liver

Overt hepatic encephalopathy after elective and preemptive TIPS: Risk factors and prognosis.

<p><b>BACKGROUND & AIMS</b></p><p>Overt hepatic encephalopathy (OHE) develops in 30-50% of patients after transjugular intrahepatic portosystemic shunt (TIPS) placement, depending on patient characteristics and TIPS indication. Data on OHE after preemptive TIPS (pTIPS) are limited. We aimed to assess the prevalence...

๐Ÿ—“๏ธ 2025-10-29
๐Ÿ“ฐ Publication: Jhep Reports
Read MoreOvert hepatic encephalopathy after elective and preemptive TIPS: Risk factors and prognosis.

Sarcopenia and gender disparities in liver transplant waiting lists: evaluating predictive scores and delisting risks.

<p><b>BACKGROUND</b></p><p>The model for end-stage liver disease (MELD) and model for end-stage liver disease-sodium (MELD-Na) scores are the most widely used for prioritizing patients on the liver transplant (LT) waiting list. However, the quality and accuracy of these scores are questionable....

๐Ÿ—“๏ธ 2025-10-01
๐Ÿ“ฐ Publication: Hepatobiliary Surgery And Nutrition
Read MoreSarcopenia and gender disparities in liver transplant waiting lists: evaluating predictive scores and delisting risks.

Association of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

<p><b>BACKGROUND AND AIMS</b></p><p>Sarcopenia and frailty have been associated with hormonal dysregulation in non-cirrhotic populations. The aim of the study was to evaluate hypothalamic-pituitary-adrenal and gonadal (HPA-HPG) axes as well as growth hormone/insulin-like growth factor-1 (GH/IGF-1) levels in patients with cirrhosis...

๐Ÿ—“๏ธ 2025-11-01
๐Ÿ“ฐ Publication: Liver International
Read MoreAssociation of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

Management of Children Awaiting Liver Transplantation: Sarcopenia, Cholestasis and Beyond.

Sarcopenia has been increasingly recognized as a risk factor for worse outcomes in liver transplantation; however, the data remain limited on pediatric-specific outcomes. These gaps in knowledge are in part due to the lack of a standardized definition, challenges inherent...

๐Ÿ—“๏ธ 2025-11-01
๐Ÿ“ฐ Publication: Pediatric Transplantation
Read MoreManagement of Children Awaiting Liver Transplantation: Sarcopenia, Cholestasis and Beyond.

Silencing Myostatin Using In Vivo Self-Assembled siRNA Protects Against Cancer- and Dexamethasone-Induced Muscle Atrophy.

Maintaining skeletal muscle mass is crucial for health, as muscle atrophy caused by drugs, cancer, or aging poses serious risks. However, there are few effective pharmacological interventions targeting muscle atrophy, highlighting the need for new therapeutic strategies. In this study,...

๐Ÿ—“๏ธ 2025-10-03
๐Ÿ“ฐ Publication: Advanced Healthcare Materials
Read MoreSilencing Myostatin Using In Vivo Self-Assembled siRNA Protects Against Cancer- and Dexamethasone-Induced Muscle Atrophy.

Type II fibre atrophy and nuclear disruption in decompensated cirrhosis.

Loss of skeletal muscle mass is a common complication in cirrhosis that is associated with higher morbidity and mortality. Since the specific pathophysiology of cirrhosis-related muscle loss is unclear, we performed histological evaluation of muscle tissue from patients with cirrhosis...

๐Ÿ—“๏ธ 2025-05-24
๐Ÿ“ฐ Publication: Jhep Reports
Read MoreType II fibre atrophy and nuclear disruption in decompensated cirrhosis.

Vagal blockade of the brain-liver axis deters cancer-associated cachexia.

Cancer-associated cachexia (CAC) is a multifactorial and currently incurable syndrome responsible for nearly one-third of cancer-related deaths. It contributes to therapy resistance and increases mortality among affected patients. In this study, we show that cancer-induced systemic inflammation alters vagal tone...

๐Ÿ—“๏ธ 2025-07-29
๐Ÿ“ฐ Publication: Cell
Read MoreVagal blockade of the brain-liver axis deters cancer-associated cachexia.

Cancer therapy and cachexia.

