muscles

Blood and urine cell-free circulating DNA in older adults with sarcopenia: a hypothesis-generating study.

PURPOSE

This preliminary study evaluated effect sizes of differences in circulating cell-free DNA (cfDNA) levels in blood and urine between older adults with and without sarcopenia.

METHODS

This was a subanalysis of the 2021 Itabashi Longitudinal Study on Aging. Twenty-four participants were selected...

🗓️ 2026-03-20
📰 Publication: European Geriatric Medicine
Read MoreBlood and urine cell-free circulating DNA in older adults with sarcopenia: a hypothesis-generating study.

Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.

BACKGROUND

Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While cardiac manifestations of BTHS are well characterized in male patients, the mechanisms underlying skeletal muscle...

🗓️ 2026-03-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.

Moderate Aerobic Training Causes Muscle Wasting in a DMBA-Induced Sarcoma Rat Model.

Cancer cachexia, characterized by severe body weight loss, negatively affects patient quality of life and survival. Although moderate exercise benefits healthy and chronically ill individuals, and the effect of exercise in cachexia generally appears beneficial, conflicting results have been reported...

🗓️ 2026-03-14
📰 Publication: International Journal Of Molecular Sciences
Read MoreModerate Aerobic Training Causes Muscle Wasting in a DMBA-Induced Sarcoma Rat Model.

Muscle Movement and Metabolism: Exercise and Skeletal Muscle as Mediators of Health. A Report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.

Skeletal muscle is a crucial facilitator of many of the effects of exercise on metabolic health. Intrinsic myocellular mechanisms, exercise-induced myokine secretion, and crosstalk between multiple organ systems contribute to the maintenance of energy homeostasis, cardiovascular health, strength, cognition, and...

🗓️ 2026-03-12
📰 Publication: American Journal Of Clinical Nutrition
Read MoreMuscle Movement and Metabolism: Exercise and Skeletal Muscle as Mediators of Health. A Report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.

Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.

Cerebral palsy (CP) is the most common cause of childhood-onset physical disability. It results from injury to the developing brain and is characterized by motor impairments, muscle weakness, and fatigue. CP is commonly associated with marked deficits in muscle mass...

🗓️ 2026-03-10
📰 Publication: Faseb Journal
Read MoreDoes Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.

Exploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

INTRODUCTION

People with chronic kidney disease (CKD) often experience poor muscle quality and elevations in skeletal muscle wasting and dysfunction, contributing to a reduced quality of life and an increased risk of morbidity and mortality. The adipokine chemerin is associated with...

🗓️ 2026-02-28
📰 Publication: Translational Research
Read MoreExploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

A Novel Mouse Model to Identify Antigen-Specific Immune Responses in Pancreatic Cancer Cachexia.

BACKGROUND

Pancreatic Ductal Adenocarcinoma (PDAC) has a dismal five-year survival rate of 13% and is closely associated with cachexia. Cancer cachexia is a multifactorial syndrome characterized by irreversible wasting of skeletal muscles, fat loss and systemic inflammation. While cachexia is known...

🗓️ 2026-02-27
Read MoreA Novel Mouse Model to Identify Antigen-Specific Immune Responses in Pancreatic Cancer Cachexia.

Mitochondrial Permeability Transition in Skeletal Muscle Phenocopies Muscle Alterations seen in Cancer Cachexia and other Wasting Conditions.

BACKGROUND

Skeletal muscle in wasting conditions often exhibits a common set of phenotypes that include atrophy, mitochondrial respiratory dysfunction, and fragmentation of the acetylcholine receptor (AChR) cluster at the endplate. Mitochondria are frequently implicated in driving muscle pathology in these conditions,...

🗓️ 2026-02-23
Read MoreMitochondrial Permeability Transition in Skeletal Muscle Phenocopies Muscle Alterations seen in Cancer Cachexia and other Wasting Conditions.

High Fat Diet and Obesity Each Increase Tumor Cell Proliferation and Muscle Wasting in Experimental Cancer Cachexia.

High fat diet (HFD) and associated obesity are suggested to predispose to cancer development, complicate cancer treatment, and accelerate mortality. Paradoxically, obese patients with lung cancer are reported to live longer, suggesting that high body mass is protective. Given that...

