muscles

Sex-divergent skeletal muscle remodeling emerges early in cancer cachexia.

Cancer cachexia is characterised by progressive skeletal muscle wasting and dysfunction, yet the early events that precede overt muscle wasting remain poorly defined. Here, we utilised a time-coursed C26 carcinoma model in male and female mice to define the pre-cachectic...

🗓️ 2026-07-17
📰 Publication: American Journal Of Physiology-Cell Physiology
Read MoreSex-divergent skeletal muscle remodeling emerges early in cancer cachexia.

Sarcopenia Predicts Postoperative Cognitive Impairment and Poor Surgical Outcomes in Older Adults: A Prospective Cohort Study.

BACKGROUND

Sarcopenia is a progressive skeletal muscle disorder prevalent in older adults, yet its role as a risk factor for acute postoperative cognitive decline-an early manifestation within the spectrum of perioperative neurocognitive disorders (PND)-remains underexplored. We hypothesize that preoperative sarcopenia increases...

🗓️ 2026-07-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenia Predicts Postoperative Cognitive Impairment and Poor Surgical Outcomes in Older Adults: A Prospective Cohort Study.

Prognostic performance of Asian Working Group for Sarcopenia 2019 and 2025 sarcopenia definitions in cirrhosis.

BACKGROUND/PURPOSE OF THE STUDY

The Asian Working Group for Sarcopenia (AWGS) updated its criteria in 2025, adding a body mass index (BMI)-adjusted muscle index (ASM/BMI) to the conventional skeletal muscle index (SMI). We aimed to compare the prognostic performances of the...

🗓️ 2026-07-15
📰 Publication: Hepatology International
Read MorePrognostic performance of Asian Working Group for Sarcopenia 2019 and 2025 sarcopenia definitions in cirrhosis.

Defining Healthy Weight Loss and Target Weight in the Era of Highly Effective Treatment of Patients With Obesity.

BACKGROUND

Highly effective anti-obesity medications (AOMs) induce substantial weight loss and have renewed debate on appropriate treatment targets. Weight loss comprises reductions in fat mass (FM) and fat-free mass (FFM), with skeletal muscle (SM) as the major component of FFM. Clinical...

🗓️ 2026-07-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDefining Healthy Weight Loss and Target Weight in the Era of Highly Effective Treatment of Patients With Obesity.

Differential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a pre-clinical model of colorectal cancer by biological sex.

Cancer cachexia is a wasting condition characterized by muscle loss and reduced quality of life in cancer patients. Although biological sex differences in the progression of cancer cachexia have been increasingly recognized, their role during chemotherapy-treated cancer cachexia remains largely...

🗓️ 2026-07-15
📰 Publication: American Journal Of Physiology-Endocrinology And Metabolism
Read MoreDifferential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a pre-clinical model of colorectal cancer by biological sex.

Calcium Beta-Hydroxy-Beta-Methylbutyrate-Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial.

BACKGROUND

Dietary and pharmacologic weight loss can reduce skeletal muscle. Whether calcium beta-hydroxy-beta-methylbutyrate (CaHMB)-enriched supplementation preserves muscle while promoting fat loss in adults with obesity remains uncertain. We evaluated a CaHMB-enriched nutritional supplement during energy restriction.

METHODS

In this randomized, double-blind, controlled trial,...

🗓️ 2026-07-14
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCalcium Beta-Hydroxy-Beta-Methylbutyrate-Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial.

Sarcopenic Obesity and Risk of Incident Type 2 Diabetes: A Prospective Cohort Study and Landmark Analysis From the UK Biobank.

OBJECTIVE

To examine whether sarcopenic obesity (SO) is associated with incident type 2 diabetes (T2D) beyond obesity or sarcopenia alone and whether associations differ by sex, age, and transitions in body composition phenotypes over time.

RESEARCH DESIGN AND METHODS

We studied 479,607 diabetes-free...

