neoplasms

RAGE Re-Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions.

BACKGROUND

Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end-products (RAGE) is expressed by several cell types and sustains the inflammatory response in...

🗓️ 2026-05-09
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRAGE Re-Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions.

De novo and scaffold-based design of GDF15 binders for cancer cachexia diagnostics and therapeutics.

Growth differentiation factor-15 (GDF15), a stress-responsive cytokine of the transforming growth factor-β superfamily, is elevated in cancer cachexia, chemotherapy-induced nausea, and hyperemesis gravidarum, making it both a biomarker and a therapeutic target. Here, we developed high-affinity GDF15 binders using an...

🗓️ 2026-05-09
📰 Publication: Experimental And Molecular Medicine
Read MoreDe novo and scaffold-based design of GDF15 binders for cancer cachexia diagnostics and therapeutics.

FcRn function alone cannot account for elevated IgG clearance in the Lewis lung carcinoma model of cancer cachexia.

PURPOSE

The neonatal Fc receptor (FcRn) protects IgG-based monoclonal antibodies (mAbs) from catabolism by direct binding within endosomes and facilitates their recycling to extracellular spaces. Elevated clearance of immune checkpoint inhibitors (ICIs) and other IgG-based mAbs is often observed in patients...

🗓️ 2026-05-09
📰 Publication: International Immunopharmacology
Read MoreFcRn function alone cannot account for elevated IgG clearance in the Lewis lung carcinoma model of cancer cachexia.

Development of High-Affinity Ligands for Human UBR2.

UBR box-containing ubiquitin E3 ligases recognize the N-termini of their target proteins through the UBR box, and a member of the family, UBR2, has been established as a target to treat cancer- and diabetes-associated cachexia. However, the development of high-affinity...

🗓️ 2026-05-08
📰 Publication: Journal Of Medicinal Chemistry
Read MoreDevelopment of High-Affinity Ligands for Human UBR2.

Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota-immune signaling via Phocaeicola vulgatus enrichment.

BACKGROUND

Cancer cachexia profoundly impacts patient survival and quality of life. Current treatments fail to halt this trajectory, highlighting an urgent clinical need for host-directed therapies capable of uncoupling skeletal muscle wasting from tumor progression. This study investigated the therapeutic potential...

🗓️ 2026-05-06
📰 Publication: Microbiome
Read MoreMicheliolide ameliorates colon cancer cachexia by modulating gut microbiota-immune signaling via Phocaeicola vulgatus enrichment.

The Eubacterium Rectale Derived Extracellular Vesicles Alleviate Cancer Cachexia Induced Lipolysis by Inhibiting Macrophage Polarization.

Cancer cachexia (CC) is a complex pathological condition associated with cancer progression and poor prognosis, particularly in gastrointestinal cancers, and is closely linked to the gut microbiota. Lipolysis in CC may play a key role in driving cachexia progression. However,...

🗓️ 2026-05-06
📰 Publication: Journal Of Extracellular Vesicles
Read MoreThe Eubacterium Rectale Derived Extracellular Vesicles Alleviate Cancer Cachexia Induced Lipolysis by Inhibiting Macrophage Polarization.

Sarcopenia in Patients With Cancer and Its Association With Chemotherapy-Induced Peripheral Neurotoxicity.

BACKGROUND AND OBJECTIVES

Chemotherapy-induced peripheral neurotoxicity (CIPN) is the most common neurologic complication of cancer treatment. Sarcopenia, characterized by muscle mass loss, has been associated with treatment-related toxicity, but its association with CIPN remains unclear. We aimed to assess the association...

🗓️ 2026-05-05
📰 Publication: Neurology
Read MoreSarcopenia in Patients With Cancer and Its Association With Chemotherapy-Induced Peripheral Neurotoxicity.

Biosacetalin (1,1-Diethoxyethane) Prolongs Survival and Alleviates Cachexia in the NSG Mice Bearing Neuroblastoma SH-SY5Y Cells.

Neuroblastoma remains a formidable pediatric malignancy characterized by profound metabolic plasticity and limited therapeutic responsiveness in high-risk disease. Emerging evidence positions the interplay between Reactive Oxygen Species (ROS) and the metabolic sentinel AMP-activated protein kinase (AMPK) as a critical regulator...

🗓️ 2026-05-04
Read MoreBiosacetalin (1,1-Diethoxyethane) Prolongs Survival and Alleviates Cachexia in the NSG Mice Bearing Neuroblastoma SH-SY5Y Cells.

Cancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes.

Cancer-associated cachexia (CAC) is a multifactorial wasting syndrome characterized by progressive loss of fat and lean mass, systemic inflammation, and poor therapeutic responsiveness. While brown adipose tissue (BAT) is traditionally considered a protective, energy-dissipating organ, its qualitative remodeling in CAC...

🗓️ 2026-05-03
📰 Publication: Cell Death & Disease
Read MoreCancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes.

Independent validation of the Mosamatic deep learning automated skeletal muscle and adipose tissue segmentation tool in an external Chinese cancer patient cohort.

OBJECTIVES

Deep learning neural network (DLNN)-based tools can automate body composition analysis for cancer cachexia research. We aimed to evaluate a DLNN tool trained on a European population of Chinese cancer patients.

METHODS

Computed tomography (CT) images at the 3rd lumbar vertebral (L3)...

🗓️ 2026-05-01
Read MoreIndependent validation of the Mosamatic deep learning automated skeletal muscle and adipose tissue segmentation tool in an external Chinese cancer patient cohort.

The pathology and diagnosis of cancer cachexia and a treatment insight from natural products: A review.

Cancer cachexia, which is characterized by weight loss and muscle wasting with or without fat depletion, is a complex syndrome that commonly seen in patients with advanced cancer. The underlying pathophysiological mechanisms of cancer cachexia involve in systemic inflammation, abnormal...

🗓️ 2026-04-30
📰 Publication: Biochimica Et Biophysica Acta-Reviews On Cancer
Read MoreThe pathology and diagnosis of cancer cachexia and a treatment insight from natural products: A review.

Muscle Health and Prognosis in Patients With Cancer: New Insights.

BACKGROUND

Reduced muscle mass and impaired composition have each been independently associated with worse outcomes in patients with cancer. However, emerging evidence suggests that reduced muscle strength-namely, dynapenia-may be particularly important for prognostication, as it is easier to assess in clinical...

🗓️ 2026-04-30
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Health and Prognosis in Patients With Cancer: New Insights.

Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.

Sarcopenia is an age-related condition characterized by loss of skeletal muscle mass and strength and is associated with increased cancer incidence and mortality, yet how muscle decline promotes tumorigenesis remains unclear. Here, we show that skeletal muscle functions as an...

🗓️ 2026-04-28
📰 Publication: Nature Communications
Read MoreSarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.

Simple clinical parameters to identify sarcopenia 1 year after gastrectomy for gastric cancer.

BACKGROUND

New-onset sarcopenia may develop after gastrectomy even in patients with normal muscle mass, but its detection in routine practice remains challenging. This study evaluated body composition changes after gastrectomy and identified clinical parameters associated with sarcopenia development.

METHODS

This retrospective study included...

🗓️ 2026-04-27
📰 Publication: Gastric Cancer
Read MoreSimple clinical parameters to identify sarcopenia 1 year after gastrectomy for gastric cancer.

Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.

BACKGROUND

Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific...

🗓️ 2026-04-24
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.

Subscribe to the SCWD Newsletter

Stay Informed with the Latest Updates and Exclusive Insights!