muscles

Brain-Derived Neurotrophic Factor, Sarcopenia and Digital Gait Characteristics in Older Adults: Insights Into the Brain-Muscle Axis.

BACKGROUND

Brain-derived neurotrophic factor (BDNF) is a core biomarker involved in the brain-muscle axis. This study aimed to investigate the associations of plasma BDNF with sarcopenia and multidimensional gait characteristics in older adults.

METHODS

We enrolled 646 adults aged 60 years and older (mean...

🗓️ 2026-06-30
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBrain-Derived Neurotrophic Factor, Sarcopenia and Digital Gait Characteristics in Older Adults: Insights Into the Brain-Muscle Axis.

A plasma proteomic signature of cancer-related sarcopenia implicates the IGFBP axis in muscle dysfunction.

BACKGROUND

Cancer-related sarcopenia is associated with poor clinical outcomes but remains difficult to define and quantify in routine oncology practice. Current assessments rely on imaging and functional scales that are time-consuming and provide limited biological insight. We aimed to identify a...

🗓️ 2026-06-30
📰 Publication: Molecular Cancer
Read MoreA plasma proteomic signature of cancer-related sarcopenia implicates the IGFBP axis in muscle dysfunction.

Cellular senescence in musculoskeletal diseases: biological mechanisms and clinical implications.

Cellular senescence is a persistent state of irreversible growth arrest that occurs when cells encounter various stress signals. It is marked by elevated expression of cell cycle inhibitors, dysregulated gene transcription, and secretion of the senescence-associated secretory phenotype (SASP). These...

🗓️ 2026-06-29
📰 Publication: Theranostics
Read MoreCellular senescence in musculoskeletal diseases: biological mechanisms and clinical implications.

Beyond body surface area: CT-derived body composition as a predictor of chemotherapy toxicity and survival in pancreatic ductal adenocarcinoma: a systematic review.

BACKGROUND

Pancreatic ductal adenocarcinoma (PDAC) is characterised by a high prevalence of severe muscle wasting (sarcopenia) and fatty muscle infiltration (myosteatosis), yet chemotherapy dosing still relies on body surface area (BSA), a metric that does not reflect individual patients' lean body...

🗓️ 2026-06-27
📰 Publication: Cancer Treatment Reviews
Read MoreBeyond body surface area: CT-derived body composition as a predictor of chemotherapy toxicity and survival in pancreatic ductal adenocarcinoma: a systematic review.

Icariin ameliorates sarcopenia via activation of the estrogen receptor α/fatty acid transport protein 1 pathway.

BACKGROUND

Sarcopenia is a prevalent disorder among postmenopausal women, representing a debilitating condition with limited treatment options. Icariin (ICA), a prenylated flavonol glycoside, is commonly used in conditions associated with estrogen deficiency; however, its efficacy and mechanism in postmenopausal sarcopenia remain...

🗓️ 2026-06-25
📰 Publication: Phytomedicine
Read MoreIcariin ameliorates sarcopenia via activation of the estrogen receptor α/fatty acid transport protein 1 pathway.

Associations of length of stay with sarcopenia parameters in geriatric patients: age and sex differences in the oldest old.

BACKGROUND

Hospital-associated deconditioning is a contributor to secondary sarcopenia, which may be driven by prolonged hospital length of stay (LoS). This study investigated the bidirectional association of LoS and sarcopenia indices (lean soft tissue, muscle strength, physical function) in older inpatients,...

🗓️ 2026-06-25
📰 Publication: Aging Clinical And Experimental Research
Read MoreAssociations of length of stay with sarcopenia parameters in geriatric patients: age and sex differences in the oldest old.

Prognostic Impact of Sarcopenia Following Myocardial Infarction: A Systematic Review and Meta-analysis of Mortality and Recurrent MI.

AIM

Sarcopenia, defined as progressive loss of skeletal muscle mass and function, may influence cardiovascular outcomes, yet its prognostic role after myocardial infarction (MI) remains uncertain. This study aimed to assess the association between sarcopenia and outcomes following MI, focusing on...

🗓️ 2026-06-19
📰 Publication: European Journal Of Preventive Cardiology
Read MorePrognostic Impact of Sarcopenia Following Myocardial Infarction: A Systematic Review and Meta-analysis of Mortality and Recurrent MI.

