Ubiquitin

Muscle

RNF10 Attenuates Age-Related Muscle Atrophy by Promoting p53 Degradation and Alleviating Oxidative Stress.

Evidence identifies proteostasis imbalance and oxidative stress serve as fundamental pathological hallmarks of muscular atrophy, yet ring finger protein 10 (RNF10), a novel E3 ubiquitin ligase, in age-related muscular atrophy remains poorly characterized. Employing a natural aging mouse model and...

🗓️ 2026-06-18

📰 Publication: Free Radical Biology And Medicine

Aging / Galactose / Genes,_p53 / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Muscular_atrophy / Oxidative_stress / Sarcopenia / Stress,_physiological / Ubiquitin / Ubiquitin-protein_ligases

Sarcopenia

Juyuanjian attenuates sarcopenia through dual regulation of the Akt/FoxO1 and SIRT1/PGC-1α pathways.

BACKGROUND

Sarcopenia, an age-related degenerative disease, corresponds to "Qi Xu" syndrome in traditional Chinese medicine. Juyuanjian (JYJ), a classical Qi-tonifying formula, has shown potential against muscle atrophy and functional decline, but its molecular mechanisms are not well understood.

PURPOSE

To investigate whether JYJ...

🗓️ 2026-05-03

📰 Publication: Phytomedicine

Herbal_medicine / Interleukin-6 / muscles / Muscular_atrophy / Organelle_biogenesis / Pharmacology / Plants,_medicinal / Sirtuin_1 / therapeutics / Ubiquitin

Muscle

Deubiquitinase YOD1 Inhibition Suppresses DEX- and Denervation-Induced Muscle Atrophy Through MAFbx Destabilization.

BACKGROUNDS

Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle-specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin-proteasome system remains unclear. This...

🗓️ 2026-04-29

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Denervation / Deubiquitinating_enzymes / Genes / Hand_strength / Ligases / Muscle,_skeletal / muscles / Muscular_atrophy / Sarcopenia / therapeutics / Ubiquitin

Muscle

The Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI-α and Controls Myogenic Differentiation.

BACKGROUND

Muscle RING finger (MuRF) proteins are striated muscle-specific E3 ubiquitin ligases essential for muscle homeostasis. Whereas MuRF1 is well known for its role in muscle atrophy, MuRF2 and MuRF3 contribute to microtubule stabilization, influencing muscle differentiation and function. Their cooperative...

🗓️ 2025-01-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

CELLS / Endosomes / Microtubules / Muscle_cells / muscles / Myostatin / Protein_isoforms / Sarcopenia / therapeutics / Ubiquitin / Ubiquitination

Muscle

Ferulic Acid Attenuates Sarcopenia Progression by Inhibiting Peroxisomal ACOX1.

Sarcopenia, an age-related syndrome characterized by progressive loss of skeletal muscle mass, strength, and function, is closely associated with oxidative stress, inflammation, and protein metabolism imbalance. Ferulic acid (FA), a natural antioxidant, may improve sarcopenia, but its mechanism remains unclear....

🗓️ 2025-08-13

📰 Publication: Free Radical Biology And Medicine

Cell_survival / CELLS / Enzymes / Free_radicals / Muscle_fibers,_skeletal / muscles / Oxidative_stress / Sarcopenia / Stress,_physiological / Ubiquitin / Ubiquitin-protein_ligases

Muscle

Umbelliferone attenuates diabetic sarcopenia by modulating mitochondrial quality and the ubiquitin-proteasome system.

Sarcopenia, characterized by the progressive loss of skeletal muscle mass, strength, and physical performance, is traditionally associated with aging. However, chronic conditions such as type 2 diabetes mellitus (T2DM) have been recognized as key accelerators of its progression. In this...

🗓️ 2025-05-31

📰 Publication: Phytomedicine

Diabetes_mellitus / Diabetes_mellitus,_type_2 / Herbal_medicine / Muscle_fibers,_skeletal / Muscle_proteins / Muscle,_skeletal / muscles / Muscular_atrophy / Myoblasts / Organelle_biogenesis / Phytochemicals / Plants,_medicinal / Proteasome_endopeptidase_complex / Quality_control / Sarcopenia / SERUM / therapeutics / Ubiquitin

Muscle

GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice.

The survival rate for children and adolescents has increased to over 85%. However, there is limited understanding of the impact of pediatric cancers on muscle development and physiology. Given that brain tumors alone account for 26% of all pediatric cancers,...

🗓️ 2025-04-18

📰 Publication: American Journal Of Physiology-Regulatory Integrative And Comparative Physiology

Body_weight / cachexia / CELLS / Glioblastoma / Growth / Muscle_development / Muscle_fibers,_skeletal / Muscle_proteins / Muscle,_skeletal / muscles / neoplasms / Ubiquitin / Weight_gain

Muscle

HD6277 Suppresses Muscle Atrophy by Promoting Myogenic Factors and Inhibiting Proteolysis in Aged Mice.

