Organelle_biogenesis

Sarcopenia

Juyuanjian attenuates sarcopenia through dual regulation of the Akt/FoxO1 and SIRT1/PGC-1α pathways.

BACKGROUND

Sarcopenia, an age-related degenerative disease, corresponds to "Qi Xu" syndrome in traditional Chinese medicine. Juyuanjian (JYJ), a classical Qi-tonifying formula, has shown potential against muscle atrophy and functional decline, but its molecular mechanisms are not well understood.

PURPOSE

To investigate whether JYJ...

🗓️ 2026-05-03

📰 Publication: Phytomedicine

Herbal_medicine / Interleukin-6 / muscles / Muscular_atrophy / Organelle_biogenesis / Pharmacology / Plants,_medicinal / Sirtuin_1 / therapeutics / Ubiquitin

Sarcopenia

Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.

Sarcopenia is an age-related condition characterized by loss of skeletal muscle mass and strength and is associated with increased cancer incidence and mortality, yet how muscle decline promotes tumorigenesis remains unclear. Here, we show that skeletal muscle functions as an...

🗓️ 2026-04-28

📰 Publication: Nature Communications

Carcinogenesis / Extracellular_vesicles / Growth / Muscle,_skeletal / muscles / neoplasms / Organelle_biogenesis

Muscle

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.

Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a,...

🗓️ 2026-04-16

📰 Publication: Aging Cell

Aging / Mitochondria / Mitophagy / Muscle_strength / muscles / Organelle_biogenesis / Receptors,_ghrelin / Sarcopenia

Muscle

Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis.

Sarcopenia, a prevalent age-related degenerative disorder, poses significant challenges in geriatric care. Chinese leek demonstrates therapeutic potential against sarcopenia progression, with emerging evidence suggesting its extracellular vesicles (EVs) may mediate these effects. Notably, plant-derived EVs have garnered increasing attention due...

🗓️ 2025-11-20

📰 Publication: Journal Of Nanobiotechnology

Atrophy / Autophagy / Extracellular_vesicles / Homeostasis / Multiple_chronic_conditions / Muscle_fibers,_skeletal / muscles / Myosins / Nanotechnology / Organelle_biogenesis / Sarcopenia / therapeutics

Muscle

STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

BACKGROUND

Mitochondrial homeostasis is vital for optimal skeletal muscle integrity. Mitochondrial quality control (MQC) mechanisms that are essential for maintaining proper functions of mitochondria include mitochondrial biogenesis, dynamics and mitophagy. Previously, Syntaxin 4 (STX4), traditionally considered a cell surface protein known...

🗓️ 2025-11-11

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / CELLS / Genes / Homeostasis / Mitochondria / Mitophagy / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Organelle_biogenesis / Quality_control / Sarcopenia

Muscle

Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia.

Although the decline in muscle mass, function and increased visceral obesity are attracting substantial attention in the ageing society, approved treatment modalities for sarcopenia/sarcopenic obesity (SO) remain limited. Elucidating effects and mechanisms of adipose tissue and lipids on skeletal muscle...

🗓️ 2025-01-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Athletes / cachexia / CELLS / Insulin / Lipid_droplets / Muscle_cells / Muscle,_skeletal / muscles / Obesity / Organelle_biogenesis / Oxidative_stress / Sarcopenia / Stress,_physiological / therapeutics / tissues

Muscle

Soyasapogenol B prevents sarcopenia by increasing skeletal muscle mass and function through the Sirt1/PGC-1α and PI3K pathway.

Sarcopenia, caused by aging, is characterized by the reduction of muscle mass and function. In this study, we investigated the effects of soyasapogenol B on skeletal muscle and the underlying mechanisms to determine its potential as a prevention for sarcopenia....

🗓️ 2025-07-05

📰 Publication: Biomedicine & Pharmacotherapy

Drug_therapy / Mitochondria / Muscle,_skeletal / muscles / Organelle_biogenesis / Research / Sarcopenia / Sirtuin_1

Muscle

Umbelliferone attenuates diabetic sarcopenia by modulating mitochondrial quality and the ubiquitin-proteasome system.

Sarcopenia, characterized by the progressive loss of skeletal muscle mass, strength, and physical performance, is traditionally associated with aging. However, chronic conditions such as type 2 diabetes mellitus (T2DM) have been recognized as key accelerators of its progression. In this...

