Aging

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.

Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a,...

🗓️ 2026-04-16
📰 Publication: Aging Cell
Read MoreGhrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

BACKGROUND

Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise ('cycling hypothesis'). Whether this concept translates to older adults is unknown. This exploratory trial assessed whether once-weekly sirolimus (rapamycin) 6 mg...

🗓️ 2026-04-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreExercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

The sarcopenia-pain connection: why mechanisms matter for patient care?

Sarcopenia and pain are two highly prevalent conditions in aging populations, each exerting profound effects on mobility, independence, and quality of life. Emerging evidence demonstrates that these conditions are not merely coincidental but are closely interconnected through shared biological, mechanical,...

🗓️ 2026-04-15
Read MoreThe sarcopenia-pain connection: why mechanisms matter for patient care?

Semaglutide ameliorates aortic endothelial cell dysfunction in sarcopenia through the SIRT1/cGAS-STING signaling axis.

Sarcopenia associated with aging is a significant health issue affecting the quality of life in the elderly, yet research on effective treatments remains insufficient. This study aims to investigate the therapeutic effects and mechanisms of Semaglutide (Sema) in D-gal-induced aging-related...

🗓️ 2026-04-09
📰 Publication: Free Radical Biology And Medicine
Read MoreSemaglutide ameliorates aortic endothelial cell dysfunction in sarcopenia through the SIRT1/cGAS-STING signaling axis.

The Interplay Between Osteosarcopenia and Intrinsic Capacity: Insights and Associations With All-Cause Mortality in the Toledo Study for Healthy Aging.

BACKGROUND

Osteosarcopenia-the coexistence of osteopenia/osteoporosis and sarcopenia-is associated with numerous adverse health outcomes, but its association with intrinsic capacity (IC) remains unknown. We aimed to explore the associations of osteosarcopenia with IC and all-cause mortality in older adults.

METHODS

We conducted a cross-sectional...

🗓️ 2026-04-09
📰 Publication: Journals Of Gerontology Series A-Biological Sciences And Medical Sciences
Read MoreThe Interplay Between Osteosarcopenia and Intrinsic Capacity: Insights and Associations With All-Cause Mortality in the Toledo Study for Healthy Aging.

An exploratory multi-biomarker panel including fecal calprotectin, Brain-Derived Neurotrophic Factor, Fibroblast-Growth Factor-21 and irisin shows poor diagnostic accuracy for detecting probable sarcopenia in community-dwelling older persons.

🗓️ 2026-04-06
📰 Publication: Aging Clinical And Experimental Research
Read MoreAn exploratory multi-biomarker panel including fecal calprotectin, Brain-Derived Neurotrophic Factor, Fibroblast-Growth Factor-21 and irisin shows poor diagnostic accuracy for detecting probable sarcopenia in community-dwelling older persons.

Advancing sarcopenia assessment with wearable and app-based technology: a scoping review.

Sarcopenia, a condition characterized by loss of skeletal muscle mass (SMM) and strength, contributes to frailty, disability, and increased healthcare burden, yet remains underdiagnosed due to limitations of conventional assessment methods. Wearable and mobile technologies have emerged as potential tools...

🗓️ 2026-03-13
📰 Publication: Journal Of Nutrition Health & Aging
Read MoreAdvancing sarcopenia assessment with wearable and app-based technology: a scoping review.

Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.

Cerebral palsy (CP) is the most common cause of childhood-onset physical disability. It results from injury to the developing brain and is characterized by motor impairments, muscle weakness, and fatigue. CP is commonly associated with marked deficits in muscle mass...

🗓️ 2026-03-10
📰 Publication: Faseb Journal
Read MoreDoes Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.

Arabic Translation & Validation of Strength, Ambulation, Rising from A Chair, Stair Climbing and History of Falling Scale (SARC-F).

BACKGROUND

Sarcopenia, characterized by a progressive decline in muscle mass and function associated with aging, impacts around 10% of older adults worldwide and leads to heightened morbidity, increased hospitalization, and escalating healthcare costs. Early detection is crucial for timely intervention. The...

🗓️ 2026-02-19
Read MoreArabic Translation & Validation of Strength, Ambulation, Rising from A Chair, Stair Climbing and History of Falling Scale (SARC-F).

Do myokines influence the associations between sarcopenia-related parameters and cognitive function in community-dwelling older adults: exploratory results from the ENHANce study.

BACKGROUND

Studies have shown that sarcopenia and its related parameters are associated with cognition. Preclinical evidence suggests that myokines, such as irisin, Brain-Derived Neurotrophic Factor(BDNF), myostatin and Insulin-like Growth Factor-1(IGF-1) might explain this relationship. This study aimed to explore the associations...

🗓️ 2026-01-19
📰 Publication: Experimental Gerontology
Read MoreDo myokines influence the associations between sarcopenia-related parameters and cognitive function in community-dwelling older adults: exploratory results from the ENHANce study.

Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Gut microbiome plays an important role in several metabolic, immune, and inflammatory pathways; however, there is limited evidence for its role in body composition and musculoskeletal health. Sarcopenia, defined as a loss of skeletal muscle mass and function, and obesity,...

🗓️ 2026-01-09
📰 Publication: Osteoporosis International
Read MoreImpact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Public Health.

BACKGROUND

Sarcopenia is associated with an increased risk of cognitive impairment, yet very few studies have examined structural brain changes in sarcopenia. The current study aims to explore cognitive changes and their neuroimaging correlates of individuals with sarcopenia in an urban...

🗓️ 2025-12-23
📰 Publication: Alzheimers & Dementia
Read MorePublic Health.

Skeletal Muscle HSF1 Alleviates Age-Associated Sarcopenia and Mitochondrial Function Decline via SIRT3-PGC1α Axis.

Age-related sarcopenia, characterized by progressive loss of skeletal muscle mass and strength, impacts metabolic health and quality of life in the elderly. Heat shock factor 1 (HSF1) is a transcription factor that orchestrates cellular responses to various stresses, while its...

🗓️ 2025-12-16
Read MoreSkeletal Muscle HSF1 Alleviates Age-Associated Sarcopenia and Mitochondrial Function Decline via SIRT3-PGC1α Axis.

Statin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score.

BACKGROUND

Statins are cholesterol-lowering drugs widely prescribed for preventing cardiovascular diseases. They may cause adverse effects on skeletal muscle, but it remains unclear whether they affect muscle function and mass. We aimed to evaluate the association between statin use and muscle...

🗓️ 2025-11-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreStatin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score.

Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.

AIM

To investigate effects of host- and gut microbiota (GM)-altering interventions on sarcopenia (parameters).

METHODS

Upon PROSPERO registration (CRD42022347363), six databases and one registry were searched until January 5th 2024 and updated on June 10th 2025 for diet, pre-, pro-, or synbiotics mono-interventions...

🗓️ 2025-11-21
📰 Publication: Aging Clinical And Experimental Research
Read MoreEffect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.

Subscribe to the SCWD Newsletter

Stay Informed with the Latest Updates and Exclusive Insights!