muscles

Different Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.

Sarcopenia, characterized by decreased skeletal muscle mass and strength, is classified as "primary" (due to aging) or "secondary" (due to diseases). MicroRNA-22-3p (miR-22) regulates muscle differentiation and function. We assessed the diagnostic value of circulating miR-22 levels in patients with...

๐Ÿ—“๏ธ 2025-11-15
๐Ÿ“ฐ Publication: Aging Cell
Read MoreDifferent Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.

Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 + T cell-secreted CCL5.

<p><b>BACKGROUND</b></p><p>Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk.</p><p><b>METHODS</b></p><p>A cohort study was conducted to elucidate the associations among circulating IL-33, osteoporosis, and...

๐Ÿ—“๏ธ 2025-11-15
๐Ÿ“ฐ Publication: Ebiomedicine
Read MoreSkeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 + T cell-secreted CCL5.

Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.

<p><b>BACKGROUND</b></p><p>Systemic muscle wasting is a prevalent condition that predicts adverse health outcomes in aging and disease. Despite its clinical relevance, the development of predictive biomarkers and effective pharmacological therapies remains limited. Peptides have recently gained attention for their diverse bioactive...

๐Ÿ—“๏ธ 2025-11-13
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRole of Peptides in Skeletal Muscle Wasting: A Scoping Review.

Impaired cAMP-PKA-CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia.

Skeletal muscle wasting is a defining feature of cancer cachexia, a multifactorial syndrome that drastically compromises patient quality of life and treatment outcomes. Mitochondrial dysfunction is a major contributor to skeletal muscle wasting in cancer cachexia, yet the upstream molecular...

๐Ÿ—“๏ธ 2025-11-13
Read MoreImpaired cAMP-PKA-CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia.

Primary-Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity.

<p><b>BACKGROUND</b></p><p>Colon cancer (CC), the third most common cancer worldwide, is accompanied by cachexia in 30% of patients. Its associated muscle loss directly impairs therapeutic response and survival. Early intervention is crucial, yet the underlying mechanisms of early-stage muscle dysfunction remain...

๐Ÿ—“๏ธ 2025-11-12
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePrimary-Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity.

STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

<p><b>BACKGROUND</b></p><p>Mitochondrial homeostasis is vital for optimal skeletal muscle integrity. Mitochondrial quality control (MQC) mechanisms that are essential for maintaining proper functions of mitochondria include mitochondrial biogenesis, dynamics and mitophagy. Previously, Syntaxin 4 (STX4), traditionally considered a cell surface protein known...

๐Ÿ—“๏ธ 2025-11-11
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSTX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

Muscle Structure and Function Recovery: Adalimumab-Calcium Channel Synergy in Post-Ischemic Stroke Sarcopenia.

<p><b>BACKGROUND</b></p><p>Adalimumab, a TNF-ฮฑ inhibitor, is widely used clinically. Recent studies suggest Adalimumab can improve muscle damage after ischemic stroke (IS), but its protective mechanisms remain unclear. This study investigates the effect of adalimumab on muscle structure post-IS and the role...

๐Ÿ—“๏ธ 2025-11-10
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Structure and Function Recovery: Adalimumab-Calcium Channel Synergy in Post-Ischemic Stroke Sarcopenia.

Targeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis.

<p><b>BACKGROUND</b></p><p>Type 2 diabetes mellitus (T2D) arises from the interplay between peripheral insulin resistance and pancreatic ฮฒ-cell dysfunction, ultimately leading to impaired glucose utilization and chronic hyperglycemia. Despite therapeutic advances, the multifactorial nature of T2D continues to demand the development of...

๐Ÿ—“๏ธ 2025-11-10
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreTargeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis.

Rethinking Muscle Aging Through the Lens of Fibro-Adipogenic Progenitors.

Aging of skeletal muscles is accompanied by a progressive deposition of adipose and fibrotic tissue within the interstitial compartment. This process profoundly disrupts the structural integrity and contractile function of the muscle. Such maladaptive remodeling not only compromises muscle performance...

