Sarcopenia

Skeletal Muscle PGC-1α Remodels Mitochondrial Phospholipidome but Does Not Alter Energy Efficiency for ATP Synthesis.

BACKGROUND

The coupling of oxygen consumption to ATP synthesis via oxidative phosphorylation (OXPHOS) is central for cellular energy homeostasis. Some studies suggest exercise training increases the efficiency of ATP synthesis, but the molecular mechanisms are unclear. We have previously shown that...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal Muscle PGC-1α Remodels Mitochondrial Phospholipidome but Does Not Alter Energy Efficiency for ATP Synthesis.

Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans.

Taurine deficiency was recently proposed as a driver of aging in various species, including humans. To test this hypothesis, we assessed whether circulating taurine was associated with aging and physical performance in 137 physically inactive and physically active men aged...

🗓️ 2025-10-01
📰 Publication: Aging Cell
Read MoreExperimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans.

Microenvironment-driven satellite cell regeneration and repair in aging-related sarcopenia: mechanisms and therapeutic frontiers.

Sarcopenia, a progressive age-related decline in skeletal muscle mass and function, is closely linked to impaired regenerative capacity of satellite cells (SCs), also known as satellite cells. Age-dependent SCs dysfunction, driven by intrinsic senescence and niche dysregulation, disrupts activation, proliferation,...

🗓️ 2025-10-07
Read MoreMicroenvironment-driven satellite cell regeneration and repair in aging-related sarcopenia: mechanisms and therapeutic frontiers.

CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.

Sarcopenia, a degenerative condition marked by progressive skeletal muscle atrophy and impaired regeneration, is closely associated with aging, chronic inflammation, and disrupted proteostasis. While macroautophagy has been extensively studied in this context, little of the role of chaperone-mediated autophagy (CMA)...

🗓️ 2025-10-07
📰 Publication: Cell Death & Disease
Read MoreCTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.

Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies.

Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes and undermine quality of life among older adults with cancer. Despite their prognostic value and negative effects on older patients' well-being, sarcopenia and...

🗓️ 2025-10-08
📰 Publication: Drugs & Aging
Read MoreSarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies.

ARC-18 Improved Motor Performance Through Inhibiting ACLY-Mediated Smad2/3 Acetylation in a Model of Duchenne Muscular Dystrophy.

BACKGROUND

Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by progressive muscle weakness, with inflammation and fibrosis contributing to its pathogenesis. Despite advancements in genetic disease-modifying treatment, there is currently no effective pharmacological treatment for DMD.

METHODS

New compound ARC-18, a derivative...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreARC-18 Improved Motor Performance Through Inhibiting ACLY-Mediated Smad2/3 Acetylation in a Model of Duchenne Muscular Dystrophy.

Emerging basic science concepts in geriatric fracture fixation and patient recovery.

In recent history, human life expectancy has increased significantly, resulting in a high burden of late-life morbidity and geriatric fractures. Changes to the body as a result of aging, such as degeneration of the bone marrow, osteoblast apoptosis, and a...

🗓️ 2025-10-01
Read MoreEmerging basic science concepts in geriatric fracture fixation and patient recovery.

High "sarcopenia index" reduce all-cause mortality in patients with acute myocardial infarction.

BACKGROUNDThe product of serum creatinine and cystatin C-based estimated glomerular filtration rate (hereinafter referred to as "Cr × eGFRcys"), serving as the formula for the Sarcopenia Index (SI), could be regarded as a representative marker for sarcopenia. However, no studies...

🗓️ 2025-09-24
📰 Publication: Clinical Nutrition
Read MoreHigh "sarcopenia index" reduce all-cause mortality in patients with acute myocardial infarction.

Muscle-Specific Strength Better Predicts Physical Performance Decline Than Conventional Metrics: The I-Lan Longitudinal Aging Study.

Muscle-specific strength (MSS), defined as grip strength normalized to arm muscle mass, may better reflect muscle efficiency than grip strength. Despite its potential utility in diagnosing sarcopenia, longitudinal studies evaluating MSS as a predictor of sarcopenia-related outcomes remain limited. This...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle-Specific Strength Better Predicts Physical Performance Decline Than Conventional Metrics: The I-Lan Longitudinal Aging Study.

