Adrenergic_agents

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.

Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning in both physiological...

🗓️ 2026-09-23
📰 Publication: Nature Cancer
Read MoreAn iron-regulated methionine redox axis governs adipose browning and cancer cachexia.

Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart.

Cancer cachexia is a metabolic syndrome commonly observed in patients with pancreatic ductal adenocarcinoma (PDAC), characterized by wasting of skeletal and cardiac muscle. This condition is associated with the neurohormonal stress response and activation of the sympathetic nervous system. However...

🗓️ 2026-07-17
📰 Publication: Journal Of Physiology-London
Read MorePancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart.

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