Microbiota

Sarcopenia

The Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.

Sarcopenia is an age-related skeletal muscle disorder characterized by reduced muscle mass, strength, and physical performance, as well as increased risk of disability, hospitalization, and mortality. Emerging evidence suggests that gut microbiota alterations may contribute to muscle decline via a...

🗓️ 2026-05-27

Aging / Dysbiosis / EXERCISE / Fatty_acids / Fatty_acids,_volatile / Gastrointestinal_microbiome / Microbiota / Multiple_chronic_conditions / muscles

Sarcopenia

Ginsenoside Ro ameliorates d-galactose-induced sarcopenia by modulating oxidative stress, inflammation, and gut microbiota in mice.

BACKGROUND

Sarcopenia is an age-related disorder primarily characterized by progressive muscle degeneration, and effective therapeutic interventions for this condition remain limited. Ginsenoside Ro (GRo) exhibits antioxidant and anti-inflammatory effects. However, the impact of GRo on skeletal muscle aging, myoblast differentiation, and...

🗓️ 2026-05-22

📰 Publication: Phytomedicine

Antioxidants / Galactose / Gastrointestinal_microbiome / Ginsenosides / Herbal_medicine / Microbiota / muscles / Oxidative_stress / Plants,_medicinal / Stress,_physiological / therapeutics

Muscle

Food-derived bioactive peptides in gut-muscle Axis regulation: Potential and challenges from microbiota homeostasis to muscle metabolism remodeling.

The global population is aging at an accelerating pace, and sarcopenia has emerged as a central challenge to elderly health. Food-derived bioactive peptides, as natural functional compounds, can interact significantly with the gut microbiota, thereby indirectly influencing muscle metabolism and...

🗓️ 2026-05-22

📰 Publication: Food Research International

Aging / Bioactive_peptides,_dietary / Food / Gastrointestinal_microbiome / Homeostasis / Microbiota / Multiple_chronic_conditions / muscles / Research / Sarcopenia

Cachexia

Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota-immune signaling via Phocaeicola vulgatus enrichment.

BACKGROUND

Cancer cachexia profoundly impacts patient survival and quality of life. Current treatments fail to halt this trajectory, highlighting an urgent clinical need for host-directed therapies capable of uncoupling skeletal muscle wasting from tumor progression. This study investigated the therapeutic potential...

🗓️ 2026-05-06

📰 Publication: Microbiome

Cancer-associated_cachexia / CELLS / COLON / Colonic_neoplasms / Gastrointestinal_microbiome / Microbiota / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / neoplasms / therapeutics

Cachexia

The Eubacterium Rectale Derived Extracellular Vesicles Alleviate Cancer Cachexia Induced Lipolysis by Inhibiting Macrophage Polarization.

Cancer cachexia (CC) is a complex pathological condition associated with cancer progression and poor prognosis, particularly in gastrointestinal cancers, and is closely linked to the gut microbiota. Lipolysis in CC may play a key role in driving cachexia progression. However,...

🗓️ 2026-05-06

📰 Publication: Journal Of Extracellular Vesicles

Cancer-associated_cachexia / Eubacterium / Extracellular_vesicles / Gastrointestinal_microbiome / Macrophages / Microbiota / neoplasms

Muscle

Gut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

BACKGROUND

Ageing is an inevitable biological process that contributes to increased prevalence of age-associated diseases, including sarcopenia, defined by progressive loss of muscle mass, functional decline and a heightened risk of injury. Developing effective interventions remains a critical clinical priority. This...

🗓️ 2026-04-21

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aged / cachexia / Gastrointestinal_microbiome / Hand_strength / Microbiota / Muscle,_skeletal / muscles / Sarcopenia / therapeutics

Sarcopenia

Associations Between Gut Microbiota and Mitochondrial Metabolites, with Growth Differentiation Factor-15 as a Marker of Oxidative Stress in Heart Failure vs. Healthy Ageing.