🗓️ 2025-05-31

📰 Publication: Phytomedicine

Diabetes_mellitus / Diabetes_mellitus,_type_2 / Herbal_medicine / Muscle_fibers,_skeletal / Muscle_proteins / Muscle,_skeletal / muscles / Muscular_atrophy / Myoblasts / Organelle_biogenesis / Phytochemicals / Plants,_medicinal / Proteasome_endopeptidase_complex / Quality_control / Sarcopenia / SERUM / therapeutics / Ubiquitin

Muscle

Prepregnancy Obesity Reprograms Offspring Skeletal Muscle Fibre Transition Through H3K9me3.

Maternal prepregnancy obesity predisposes offspring to obesity and metabolic disorders, yet its impact on skeletal muscle fibre transition remains unclear. Given that skeletal muscle plays a crucial role in systemic metabolism, we investigated how maternal prepregnancy high-fat diet (HFD) influences...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Diet / Diet,_high-fat / Genes / Histones / Insulin / Insulin_resistance / Muscle,_skeletal / muscles / Nadp / Obesity / Organelle_biogenesis / Promoter_regions,_genetic / Rna / Sarcopenia

Exercise

Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy.

Spinal muscular atrophy (SMA) is a health- and life-limiting neuromuscular disorder. Although varying degrees of mitochondrial abnormalities have been documented in SMA skeletal muscle, the influence of disease progression on pathways that govern organelle turnover and dynamics are poorly understood....

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagosomes / Autophagy / Disease_progression / Mitochondria / Mitochondria,_muscle / Mitochondrial_turnover / Mitophagy / Muscle,_skeletal / muscles / Muscular_atrophy / Muscular_atrophy,_spinal / Organelle_biogenesis / Organelles / Sarcopenia / Spine / therapeutics

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

2,2'-dipyridyl / 3-iodobenzylguanidine / 3,3'-diaminobenzidine / 3'_untranslated_regions / 5-methylcytosine / 5'_untranslated_regions / Abattoirs / Abdominal_muscles / Abdominal_neoplasms / Abdominal_pain / Abdominoplasty / Abortion,_spontaneous / Absenteeism / Absorption / Academic_medical_centers / Academic_performance / Accidental_falls / Accidents / Accounting / Acepromazine / Acetaldehyde / Acetals / Acetates / Acetylcholine / Acetylcholinesterase / Acetylcysteine / Acetylene / Acetylglucosamine / Acetyltransferases / Achievement / Acid_ceramidase / Acid_sensing_ion_channels / Acid-base_equilibrium / Acidosis / Acinetobacter / Acinetobacter_baumannii / Acne_vulgaris / Acoustics / Acquired_immunodeficiency_syndrome / Acromegaly / Acrylamide / Actins / Action_potentials / Activities_of_daily_living / Acute_care_surgery / Acute_coronary_syndrome / Acute_kidney_injury / Acute_lung_injury / Acyltransferases / Adaptation,_physiological / Adenocarcinoma_of_lung / Adenoma / 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Protein_isoforms / Protein_kinases / Protein_phosphatase_1 / Protein_processing,_post-translational / Protein_serine-threonine_kinases / Protein-tyrosine_kinases / Proteogenomics / Proteome / Proteomics / Prothrombin / Prothrombin_time / Proton_pump_inhibitors / Proton_pumps / Proton_therapy / Pruritus / Pseudogenes / Pseudomonas / Pseudomonas_aeruginosa / Pseudomonas_stutzeri / Pseudouridine / Psoriasis / Psychiatrists / Psychological_distress / Psychological_well-being / Psychology,_positive / Psychometrics / Psychosocial_intervention / Psychotherapy / Psychotic_disorders / Psychotropic_drugs / Public_health / Public_health_surveillance / Public_sector / Pulmonary_arterial_hypertension / Pulmonary_disease,_chronic_obstructive / Pulmonary_embolism / Pulmonary_fibrosis / Pulmonary_surfactant-associated_protein_a / Pulmonary_valve / Pulpectomy / Pulpotomy / Pulse / Punctures / Punishment / Pupa / Pupil / Purpura / Purpura,_thrombocytopenic / Putamen / Pyoderma / Pyoderma_gangrenosum / Pyrans / Pyrazoles / Pyridoxine / Pyrophosphatases / Pyroptosis / Pyrrolidinones / Pyruvate_kinase / Quadriceps_muscle / Qualitative_research / Quality_improvement / Quality_of_life / Quality-adjusted_life_years / Quantitative_trait_loci / Quantum_dots / Quarantine / Quercetin / Quinazolines / Quinoxalines / Quorum_sensing / Racism / Radar / Radiation_exposure / Radiation_fibrosis_syndrome / Radio / Radiofrequency_ablation / Radiography / Radiologists / Radiology / Radiology,_interventional / Radionuclide_imaging / radiotherapy / Radius_fractures / Rainforest / Random_allocation / Range_of_motion,_articular / Ranula / Rare_diseases / Reaction_time / Reading / Reading_frames / Receptor_activity-modifying_proteins / Receptor_for_advanced_glycation_end_products / Receptors,_adrenergic / Receptors,_antigen / Receptors,_antigen,_t-cell / Receptors,_calcitriol / Receptors,_cannabinoid / Receptors,_chemokine / Receptors,_chimeric_antigen / Receptors,_cxcr4 / Receptors,_estrogen / 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Exercise

