muscles

Anabolic Effects of Salbutamol Are Lost Upon Immobilization.

<p><b>BACKGROUND</b></p><p>Periods of muscle disuse occur during hospitalization, illness or the recovery from (sports) injury and lead to a rapid loss of muscle mass and the development of insulin resistance. Salbutamol is a fast-acting ฮฒ2-adrenoreceptor agonist that may improve muscle protein...

๐Ÿ—“๏ธ 2025-11-06
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAnabolic Effects of Salbutamol Are Lost Upon Immobilization.

Sarcopenia and MASLD: novel insights and the future.

Metabolic dysfunction-associated steatotic liver disease (MASLD; previously known as non-alcoholic fatty liver disease) is the leading cause of chronic liver disease worldwide and is closely linked to the obesity epidemic. MASLD often coexists with sarcopenia, an age-related loss of muscle...

๐Ÿ—“๏ธ 2025-11-06
๐Ÿ“ฐ Publication: Nature Reviews Endocrinology
Read MoreSarcopenia and MASLD: novel insights and the future.

EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster.

Studying intercellular and interorgan interactions in animal models is key to understanding development, physiology, and disease. We introduce EyaHOST, a system for clonal combinatorial loss- and gain-of-function genetics in fluorescently labeled cells under QF2-QUAS eya promoter control. Distinct from mosaic...

๐Ÿ—“๏ธ 2025-11-06
Read MoreEyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster.

Glucagon-like peptide-1 receptor agonists and sarcopenia-related markers in diabetes: A systematic review and meta-analysis.

<p><b>AIMS</b></p><p>GLP-1 receptor agonists (GLP-1RAs) are first-line therapies for type 2 diabetes (T2DM) due to their additional weight-lowering and cardiovascular benefits. However, their impact on muscle mass is debated, posing a concern for sarcopenia in older adults with T2DM. This systematic...

๐Ÿ—“๏ธ 2025-11-05
๐Ÿ“ฐ Publication: Clinical Nutrition
Read MoreGlucagon-like peptide-1 receptor agonists and sarcopenia-related markers in diabetes: A systematic review and meta-analysis.

A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update.

The Asian Working Group for Sarcopenia (AWGS) presents an updated 2025 consensus reframing sarcopenia management through a life-course approach to muscle health promotion. While aligning with the Global Leadership Initiative in Sarcopenia (GLIS), this update provides healthcare providers with Asia-specific...

๐Ÿ—“๏ธ 2025-11-05
Read MoreA focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update.

Postinactivity Exercise Training Improves Sarcopenia Traits in 40-60-Year-Old Women Regardless of Fortified Milk Supplementation.

<p><b>BACKGROUND</b></p><p>The term sarcopenia was introduced to describe the age-related decline in muscle mass, but current definitions also include measures of muscle strength and function. Menopause increases sarcopenia risk and may exacerbate the adverse effects of physical inactivity. Exercise training is...

๐Ÿ—“๏ธ 2025-11-04
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePostinactivity Exercise Training Improves Sarcopenia Traits in 40-60-Year-Old Women Regardless of Fortified Milk Supplementation.

Effect of Skeletal Muscle Mass and Its Associated Mediators on the Development of Steatotic Liver Disease: A Cohort Study in China.

<p><b>BACKGROUND</b></p><p>Understanding the relationship between relative skeletal muscle mass and newly proposed steatotic liver disease (SLD) is crucial, but research gaps still exist. Based on a cohort study, we investigated the impact of relative skeletal muscle mass on incident SLD and...

๐Ÿ—“๏ธ 2025-11-04
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEffect of Skeletal Muscle Mass and Its Associated Mediators on the Development of Steatotic Liver Disease: A Cohort Study in China.

Changes in Lean Muscle Mass, Muscle Strength, and Physical Performance Following First-Line Chemotherapy in Patients With Lymphoma.

Lymphomas are common cancers affecting the lymphatic system. Chemotherapy is a standard treatment, yet its impact on patient's physical capacity remains understudied. This study aimed to evaluate changes in body composition, muscle strength, and physical performance in patients diagnosed with...

๐Ÿ—“๏ธ 2025-11-04
๐Ÿ“ฐ Publication: Hematological Oncology
Read MoreChanges in Lean Muscle Mass, Muscle Strength, and Physical Performance Following First-Line Chemotherapy in Patients With Lymphoma.