Growth differentiation factor-15 (GDF-15) is an established marker of oxidative stress and a general stress-response mitokines. In this study, we aim to investigate the association of GDF-15 with the metabolic signature of gut and mitochondrial activity in HF and ageing...

🗓️ 2026-02-27

Gastrointestinal_microbiome / Growth / Growth_differentiation_factor_15 / Healthy_aging / heart / Heart_failure / Microbiota / Oxidative_stress / Sarcosine / Stress,_physiological

Muscle

Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Gut microbiome plays an important role in several metabolic, immune, and inflammatory pathways; however, there is limited evidence for its role in body composition and musculoskeletal health. Sarcopenia, defined as a loss of skeletal muscle mass and function, and obesity,...

🗓️ 2026-01-09

📰 Publication: Osteoporosis International

Aging / Bacteria / Body_composition / Gastrointestinal_microbiome / Growth / Microbiota / muscles / Obesity / Osteoporosis / Prebiotics / Probiotics / Quality_of_life / Sarcopenia / Synbiotics

Muscle

Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.

AIM

To investigate effects of host- and gut microbiota (GM)-altering interventions on sarcopenia (parameters).

METHODS

Upon PROSPERO registration (CRD42022347363), six databases and one registry were searched until January 5th 2024 and updated on June 10th 2025 for diet, pre-, pro-, or synbiotics mono-interventions...

🗓️ 2025-11-21

📰 Publication: Aging Clinical And Experimental Research

Aging / Diet / Food / Gait / Gastrointestinal_microbiome / Microbiota / Muscle_strength / muscles / Probiotics / Sarcopenia / Synbiotics / Walking_speed

Muscle

Coix seed oil alleviates collagen-induced arthritis-associated muscle atrophy and functional decline by modulating gut microbiota dysbiosis.

The gut microbiota composition influences the pathogenesis of sarcopenia via the "gut microbiota-muscle axis", with probiotics serving as potential therapeutic agents. Coix seed oil (CSO), a bioactive component of Coix lacryma-jobi l., exhibit potent anti-inflammatory effects, however, its therapeutic role...

🗓️ 2025-08-05

📰 Publication: Phytomedicine

Arthritis / CELLS / Collagen / Dysbiosis / Gastrointestinal_microbiome / Genes / Genes,_rrna / Herbal_medicine / Leptin / Microbiota / muscles / Muscular_atrophy / Sarcopenia / Seeds / therapeutics

Muscle

Corn-derived peptide LQQQLL alleviates skeletal muscle attenuation by mTOR signaling pathway and intestinal microbiota.

A novel peptide attenuating skeletal muscle atrophy was prepared, identified, screened from corn and its molecular mechanism was explored using two-step enzymatic hydrolysis, molecular docking, and sarcopenia mice model. The results showed that the DPPH free radical scavenging rate of...

🗓️ 2025-06-13

📰 Publication: Food Research International

Food / Microbiota / Muscle,_skeletal / muscles / Muscular_atrophy / Sarcopenia

Sarcopenia

Association of the Dietary Index for Gut Microbiota With Severity, Renal Function, and Sarcopenia in Patients With Chronic Kidney Disease: A Population-Based Cross-Sectional Study.

The aim of this research was to clarify the relationship between the Dietary Index for Gut Microbiota (DI-GM) and the severity of chronic kidney disease (CKD), renal function, and the prevalence of sarcopenia in patients with CKD, as well as...

🗓️ 2025-05-18

Cross-sectional_studies / Gastrointestinal_microbiome / Kidney / Kidney_diseases / Microbiota / PREVALENCE

Sarcopenia

Distinct gut microbiota signatures in older people with sarcopenic obesity and sarcopenia without obesity.

Previous evidence suggests that gut dysbiosis plays an important role in the development and progression of sarcopenia and sarcopenic obesity (SO), but evidence supporting this association is lacking. Thus, this study aimed to investigate the characteristics of gut microbiota in...

🗓️ 2025-04-08

📰 Publication: Clinical Nutrition

Gastrointestinal_microbiome / Microbiota / Obesity

Cachexia

The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia.

