Not All Weight Loss Is Equal: Towards Muscle-Preserving Therapies in Obesity.
🗓️ 2026-04-28
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNot All Weight Loss Is Equal: Towards Muscle-Preserving Therapies in Obesity.Sarcopenia
Adipose Tissue and Lipid Dysregulation Contributions to Cachexia, Sarcopenia and Muscle Function.
🗓️ 2026-04-28
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAdipose Tissue and Lipid Dysregulation Contributions to Cachexia, Sarcopenia and Muscle Function.Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.
BACKGROUND
Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific...
🗓️ 2026-04-24
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood. We performed this...
🗓️ 2026-04-24
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreWhole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.Longitudinal Study of Frailty Phenotype in Relation to Chronic Kidney Disease Incidence.
BACKGROUND
The longitudinal relationship between frailty phenotype and CKD development, and the modifying role of genetic CKD risk in this association, remains unclear. Research on simple, noninvasive and quantifiable CKD prediction models incorporating frailty is limited.
METHODS
We analysed 214 502 CKD-free participants from...
🗓️ 2026-04-22
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLongitudinal Study of Frailty Phenotype in Relation to Chronic Kidney Disease Incidence.Gut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.
BACKGROUND
Ageing is an inevitable biological process that contributes to increased prevalence of age-associated diseases, including sarcopenia, defined by progressive loss of muscle mass, functional decline and a heightened risk of injury. Developing effective interventions remains a critical clinical priority. This...
🗓️ 2026-04-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreGut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.Associations of Body Composition and Physical Function With Incident Diabetes in Older Adults: A 14-Year Prospective Cohort Study.
BACKGROUND
Longitudinal associations between age-related changes in body composition, physical performance and incident diabetes mellitus (DM) in older adults and the mediating role of branched-chain amino acids (BCAAs) remain understudied.
METHODS
This prospective cohort study included 4000 community-dwelling older adults at baseline. Longitudinal...
🗓️ 2026-04-20
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociations of Body Composition and Physical Function With Incident Diabetes in Older Adults: A 14-Year Prospective Cohort Study.Dual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.
Skeletal muscle accounts for approximately 40% of total body mass and is essential for locomotion, metabolic regulation and systemic homeostasis. Adipose tissue is increasingly recognized as an active component of the muscle's regenerative microenvironment. During muscle repair, adipose tissue contributes...
🗓️ 2026-04-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.Comment on 'Effect of Skeletal Muscle Mass and Its Associated Mediators on the Development of Steatotic Liver Disease: A Cohort Study in China' by Liang et al.
🗓️ 2026-04-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreComment on 'Effect of Skeletal Muscle Mass and Its Associated Mediators on the Development of Steatotic Liver Disease: A Cohort Study in China' by Liang et al.Sarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community.
Sarcopenic obesity (SO; defined as obesity with low skeletal muscle function and mass) has been recently recognized as a relevant obesity phenotype, with substantial negative clinical impact. The prevalence of SO is likely increasing, due to the growing prevalence of...
🗓️ 2026-04-17
📰 Publication: Clinical Nutrition
Read MoreSarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community.Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.
Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a,...
🗓️ 2026-04-16
📰 Publication: Aging Cell
Read MoreGhrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.
BACKGROUND
Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise ('cycling hypothesis'). Whether this concept translates to older adults is unknown. This exploratory trial assessed whether once-weekly sirolimus (rapamycin) 6 mg...
🗓️ 2026-04-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreExercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.Disuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.
BACKGROUND
Exercise has been proposed as both a preventive and therapeutic countermeasure; however, its effectiveness across different disuse conditions and timings of implementation remains uncertain.
METHODS
This systematic review and meta-analysis (PROSPERO: CRD42021256599) searched ClinicalTrials.gov, Cochrane Central, PubMed, SPORTDiscus, Web of Science, Scopus,...
🗓️ 2026-04-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDisuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.Correction to 'Sit- to- Stand Power From 2D Pose Estimation as an Indicator of Muscle Strength in Older Adults'.
🗓️ 2026-04-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCorrection to 'Sit- to- Stand Power From 2D Pose Estimation as an Indicator of Muscle Strength in Older Adults'.Muscle Atrophy-Related Adverse Events of Antidiabetic Drug Classes: A Pharmacovigilance Analysis Using VigiBase Data.
BACKGROUND
Diabetes mellitus-a chronic metabolic disorder associated with an increased risk of muscle atrophy-can significantly impact patients' quality of life and overall health outcomes. While antidiabetic medications are crucial for managing blood glucose levels, some have been linked to muscle-related adverse...
🗓️ 2026-04-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Atrophy-Related Adverse Events of Antidiabetic Drug Classes: A Pharmacovigilance Analysis Using VigiBase Data.MCC950-Loaded M12-Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis-Induced Muscle Atrophy.
BACKGROUND
Sepsis-induced myopathy (SIM) is a severe complication that contributes to late-stage mortality and functional impairment in sepsis patients. The NLRP3 inflammasome plays a pivotal role in the pathogenesis of SIM, and its selective inhibitor MCC950 has shown promising therapeutic potential....
🗓️ 2026-04-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMCC950-Loaded M12-Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis-Induced Muscle Atrophy.