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Niacin

Preventing loss of sirt1 lowers mitochondrial oxidative stress and preserves C2C12 myotube diameter in an inย vitro model of cancer cachexia.

Cancer cachexia is a multifactorial syndrome associated with advanced cancer that contributes to mortality. Cachexia is characterized by loss of body weight and muscle atrophy. Increased skeletal muscle mitochondrial reactive oxygen species (ROS) is a contributing factor to loss of...
๐Ÿ—“๏ธ 2024-07-01
Read MorePreventing loss of sirt1 lowers mitochondrial oxidative stress and preserves C2C12 myotube diameter in an inย vitro model of cancer cachexia.

NAD repletion with niacin counteracts cancer cachexia.

Cachexia is a debilitating wasting syndrome and highly prevalent comorbidity in cancer patients. It manifests especially with energy and mitochondrial metabolism aberrations that promote tissue wasting. We recently identified nicotinamide adenine dinucleotide (NAD) loss to associate with muscle mitochondrial dysfunction...
๐Ÿ—“๏ธ 2023-04-03
๐Ÿ“ฐ Publication: Nat Commun
Read MoreNAD repletion with niacin counteracts cancer cachexia.

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