Alterations in bile acid profile and pathways contribute to hepatic inflammation in cancer cachexia, a syndrome worsening the prognosis of cancer patients. As the gut microbiota impinges on host metabolism through bile acids, the current study aimed to explore the...

🗓️ 2025-01-08

📰 Publication: Gut Microbes

Bile / Cancer-associated_cachexia / Cholesterol / Colorectal_neoplasms / Dysbiosis / Gastrointestinal_microbiome / Homeostasis / Hydroxysteroid_dehydrogenases / liver / Microbiota / Muscular_atrophy / neoplasms / Oxidoreductases / Taurodeoxycholic_acid / Work

Muscle

Melatonin Ameliorates Age-Related Sarcopenia via the Gut-Muscle Axis Mediated by Serum Lipopolysaccharide and Metabolites.

Sarcopenia affects the quality of life and increases adverse outcomes in the elderly. However, as a potential safe and effective remedy to many age-related disorders, little is known about the protective effect of melatonin against sarcopenia, especially the underlying mechanisms...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aged / Apoptosis / Caspase_8 / Caspases / Gastrointestinal_microbiome / Lipopolysaccharides / Mediation_analysis / Melatonin / Microbiota / Muscle_strength / Muscle,_skeletal / muscles / Sarcopenia / SERUM

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

2,2'-dipyridyl / 3-iodobenzylguanidine / 3,3'-diaminobenzidine / 3'_untranslated_regions / 5-methylcytosine / 5'_untranslated_regions / Abattoirs / Abdominal_muscles / Abdominal_neoplasms / Abdominal_pain / Abdominoplasty / Abortion,_spontaneous / Absenteeism / Absorption / Academic_medical_centers / Academic_performance / Accidental_falls / Accidents / Accounting / Acepromazine / Acetaldehyde / Acetals / Acetates / Acetylcholine / Acetylcholinesterase / Acetylcysteine / Acetylene / Acetylglucosamine / Acetyltransferases / Achievement / Acid_ceramidase / Acid_sensing_ion_channels / Acid-base_equilibrium / Acidosis / Acinetobacter / Acinetobacter_baumannii / Acne_vulgaris / Acoustics / Acquired_immunodeficiency_syndrome / Acromegaly / Acrylamide / Actins / Action_potentials / Activities_of_daily_living / Acute_care_surgery / Acute_coronary_syndrome / Acute_kidney_injury / Acute_lung_injury / Acyltransferases / Adaptation,_physiological / Adenocarcinoma_of_lung / Adenoma / 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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Microbiota

The Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.

Ginsenoside Ro ameliorates d-galactose-induced sarcopenia by modulating oxidative stress, inflammation, and gut microbiota in mice.

Food-derived bioactive peptides in gut-muscle Axis regulation: Potential and challenges from microbiota homeostasis to muscle metabolism remodeling.

Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota-immune signaling via Phocaeicola vulgatus enrichment.

The Eubacterium Rectale Derived Extracellular Vesicles Alleviate Cancer Cachexia Induced Lipolysis by Inhibiting Macrophage Polarization.

Gut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

Associations Between Gut Microbiota and Mitochondrial Metabolites, with Growth Differentiation Factor-15 as a Marker of Oxidative Stress in Heart Failure vs. Healthy Ageing.

Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.

Coix seed oil alleviates collagen-induced arthritis-associated muscle atrophy and functional decline by modulating gut microbiota dysbiosis.

Corn-derived peptide LQQQLL alleviates skeletal muscle attenuation by mTOR signaling pathway and intestinal microbiota.

Association of the Dietary Index for Gut Microbiota With Severity, Renal Function, and Sarcopenia in Patients With Chronic Kidney Disease: A Population-Based Cross-Sectional Study.

Distinct gut microbiota signatures in older people with sarcopenic obesity and sarcopenia without obesity.

The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia.

Melatonin Ameliorates Age-Related Sarcopenia via the Gut-Muscle Axis Mediated by Serum Lipopolysaccharide and Metabolites.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

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