Sarcopenia

R405W Desmin Knock-In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy.

BACKGROUND

Mutations in the desmin gene cause skeletal myopathies and cardiomyopathies. The objective of this study was to elucidate the molecular pathology induced by the expression of R405W mutant desmin in murine skeletal muscle.

METHODS

A comprehensive characterization of the skeletal muscle pathology...

🗓️ 2025-10-30
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreR405W Desmin Knock-In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy.

Role of Branched-Chain Amino Acids in Mitigating Osteosarcopenia: An Experimental Study Using Ovariectomised Mice Models.

BACKGROUND

Osteosarcopenia, characterised by concurrent bone loss and muscle atrophy, presents a significant challenge in aging populations, particularly in postmenopausal women. The current therapeutic options potentially treat bone and muscle loss independently, highlighting the importance of an integrated approach. This study...

🗓️ 2025-10-29
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRole of Branched-Chain Amino Acids in Mitigating Osteosarcopenia: An Experimental Study Using Ovariectomised Mice Models.

PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging.

BACKGROUND

Skeletal muscle aging is associated with oxidative stress and mitochondrial dysfunction. Peroxiredoxins (PRDXs), particularly PRDX3 and PRDX5, are antioxidant enzymes that are uniquely localized to mitochondria. While PRDX3 has been reported to play a role in maintaining mitochondrial function in...

🗓️ 2025-10-28
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging.

Rectus femoris ultrasound identifies sarcopenia and predicts poor outcomes in patients with acute decompensation of cirrhosis.

BACKGROUND & AIMS

Sarcopenia is common and associated with poor outcomes in decompensated cirrhosis. While computed tomography (CT) scan, with measurement of skeletal muscle index (SMI) at L3, is the gold standard for assessing sarcopenia in patients with cirrhosis, it is...

🗓️ 2025-10-27
📰 Publication: Jhep Reports
Read MoreRectus femoris ultrasound identifies sarcopenia and predicts poor outcomes in patients with acute decompensation of cirrhosis.

Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review.

Population aging has become a widespread health problem that leads to huge socioeconomic burden. Skeletal muscle as an important component of motor system, gradually degenerates with age. Age-related muscle disorders, such as sarcopenia is associated with higher risks of falls,...

🗓️ 2025-10-24
📰 Publication: Aging And Disease
Read MoreAdvancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review.

Drug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO-10-27.

BACKGROUND

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of survival of motor neuron (SMN) protein inducing progressive muscle weakness and atrophy due to motor neurons degeneration. Despite benefits of SMN restoration therapies in patients, motor defects are...

🗓️ 2025-10-23
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDrug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO-10-27.

Multispectral Optoacoustic Tomography of Skeletal Muscle Unveils Microcirculation and Oxygen Metabolism Alterations in Sarcopenia.

BACKGROUND

Sarcopenia, a significant geriatric syndrome, faces challenges in accurate diagnosis due to limitations of current imaging techniques. This study explores the novel application of multispectral optoacoustic tomography (MSOT) in evaluating sarcopenia, focusing on quantifying oxygen dynamics and collagen distribution in...

🗓️ 2025-10-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMultispectral Optoacoustic Tomography of Skeletal Muscle Unveils Microcirculation and Oxygen Metabolism Alterations in Sarcopenia.

3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.

BACKGROUND

In order to identify patients with sarcopenia, the use of routine imaging could provide valuable support. One of the most common radiological examinations, especially in geriatric inpatient care, is CT thoracic imaging. Therefore, it would be desirable to generate muscle...

🗓️ 2025-10-21
📰 Publication: Aging Clinical And Experimental Research
Read More3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.

Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.

BACKGROUND

Sarcopenia (SP) is characterized by progressive loss of skeletal muscle mass and function, and is a significant health burden in an aging society. Existing therapies have limited effectiveness. While ferroptosis plays a key role in sarcopenia, its regulatory mechanism remains...

🗓️ 2025-10-05
📰 Publication: Phytomedicine
Read MoreCistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.

Association of Pre- and Postdiagnosis Physical Activity, Promotion and Maintenance With Lung Cancer Survival: A Nationwide Cohort Study.

BACKGROUND

Physical activity (PA) is important for improving life expectancy and is suggested as a prognostic factor for various diseases. However, the association between PA and mortality outcomes in survivors of lung cancer remains unclear. Therefore, this study aimed to determine...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Pre- and Postdiagnosis Physical Activity, Promotion and Maintenance With Lung Cancer Survival: A Nationwide Cohort Study.

Sarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

BACKGROUND

Sarcopenic obesity (SO) is a clinical condition defined by the coexistence of high body fat mass and low muscle function and mass, which increases the risk of adverse health outcomes, including disability and mortality. Early detection and frequent monitoring of...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

A triad strategy of rehabilitation, nutrition, and oral management for malnutrition, sarcopenia, and frailty in super-aged societies.

BACKGROUND

Rapid population aging has intensified the prevalence of malnutrition, sarcopenia, frailty, and oral dysfunction, significantly affecting healthcare outcomes and quality of life in older adults. A growing body of evidence suggests that integrating rehabilitation, nutrition support, and oral health management-a...

🗓️ 2025-09-15
📰 Publication: Nutrition
Read MoreA triad strategy of rehabilitation, nutrition, and oral management for malnutrition, sarcopenia, and frailty in super-aged societies.

Association of Android and Gynoid Fatness With Incident Dementia and Brain Structure.

BACKGROUND

The relationship between regional adiposity and dementia remains poorly understood.

METHODS

This study included 440 861 UK Biobank participants initially free of dementia, stroke and cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia across quartiles of waist circumference (WC) or...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Android and Gynoid Fatness With Incident Dementia and Brain Structure.

Association of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

BACKGROUND AND AIMS

Sarcopenia and frailty have been associated with hormonal dysregulation in non-cirrhotic populations. The aim of the study was to evaluate hypothalamic-pituitary-adrenal and gonadal (HPA-HPG) axes as well as growth hormone/insulin-like growth factor-1 (GH/IGF-1) levels in patients with cirrhosis...

🗓️ 2025-11-01
📰 Publication: Liver International
Read MoreAssociation of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

Interplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in maintaining skeletal muscle homeostasis by regulating cell growth, protein degradation, and nutrient sensing. Beyond its role in muscle growth and atrophy, recent findings suggest that mTORC1 also...

🗓️ 2025-10-12
📰 Publication: Free Radical Biology And Medicine
Read MoreInterplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

Subscribe to the SCWD Newsletter

Stay Informed with the Latest Updates and Exclusive Insights!