CSE/H 2S/SESN2 Signalling Mediates the Protective Effect of Exercise Against Immobilization-Induced Muscle Atrophy in Mice.

Hydrogen sulphide (H 2S), a gasotransmitter synthesized by cystathionine-γ-lyase (CSE), exhibits antioxidant properties and may mimic exercise-induced muscle protection. However, its mechanistic role in muscle atrophy and exercise intervention remains unclear. Six-month-old male wild-type (WT) and SESN2 knockout (SESN2 -/-)...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCSE/H 2S/SESN2 Signalling Mediates the Protective Effect of Exercise Against Immobilization-Induced Muscle Atrophy in Mice.

Muscle Abnormalities in Nonhospitalised Patients With Post-COVID-19 Condition.

Post-COVID condition (PCC) affects ~10% of SARS-CoV-2-infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the skeletal muscle of these patients and compare them with healthy controls. Biopsies were...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Abnormalities in Nonhospitalised Patients With Post-COVID-19 Condition.

Coix seed oil alleviates collagen-induced arthritis-associated muscle atrophy and functional decline by modulating gut microbiota dysbiosis.

The gut microbiota composition influences the pathogenesis of sarcopenia via the "gut microbiota-muscle axis", with probiotics serving as potential therapeutic agents. Coix seed oil (CSO), a bioactive component of Coix lacryma-jobi l., exhibit potent anti-inflammatory effects, however, its therapeutic role...

🗓️ 2025-08-05
📰 Publication: Phytomedicine
Read MoreCoix seed oil alleviates collagen-induced arthritis-associated muscle atrophy and functional decline by modulating gut microbiota dysbiosis.

Sarcopenia Assessment Using Fully Automated Deep Learning Predicts Cardiac Allograft Survival in Heart Transplant Recipients.

Sarcopenia is associated with adverse outcomes in patients with end-stage heart failure. Muscle mass can be quantified via manual segmentation of computed tomography images, but this approach is time-consuming and subject to interobserver variability. We sought to determine whether fully...

🗓️ 2025-08-20
Read MoreSarcopenia Assessment Using Fully Automated Deep Learning Predicts Cardiac Allograft Survival in Heart Transplant Recipients.

Ferulic Acid Attenuates Sarcopenia Progression by Inhibiting Peroxisomal ACOX1.

Sarcopenia, an age-related syndrome characterized by progressive loss of skeletal muscle mass, strength, and function, is closely associated with oxidative stress, inflammation, and protein metabolism imbalance. Ferulic acid (FA), a natural antioxidant, may improve sarcopenia, but its mechanism remains unclear....

🗓️ 2025-08-13
📰 Publication: Free Radical Biology And Medicine
Read MoreFerulic Acid Attenuates Sarcopenia Progression by Inhibiting Peroxisomal ACOX1.

High-Density Lipoprotein-Associated Cholesterol Abnormalities in a Clinical Outcomes Study of Dysferlin-Deficient Limb-Girdle Muscular Dystrophy Type R2.

Limb-girdle muscular dystrophy (MD) type R2 (LGMDR2, formerly LGMD2B) is an autosomal recessive form of MD caused by variants in the dysferlin gene, DYSF. It leads to slow proximal and distal muscle weakening that generally results in loss of ambulation...

🗓️ 2025-08-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHigh-Density Lipoprotein-Associated Cholesterol Abnormalities in a Clinical Outcomes Study of Dysferlin-Deficient Limb-Girdle Muscular Dystrophy Type R2.

Biological Ageing Acceleration and Functional Capacities Across the Lifespan in the INSPIRE-T Cohort.

Biological clocks are promising tools for the evaluation of biological age deviations (i.e., positive/negative acceleration). Here, we explored the associations of biological age acceleration (BAA) assessed by Horvath's, Hannum's, PhenoAge, and GrimAge epigenetic clocks, as well as the iAge inflammation-based...

🗓️ 2025-08-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBiological Ageing Acceleration and Functional Capacities Across the Lifespan in the INSPIRE-T Cohort.

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