A central challenge in cancer therapy is the effective delivery of anticancer treatments while minimizing adverse effects on patient health. The potential dual impact of therapy is clearly illustrated in cancer-associated cachexia, a multifactorial syndrome characterized by involuntary weight loss,...

๐Ÿ—“๏ธ 2025-08-01
๐Ÿ“ฐ Publication: Journal Of Clinical Investigation
Read MoreCancer therapy and cachexia.

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia.

In cancer cachexia, the presence of a tumor triggers systemic metabolic disruption that leads to involuntary body weight loss and accelerated mortality in affected patients. Here, we conducted transcriptomic and epigenomic profiling of the liver in various weight-stable cancer and...

๐Ÿ—“๏ธ 2025-07-18
๐Ÿ“ฐ Publication: Cell
Read MoreFunctional liver genomics identifies hepatokines promoting wasting in cancer cachexia.

Impact of physical activities in metabolic dysfunction associated steatotic liver disease, sarcopenia, and cardiovascular disease.

There are no comprehensive studies that investigated differential effects of physical activity (PA) types on metabolic dysfunction associated steatotic liver disease (MASLD) and their associations with sarcopenia and cardiovascular disease. A cross-sectional analysis using data from 66,021 participants from the...

๐Ÿ—“๏ธ 2025-04-28
๐Ÿ“ฐ Publication: Diabetes Research And Clinical Practice
Read MoreImpact of physical activities in metabolic dysfunction associated steatotic liver disease, sarcopenia, and cardiovascular disease.

Integrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol-Related Liver Disease.

Skeletal muscle is a major target for ethanol-induced perturbations, leading to sarcopenia in alcohol-related liver disease (ALD). The complex interactions and pathways involved in adaptive and maladaptive responses to ethanol in skeletal muscle are not well understood. Unlike hypothesis-driven experiments,...

๐Ÿ—“๏ธ 2025-06-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreIntegrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol-Related Liver Disease.

Severe Dietary Energy Restriction for Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomised Controlled Trial.

Compensated cirrhosis due to metabolic dysfunction-associated steatotic liver disease (CC-MASLD) increases morbidity and mortality risk but has no aetiology-specific treatment. We investigated the safety and efficacy signals of severe energy restriction. In this randomised controlled trial, adults with CC-MASLD and...

๐Ÿ—“๏ธ 2025-06-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSevere Dietary Energy Restriction for Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomised Controlled Trial.

Low Visceral Adipose Tissue Predicts the Outcome of Neoadjuvant Chemotherapy for Colorectal Liver Metastases: A Multicentre Real-World Study.

Visceral obesity (VO), associated with excessive visceral adipose tissue (VAT), has been extensively studied in cancer. However, whether low VAT can predict the prognosis of colorectal liver metastases (CRLM) undergoing neoadjuvant chemotherapy (NAC) remains unknown. This multicentre real-world cohort study...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLow Visceral Adipose Tissue Predicts the Outcome of Neoadjuvant Chemotherapy for Colorectal Liver Metastases: A Multicentre Real-World Study.

Comment on "Myosteatosis and Muscle Loss Impact Liver Transplant Outcomes in Male Patients With Hepatocellular Carcinoma" by Lu etย al.-The Authors' Reply.

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreComment on "Myosteatosis and Muscle Loss Impact Liver Transplant Outcomes in Male Patients With Hepatocellular Carcinoma" by Lu etย al.-The Authors' Reply.

Association Between Handgrip Strength and Cardiovascular Disease Risk in MASLD: A Prospective Study From UK Biobank.

This study aimed to investigate the association between handgrip strength (HGS) and cardiovascular disease (CVD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) using data from the UK Biobank cohort. A total of 201โ€‰563 participants were enrolled in this...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation Between Handgrip Strength and Cardiovascular Disease Risk in MASLD: A Prospective Study From UK Biobank.

Fat-Free Mass: Friend or Foe to Metabolic Health?

Fat mass (FM) and fat-free mass (FFM) are body composition estimates commonly reported in research studies and clinical settings. Recently, fat-free mass indexed to height (fat-free mass index; FFMI) has been shown to be positively associated with impaired insulin sensitivity...

๐Ÿ—“๏ธ 2025-02-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreFat-Free Mass: Friend or Foe to Metabolic Health?

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