heart

Body Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.

BACKGROUND

Metabolic and musculoskeletal abnormalities in patients with heart failure (HF) may not be fully captured by body mass index.

OBJECTIVES

Body composition was studied in participants with HF and matched control subjects in the UK Biobank Imaging Study, and findings were compared...

🗓️ 2026-08-05
📰 Publication: Jacc-Heart Failure
Read MoreBody Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.

Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart.

Cancer cachexia is a metabolic syndrome commonly observed in patients with pancreatic ductal adenocarcinoma (PDAC), characterized by wasting of skeletal and cardiac muscle. This condition is associated with the neurohormonal stress response and activation of the sympathetic nervous system. However...

🗓️ 2026-07-17
📰 Publication: Journal Of Physiology-London
Read MorePancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart.

Imaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology.

BACKGROUND

The prognostic value of obesity in cardiovascular disease is complex. Measures such as body mass index and waist-to-height ratio show differing associations with outcomes, especially in heart failure. Assessing sarcopenic obesity, the coexistence of excess fat and low muscle mass,...

🗓️ 2026-07-01
📰 Publication: Journal Of The American College Of Cardiology
Read MoreImaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology.

Combined GLIM-defined malnutrition and sarcopenia and the risk of 2-year mortality in adults with heart failure: A FRAGILE-HF study post hoc analysis.

BACKGROUND

Malnutrition is common in older patients with heart failure and predicts poor outcomes. However, the prognostic value of assessing muscle function and fat stores alongside GLIM remains unclear. We therefore tested whether assessing handgrip strength and fat mass index alongside...

🗓️ 2026-06-03
📰 Publication: Journal Of Parenteral And Enteral Nutrition
Read MoreCombined GLIM-defined malnutrition and sarcopenia and the risk of 2-year mortality in adults with heart failure: A FRAGILE-HF study post hoc analysis.

Combined Bisoprolol and Megestrol Acetate Improves Survival and Preserves Cardiac Performance in a Rat Model of Cancer Cachexia.

BACKGROUND

Cancer cachexia is associated with rapid body wasting and cardiac dysfunction. Bisoprolol (BIS) and megestrol acetate (MA) improve selected cachexia phenotypes in the Yoshida AH-130 model, but their combined effects are not defined. We tested reduced-dose combined treatment of BIS...

🗓️ 2026-05-23
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCombined Bisoprolol and Megestrol Acetate Improves Survival and Preserves Cardiac Performance in a Rat Model of Cancer Cachexia.

Associations Between Gut Microbiota and Mitochondrial Metabolites, with Growth Differentiation Factor-15 as a Marker of Oxidative Stress in Heart Failure vs. Healthy Ageing.

Growth differentiation factor-15 (GDF-15) is an established marker of oxidative stress and a general stress-response mitokines. In this study, we aim to investigate the association of GDF-15 with the metabolic signature of gut and mitochondrial activity in HF and ageing...

🗓️ 2026-02-27
Read MoreAssociations Between Gut Microbiota and Mitochondrial Metabolites, with Growth Differentiation Factor-15 as a Marker of Oxidative Stress in Heart Failure vs. Healthy Ageing.

High Fat Diet and Obesity Each Increase Tumor Cell Proliferation and Muscle Wasting in Experimental Cancer Cachexia.

High fat diet (HFD) and associated obesity are suggested to predispose to cancer development, complicate cancer treatment, and accelerate mortality. Paradoxically, obese patients with lung cancer are reported to live longer, suggesting that high body mass is protective. Given that...

🗓️ 2026-02-21
📰 Publication: American Journal Of Physiology-Cell Physiology
Read MoreHigh Fat Diet and Obesity Each Increase Tumor Cell Proliferation and Muscle Wasting in Experimental Cancer Cachexia.

Skeletal muscle morphology and metabolism in heart failure compared to healthy controls: a systematic review and meta-analysis.

Background: Heart failure (HF) is characterised by altered skeletal muscle morphology. The aim of this systematic review and meta-analysis was to explore cross-sectional differences in muscle morphology and metabolism between patients with HF and healthy controls. Methods: A literature search...

🗓️ 2026-02-10
📰 Publication: Journal Of Applied Physiology
Read MoreSkeletal muscle morphology and metabolism in heart failure compared to healthy controls: a systematic review and meta-analysis.

Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.

BACKGROUND

Dyslipidaemia is among the major risk factors for atherosclerotic cardiovascular disease. Paradoxically, higher cholesterol levels are associated with better survival in heart failure (HF) of any aetiology. Because cholesterol is an integral component of skeletal muscle structure, one possible explanation...

🗓️ 2026-01-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.

Prognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.

AIM

Respiratory sarcopenia, characterised by reduced respiratory muscle mass and function, can impair ventilatory reserve and physical capacity, potentially worsening outcomes. However, its prevalence and prognostic significance in older patients with heart failure remain unclear. This study aimed to investigate the...

🗓️ 2026-01-07
📰 Publication: European Journal Of Preventive Cardiology
Read MorePrognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.

Sex-specific differences between C-reactive protein and appendicular lean soft tissue index in heart failure: findings from the National Health and Nutrition Examination Survey.

INTRODUCTION

Heart failure (HF) is often accompanied by muscle wasting and elevated C-reactive protein (CRP). This study aimed to examine the association between CRP and appendicular lean soft tissue index (ALSTI) in patients with HF, focusing on potential sex differences.

METHODS

Using data...

🗓️ 2025-12-05
📰 Publication: Acta Cardiologica
Read MoreSex-specific differences between C-reactive protein and appendicular lean soft tissue index in heart failure: findings from the National Health and Nutrition Examination Survey.

Air pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study.

BACKGROUND

Ambient air pollution aggravates cardiovascular-kidney-metabolic (CKM) disorders and sarcopenia, yet the shared genetic and epigenetic mechanisms that underlie their frequent co-occurrence remain poorly understood.

METHODS

We integrated genome-wide association study (GWAS) data for CKM components (cardiovascular disease [CVD], chronic kidney disease [CKD],...

🗓️ 2025-11-22
📰 Publication: Metabolism-Clinical And Experimental
Read MoreAir pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study.

The Monocrotaline Model of Hypertension Leads to Cachexia in Male but Not Female Mice.

BACKGROUND

The monocrotaline (MCT) model of cardiac cachexia is a pharmaceutical approach to pulmonary hypertension that has been used to study heart failure and muscle wasting in rodents; however, little is known of how this pyrrolizidine alkaloid leads to peripheral changes...

🗓️ 2025-11-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe Monocrotaline Model of Hypertension Leads to Cachexia in Male but Not Female Mice.

Differences in peak oxygen uptake in heart failure patients with and without cachexia: A systematic review and meta-analysis.

Chronic heart failure (CHF) is characterized by reduced peak oxygen consumption (VO 2peak). Cachexia may exacerbate the decline in VO 2peak from reductions in muscle mass and strength. We sought to assess differences in VO 2peak between patients with CHF...

🗓️ 2025-11-17
Read MoreDifferences in peak oxygen uptake in heart failure patients with and without cachexia: A systematic review and meta-analysis.

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