muscles

Metabolomics Reveals Multiple Metabolic Alterations and Biomarkers of Disease Severity in Facioscapulohumeral Muscle Dystrophy.

BACKGROUND

Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is one of the most common adult-onset myopathies and is causally associated with a contraction of the D4Z4 macrosatellite repeat array on chromosome 4. It presents with a variable pattern of progressive muscle weakness...

🗓️ 2026-11-08
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMetabolomics Reveals Multiple Metabolic Alterations and Biomarkers of Disease Severity in Facioscapulohumeral Muscle Dystrophy.

Atovaquone impedes muscle wasting in pancreatic cancer by AMPK modulation.

Cancer-induced cachexia is a multifactorial syndrome characterized by systemic inflammation and progressive skeletal muscle and fat wasting. More than 80% pancreatic cancer patients exhibit a cachectic phenotype, which significantly contributes to the overall mortality of cancer patients. Till now, there...

🗓️ 2026-11-08
📰 Publication: Cancer Letters
Read MoreAtovaquone impedes muscle wasting in pancreatic cancer by AMPK modulation.

Molecular targets for the treatment of sarcopenia: a geroscience approach.

INTRODUCTION

Sarcopenia is increasingly recognized as a multisystem geroscience condition. The limited efficacy of first-generation anabolic therapies has challenged the paradigm that increasing muscle mass is sufficient to restore physical performance, highlighting the need for therapeutic strategies that address the biological...

🗓️ 2026-11-08
📰 Publication: Expert Opinion On Therapeutic Targets
Read MoreMolecular targets for the treatment of sarcopenia: a geroscience approach.

Sexually Dimorphic Response to Dietary Restriction-Induced Longevity and Muscle Preservation in Nothobranchius furzeri.

Age-related skeletal muscle decline (sarcopenia) contributes to frailty and mortality, yet how sex influences muscle aging and dietary interventions remains unclear. Using the short-lived vertebrate Nothobranchius furzeri, we investigated how sex and intermittent fasting (IF) interact to regulate lifespan and...

🗓️ 2026-11-06
📰 Publication: Aging Cell
Read MoreSexually Dimorphic Response to Dietary Restriction-Induced Longevity and Muscle Preservation in Nothobranchius furzeri.

Bioactive isoprenylflavonoids contribute to the dual protective effects of Xianling Gubao against sarcopenia and osteoarthritis in SAMP8 mice.

BACKGROUND

Osteoarthritis and sarcopenia increasingly contribute to the burden of age-related musculoskeletal disorders. Xianling Gubao (XLGB), a traditional Chinese medicine formula, has been used for musculoskeletal conditions including osteoporosis and osteoarthritis; however, its effects on sarcopenia and structural joint degeneration, and...

🗓️ 2026-11-06
📰 Publication: Journal Of Orthopaedic Translation
Read MoreBioactive isoprenylflavonoids contribute to the dual protective effects of Xianling Gubao against sarcopenia and osteoarthritis in SAMP8 mice.

Chronic Exercise Accelerates Disease Progression in a Rat Model of Desminopathy.

BACKGROUND

Desminopathy is a progressive myopathy and the most common intermediate filament disease in humans. Desmin is an essential part of the filamentous network that aligns myofibrils, anchors nuclei and mitochondria and connects the z discs to the sarcolemma. We challenged...

🗓️ 2026-11-06
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreChronic Exercise Accelerates Disease Progression in a Rat Model of Desminopathy.

Mitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca 2+ Overload-Mitophagy-Ferroptosis Circuit.

BACKGROUND

Denervation-induced muscle atrophy progresses during the interval between nerve injury and reinnervation, and depletion of muscle satellite cells (MuSCs) contributes to impaired functional recovery. Although mitochondrial dysfunction and impaired quality control are implicated in muscle wasting, whether excessive mitochondrial turnover...

🗓️ 2026-11-05
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca 2+ Overload-Mitophagy-Ferroptosis Circuit.

S100A9 Mediates Neuroblastoma-Associated Skeletal Muscle Atrophy via O-GlcNAcylation Repression and Activate Mitophagy Activation.

BACKGROUND

In patients with neuroblastoma (NB), skeletal muscle atrophy is a key factor linked to poor survival and decreased long-term quality of life. Nevertheless, there are still insufficient therapeutic methods that work, and the underlying mechanisms remain unclear. As persistent inflammation...

🗓️ 2026-11-05
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreS100A9 Mediates Neuroblastoma-Associated Skeletal Muscle Atrophy via O-GlcNAcylation Repression and Activate Mitophagy Activation.

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice.

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both sexes. Using different mouse models,...

🗓️ 2026-11-05
📰 Publication: Nature Communications
Read MoreNeonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice.

Remodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

BACKGROUND

The global prevalence of iron deficiency anaemia (IDA) is about 25% and even higher in women of reproductive age and children. IDA can impair skeletal muscle by disrupting oxygen utilization, energy production and contractile function. Haematological effects of intravenous (IV)...

🗓️ 2026-11-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRemodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway.

Cancer-associated cachexia (CAC) is a devastating multifactorial syndrome characterized by progressive skeletal muscle atrophy. Its mechanisms remain incompletely clarified, with limited effective therapeutic targets. NUB1, a negative regulator of ubiquitin-like proteins mediating protein degradation, has not been fully elucidated in...

🗓️ 2026-11-01
Read MoreNUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway.

Associations of Coexisting Metabolic Dysfunction-Associated Steatotic Liver Disease and Sarcopenia-Related Abnormalities With Adverse Clinical Outcomes Across Obesity States.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with adverse liver and non-liver outcomes, but the impact of coexisting sarcopenia-related abnormalities (e.g., low muscle strength [MS], muscle mass, and physical performance) remains unclear. In a prospective UK Biobank cohort (n...

🗓️ 2026-10-30
Read MoreAssociations of Coexisting Metabolic Dysfunction-Associated Steatotic Liver Disease and Sarcopenia-Related Abnormalities With Adverse Clinical Outcomes Across Obesity States.

Sulforaphane as a Therapeutic Target for Sarcopenia in Type 2 Diabetes: Mechanistic Insights and Translational Evidence.

Sulforaphane, a bioactive isothiocyanate abundant in cruciferous vegetables, has emerged as a potential multi-target therapeutic agent capable of mitigating these pathological processes. Here, using evidence from preclinical and clinical literature, we review the mechanistic and translational evidence linking sulforaphane with...

🗓️ 2026-10-27
Read MoreSulforaphane as a Therapeutic Target for Sarcopenia in Type 2 Diabetes: Mechanistic Insights and Translational Evidence.

Aquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline.

BACKGROUND

Impaired muscle regeneration is a key contributor to age-related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin-4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that...

🗓️ 2026-10-27
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline.

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