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  The Journal of Cachexia, Sarcopenia & Muscle ⟶
  The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing both research and clinical materials related to cachexia and sarcopenia from all fields of the life sciences.
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muscles

Muscle

Normative data for age-specific skeletal muscle area based on computed tomography in Korean population.

Sarcopenia, a progressive loss of muscle mass and function, increases health risks in older adults, especially in rapidly ageing populations like Korea. Computed tomography (CT) imaging at the third lumbar vertebra (L3) level is a gold standard for assessing skeletal...

🗓️ 2025-05-03

📰 Publication: Age And Ageing

Aging / Muscle,_skeletal / muscles / PREVALENCE / Sarcopenia / Sex / Tomography

Muscle

Iron Metabolism and Muscle Aging: Where Ferritinophagy Meets Mitochondrial Quality Control.

In older adults with reduced physical performance, an increase in the labile iron pool within skeletal muscle is observed. This accumulation is associated with an altered expression of mitochondrial quality control (MQC) markers and increased mitochondrial DNA damage, supporting the...

🗓️ 2025-05-03

Aging / Autophagy / Cell_death / CELLS / cytokines / Ferritins / Ferroptosis / Hepcidins / Lysosomes / Mitophagy / muscles / Quality_control / Sarcopenia / therapeutics / Transferrin

Muscle

Potential framework of the Global Leadership Initiative in Sarcopenia (GLIS) criteria based on muscle mass and/or strength for predicting survival in cancer patients: A nationwide multicenter cohort study.

The Global Leadership Initiative on Sarcopenia (GLIS) was proposed recently by creating a widely recognized conceptual definition of sarcopenia, however, the diagnostic framework of GLIS in cancer patients remains unclear. This study aims to evaluate the potential framework of GLIS...

🗓️ 2025-04-24

📰 Publication: Clinical Nutrition

Cohort_studies / Enteral_nutrition / Hand_strength / muscles / neoplasms / Sarcopenia

Muscle

MG53 deficiency mediated skeletal muscle dysfunction in chronic obstructive pulmonary disease via impairing mitochondrial fission.

Myokine dysregulation and mitochondrial dysfunction are implicated in the pathogenesis of sarcopenia in chronic obstructive pulmonary disease. The objective of this study is to explore the role of myokines and mitochondrial dysfunction in sarcopenia in chronic obstructive pulmonary disease. We...

🗓️ 2025-05-03

📰 Publication: Redox Biology

CELLS / Cigarette_smoking / Lung_diseases / Lung_diseases,_obstructive / Mitochondria / Muscle,_skeletal / muscles / Muscular_atrophy / Pulmonary_disease,_chronic_obstructive / Sarcopenia

Muscle

The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy.

Cancer cachexia, a multifactorial metabolic syndrome impacts 50-80% cancer patients, is mainly characterized by skeletal muscle atrophy. In this study, we demonstrated that the thousand-and-one amino acid kinase 1 (TAOK1) was activated in both C2C12 myotubes treated with simulated cancer...

🗓️ 2025-05-06

📰 Publication: Pharmacological Research

cachexia / Cancer-associated_cachexia / CELLS / Muscle_fibers,_skeletal / muscles / Muscular_atrophy / neoplasms / Pharmacology / therapeutics / Wounds_and_injuries

Muscle

Prevalence of sarcopenia in middle-aged and older adults with cognitive impairment: a meta-analysis.

Cognitive impairment, dementia and sarcopenia significantly reduce the quality of life in middle-aged and older adults by impairing daily functioning, making cognitive decline a major concern for healthcare professionals. To estimate the prevalence of sarcopenia and probable sarcopenia in middle-aged...

🗓️ 2025-05-03

📰 Publication: Age And Ageing

Aged / Aging / Cognition_disorders / Cognitive_dysfunction / Dementia / Geriatrics / muscles / PREVALENCE / Sarcopenia

Muscle

Comment on "Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage" by Korhonen et al.-The authors' reply.

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / DRAINAGE / muscles / Sarcopenia / Temporal_muscle

Muscle

The extract of chrysanthemum flos mitigates post-stroke sarcopenia by inhibiting PANoptosis and restoring muscle homeostasis.

Sarcopenia and muscle weakness are prevalent complications of ischemic stroke (IS), with limited pharmacological options. This study identifies high-dose extracts of Chrysanthemum Flos (ECF) as a potential therapy for post-stroke muscle dysfunction by targeting PANoptosis-a pro-inflammatory programmed cell death pathway....