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / Antihypertensive_agents / Antimicrobial_stewardship / Antineoplastic_agents / Antioxidants / Antiphospholipid_syndrome / Antipsychotic_agents / Antitubercular_agents / Antiviral_agents / Aorta / Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_dissection / Aortic_valve / Aphasia / Aphasia,_primary_progressive / Apicoplasts / Apolipoproteins / Apoptosis / Apoptosis_regulatory_proteins / Appendiceal_neoplasms / Appendicitis / Appendix / Appetite / Arboviruses / Arenavirus / Arginine / Arrhythmias,_cardiac / Arteriovenous_malformations / Arthralgia / Arthritis / Arthritis,_rheumatoid / Arthroplasty / Arthroplasty,_replacement,_knee / Artificial_intelligence / Artificially_sweetened_beverages / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillosis / Aspergillosis,_allergic_bronchopulmonary / Asthenozoospermia / Astrocytes / Astrocytoma / Astronauts / Ataxia / Ataxia_telangiectasia / Atherectomy / Atherosclerosis / Athletes / Atrasentan / Atrial_fibrillation / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Attitude_to_health / Audiology / Augmented_reality / Authorship / Autism_spectrum_disorder / Autistic_disorder / Autoantibodies / Autoimmune_diseases / Autophagy / Autopsy / Axial_spondyloarthritis / Axons / B-lymphocytes / Back_pain / Bacterial_adhesion / Bacteriocins / Bacteriophages / Balantidiasis / Bariatric_surgery / Bartonella / Base_sequence / Basement_membrane / Basophils / Beds / Begomovirus / Behcet_syndrome / Benzene / Benzimidazoles / Benzocaine / Bevacizumab / Bezafibrate / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bilirubin / Biochemistry / Biocompatible_materials / Biodiversity / Biofilms / Biogenic_amines / Biological_availability / Biological_factors / Biological_monitoring / Biological_oxygen_demand_analysis / Biological_therapy / Biomarkers / Biomass / Biomedical_research / Biomimetics / Biophysics / Biopolymers / Biopsy / Biosimilar_pharmaceuticals / Biostatistics / 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Ischemia / Ischemic_preconditioning / Ischemic_stroke / Islet_amyloid_polypeptide / Isocitrate_dehydrogenase / Ivermectin / Janus_kinase_inhibitors / Jaundice / Jaundice,_neonatal / Jejunum / Joint_dislocations / Junctional_adhesion_molecule_c / Jurisprudence / Kanamycin / Kelp / Keratitis / Keratoconus / Ketamine / Ketosis / Kidney / Kidney_failure,_chronic / Kidney_neoplasms / Kidney_transplantation / Killer_cells,_natural / Kynurenic_acid / Kynurenine / Laboratories / Lacerations / Lactams / Lactic_acid / Lactobacillus / Lactones / Landslides / Language / Laparoscopy / Larva / Laryngeal_neoplasms / Laser_therapy / Lasers / Latent_infection / Latent_tuberculosis / Laxatives / Learning_disabilities / Lecithins / Length_of_stay / Leptospirosis / Lethargy / Leucine / Leukemia / Leukemia,_myeloid / Leukemia,_myeloid,_acute / Leukocyte_l1_antigen_complex / Lichen_sclerosus_et_atrophicus / Lichens / Lidocaine / Life_expectancy / Life_style / Ligaments / Ligands / Ligation / Lignin / Limit_of_detection / Limonene / Linagliptin / Linguistics / Lipid_droplets / Lipid_metabolism_disorders / Lipid_nanoparticles / Lipid_peroxides / Lipopolysaccharides / Lipoprotein(a) / Lipoproteins / Liposarcoma / Liquid_biopsy / Liquid_crystals / Lithiasis / Live_birth / Liver_cirrhosis / Liver_failure / Liver_failure,_acute / Liver_neoplasms / Liver_transplantation / Local_area_networks / Locomotion / Longevity / Longitudinal_studies / Lordosis / Low_back_pain / Low_tension_glaucoma / Lubiprostone / Luciferases / Lung / Lung_diseases / Lung_diseases,_interstitial / Lung_diseases,_obstructive / Lung_injury / Lung_neoplasms / Lupus_erythematosus,_systemic / Luteal_phase / Lyme_disease / Lymph_nodes / Lymphatic_diseases / Lymphatic_system / Lymphedema / Lymphocytes / Lymphocytes,_tumor-infiltrating / Lymphohistiocytosis,_hemophagocytic / Lymphoma / Lymphoma,_b-cell / Lymphoma,_follicular / Lymphoma,_large_b-cell,_diffuse / Lymphoma,_t-cell / Lymphoma,_t-cell,_peripheral / Lysine / Lysophosphatidylcholines / Lysosomes / Machine_learning / Macrophages / Macrophages,_alveolar / Magnetic_resonance_imaging / Maintenance / Malnutrition / Mammaplasty / Mannans / Mannitol / Mannose-binding_lectin / Mannosyltransferases / Margins_of_excision / Marijuana_use / Marketing / Masculinity / Masks / Mast_cells / Mastitis / Mastitis,_bovine / Mastoiditis / Maternal_mortality / Mathematics / Meals / Meat / Mechanistic_target_of_rapamycin_complex_1 / Medial_tibial_stress_syndrome / Mediation_analysis / Medical_laboratory_science / Medical_marijuana / Medical_oncology / Medical_records / Medical_staff / Medical_waste / Medicare / Medication_adherence / Medication_errors / Medicine,_chinese_traditional / Medicine,_traditional / Meditation / Medulloblastoma / Melanins / Melanoma / Meloxicam / Membrane_proteins / Membranes / Memory / Menarche / Mendelian_randomization_analysis / Meninges / Meningioma / Meningitis / Menstruation / Mental_disorders / Mental_health / Mental_health_services / Menthol / Mentoring / Mesalamine / Mesangial_cells / Mesencephalon / Mesenchymal_stem_cells / Metabolic_diseases / Metabolic_equivalent / Metabolic_syndrome / Metabolomics / Metagenomics / Metal-organic_frameworks / Metastasectomy / Metformin / Methanol / Methemoglobin / Methemoglobinemia / Methicillin / Methotrexate / Methylphenidate / Methylprednisolone / Metronidazole / Metschnikowia / Micelles / Microbial_interactions / Microbiology / Microfluidics / Micronutrients / Micrornas / Microsatellite_repeats / Microscopic_polyangiitis / MICROSCOPY / Microscopy,_electron,_scanning_transmission / Microscopy,_electron,_transmission / Microspheres / Middle_cerebral_artery / Migraine_disorders / Military_personnel / Milk / Milk,_human / Mineralocorticoids / Miniaturization / Minimally_invasive_surgical_procedures / Mitochondria / Mitochondrial_dynamics / Mixed_function_oxygenases / Models,_statistical / Molecular_biology / Molecular_dynamics_simulation / Monocytes / Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Organelle_biogenesis

Juyuanjian attenuates sarcopenia through dual regulation of the Akt/FoxO1 and SIRT1/PGC-1α pathways.

Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.

Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis.

STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia.

Soyasapogenol B prevents sarcopenia by increasing skeletal muscle mass and function through the Sirt1/PGC-1α and PI3K pathway.

Umbelliferone attenuates diabetic sarcopenia by modulating mitochondrial quality and the ubiquitin-proteasome system.

Prepregnancy Obesity Reprograms Offspring Skeletal Muscle Fibre Transition Through H3K9me3.

Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

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