neoplasms

The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy.

Cancer cachexia, a multifactorial metabolic syndrome impacts 50-80% cancer patients, is mainly characterized by skeletal muscle atrophy. In this study, we demonstrated that the thousand-and-one amino acid kinase 1 (TAOK1) was activated in both C2C12 myotubes treated with simulated cancer...

๐Ÿ—“๏ธ 2025-05-06
๐Ÿ“ฐ Publication: Pharmacological Research
Read MoreThe potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy.

Artificial Intelligence in the Management of Malnutrition in Cancer Patients: A Systematic Review.

Malnutrition is a critical complication among cancer patients, affecting up to 80% of individuals depending on cancer type, stage, and treatment. Artificial Intelligence (AI) has emerged as a promising tool in healthcare, with potential applications in nutritional management to improve...

๐Ÿ—“๏ธ 2025-05-05
Read MoreArtificial Intelligence in the Management of Malnutrition in Cancer Patients: A Systematic Review.

Stool Microbiome Features and Weight Change Response to Treatment for cancer cachexia.

Cancer cachexia is characterised by significant weight loss and muscle wasting that adversely affects patient outcomes. Nutritional interventions in cancer cachexia leads to improved outcomes, including improved weight change. However, there are wide variations in weight response to dietary interventions....

๐Ÿ—“๏ธ 2025-06-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreStool Microbiome Features and Weight Change Response to Treatment for cancer cachexia.

Walking Speed and Risk of Cancer in Two Prospective Cohort Studies.

Walking speed is a reliable marker of sarcopenia and a strong predictor of mortality, but its relationship with cancer incidence remains largely unexplored. We aimed to investigate the association between walking speed and the risk of any cancer and five...

๐Ÿ—“๏ธ 2025-06-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreWalking Speed and Risk of Cancer in Two Prospective Cohort Studies.

Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice.

Cachexia, a severe wasting syndrome characterized by tumour-induced metabolic dysregulation, is a leading cause of death in people with cancer, yet its underlying mechanisms remain poorly understood. Here we show that a longitudinal full-body single-nuclei-resolution transcriptome analysis in a Drosophila...

๐Ÿ—“๏ธ 2025-04-16
Read MoreHepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice.

Myocellular adaptations to short-term weighted wheel-running exercise are largely conserved during C26-tumour induction in male and female mice.

This study investigated whether performing a translatable murine model of concurrent training after tumour induction affects adaptations in juvenile male and female tumour-bearing mice. Male and female Balb/c mice were injected bilaterally with colon-26 adenocarcinoma (C26) cells or PBS at...

๐Ÿ—“๏ธ 2025-04-24
๐Ÿ“ฐ Publication: Experimental Physiology
Read MoreMyocellular adaptations to short-term weighted wheel-running exercise are largely conserved during C26-tumour induction in male and female mice.

INFLAMMATION IN CANCER CACHEXIA: STILL THE CENTRAL TENET OR JUST ANOTHER PLAYER?

Cancer cachexia, a multifactorial syndrome characterised by body weight loss, muscle and adipose tissue wasting, affects cancer patients. Over time, the definition of cachexia has been modified, including inflammation as one of the main causal factors. Evidences have suggested that...

๐Ÿ—“๏ธ 2025-04-18
๐Ÿ“ฐ Publication: American Journal Of Physiology-Cell Physiology
Read MoreINFLAMMATION IN CANCER CACHEXIA: STILL THE CENTRAL TENET OR JUST ANOTHER PLAYER?

GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice.

The survival rate for children and adolescents has increased to over 85%. However, there is limited understanding of the impact of pediatric cancers on muscle development and physiology. Given that brain tumors alone account for 26% of all pediatric cancers,...

๐Ÿ—“๏ธ 2025-04-18
๐Ÿ“ฐ Publication: American Journal Of Physiology-Regulatory Integrative And Comparative Physiology
Read MoreGL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice.

Blood-Brain Barrier-Penetrating Nanocarriers Enable Microglial-Specific Drug Delivery in Hypothalamic Neuroinflammation.

Hypothalamic inflammation plays a pivotal role in appetite dysregulation across various pathological conditions, including cancer cachexia. However, delivering anti-inflammatory agents to microglia, key mediators of hypothalamic inflammation, remains challenging due to the unsurmountable blood-brain barrier (BBB). To overcome this challenge,...

๐Ÿ—“๏ธ 2025-04-03
๐Ÿ“ฐ Publication: Advanced Healthcare Materials
Read MoreBlood-Brain Barrier-Penetrating Nanocarriers Enable Microglial-Specific Drug Delivery in Hypothalamic Neuroinflammation.

Nuciferine Attenuates Cancer Cachexia-Induced Muscle Wasting in Mice via HSP90AA1.

Around 80% of patients with advanced cancer have cancer cachexia (CC), a serious complication for which there are currently no FDA-approved treatments. Nuciferine (NF) is the main active ingredient of lotus leaf, which has anti-inflammatory, anti-tumour and other effects. The...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNuciferine Attenuates Cancer Cachexia-Induced Muscle Wasting in Mice via HSP90AA1.

Body Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease.

Additional tools are needed to assess mortality risk among patients with cancer. Patients with chronic graft vs. host disease (cGVHD) after allogeneic haematopoietic cell transplantation (HCT) represent a high-risk cancer population with mortality risk explained by cGVHD severity, but also...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBody Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease.

A Dynamic Time Warping Extension to Consensus Weight-Based Cachexia Criteria Improves Prediction of Cancer Patient Outcomes.

Cachexia is a complex syndrome that impacts up to half of patients with cancer. Criteria systems have been developed for the purpose of diagnosing and grading cachexia severity in clinical settings. One of the most widely known is those developed...

๐Ÿ—“๏ธ 2025-01-29
Read MoreA Dynamic Time Warping Extension to Consensus Weight-Based Cachexia Criteria Improves Prediction of Cancer Patient Outcomes.

Prevalence and Prognostic Value of Global Leadership Initiative on Malnutrition (GLIM) Phenotypic Cachexia Criteria in Cancer Patients: A Systematic Review and Meta-Analysis.

The Global Leadership Initiative on Malnutrition (GLIM) criteria provide a framework for evaluating cachexia in cancer patients, yet variability in diagnostic application hinders its use. The aim of the present study was to examine the prevalence and prognostic value of...

๐Ÿ—“๏ธ 2025-03-25
Read MorePrevalence and Prognostic Value of Global Leadership Initiative on Malnutrition (GLIM) Phenotypic Cachexia Criteria in Cancer Patients: A Systematic Review and Meta-Analysis.

Multimodal interventions for cachexia management.

Cachexia (disease-related wasting) is a complex metabolic syndrome which occurs in people with chronic illnesses, including cancer, HIV/AIDS, kidney disease, heart disease, and chronic obstructive pulmonary disease (COPD). People with cachexia experience unintentional weight loss, muscle loss, fatigue, loss of...

๐Ÿ—“๏ธ 2025-03-25
๐Ÿ“ฐ Publication: Cochrane Database Of Systematic Reviews
Read MoreMultimodal interventions for cachexia management.

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