muscles

Validation and application of automated CT analysis to musculoskeletal profiling in MVC occupants.

OBJECTIVE

Bone mineral density (BMD) and muscle health influence an occupant's tolerance to motor vehicle crash (MVC), and these musculoskeletal factors can be used to design more effective countermeasures. CT imaging routinely acquired during trauma evaluation can be leveraged to obtain...

🗓️ 2026-06-11
📰 Publication: Traffic Injury Prevention
Read MoreValidation and application of automated CT analysis to musculoskeletal profiling in MVC occupants.

Hepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH.

A bidirectional relationship exists between metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), and sarcopenia, with each worsening the prevalence and prognosis of the other. Hepatokines have recently been shown to affect skeletal...

🗓️ 2026-06-11
📰 Publication: Molecular Metabolism
Read MoreHepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH.

Autophagy in cancer cachexia: From mechanisms to therapeutic opportunities.

Cancer cachexia is a multifactorial syndrome characterized by body weight loss, muscle wasting, and systemic metabolic alterations, significantly contributing to patient morbidity and mortality. A key feature of cachexia is the excessive degradation of muscle proteins and mitochondria, largely mediated...

🗓️ 2026-06-11
Read MoreAutophagy in cancer cachexia: From mechanisms to therapeutic opportunities.

Endocannabinoid system and skeletal muscle health: insights from cannabidiol.

The endocannabinoid (EC) system is a complex network comprising endogenous ligands, enzymes responsible for their synthesis and degradation, and various receptors (including CB1 and CB2). Present in many peripheral tissues, including skeletal muscle, EC system is now recognized to influence...

🗓️ 2026-06-10
📰 Publication: Molecular Metabolism
Read MoreEndocannabinoid system and skeletal muscle health: insights from cannabidiol.

MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia.

BACKGROUND

Cancer cachexia is a multifactorial metabolic syndrome marked by progressive skeletal muscle loss, reduced function, and increased mortality. Mitochondrial dysfunction is a key driver of this phenotype. MOTS-c, a mitochondrial-derived peptide that regulates metabolic homeostasis and mimics exercise signaling, may...

🗓️ 2026-06-10
Read MoreMOTS-c partially protects against skeletal muscle deterioration in C26 cachexia.

Diagnostic Utility of Muscle Ultrasound for Sarcopenia in Prader-Willi Syndrome: A Cross-Sectional Study.

BACKGROUND

Prader-Willi syndrome (PWS) is characterized by sarcopenic obesity; however, validated screening tools for muscle mass in clinical settings are lacking. This study aimed to evaluate the diagnostic utility of muscle ultrasound (US) for detecting low muscle mass in individuals with...

🗓️ 2026-06-09
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDiagnostic Utility of Muscle Ultrasound for Sarcopenia in Prader-Willi Syndrome: A Cross-Sectional Study.

Sarcopenic obesity and dementia risk: Primary associations and landmark analyses of muscle strength and body composition trajectories.

BACKGROUND AND AIMS

Sarcopenic obesity (SO) has been proposed as a risk factor for cognitive impairment. Yet evidence is inconsistent and often limited by heterogeneous definitions and lack of longitudinal assessments. This study aimed to examine associations of SO with all-cause...

🗓️ 2026-06-07
📰 Publication: Clinical Nutrition
Read MoreSarcopenic obesity and dementia risk: Primary associations and landmark analyses of muscle strength and body composition trajectories.

Muscle-Adipose Aging Dynamics and Inflammaging Patterns Across Ethnically Diverse Populations: Exploring Potential Roles of Lipolysis.

BACKGROUND

Muscle-adipose aging reflects interactions between body composition changes and chronic inflammatory processes, but age-related patterns in these measures across ethnically diverse populations remain incompletely described. Understanding population-specific patterns is crucial for developing tailored prevention and intervention strategies. We aimed to...

🗓️ 2026-06-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle-Adipose Aging Dynamics and Inflammaging Patterns Across Ethnically Diverse Populations: Exploring Potential Roles of Lipolysis.

PEBP4 alleviates muscle wasting in lung cancer cachexia via KEAP1-NRF2-mediated redox homeostasis.

