SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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HQ8: Do Nutritional Interventions Prevent the Onset and Progression of Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

📰 Journal: Geriatrics & Gerontology International
Read MoreHQ8: Do Nutritional Interventions Prevent the Onset and Progression of Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

Screening for Malnutrition, Sarcopenia, and Physical Frailty Beyond One Year after Liver Transplantation.

BACKGROUND/AIMS

Malnutrition, sarcopenia, and frailty negatively impact quality of life and increase mortality following liver transplantation (LT). However, long-term follow-up data remain limited. This study aimed primarily to assess the malnutrition risk at 1-, 2-, and 3-years post-LT. Secondary objectives included...

Read MoreScreening for Malnutrition, Sarcopenia, and Physical Frailty Beyond One Year after Liver Transplantation.

Tumor intrinsic properties dictate Fc receptor expression and cancer cachexia associated increase in checkpoint inhibitor clearance.

PURPOSE

Patients with cancer cachexia display a general resistance to immune checkpoint inhibitor (ICI) therapy, and baseline ICI catabolic clearance is a predictive indicator for overall survival, independent of dose and drug exposure. Fc-gamma (FcγRs) and neonatal Fc receptors (FcRn) play...

📰 Journal: Frontiers In Immunology
Read MoreTumor intrinsic properties dictate Fc receptor expression and cancer cachexia associated increase in checkpoint inhibitor clearance.

Association of nutrition impact symptoms with dietary intake among patients with advanced cancer referred to palliative care.

BACKGROUND & AIMS

Considering that cachexia-related symptoms interfere with dietary intake and compromise nutritional status in advanced cancer patients, these symptoms are classified as nutrition impact symptoms (NISs). However, the extent to which each NIS interferes with dietary intake remains unclear....

Read MoreAssociation of nutrition impact symptoms with dietary intake among patients with advanced cancer referred to palliative care.

Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Gut microbiome plays an important role in several metabolic, immune, and inflammatory pathways; however, there is limited evidence for its role in body composition and musculoskeletal health. Sarcopenia, defined as a loss of skeletal muscle mass and function, and obesity,...

📰 Journal: Osteoporosis International
Read MoreImpact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Prognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.

AIM

Respiratory sarcopenia, characterised by reduced respiratory muscle mass and function, can impair ventilatory reserve and physical capacity, potentially worsening outcomes. However, its prevalence and prognostic significance in older patients with heart failure remain unclear. This study aimed to investigate the...

📰 Journal: European Journal Of Preventive Cardiology
Read MorePrognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.

A Systematic Review of Digital Health for Non-older Adults with Risk of Sarcopenia.

OBJECTIVES

Non-older adults are at risk of developing sarcopenia, and exercise and increased physical activity are effective preventive interventions. Digital interventions, including gamification, may enhance the effects of exercise interventions. This systematic review and meta-analysis examined the effects of digital health...

Read MoreA Systematic Review of Digital Health for Non-older Adults with Risk of Sarcopenia.

Plant-based protein for older adults with obesity.

The global syndemic of obesity, undernutrition, and climate change - three interconnected challenges - threatens both human and planetary health. This review focuses on one critical intersection: older populations living with overweight and obesity in the context of sustainable nutrition....

📰 Journal: Proceedings Of The Nutrition Society
Read MorePlant-based protein for older adults with obesity.

Secreted protein acidic and rich in cysteine-guided biomimetic delivery of nano-antioxidants reverses muscle atrophy in a mouse model of sarcopenia.

Sarcopenia is currently classified as an unmet medical need with an increasing incidence because of population aging. Excessive reactive oxygen species (ROS) production plays a critical role in the pathogenesis of muscle atrophy, a key feature of sarcopenia, whereas edaravone...

📰 Journal: Journal Of Controlled Release
Read MoreSecreted protein acidic and rich in cysteine-guided biomimetic delivery of nano-antioxidants reverses muscle atrophy in a mouse model of sarcopenia.

Can a consumer-grade bioimpedance device accurately estimate sarcopenia in women with type 2 diabetes? A cross-sectional agreement study with dual-energy X-ray absorptiometry.

AIMS

To evaluate the diagnostic performance of a consumer-grade bioelectrical impedance analyzer (OMRON HBF-514C) against dual-energy X-ray absorptiometry (DXA) for detecting sarcopenia in women with type 2 diabetes (T2DM).

METHODS

In this cross‑sectional study, 103 women with T2DM underwent body composition assessment using...

📰 Journal: Diabetes Research And Clinical Practice
Read MoreCan a consumer-grade bioimpedance device accurately estimate sarcopenia in women with type 2 diabetes? A cross-sectional agreement study with dual-energy X-ray absorptiometry.

Consensus statement on vitamin D role in metabolic health.

The 8th International Conference Controversies in Vitamin D, held in September 2024, convened leading experts to address the multifaceted role of vitamin D in human health. Key discussions focused on its influence on metabolic health, including effects on sarcopenia, muscle...

📰 Journal: Metabolism-Clinical And Experimental
Read MoreConsensus statement on vitamin D role in metabolic health.

Public Health.

BACKGROUND

Sarcopenia is associated with an increased risk of cognitive impairment, yet very few studies have examined structural brain changes in sarcopenia. The current study aims to explore cognitive changes and their neuroimaging correlates of individuals with sarcopenia in an urban...

📰 Journal: Alzheimers & Dementia
Read MorePublic Health.

Changes in Frailty and Incident Cancer: Evidence From the Health and Retirement Study.

BACKGROUND

Although frailty has been identified as a potential risk factor for cancer, most previous studies have only considered frailty status at a single time point. The relationship between dynamic changes in frailty and incident cancer is less well understood. This...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreChanges in Frailty and Incident Cancer: Evidence From the Health and Retirement Study.

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