Deletion of Tgf-β1 From CD206 + M2 Macrophages Ameliorates Obesity-Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle.

BACKGROUNDS

Obesity and diabetes impair the ability of the muscle to regenerate, repair and remodel, resulting in a gradual decrease in muscle mass and function. However, the underlying mechanisms and effective therapeutic strategies remain poorly understood. M2 macrophages within skeletal muscle...

🗓️ 2026-06-19
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeletion of Tgf-β1 From CD206 + M2 Macrophages Ameliorates Obesity-Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle.

3,3'-Diindolylmethane ameliorates muscle atrophy by modulating mitochondrial function and calcium homeostasis.

BACKGROUND

Sarcopenia is a chronic degenerative condition characterized by the progressive loss of muscle mass and function. Current therapeutic strategies exhibit limited therapeutic efficacy and present substantial challenges in ensuring sustained patient compliance. Although mitochondrial dysfunction is a confirmed biomarker of...

🗓️ 2026-06-18
📰 Publication: Phytomedicine
Read More3,3'-Diindolylmethane ameliorates muscle atrophy by modulating mitochondrial function and calcium homeostasis.

RNF10 Attenuates Age-Related Muscle Atrophy by Promoting p53 Degradation and Alleviating Oxidative Stress.

Evidence identifies proteostasis imbalance and oxidative stress serve as fundamental pathological hallmarks of muscular atrophy, yet ring finger protein 10 (RNF10), a novel E3 ubiquitin ligase, in age-related muscular atrophy remains poorly characterized. Employing a natural aging mouse model and...

🗓️ 2026-06-18
📰 Publication: Free Radical Biology And Medicine
Read MoreRNF10 Attenuates Age-Related Muscle Atrophy by Promoting p53 Degradation and Alleviating Oxidative Stress.

Creatine/Creatinine Ratio and Myostatin as Biomarkers to Monitor Muscle Function in Duchenne Muscular Dystrophy Patients.

BACKGROUND

Duchenne Muscular Dystrophy (DMD) is characterized by progressive muscle wasting leading to early loss of motor function. Functional tests monitor disease progression and serve as clinical trial endpoints but are influenced by maturation in younger patients, high intra-patient variability and...

🗓️ 2026-06-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCreatine/Creatinine Ratio and Myostatin as Biomarkers to Monitor Muscle Function in Duchenne Muscular Dystrophy Patients.

Effects of Omega-3 Supplementation in Sarcopenia After Bariatric Surgery: A Triple-Blind Randomized Controlled Clinical Trial.

BACKGROUND

Bariatric surgery is an effective treatment for obesity but induces substantial muscle loss, potentially leading to sarcopenia. Omega-3 fatty acids have been associated with improved muscle metabolism, but their effect in the postoperative period of bariatric surgery remains unclear.

METHODS

A triple-blind...

🗓️ 2026-06-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEffects of Omega-3 Supplementation in Sarcopenia After Bariatric Surgery: A Triple-Blind Randomized Controlled Clinical Trial.

Muscle Ageing and Sarcopenia Study (MASS) Lifecourse: a valuable resource for understanding skeletal muscle ageing.

Advances in our understanding of the biology of skeletal muscle ageing are being made at pace, with great potential for these findings to inform the identification of novel treatments for sarcopenia. However, translation of findings from animal models to humans...

🗓️ 2026-06-15
Read MoreMuscle Ageing and Sarcopenia Study (MASS) Lifecourse: a valuable resource for understanding skeletal muscle ageing.

Sarcopenia and body composition abnormalities in chronic pancreatitis: Pathophysiology, assessment, and clinical impact.

Chronic pancreatitis is a progressive inflammatory disease associated with substantial nutritional and metabolic consequences. Beyond classical malnutrition, patients frequently develop alterations in body composition, particularly sarcopenia, which are increasingly recognised as clinically relevant but remain inconsistently assessed. The reported prevalence...

🗓️ 2026-06-12
📰 Publication: Clinical Nutrition
Read MoreSarcopenia and body composition abnormalities in chronic pancreatitis: Pathophysiology, assessment, and clinical impact.

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