Cancer-associated cachexia (CAC) is a multifactorial metabolic syndrome characterized by progressive skeletal muscle wasting. However, the molecular link between tumor metabolic stress and muscle degradation remains elusive. Here, we identify phosphatidylethanolamine-binding protein 4 (PEBP4) as a key regulator of muscle...

🗓️ 2026-06-04
📰 Publication: Cell Death & Disease
Read MorePEBP4 alleviates muscle wasting in lung cancer cachexia via KEAP1-NRF2-mediated redox homeostasis.

Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia.

We investigated the prophylactic effects of exercise before and during cancer cachexia (CC) using a model designed to mimic endurance and resistance (i.e., concurrent) adaptations. Male and female Balb/c mice were randomly assigned to exercise or control groups whereby exercise...

🗓️ 2026-06-04
📰 Publication: Journal Of Physiology-London
Read MoreExercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia.

Positive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor.

The muscle nicotinic acetylcholine receptor (AChR) is the key mediator of neuromuscular signal transmission and is essential for all voluntary movement in our body. In this study, we present DC-98-LC74, a positive allosteric modulator (PAM) for the adult skeletal muscle-type...

🗓️ 2026-06-02
📰 Publication: Proceedings Of The National Academy Of Sciences Of The United States Of America
Read MorePositive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor.

Longitudinal Assessment of Muscle Involvement in Late-Onset Pompe Disease Using Quantitative MRI: A Prospective Cohort Study.

BACKGROUND

Late-onset Pompe disease (LOPD) is a progressive metabolic myopathy characterised by lysosomal glycogen accumulation and leading to secondary disruptions in autophagy and cellular energy metabolism. While enzyme replacement therapy (ERT) has improved outcomes, early detection remains critical, because irreversible muscle...

🗓️ 2026-06-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLongitudinal Assessment of Muscle Involvement in Late-Onset Pompe Disease Using Quantitative MRI: A Prospective Cohort Study.

Restoration of circadian rhythm as novel targets against sarcopenia.

Sarcopenia, characterized by the age-related decline in skeletal muscle mass, strength, and function, is associated with high healthcare costs and significant health risks, including falls, fractures, functional decline, and mortality. Despite its prevalence and extensive research, there are currently no...

🗓️ 2026-05-31
📰 Publication: Chinese Medical Journal
Read MoreRestoration of circadian rhythm as novel targets against sarcopenia.

Cluster Randomized Trial of Reablement Strategies Targeting Sarcopenia (ReStart-S) in Long-Term Care Settings.

BACKGROUND

Sarcopenia prevalence is high in long-term care settings (LTCS), yet existing guidelines often overlook this population. The Reablement Strategies targeting Sarcopenia (ReStart-S) program was developed to address this gap. This study evaluated its effects on muscle outcomes, physical performance, quality...

🗓️ 2026-05-31
📰 Publication: Journals Of Gerontology Series A-Biological Sciences And Medical Sciences
Read MoreCluster Randomized Trial of Reablement Strategies Targeting Sarcopenia (ReStart-S) in Long-Term Care Settings.

Sema4A Protects Against Muscle Atrophy and Promotes Repair by Regulating Intracellular Metabolic Signalling.

BACKGROUND

Skeletal muscle atrophy is a debilitating condition associated with diverse diseases and clinical interventions. Although triggers such as glucocorticoid excess or direct muscle injury disrupt the balance between protein homeostasis and tissue repair, the upstream molecular signals that actively preserve...

🗓️ 2026-05-30
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSema4A Protects Against Muscle Atrophy and Promotes Repair by Regulating Intracellular Metabolic Signalling.

Artificial intelligence analysis of temporalis muscle thickness for monitoring sarcopenia and clinical outcomes in individuals with paediatric brain tumours: a retrospective cohort study.

BACKGROUND

People with and who have survived paediatric brain tumour (PBT) have a poor quality of life due to physiological frailty, a primary component of which is sarcopenia (ie, low lean muscle mass) and the associated condition, sarcopenic overweight. MRI-based temporalis...

🗓️ 2026-05-28
Read MoreArtificial intelligence analysis of temporalis muscle thickness for monitoring sarcopenia and clinical outcomes in individuals with paediatric brain tumours: a retrospective cohort study.

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