๐Ÿ—“๏ธ 2025-11-10
๐Ÿ“ฐ Publication: Aging And Disease
Read MoreRethinking Muscle Aging Through the Lens of Fibro-Adipogenic Progenitors.

An Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins.

<p><b>BACKGROUND</b></p><p>Cystinosis is a rare multisystem, autosomal recessive disease caused by dysfunction or loss of cystinosin (CTNS), which results in lysosomal cystine accumulation, primarily affecting the kidneys. Advances in renal transplantation, cysteamine treatment and improved medical care have increased life expectancy,...

๐Ÿ—“๏ธ 2025-11-10
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAn Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins.

Sarcopenia in Atrial Fibrillation: A Risk Factor for Adverse Outcomes in a UK Biobank Study.

<p><b>BACKGROUND AND AIMS</b></p><p>Sarcopenia, characterized by reduced muscle mass and function, has been increasingly implicated in cardiovascular disorders. However, its prognostic relevance in atrial fibrillation (AF) remains unclear. This study evaluated the association between sarcopenia and adverse outcomes in individuals with...

๐Ÿ—“๏ธ 2025-11-09
๐Ÿ“ฐ Publication: Europace
Read MoreSarcopenia in Atrial Fibrillation: A Risk Factor for Adverse Outcomes in a UK Biobank Study.

Budget impact analysis of a muscle-targeted nutritional intervention for sarcopenia.

<p><b>BACKGROUND</b></p><p>In old adult patients with sarcopenia hospitalized for rehabilitation, the superior clinical benefit of a muscle-targeted formula (MTF; whey protein-based enriched with leucine and vitamin D) over an iso-caloric protein-free one was assessed through the IRIS trial (NCT03120026). The aim...

๐Ÿ—“๏ธ 2025-11-09
๐Ÿ“ฐ Publication: Clinical Nutrition
Read MoreBudget impact analysis of a muscle-targeted nutritional intervention for sarcopenia.

Anabolic Effects of Salbutamol Are Lost Upon Immobilization.

<p><b>BACKGROUND</b></p><p>Periods of muscle disuse occur during hospitalization, illness or the recovery from (sports) injury and lead to a rapid loss of muscle mass and the development of insulin resistance. Salbutamol is a fast-acting ฮฒ2-adrenoreceptor agonist that may improve muscle protein...

๐Ÿ—“๏ธ 2025-11-06
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAnabolic Effects of Salbutamol Are Lost Upon Immobilization.

Sarcopenia and MASLD: novel insights and the future.

Metabolic dysfunction-associated steatotic liver disease (MASLD; previously known as non-alcoholic fatty liver disease) is the leading cause of chronic liver disease worldwide and is closely linked to the obesity epidemic. MASLD often coexists with sarcopenia, an age-related loss of muscle...

๐Ÿ—“๏ธ 2025-11-06
๐Ÿ“ฐ Publication: Nature Reviews Endocrinology
Read MoreSarcopenia and MASLD: novel insights and the future.

EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster.

Studying intercellular and interorgan interactions in animal models is key to understanding development, physiology, and disease. We introduce EyaHOST, a system for clonal combinatorial loss- and gain-of-function genetics in fluorescently labeled cells under QF2-QUAS eya promoter control. Distinct from mosaic...

๐Ÿ—“๏ธ 2025-11-06
Read MoreEyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster.

Glucagon-like peptide-1 receptor agonists and sarcopenia-related markers in diabetes: A systematic review and meta-analysis.

<p><b>AIMS</b></p><p>GLP-1 receptor agonists (GLP-1RAs) are first-line therapies for type 2 diabetes (T2DM) due to their additional weight-lowering and cardiovascular benefits. However, their impact on muscle mass is debated, posing a concern for sarcopenia in older adults with T2DM. This systematic...

๐Ÿ—“๏ธ 2025-11-05
๐Ÿ“ฐ Publication: Clinical Nutrition
Read MoreGlucagon-like peptide-1 receptor agonists and sarcopenia-related markers in diabetes: A systematic review and meta-analysis.

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