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Fluid retention and weight loss in refractory cancer cachexia.

It is unknown to what extent the fluid retention (FR) status disrupts the detection of weight loss rate (WLR) in adult patients with advanced cancer. This study aimed to determine the association of FR status with WLR.

This study was a secondary analysis of a prospective cohort study. FR was evaluated as follows: oedema (0, no; 1, yes), pleural effusion (0, no; 1, yes but asymptomatic; 2, symptomatic) and ascites (0, no; 1, yes but asymptomatic; 2, symptomatic).

Patients were divided into three groups according to their FR scores: no-FR (0), moderate-FR (1-2) and high-FR (3-5). Multiple regression analysis was performed.

Four hundred and twenty patients were categorised: no-FR group (n=164), moderate-FR group (n=158) and high-FR group (n=98). The prevalence of oedema, pleural effusion and ascites was 63.9%, 27.8% and 36.7% in the moderate-FR group, and 93.9%, 61.3% and 82.6% in high-FR group.

The means of WLR were 9.2, 8.4 and 3.8 in the groups. The high-FR group and the FR score of 5 were correlated with WLR (estimate -4.71, 95% CI -7.84 to -1.58; estimate -10.29, 95% CI -17.84 to -2.74).

The coexistence of FR was significantly correlated with WLR.

Koji Amano

Palliative Medicine

Aichi Medical University

Japan

218

ScienceLeadR Reputation
profile photo of Koji Amano

Main topics

Publications Clinical Trials

Palliative Care
Body Weight
Weight Loss
Cachexia
Psychophysiology
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Naoharu Mori

Nutrition

Aichi Medical University

Japan

200

ScienceLeadR Reputation
profile photo of Naoharu Mori

Main topics

Publications Clinical Trials

Body Weight
Weight Loss
Cachexia
Sarcopenia
Malnutrition
View detailed profile

Vickie E Baracos

Nutrition

Cross Cancer Institute

Canada

1250

ScienceLeadR Reputation
profile photo of Vickie E Baracos

Main topics

Publications Clinical Trials

Body Weight
Weight Loss
Public Health
Epidemiologic Methods
Cachexia
View detailed profile

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