G protein-coupled receptor 40 (GPR40) acts as a modulator of various physiological functions, including glycaemic lowering, anti-inflammation and antioxidative stress, in several tissues. However, the role of GPR40 in skeletal muscles remains unclear. To investigate the roles of muscle GPR40,...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aged / Ligases / Muscle_fibers,_skeletal / muscles / Muscular_atrophy / Myoblasts / Palmitates / Sarcopenia / Ubiquitin / Ubiquitin-protein_ligases

Muscle

Low-Carbohydrate Diet Exacerbates Denervation-Induced Atrophy of Rat Skeletal Muscle Under the Condition of Identical Protein Intake.

While decreased protein intake is associated with muscle mass loss, it is unclear whether a decrease in carbohydrate intake adversely affects muscle atrophy independently of protein intake. Herein, we examined whether a low-carbohydrate (low-CHO) diet exacerbates denervation-induced muscle atrophy under...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Carbohydrates / Denervation / Diet / Diet,_carbohydrate-restricted / Genes / Ligases / Muscle,_skeletal / muscles / Muscular_atrophy / Sarcopenia / Ubiquitin

Muscle

Characterization of SARS-CoV-2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection.

COVID-19 has been associated with both respiratory (diaphragm) and non-respiratory (limb) muscle atrophy. It is unclear if SARS-CoV-2 infection of skeletal muscle plays a role in these changes. This study sought to: 1) determine if cells comprising skeletal muscle tissue,...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagy / cachexia / CELLS / Covid-19 / Diaphragm / Genes / Infections / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Muscular_atrophy / Sarcopenia / Sars-cov-2 / Severe_acute_respiratory_syndrome-related_coronavirus / Ubiquitin / Virus_internalization

Muscle

Transcriptomic Profiling Reveals 17β-Estradiol Treatment Represses Ubiquitin-Proteasomal Mediators in Skeletal Muscle of Ovariectomized Mice.

With a decline of 17β-estradiol (E2) at menopause, E2 has been implicated in the accompanied loss of skeletal muscle mass and strength. We aimed at characterizing transcriptomic responses of skeletal muscle to E2 in female mice, testing the hypothesis that...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aging / Estradiol / Estrogens / Genes / Muscle,_skeletal / muscles / Promoter_regions,_genetic / Sarcopenia / therapeutics / Ubiquitin

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

2,2'-dipyridyl / 3-iodobenzylguanidine / 3,3'-diaminobenzidine / 3'_untranslated_regions / 5-methylcytosine / 5'_untranslated_regions / Abattoirs / Abdominal_muscles / Abdominal_neoplasms / Abdominal_pain / Abdominoplasty / Abortion,_spontaneous / Absenteeism / Absorption / Academic_medical_centers / Academic_performance / Accidental_falls / Accidents / Accounting / Acepromazine / Acetaldehyde / Acetals / Acetates / Acetylcholine / Acetylcholinesterase / Acetylcysteine / Acetylene / Acetylglucosamine / Acetyltransferases / Achievement / Acid_ceramidase / Acid_sensing_ion_channels / Acid-base_equilibrium / Acidosis / Acinetobacter / Acinetobacter_baumannii / Acne_vulgaris / Acoustics / Acquired_immunodeficiency_syndrome / Acromegaly / Acrylamide / Actins / Action_potentials / Activities_of_daily_living / Acute_care_surgery / Acute_coronary_syndrome / Acute_kidney_injury / Acute_lung_injury / Acyltransferases / Adaptation,_physiological / Adenocarcinoma_of_lung / Adenoma / Adenoma,_pleomorphic / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipocytes,_brown / Adipocytes,_white / Adipogenesis / Adiponectin / Adipose_tissue / Adiposity / Administration,_intranasal / Administration,_oral / Adolescent / Adrenal_cortex_hormones / Adrenocorticotropic_hormone / Adult_stem_cells / Advance_care_planning / Adverse_childhood_experiences / Advertising / Aeromonas_veronii / Aerosols / Aflatoxin_m1 / Aflatoxins / African_swine_fever / Aftercare / Agar / Agaricales / Age_distribution / Aged / Agent_orange / Aggregatibacter / Aggregatibacter_aphrophilus / Aggression / Aging,_premature / Agranulocytosis / Agricultural_irrigation / Agriculture / Agrochemicals / Aids-related_complex / Air_pollution / Alanine / Alcohol_drinking / Alcoholics / Aldehydes / Aldosterone / Alendronate / Alginates / Algorithms / Alkaline_phosphatase / Alkalosis / Alkanesulfonates / Alkynes / Alleles / Allergens / Allografts / Allopurinol / Alloys / Alopecia / Alopecia_areata / 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Bronchogenic_cyst / Bronchopulmonary_sequestration / Bronchoscopy / Brucella / Brucellosis / Brugada_syndrome / Budesonide / Buffers / Bulimia / Bundle-branch_block / Bupropion / Burning_mouth_syndrome / Burnout,_psychological / Burns / Butter / Butyrylcholinesterase / C-peptide / C-reactive_protein / Ca-19-9_antigen / cachexia / Caco-2_cells / Cadherins / Caffeine / Calcitonin_gene-related_peptide / Calcium / Calcium_channel_blockers / Calcium_channels / Calcium_signaling / Cancer_vaccines / Cancer-associated_cachexia / Cancer-associated_fibroblasts / Candidemia / Candidiasis / Candidiasis,_invasive / Candidiasis,_vulvovaginal / Cannabidiol / Cannula / Capacity_building / Capillaries / Capsaicin / Capsid / Capsules / Car-t_cell / Carbamazepine / Carbapenems / Carbidopa / Carbohydrates / Carboxylic_acids / Carcinogenesis / Carcinogens / Carcinoid_tumor / Carcinoma_in_situ / Carcinoma,_basal_cell / Carcinoma,_hepatocellular / Carcinoma,_intraductal,_noninfiltrating / 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Exercise

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / 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Lysophosphatidylcholines / Lysosomes / Machine_learning / Macrophages / Macrophages,_alveolar / Magnetic_resonance_imaging / Maintenance / Malnutrition / Mammaplasty / Mannans / Mannitol / Mannose-binding_lectin / Mannosyltransferases / Margins_of_excision / Marijuana_use / Marketing / Masculinity / Masks / Mast_cells / Mastitis / Mastitis,_bovine / Mastoiditis / Maternal_mortality / Mathematics / Meals / Meat / Mechanistic_target_of_rapamycin_complex_1 / Medial_tibial_stress_syndrome / Mediation_analysis / Medical_laboratory_science / Medical_marijuana / Medical_oncology / Medical_records / Medical_staff / Medical_waste / Medicare / Medication_adherence / Medication_errors / Medicine,_chinese_traditional / Medicine,_traditional / Meditation / Medulloblastoma / Melanins / Melanoma / Meloxicam / Membrane_proteins / Membranes / Memory / Menarche / Mendelian_randomization_analysis / Meninges / Meningioma / Meningitis / Menstruation / Mental_disorders / Mental_health / 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Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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Cachexia

Hydrogen sulfide inhibits skeletal muscle ageing by up-regulating autophagy through promoting deubiquitination of adenosine 5'-monophosphate (AMP)-activated protein kinase α1 via ubiquitin specific peptidase 5.

Hydrogen sulfide (HS), the third gasotransmitter discovered, regulates a variety of physiological functions. Whether HS alleviates skeletal muscle ageing by regulating autophagy has not been reported. Mice were administered 150 mg/kg/day of D-galactose ( D-gal), and C2C12 myotubes were cultured in...

🗓️ 2024-08-27

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adenosine / Amp-activatedproteinkinases / Autophagy / F-boxproteins / Galactose / Muscle,Skeletal / Musclefibers,skeletal / muscles / Peptidehydrolases / Proteinkinases / Sarcopenia / Sulfides / tissues / Ubiquitin / Ubiquitin-specificproteases / Ubiquitination

Cachexia

Ubiquitylomics: An Emerging Approach for Profiling Protein Ubiquitylation in Skeletal Muscle.

Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely acknowledged, unravelling the underlying molecular mechanisms poses ongoing challenges. Protein ubiquitylation, a crucial...

🗓️ 2024-09-16

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Muscle,Skeletal / muscles / Proteinprocessing,post-translational / Proteomics / Research / Sarcopenia / Ubiquitin / Ubiquitination

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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Ubiquitin

RNF10 Attenuates Age-Related Muscle Atrophy by Promoting p53 Degradation and Alleviating Oxidative Stress.

Juyuanjian attenuates sarcopenia through dual regulation of the Akt/FoxO1 and SIRT1/PGC-1α pathways.

Deubiquitinase YOD1 Inhibition Suppresses DEX- and Denervation-Induced Muscle Atrophy Through MAFbx Destabilization.

The Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI-α and Controls Myogenic Differentiation.

Ferulic Acid Attenuates Sarcopenia Progression by Inhibiting Peroxisomal ACOX1.

Umbelliferone attenuates diabetic sarcopenia by modulating mitochondrial quality and the ubiquitin-proteasome system.

GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice.

HD6277 Suppresses Muscle Atrophy by Promoting Myogenic Factors and Inhibiting Proteolysis in Aged Mice.

Low-Carbohydrate Diet Exacerbates Denervation-Induced Atrophy of Rat Skeletal Muscle Under the Condition of Identical Protein Intake.

Characterization of SARS-CoV-2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection.

Transcriptomic Profiling Reveals 17β-Estradiol Treatment Represses Ubiquitin-Proteasomal Mediators in Skeletal Muscle of Ovariectomized Mice.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Hydrogen sulfide inhibits skeletal muscle ageing by up-regulating autophagy through promoting deubiquitination of adenosine 5'-monophosphate (AMP)-activated protein kinase α1 via ubiquitin specific peptidase 5.

Ubiquitylomics: An Emerging Approach for Profiling Protein Ubiquitylation in Skeletal Muscle.

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