🗓️ 2026-07-13
📰 Publication: Diabetes Care
Read MoreSarcopenic Obesity and Risk of Incident Type 2 Diabetes: A Prospective Cohort Study and Landmark Analysis From the UK Biobank.

Dnajb5 From Antarctic Fish Reveals a Redox-Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4.

BACKGROUND

Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4...

🗓️ 2026-07-12
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDnajb5 From Antarctic Fish Reveals a Redox-Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4.

Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.

Sarcopenia is the age-related loss of muscle strength and size that leads to mobility limitations and loss of independence in older adults. The underlying cellular mechanisms remain unclear, and treatments are limited. As the critical interface between the nervous system...

🗓️ 2026-07-09
📰 Publication: Journal Of Clinical Investigation
Read MoreNeuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.

Association of Intramuscular Fat Infiltration With Incident Venous Thromboembolism: A Population-Based Cohort Study.

BACKGROUND

Venous thromboembolism (VTE) is a major acute cardiovascular condition with high mortality, affecting nearly 10 million individuals worldwide each year. Identifying novel and modifiable risk factors is crucial for advancing prevention strategies. Intramuscular fat infiltration (IMFI), a modifiable condition linked...

🗓️ 2026-07-09
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Intramuscular Fat Infiltration With Incident Venous Thromboembolism: A Population-Based Cohort Study.

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue.

BACKGROUND

The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tissues and that impaired AKT signalling is a major molecular driver of...

🗓️ 2026-07-08
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDivergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue.

Prognostic performance of Asian Working Group for Sarcopenia 2025 Constructs for activities of daily living at discharge after stroke: a head-to-head validation.

PURPOSE

To compare the prognostic performance of the Asian Working Group for Sarcopenia (AWGS) 2025 diagnostic constructs-specifically height- versus body mass index (BMI)-indexed muscle mass-for discriminating functional outcomes in patients with stroke.

METHODS

From a cohort of 1246 consecutive post-acute stroke admissions, we...

🗓️ 2026-07-07
📰 Publication: European Geriatric Medicine
Read MorePrognostic performance of Asian Working Group for Sarcopenia 2025 Constructs for activities of daily living at discharge after stroke: a head-to-head validation.

Inter-tissue relationships of gene expression in liver, muscle and adipose tissue of children with end-stage chronic liver disease.

OBJECTIVES

End-stage chronic liver disease in children is associated with sarcopenia and aberrant adipose tissue mass. We investigated correlations between liver pathology-associated gene pathways (fibrosis, inflammation and steatosis) and metabolic genes in muscle and adipose tissue.

METHODS

Liver, rectus abdominis muscle and subcutaneous...

🗓️ 2026-07-06
📰 Publication: Journal Of Pediatric Gastroenterology And Nutrition
Read MoreInter-tissue relationships of gene expression in liver, muscle and adipose tissue of children with end-stage chronic liver disease.

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration.

BACKGROUND

Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no...

🗓️ 2026-07-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDownstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration.

Li-ginseng powder alleviates cancer cachexia in mice by regulating the ubiquitin-proteasome pathway and reducing inflammation.

BACKGROUND

As a debilitating syndrome, cancer cachexia (CC) manifests as ongoing weight reduction and skeletal muscle atrophy, which severely compromise patients' well-being and life expectancy, with no approved treatment available to date. Rare ginsenosides such as Rh2, Rg5, Rk1, and Rh4...

🗓️ 2026-07-03
📰 Publication: Journal Of Ginseng Research
Read MoreLi-ginseng powder alleviates cancer cachexia in mice by regulating the ubiquitin-proteasome pathway and reducing inflammation.

Myovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

Skeletal muscle health and regeneration are highly orchestrated processes governed by a complex interplay of muscle stem cells, fibro-adipogenic progenitors, immune cells, and endothelial cells. Among these cell types, endothelial cells play a central role not only by regulating blood...

🗓️ 2026-07-02
📰 Publication: Circulation Research
Read MoreMyovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

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