BACKGROUND
Hospital-associated deconditioning is a contributor to secondary sarcopenia, which may be driven by prolonged hospital length of stay (LoS). This study investigated the bidirectional association of LoS and sarcopenia indices (lean soft tissue, muscle strength, physical function) in older inpatients,...
BACKGROUND
Novel stroke risk factors have received widespread attention. This study examined the association between sarcopenia status, grip strength, and walking pace with incident stroke (any stroke, ischemic stroke, and hemorrhagic stroke) and poststroke mortality.
METHODS
This prospective study included 482 699 participants from...
BACKGROUND
The longitudinal relationship between frailty phenotype and CKD development, and the modifying role of genetic CKD risk in this association, remains unclear. Research on simple, noninvasive and quantifiable CKD prediction models incorporating frailty is limited.
METHODS
We analysed 214 502 CKD-free participants from...
BACKGROUND
Longitudinal associations between age-related changes in body composition, physical performance and incident diabetes mellitus (DM) in older adults and the mediating role of branched-chain amino acids (BCAAs) remain understudied.
METHODS
This prospective cohort study included 4000 community-dwelling older adults at baseline. Longitudinal...
BACKGROUND
Handgrip strength, gait speed, Five-Times-Sit-to-Stand Test (FTSST) performance, skeletal muscle mass and calf circumference are important health outcomes, particularly useful for diagnosing sarcopenia. The aim of this study was to establish reference (normative) values for handgrip strength, gait speed, FTSST...
AIM
To investigate effects of host- and gut microbiota (GM)-altering interventions on sarcopenia (parameters).
METHODS
Upon PROSPERO registration (CRD42022347363), six databases and one registry were searched until January 5th 2024 and updated on June 10th 2025 for diet, pre-, pro-, or synbiotics mono-interventions...
BACKGROUND
Emerging evidence suggests that air quality may impact muscle health. However, most studies are limited by cross-sectional designs or short follow-ups. We assessed the association of long-term exposure to ambient air pollutants with changes in muscle mass and strength in...
Lymphomas are common cancers affecting the lymphatic system. Chemotherapy is a standard treatment, yet its impact on patient's physical capacity remains understudied. This study aimed to evaluate changes in body composition, muscle strength, and physical performance in patients diagnosed with...
Patients with chronic obstructive pulmonary disease (COPD) frequently exhibit intestinal leaks and age-related muscle impairment, termed sarcopenia. The sarcopenia-related quality-of-life (SarQoL) is a tool to evaluate the quality of life of sarcopenic patients. However, the association of intestinal leak with...
Deterioration of functional capacity mostly determinates frailty in older patients with cardiovascular disease (CVD). Elucidating the pathophysiological mechanisms of physical frailty is an important goal for improving functional health-related outcomes. Our objective was the determination of the transcriptomic signature of...
Walking speed is a reliable marker of sarcopenia and a strong predictor of mortality, but its relationship with cancer incidence remains largely unexplored. We aimed to investigate the association between walking speed and the risk of any cancer and five...
Sarcopenia is associated with the loss of skeletal muscle function and mass. Nicotinamide precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), have received attention for their potential to improve NAD levels and mitigate age-related sarcopenia in preliminary models,...
Knee-osteoarthritis (OA) is often associated with increased intestinal permeability, potentially causing sarcopenia, and mobility issues. Current treatments are ineffective. The objective of this study was to investigate if butyrate improves sarcopenia and physical function in knee-OA patients, and if improvements...
Sarcopenia is a progressive muscle disorder that may lead to mobility disability. No pharmaceutical interventions are currently available, and treatment relies on physical exercise and nutrition. The aim of SARA-INT was to investigate whether BIO101 (20-hydroxyecdysone), an activator of the...
