Calcineurin

Elucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle.

Cancer cachexia is a debilitating syndrome of involuntary body mass loss featuring profound skeletal muscle wasting and high mortality. Cardiac muscle wasting is prominent in cancer patients and cancer survivors. We developed a human induced pluripotent stem cell-derived cardiac myocyte...

🗓️ 2026-11-09
Read MoreElucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle.

Histidine decarboxylase inhibition attenuates cancer-associated muscle wasting.

Cancer cachexia is a multifactorial syndrome involving muscle and fat wasting, inflammation, and metabolic dysfunction. Across cancer subtypes, pancreatic cancer has one of the highest cachexia incidence rates at ∼80%. Given the advanced age of most pancreatic cancer patients, we...

🗓️ 2025-07-02
📰 Publication: Journal Of Experimental Medicine
Read MoreHistidine decarboxylase inhibition attenuates cancer-associated muscle wasting.

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