Therapeutic potential of FGF19 in combatting osteosarcopenia: effects on muscle strength and bone health in aged male mice.

Osteosarcopenia, characterized by the coexistence of osteopenia/osteoporosis and sarcopenia, represents a significant health concern in geriatrics, with an increased risk of falls and fractures. The enterokine fibroblast growth factor 19 (FGF19) was recently shown to prevent muscle weakness in preclinical...

๐Ÿ—“๏ธ 2025-11-04
Read MoreTherapeutic potential of FGF19 in combatting osteosarcopenia: effects on muscle strength and bone health in aged male mice.

The mitochondrial-targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial-apoptotic but not necroptotic signalling during ovarian cancer.

The degree to which mitochondrial-linked programmed cell death pathways contribute to skeletal muscle atrophy during cancer remains unknown. Here we combined a novel and robust mouse model of metastatic ovarian cancer with chronic administration of the mitochondrial-targeted antioxidant SkQ1 to...

๐Ÿ—“๏ธ 2025-11-03
๐Ÿ“ฐ Publication: Journal Of Physiology-London
Read MoreThe mitochondrial-targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial-apoptotic but not necroptotic signalling during ovarian cancer.

Transcriptional landscape of skeletal muscle in cancer patients.

Bhatt et al. have identified two RNAome-based skeletal muscle subtypes in cancer cachexia. The first subtype is cachexia associated with weight and muscle loss, fiber atrophy, and shortened survival. Furthermore, this subtype has dysregulated post-transcriptional networks involving hub long noncoding...

๐Ÿ—“๏ธ 2025-11-02
๐Ÿ“ฐ Publication: Trends In Molecular Medicine
Read MoreTranscriptional landscape of skeletal muscle in cancer patients.

Jianpi Qiangji Granule ameliorates aging-associated sarcopenia via AMPK/PGC-1ฮฑ axis in SAMP8 mice.

<p><b>BACKGROUND</b></p><p>Sarcopenia is an age-related syndrome characterized primarily by the progressive decline of muscle mass and function. It is frequently associated with adverse outcomes such as falls, fractures, and hospitalization, often leading to substantial economic burdens and severe health hazards. At...

๐Ÿ—“๏ธ 2025-11-01
๐Ÿ“ฐ Publication: Phytomedicine
Read MoreJianpi Qiangji Granule ameliorates aging-associated sarcopenia via AMPK/PGC-1ฮฑ axis in SAMP8 mice.

High Loss of Adipose Tissue During Neoadjuvant Chemotherapy Predicts Poor Prognosis in Patients With Gastric Cancer.

<p><b>BACKGROUND</b></p><p>Gastric cancer (GC) patients often have nutritional risks or malnutrition, and neoadjuvant chemotherapy (NAC) tends to exacerbate malnutrition. Body composition parameters are associated with the prognosis of GC patients. Little is known about body composition changes during NAC and its...

๐Ÿ—“๏ธ 2025-10-31
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHigh Loss of Adipose Tissue During Neoadjuvant Chemotherapy Predicts Poor Prognosis in Patients With Gastric Cancer.

R405W Desmin Knock-In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy.

<p><b>BACKGROUND</b></p><p>Mutations in the desmin gene cause skeletal myopathies and cardiomyopathies. The objective of this study was to elucidate the molecular pathology induced by the expression of R405W mutant desmin in murine skeletal muscle.</p><p><b>METHODS</b></p><p>A comprehensive characterization of the skeletal muscle pathology...

๐Ÿ—“๏ธ 2025-10-30
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreR405W Desmin Knock-In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy.

Role of Branched-Chain Amino Acids in Mitigating Osteosarcopenia: An Experimental Study Using Ovariectomised Mice Models.

<p><b>BACKGROUND</b></p><p>Osteosarcopenia, characterised by concurrent bone loss and muscle atrophy, presents a significant challenge in aging populations, particularly in postmenopausal women. The current therapeutic options potentially treat bone and muscle loss independently, highlighting the importance of an integrated approach. This study...

๐Ÿ—“๏ธ 2025-10-29
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRole of Branched-Chain Amino Acids in Mitigating Osteosarcopenia: An Experimental Study Using Ovariectomised Mice Models.

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