muscles

Skeletal Muscle-Derived Extracellular Vesicles During Eccentric and Concentric Exercise Promote Muscle Regeneration After Injury.

BACKGROUND

Skeletal muscle injuries significantly impair mobility and function, yet effective therapeutic interventions remain limited. Both eccentric exercise (EE) and concentric exercise (CE) promote muscle repair, but the underlying mechanisms are not fully understood. Muscle-derived extracellular vesicles (mEVs) have emerged as...

🗓️ 2026-08-29
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal Muscle-Derived Extracellular Vesicles During Eccentric and Concentric Exercise Promote Muscle Regeneration After Injury.

Musculoskeletal (Mal)adaptations in Response to a > 30 000-km Running Challenge.

BACKGROUND

Ultra-endurance sports are increasingly popular, yet the long-term physiological consequences of sustained extreme training loads remain poorly understood. In particular, the effects of prolonged ultra-endurance exercise on skeletal muscle structure, function and molecular remodelling are largely unknown. This case study...

🗓️ 2026-08-29
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMusculoskeletal (Mal)adaptations in Response to a > 30 000-km Running Challenge.

NCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice.

Sarcopenia is an age-related pathological syndrome characterized by progressive and generalized loss of skeletal muscle mass and function, with muscle atrophy representing its cardinal pathological hallmark. Ferroptosis, an iron-dependent regulated cell death, has been implicated in the pathogenesis of muscle...

🗓️ 2026-08-26
Read MoreNCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice.

Clinical Trial: Intensive Supervised Nutritional Therapy Versus Guideline-Based Nutritional Advice for Sarcopenia in Decompensated Cirrhosis-A Randomised Controlled Trial.

BACKGROUND

Sarcopenia is highly prevalent in decompensated cirrhosis and independently predicts adverse outcomes. Although nutritional therapy is guideline-recommended, evidence comparing specialist dietitian-supervised nutritional care with routine physician-delivered dietary advice remains limited.

AIM

To compare the efficacy of dietitian-supervised intensive nutritional therapy with physician-led...

🗓️ 2026-08-26
📰 Publication: Alimentary Pharmacology & Therapeutics
Read MoreClinical Trial: Intensive Supervised Nutritional Therapy Versus Guideline-Based Nutritional Advice for Sarcopenia in Decompensated Cirrhosis-A Randomised Controlled Trial.

Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.

In mammals, nearly every cell contains an intrinsic circadian clock that functions both as a timekeeping system and an environmental sensor, integrating external cues to maintain alignment between internal physiology and the external environment. While the core clock machinery is...

🗓️ 2026-08-26
Read MoreStable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.

Systemic Inflammatory Biomarkers and Cancer-Associated Cachexia: A Narrative Review.

Cancer-associated cachexia (CAC) is a multifactorial syndrome characterized by systemic inflammation, muscle wasting, and progressive functional decline, affecting up to 80% of patients with advanced cancer. The inconsistent diagnostic criteria limit comparability across studies and hinder translation into clinical practice....

🗓️ 2026-08-26
📰 Publication: Current Oncology
Read MoreSystemic Inflammatory Biomarkers and Cancer-Associated Cachexia: A Narrative Review.

Intermuscular Adipose Tissue as a Multimodality Quantitative Imaging Biomarker: Evidence Across Metabolic, Cardiovascular and Oncologic Diseases.

Intermuscular adipose tissue (IMAT) refers to adipose tissue located between muscle groups or beneath the muscle fascia, and its accumulation is closely linked to impaired muscle quality, reduced contractile function, and adverse metabolic profiles, establishing it as a core component...

🗓️ 2026-08-18
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreIntermuscular Adipose Tissue as a Multimodality Quantitative Imaging Biomarker: Evidence Across Metabolic, Cardiovascular and Oncologic Diseases.

Circulating granulocyte colony-stimulating factor as a sex-unbiased global marker of lung and colorectal cancer cachexia pre-clinical models.

