Cardiolipins

Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.

BACKGROUND

Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While cardiac manifestations of BTHS are well characterized in male patients, the mechanisms underlying skeletal muscle...

🗓️ 2026-03-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.

Role of cardiolipin in skeletal muscle function and its therapeutic implications.

Cardiolipin, a unique phospholipid predominantly present in the inner mitochondrial membrane, is critical for maintaining mitochondrial integrity and function. Its dimeric structure and role in supporting mitochondrial dynamics, energy production, and mitophagy make it indispensable for skeletal muscle health. This...

🗓️ 2025-01-21
Read MoreRole of cardiolipin in skeletal muscle function and its therapeutic implications.

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