R405W Desmin Knock-In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy.
<p><b>BACKGROUND</b></p><p>Mutations in the desmin gene cause skeletal myopathies and cardiomyopathies. The objective of this study was to elucidate the molecular pathology induced by the expression of R405W mutant desmin in murine skeletal muscle.</p><p><b>METHODS</b></p><p>A comprehensive characterization of the skeletal muscle pathology...
๐๏ธ 2025-10-30
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreR405W Desmin Knock-In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy.