👤 Authors: Dario Saltini, Silvia Nardelli, Roberto Miraglia, Davide Roccarina, Stefania Gioia, Federico Banchelli, Luigi Maruzzelli, Cristian Caporali, Gianmarco Falcone, Marcello Bianchini, Tomas Guasconi, Angelica Ingravallo, Simone Di Cola, Rosina Maria Critelli, Fabiola Milosa, Antonio Piscopo, Federico Casari, Andrea Salomé Velasco Mayorga, Filippo Scianò, Giovanni Battinelli, Francesco Ascari, Oliviero Riggio, Fabio Marra, Manuela Merli, Francesco Vizzutti, Filippo Schepis
Sarcopenia Predicts Mortality and Hepatic Encephalopathy After TIPS in Older Adults With Cirrhosis and Improves Prognostic Scores.
BACKGROUND AND AIMS
The role of transjugular intrahepatic portosystemic shunt (TIPS) in older adults remains controversial because of limited risk-stratification tools. We aimed to assess whether sarcopenia and myosteatosis are independently associated with post-TIPS mortality and overt hepatic encephalopathy (OHE) in patients aged ≥ 70 years, and whether adding sarcopenia to established prognostic scores improves discrimination for post-TIPS mortality.
METHODS
This multicenter retrospective study included 115 consecutive patients with cirrhosis aged ≥ 70 years undergoing TIPS for refractory ascites or secondary prophylaxis of variceal bleeding.
Sarcopenia and myosteatosis were assessed by computed tomography at L3. Post-TIPS mortality and time to first OHE episode were analysed using Kaplan-Meier and Cox regression.
Sarcopenia was integrated into established prognostic scores, and predictive performance was evaluated using time-dependent ROC analyses.
RESULTS
Sarcopenia and myosteatosis were present in 60% and 80% of patients, respectively. During follow-up, 49% died and 45% developed OHE.
Sarcopenia was independently associated with both mortality and OHE, whereas myosteatosis and adipose-tissue indices were not. Incorporating sarcopenia improved the discriminative performance of all scores, with MELD 3.0-sarcopenia showing the highest accuracy (AUC 0.845).
Predicted survival probabilities clearly separated patients across MELD 3.0 categories according to sarcopenia status. For OHE, sarcopenia increased the risk while underdilated TIPS was protective, defining four distinct risk profiles.
CONCLUSIONS
Sarcopenia is highly prevalent and independently predicts both mortality and OHE after TIPS in older adults.
Its integration into prognostic tools enhances risk stratification and supports individualised decision-making in this vulnerable population.
