Deuterium-Oxide Labelling Proteomics Illustrates the Importance of Sample Timing and the Limitations of Serial Biopsies.
BACKGROUND
Measuring in vivo protein synthesis is important for testing how interventions, disease and ageing remodel the proteome. A limitation of approaches using short-term infusions of labelled amino acids was that long-term changes had to be extrapolated from short-term measurements. Deuterium oxide...