Cancer cachexia, affecting up to 80% of patients with advanced cancer, is characterized by metabolic and inflammatory dysregulation driven by tumour- and host-derived factors. Although cytokines are central to cachexia pathogenesis, their circulating profiles and transcriptional relevance across models and...

🗓️ 2026-08-13
📰 Publication: Experimental Physiology
Read MoreCirculating granulocyte colony-stimulating factor as a sex-unbiased global marker of lung and colorectal cancer cachexia pre-clinical models.

Accelerated Anthropometric Ageing Links Loss of Physical Function and Lower Extremity Body Mass.

BACKGROUND

Ageing is associated with anthropometric changes that have been linked to functional limitations and disease risk. However, previous work is limited to a few anthropometric measures, such as body mass index or waist-to-height ratio. Current imaging technology allows a rapid,...

🗓️ 2026-08-10
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAccelerated Anthropometric Ageing Links Loss of Physical Function and Lower Extremity Body Mass.

Effects of exercise and nutritional interventions on muscle-specific strength in older adults: A systematic review and meta-analysis.

PURPOSE

Deficient muscle-specific strength has been recognized as a key component of sarcopenia. However, the impact of various interventions on muscle-specific strength has not been systematically reviewed. This study aims to provide a systematic summary of research examining the effects of...

🗓️ 2026-08-09
📰 Publication: Ageing Research Reviews
Read MoreEffects of exercise and nutritional interventions on muscle-specific strength in older adults: A systematic review and meta-analysis.

Do muscle strength cut-offs used to define sarcopenia affect trajectories of disability progression in basic activities of daily living in older adults?

OBJECTIVE

This study aims to analyse trajectories of disability progression in basic activities of daily living (BADLs) as a function of sarcopenia, using different cut-off points for defining low muscle strength (LMS).

METHODS

A longitudinal study included 3,328 participants from the English Longitudinal...

🗓️ 2026-08-06
📰 Publication: Archives Of Gerontology And Geriatrics
Read MoreDo muscle strength cut-offs used to define sarcopenia affect trajectories of disability progression in basic activities of daily living in older adults?

Body Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.

BACKGROUND

Metabolic and musculoskeletal abnormalities in patients with heart failure (HF) may not be fully captured by body mass index.

OBJECTIVES

Body composition was studied in participants with HF and matched control subjects in the UK Biobank Imaging Study, and findings were compared...

🗓️ 2026-08-05
📰 Publication: Jacc-Heart Failure
Read MoreBody Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.

Preoperative swallowing muscle mass is associated with 1-year skeletal muscle loss and subsequent survival in lung cancer.

BACKGROUND & AIMS

Cancer cachexia is associated with systemic skeletal muscle loss and poor survival; however, early muscle changes preceding systemic muscle loss remain unclear. Therefore, this study aimed to determine whether tongue-complex muscle area (TCMA) can serve as an early...

🗓️ 2026-07-30
📰 Publication: Clinical Nutrition
Read MorePreoperative swallowing muscle mass is associated with 1-year skeletal muscle loss and subsequent survival in lung cancer.

Bile salt hydrolase-active bifidobacterium animalis improves sarcopenia via the gut microbiota-bile acid-FXR-FGF15 axis and its functional fermented milk preparation.

Sarcopenia is a major global health challenge associated with aging, and effective pharmacological treatments are lacking. This study investigated how bile salt hydrolase (BSH)-active probiotics alleviate sarcopenia through bile acid deconjugation and remodeling, activating the intestinal FXR-FGF15/19 signaling pathway, and...

🗓️ 2026-07-30
📰 Publication: Food Chemistry
Read MoreBile salt hydrolase-active bifidobacterium animalis improves sarcopenia via the gut microbiota-bile acid-FXR-FGF15 axis and its functional fermented milk preparation.

Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing.

BACKGROUND

Sarcopenia is a major contributor to frailty and mortality in ageing and obesity and is tightly linked to metabolic dysfunction. Imeglimin is a first-in-class oral hypoglycaemic agent targeting mitochondrial function; however, despite the central role of mitochondria in skeletal muscle...

🗓️ 2026-07-29
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing.

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