Aged

UA-30 mitigates systemic aging and motor decline by inhibiting RalA signaling in naturally aged mice.

Aging, characterized by progressive physiological decline and systemic dysfunction, represents a major risk factor for age-related diseases such as sarcopenia, which involves fibrosis that disrupts muscle regeneration and function. Effective therapeutic strategies remain limited. Here we report UA-30, a novel...

🗓️ 2026-09-16
📰 Publication: Journal Of Experimental Medicine
Read MoreUA-30 mitigates systemic aging and motor decline by inhibiting RalA signaling in naturally aged mice.

Appendicular Skeletal Muscle Mass and Sarcopenia as Prognostic Markers in Amyotrophic Lateral Sclerosis.

BACKGROUND

Amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle wasting and functional decline. Prognostic assessment in clinical practice relies largely on functional scales and traditional anthropometric measures. The prognostic relevance of muscle mass, muscle strength and sarcopenia in ALS remains...

🗓️ 2026-09-10
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAppendicular Skeletal Muscle Mass and Sarcopenia as Prognostic Markers in Amyotrophic Lateral Sclerosis.

Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing.

BACKGROUND

Sarcopenia is a major contributor to frailty and mortality in ageing and obesity and is tightly linked to metabolic dysfunction. Imeglimin is a first-in-class oral hypoglycaemic agent targeting mitochondrial function; however, despite the central role of mitochondria in skeletal muscle...

🗓️ 2026-07-29
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing.

A C. elegans-to-Mouse Discovery Framework for Prioritizing Sarcopenia Interventions.

Sarcopenia is a manifestation of musculoskeletal aging, yet no approved therapy is available. A major challenge is not the lack of potential interventions, but the difficulty of efficiently identifying which candidates should advance to aged-mammal validation. Sarcopenia is driven by...

🗓️ 2026-07-28
📰 Publication: Aging And Disease
Read MoreA C. elegans-to-Mouse Discovery Framework for Prioritizing Sarcopenia Interventions.

Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.

Sarcopenia is the age-related loss of muscle strength and size that leads to mobility limitations and loss of independence in older adults. The underlying cellular mechanisms remain unclear, and treatments are limited. As the critical interface between the nervous system...

🗓️ 2026-07-09
📰 Publication: Journal Of Clinical Investigation
Read MoreNeuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.

Association of Testosterone With Lean Soft Tissue and Handgrip Strength Across Middle-Aged Men.

BACKGROUND

Testosterone declines by 0.4%-2% annually after the age of 30 and is potentially linked with muscle mass and strength. This study examined how testosterone levels are associated with handgrip strength (HGS) and appendicular lean soft tissue index (ALSTI) in men...

🗓️ 2026-07-08
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Testosterone With Lean Soft Tissue and Handgrip Strength Across Middle-Aged Men.

Muscle Ageing and Sarcopenia Study (MASS) Lifecourse: a valuable resource for understanding skeletal muscle ageing.

Advances in our understanding of the biology of skeletal muscle ageing are being made at pace, with great potential for these findings to inform the identification of novel treatments for sarcopenia. However, translation of findings from animal models to humans...

🗓️ 2026-06-15
Read MoreMuscle Ageing and Sarcopenia Study (MASS) Lifecourse: a valuable resource for understanding skeletal muscle ageing.

Sarcopenia Predicts Mortality and Hepatic Encephalopathy After TIPS in Older Adults With Cirrhosis and Improves Prognostic Scores.

BACKGROUND AND AIMS

The role of transjugular intrahepatic portosystemic shunt (TIPS) in older adults remains controversial because of limited risk-stratification tools. We aimed to assess whether sarcopenia and myosteatosis are independently associated with post-TIPS mortality and overt hepatic encephalopathy (OHE) in...

🗓️ 2026-06-08
📰 Publication: Liver International
Read MoreSarcopenia Predicts Mortality and Hepatic Encephalopathy After TIPS in Older Adults With Cirrhosis and Improves Prognostic Scores.

Handgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.

BACKGROUND

Muscular fitness, particularly handgrip strength, is increasingly recognized as a robust marker of cardiometabolic risk (CMR) in children and adolescents. However, evidence-based diagnostic thresholds for identifying at-risk individuals remain scarce, particularly in children. This study aimed to (1) establish sex-specific...

🗓️ 2026-05-28
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHandgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.

Frailty Transforms Care Continuity-Mortality Relationships Across Age Groups: Evidence From Taiwan and South Korea.

BACKGROUND

Healthcare fragmentation typically predicts poor outcomes, yet its relationship with frailty across different age groups remains unexplored. We examined how frailty modifies the association between care patterns and mortality in middle-aged and older adults from two rapidly ageing Asian societies.

METHODS

We...

🗓️ 2026-05-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreFrailty Transforms Care Continuity-Mortality Relationships Across Age Groups: Evidence From Taiwan and South Korea.

Gut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

BACKGROUND

Ageing is an inevitable biological process that contributes to increased prevalence of age-associated diseases, including sarcopenia, defined by progressive loss of muscle mass, functional decline and a heightened risk of injury. Developing effective interventions remains a critical clinical priority. This...

🗓️ 2026-04-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreGut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

Association of the "Weekend Warrior" Exercise Pattern With Sarcopenia in Middle-Aged and Older Adults: Comparison With Regular Activity and Inactivity Patterns.

PURPOSE

Although the "weekend warrior (WW)" physical activity (PA) pattern has known health benefits, its association with sarcopenia is unclear. This study examined whether the WW PA pattern is associated with a lower likelihood of sarcopenia compared with the inactive and...

🗓️ 2026-01-30
Read MoreAssociation of the "Weekend Warrior" Exercise Pattern With Sarcopenia in Middle-Aged and Older Adults: Comparison With Regular Activity and Inactivity Patterns.

Microbes and ageing beyond the gut: the oral microbiome and frailty, sarcopenia and neurocognitive disorders in the elderly – a scoping review protocol.

INTRODUCTION

Population ageing is a global phenomenon that has resulted in an increase in the number of patients with chronic diseases and geriatric syndromes. Frailty, sarcopenia and neurocognitive disorders are among the most prevalent conditions affecting older adults and have a...

🗓️ 2026-01-29
📰 Publication: Bmj Open
Read MoreMicrobes and ageing beyond the gut: the oral microbiome and frailty, sarcopenia and neurocognitive disorders in the elderly – a scoping review protocol.

Plant-based protein for older adults with obesity.

The global syndemic of obesity, undernutrition, and climate change - three interconnected challenges - threatens both human and planetary health. This review focuses on one critical intersection: older populations living with overweight and obesity in the context of sustainable nutrition....

🗓️ 2025-12-26
📰 Publication: Proceedings Of The Nutrition Society
Read MorePlant-based protein for older adults with obesity.

Skeletal Muscle HSF1 Alleviates Age-Associated Sarcopenia and Mitochondrial Function Decline via SIRT3-PGC1α Axis.

Age-related sarcopenia, characterized by progressive loss of skeletal muscle mass and strength, impacts metabolic health and quality of life in the elderly. Heat shock factor 1 (HSF1) is a transcription factor that orchestrates cellular responses to various stresses, while its...

🗓️ 2025-12-16
Read MoreSkeletal Muscle HSF1 Alleviates Age-Associated Sarcopenia and Mitochondrial Function Decline via SIRT3-PGC1α Axis.

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