🗓️ 2025-04-18

📰 Publication: Phytomedicine

CELLS / Hand_strength / Herbal_medicine / Homeostasis / Ischemic_stroke / Muscle_proteins / muscles / Muscular_atrophy / Plants,_medicinal / Sarcopenia / therapeutics

Muscle

Integrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol-Related Liver Disease.

Skeletal muscle is a major target for ethanol-induced perturbations, leading to sarcopenia in alcohol-related liver disease (ALD). The complex interactions and pathways involved in adaptive and maladaptive responses to ethanol in skeletal muscle are not well understood. Unlike hypothesis-driven experiments,...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Chromatin / Ethanol / Genes / liver / Liver_diseases / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Proteomics / Sarcopenia / Sirtuins

Muscle

Myosteatosis as a New Risk Factor of Surgical Complications in Kidney Transplant Recipients: A Retrospective Study.

Computed tomography (CT) scan-defined myosteatosis is a common feature in ESKD patients receiving kidney transplantation (KT) and is associated with mortality after KT. We aimed to explore the impact of myosteatosis and other CT scan based morphometric data on the...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / cachexia / Kidney / muscles / Postoperative_complications / Retrospective_studies / Risk_factors / Sarcopenia / Skin / tissues / Transplants

Muscle

A 10-Year Longitudinal Study of Muscle Morphology and Performance in Masters Sprinters.

Both longitudinal and cross-sectional studies have demonstrated that muscle mass, strength and power are lost with ageing. Although longitudinal studies have shown changes in muscle morphology and function in sedentary, healthy active and endurance-trained older people, less is known about...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aged / Atrophy / Biopsy / Histology / Longitudinal_studies / Muscle,_skeletal / muscles / Sarcopenia

Muscle

Myo-Guide: A Machine Learning-Based Web Application for Neuromuscular Disease Diagnosis With MRI.

Neuromuscular diseases (NMDs) are rare disorders characterized by progressive muscle fibre loss, leading to replacement by fibrotic and fatty tissue, muscle weakness and disability. Early diagnosis is critical for therapeutic decisions, care planning and genetic counselling. Muscle magnetic resonance imaging...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Artificial_intelligence / cachexia / DIAGNOSIS / Diagnosis,_differential / Machine_learning / Multiple_chronic_conditions / muscles / Neuromuscular_diseases / Sarcopenia

Muscle

The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.

Sarcopenia is associated with the loss of skeletal muscle function and mass. Nicotinamide precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), have received attention for their potential to improve NAD levels and mitigate age-related sarcopenia in preliminary models,...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Cognitive_dysfunction / Gait / Muscle,_skeletal / muscles / Niacinamide / Nicotinamide_mononucleotide / Sarcopenia / Walking_speed

Exercise

Myocellular adaptations to short-term weighted wheel-running exercise are largely conserved during C26-tumour induction in male and female mice.

This study investigated whether performing a translatable murine model of concurrent training after tumour induction affects adaptations in juvenile male and female tumour-bearing mice. Male and female Balb/c mice were injected bilaterally with colon-26 adenocarcinoma (C26) cells or PBS at...

🗓️ 2025-04-24

📰 Publication: Experimental Physiology

cachexia / Cancer-associated_cachexia / Colorectal_neoplasms / Food / muscles / neoplasms / Physiology / Running

Muscle

Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression.

Skeletal muscle wasting results from numerous conditions, such as sarcopenia, glucocorticoid therapy or intensive care. It prevents independent living in the elderly, predisposes to secondary diseases, and ultimately reduces lifespan. There is no approved drug therapy and the major causative...

🗓️ 2025-04-22

📰 Publication: Embo Molecular Medicine

Muscle,_skeletal / muscles / Phosphoric_monoester_hydrolases / Repression,_psychology / Sarcopenia / therapeutics

Muscle

Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy.

Oestrogen receptor alpha (ERα) plays an important role in maintaining mitochondrial function and regulating metabolism in skeletal muscle. However, its alterations and potential mechanisms in Duchenne muscular dystrophy (DMD) remain incompletely understood. In this study, we demonstrated the protective role...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

CELLS / Estradiol / Fulvestrant / Muscle_cells / Muscle,_skeletal / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Myoblasts / Sarcopenia / therapeutics

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