
BACKGROUND AND AIMS
Sarcopenia is the accelerated loss of skeletal muscle mass and function associated with ageing. Sarcopenia screening consists of body composition imaging and physical function tests; however, these tests can be burdensome and inconsistent. This review aimed to synthesise...
The Association of Sarcopenic Obesity With Respiratory Function Outcomes in Adults: A Systematic Review and Meta-Analysis.
Sarcopenic obesity has been associated with various health conditions and mortality. Our objective was to systematically review and estimate the association between sarcopenic obesity and respiratory function outcomes. We searched EMBASE, MEDLINE, and Google Scholar for observational studies involving adults...
Not All Weight Loss Is Equal: Towards Muscle-Preserving Therapies in Obesity.
Beyond Sarcopenia: A Systematic Review and Meta-Analysis on Muscle Outcomes After Bariatric Surgery.
BACKGROUND
Metabolic and bariatric surgery (MBS) produces substantial and sustained weight loss, but concerns remain about skeletal muscle loss and sarcopenia.
METHODS
We conducted a systematic review of longitudinal and cross-sectional studies evaluating changes in muscle quantity, strength, and physical performance following MBS...
Sarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community.
Sarcopenic obesity (SO; defined as obesity with low skeletal muscle function and mass) has been recently recognized as a relevant obesity phenotype, with substantial negative clinical impact. The prevalence of SO is likely increasing, due to the growing prevalence of...
Systemic inflammation and body composition profiles are dependent on ethnicity in colorectal cancer.
INTRODUCTION
Changes in body composition (BC) are associated with outcomes in colorectal cancer (CRC), with adverse features such as sarcopenia, myosteatosis, and excess adiposity linked to the systemic inflammatory response (SIR). Whilst ethnic differences in BC have been identified in healthy...
Association between sarcopenic obesity and worsening physical performance in patients undergoing hemodialysis: The REPnet-HD study.
OBJECTIVE
Sarcopenic obesity, defined by excess fat mass with concurrent sarcopenia, is an emerging public health concern. In patients undergoing hemodialysis, reduced physical performance is associated with poor prognosis. This study aimed to investigate association between sarcopenic obesity and worsening physical...
