muscles

Disuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.

BACKGROUND

Exercise has been proposed as both a preventive and therapeutic countermeasure; however, its effectiveness across different disuse conditions and timings of implementation remains uncertain.

METHODS

This systematic review and meta-analysis (PROSPERO: CRD42021256599) searched ClinicalTrials.gov, Cochrane Central, PubMed, SPORTDiscus, Web of Science, Scopus,...

🗓️ 2026-04-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDisuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.

Muscle Atrophy-Related Adverse Events of Antidiabetic Drug Classes: A Pharmacovigilance Analysis Using VigiBase Data.

BACKGROUND

Diabetes mellitus-a chronic metabolic disorder associated with an increased risk of muscle atrophy-can significantly impact patients' quality of life and overall health outcomes. While antidiabetic medications are crucial for managing blood glucose levels, some have been linked to muscle-related adverse...

🗓️ 2026-04-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Atrophy-Related Adverse Events of Antidiabetic Drug Classes: A Pharmacovigilance Analysis Using VigiBase Data.

MCC950-Loaded M12-Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis-Induced Muscle Atrophy.

BACKGROUND

Sepsis-induced myopathy (SIM) is a severe complication that contributes to late-stage mortality and functional impairment in sepsis patients. The NLRP3 inflammasome plays a pivotal role in the pathogenesis of SIM, and its selective inhibitor MCC950 has shown promising therapeutic potential....

🗓️ 2026-04-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMCC950-Loaded M12-Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis-Induced Muscle Atrophy.

HQ11: Does EMS (Electrical Muscle Stimulation) Prevent the Onset and Progression of Sarcopenia in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

🗓️ 2026-04-15
📰 Publication: Geriatrics & Gerontology International
Read MoreHQ11: Does EMS (Electrical Muscle Stimulation) Prevent the Onset and Progression of Sarcopenia in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

The sarcopenia-pain connection: why mechanisms matter for patient care?

Sarcopenia and pain are two highly prevalent conditions in aging populations, each exerting profound effects on mobility, independence, and quality of life. Emerging evidence demonstrates that these conditions are not merely coincidental but are closely interconnected through shared biological, mechanical,...

🗓️ 2026-04-15
Read MoreThe sarcopenia-pain connection: why mechanisms matter for patient care?

The Interplay Between Osteosarcopenia and Intrinsic Capacity: Insights and Associations With All-Cause Mortality in the Toledo Study for Healthy Aging.

BACKGROUND

Osteosarcopenia-the coexistence of osteopenia/osteoporosis and sarcopenia-is associated with numerous adverse health outcomes, but its association with intrinsic capacity (IC) remains unknown. We aimed to explore the associations of osteosarcopenia with IC and all-cause mortality in older adults.

METHODS

We conducted a cross-sectional...

🗓️ 2026-04-09
📰 Publication: Journals Of Gerontology Series A-Biological Sciences And Medical Sciences
Read MoreThe Interplay Between Osteosarcopenia and Intrinsic Capacity: Insights and Associations With All-Cause Mortality in the Toledo Study for Healthy Aging.

Effects of Nandrolone Decanoate on Muscle Strength, Body Composition and Bone Density: A Systematic Review and Meta-Analysis.

BACKGROUND

Despite ongoing interest in anabolic therapies for sarcopenia and cachexia, pharmacological interventions are being developed to counteract age- and condition-related losses of muscle mass and strength. This systematic review and meta-analysis evaluated the effect of nandrolone decanoate on lean soft...

🗓️ 2026-04-06
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEffects of Nandrolone Decanoate on Muscle Strength, Body Composition and Bone Density: A Systematic Review and Meta-Analysis.

AI-assessed sarcopenia as an independent predictor of neoadjuvant chemotherapy outcomes in muscle-invasive bladder cancer.

PURPOSE

Sarcopenia has already been widely investigated as a potential indicator of negative outcomes in oncology patients. Our aim was to evaluate the potential predictive role of sarcopenia assessed using an Artificial Intelligence-powered software in response to neoadjuvant chemotherapy (NAC) in...

🗓️ 2026-03-31
📰 Publication: Radiologia Medica
Read MoreAI-assessed sarcopenia as an independent predictor of neoadjuvant chemotherapy outcomes in muscle-invasive bladder cancer.

Blood and urine cell-free circulating DNA in older adults with sarcopenia: a hypothesis-generating study.

PURPOSE

This preliminary study evaluated effect sizes of differences in circulating cell-free DNA (cfDNA) levels in blood and urine between older adults with and without sarcopenia.

METHODS

This was a subanalysis of the 2021 Itabashi Longitudinal Study on Aging. Twenty-four participants were selected...

🗓️ 2026-03-20
📰 Publication: European Geriatric Medicine
Read MoreBlood and urine cell-free circulating DNA in older adults with sarcopenia: a hypothesis-generating study.

Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.

BACKGROUND

Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While cardiac manifestations of BTHS are well characterized in male patients, the mechanisms underlying skeletal muscle...

🗓️ 2026-03-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.

Moderate Aerobic Training Causes Muscle Wasting in a DMBA-Induced Sarcoma Rat Model.

Cancer cachexia, characterized by severe body weight loss, negatively affects patient quality of life and survival. Although moderate exercise benefits healthy and chronically ill individuals, and the effect of exercise in cachexia generally appears beneficial, conflicting results have been reported...

🗓️ 2026-03-14
📰 Publication: International Journal Of Molecular Sciences
Read MoreModerate Aerobic Training Causes Muscle Wasting in a DMBA-Induced Sarcoma Rat Model.

Muscle Movement and Metabolism: Exercise and Skeletal Muscle as Mediators of Health. A Report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.

Skeletal muscle is a crucial facilitator of many of the effects of exercise on metabolic health. Intrinsic myocellular mechanisms, exercise-induced myokine secretion, and crosstalk between multiple organ systems contribute to the maintenance of energy homeostasis, cardiovascular health, strength, cognition, and...

🗓️ 2026-03-12
📰 Publication: American Journal Of Clinical Nutrition
Read MoreMuscle Movement and Metabolism: Exercise and Skeletal Muscle as Mediators of Health. A Report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.

Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.

Cerebral palsy (CP) is the most common cause of childhood-onset physical disability. It results from injury to the developing brain and is characterized by motor impairments, muscle weakness, and fatigue. CP is commonly associated with marked deficits in muscle mass...

🗓️ 2026-03-10
📰 Publication: Faseb Journal
Read MoreDoes Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.

Exploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

INTRODUCTION

People with chronic kidney disease (CKD) often experience poor muscle quality and elevations in skeletal muscle wasting and dysfunction, contributing to a reduced quality of life and an increased risk of morbidity and mortality. The adipokine chemerin is associated with...

🗓️ 2026-02-28
📰 Publication: Translational Research
Read MoreExploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

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