🗓️ 2026-02-21
📰 Publication: American Journal Of Physiology-Cell Physiology
Read MoreHigh Fat Diet and Obesity Each Increase Tumor Cell Proliferation and Muscle Wasting in Experimental Cancer Cachexia.

Muscle-immune metabolic crosstalk: shared pathways in cachexia and exercise.

Skeletal muscle and the immune system continuously exchange metabolites and signals that are essential for homeostasis. Disruption of this communication, such as during infection, inflammation, or cancer, triggers cachexia, a severe wasting syndrome characterized by altered amino acid flux, mitochondrial...

🗓️ 2026-02-21
📰 Publication: Current Opinion In Biotechnology
Read MoreMuscle-immune metabolic crosstalk: shared pathways in cachexia and exercise.

Human neuromuscular organoids mimic cancer-induced muscle cachexia.

Cancer cachexia, a devastating metabolic wasting syndrome affecting up to 80% of solid cancer patients, remains incurable despite advances in tumor biology understanding. This study introduces neuromuscular organoids (NMOs) derived from human-induced pluripotent stem cells (hiPSCs) as a platform to...

🗓️ 2026-02-19
Read MoreHuman neuromuscular organoids mimic cancer-induced muscle cachexia.

Nutrition Rehabilitation Programs and Cachexia Clinics for Anorexia-Cachexia Syndrome in Patients with Cancer.

The Anorexia-Cachexia Syndrome (ACS) is characterized by loss of appetite and unintentional weight loss. Important clinical outcomes are associated with ACS including increased risk of chemotherapy side-effects, decreased survival and quality of life. Because ACS is driven by complex metabolic...

🗓️ 2026-02-16
📰 Publication: Oncologist
Read MoreNutrition Rehabilitation Programs and Cachexia Clinics for Anorexia-Cachexia Syndrome in Patients with Cancer.

Asian Reference Values for Handgrip Strength, Gait Speed, Five-Times-Sit-to-Stand Test, Muscle Mass and Calf Circumference.

BACKGROUND

Handgrip strength, gait speed, Five-Times-Sit-to-Stand Test (FTSST) performance, skeletal muscle mass and calf circumference are important health outcomes, particularly useful for diagnosing sarcopenia. The aim of this study was to establish reference (normative) values for handgrip strength, gait speed, FTSST...

🗓️ 2026-02-12
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAsian Reference Values for Handgrip Strength, Gait Speed, Five-Times-Sit-to-Stand Test, Muscle Mass and Calf Circumference.

Pain characterization in osteosarcopenia: an exploratory study.

OBJECTIVE

To characterize pain in terms of frequency, intensity, and correlation with nutritional status, muscle mass, and physical performance in osteosarcopenic patients.

METHOD

We included patients affected by osteosarcopenia (OSP), according to WHO criteria and EWGSOP2 guidelines. Assessments included Bone Mineral Density, Trabecular...

🗓️ 2026-02-11
Read MorePain characterization in osteosarcopenia: an exploratory study.

Skeletal muscle morphology and metabolism in heart failure compared to healthy controls: a systematic review and meta-analysis.

Background: Heart failure (HF) is characterised by altered skeletal muscle morphology. The aim of this systematic review and meta-analysis was to explore cross-sectional differences in muscle morphology and metabolism between patients with HF and healthy controls. Methods: A literature search...

🗓️ 2026-02-10
📰 Publication: Journal Of Applied Physiology
Read MoreSkeletal muscle morphology and metabolism in heart failure compared to healthy controls: a systematic review and meta-analysis.

Cancer cachexia in STK11/LKB1-mutated non-small cell lung cancer is dependent on tumor-secreted GDF15.

Cachexia is a wasting syndrome involving adipose, muscle, and body weight loss in cancer patients. Tumor loss-of-function mutations in STK11/LKB1, a regulator of AMP-activated protein kinase, induce cancer cachexia (CC) in preclinical models and are linked to weight loss in...

🗓️ 2026-01-31
📰 Publication: Nature Communications
Read MoreCancer cachexia in STK11/LKB1-mutated non-small cell lung cancer is dependent on tumor-secreted GDF15.

Subscribe to the SCWD Newsletter

Stay Informed with the Latest Updates and Exclusive Insights!