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  The Journal of Cachexia, Sarcopenia & Muscle ⟶
  The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing both research and clinical materials related to cachexia and sarcopenia from all fields of the life sciences.
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2025 CONFERENCE

tissues

Muscle

Adipose-Derived Extracellular Vesicles and Intercellular Crosstalk With Skeletal Muscle: Implications for Sarcopenic Obesity and Metabolic Dysregulation.

Sarcopenic obesity, characterized by the concurrent presence of excess adiposity and diminished skeletal muscle mass and function, is closely linked to frailty, chronic inflammation, and insulin resistance. The increasing prevalence of sarcopenic obesity is driven by the global aging population,...

🗓️ 2025-08-13

📰 Publication: Obesity Reviews

Adipose_tissue / Extracellular_vesicles / Muscle,_skeletal / muscles / Obesity / Pathology / Research / Sarcopenia / therapeutics / tissues

Muscle

Type II fibre atrophy and nuclear disruption in decompensated cirrhosis.

Loss of skeletal muscle mass is a common complication in cirrhosis that is associated with higher morbidity and mortality. Since the specific pathophysiology of cirrhosis-related muscle loss is unclear, we performed histological evaluation of muscle tissue from patients with cirrhosis...

🗓️ 2025-05-24

📰 Publication: Jhep Reports

Atrophy / liver / Liver_transplantation / Muscle,_skeletal / muscles / Muscular_diseases / Rehabilitation / Sarcopenia / tissues / Transplants / Triglycerides

Muscle

Cancer therapy and cachexia.

A central challenge in cancer therapy is the effective delivery of anticancer treatments while minimizing adverse effects on patient health. The potential dual impact of therapy is clearly illustrated in cancer-associated cachexia, a multifactorial syndrome characterized by involuntary weight loss,...

🗓️ 2025-08-01

📰 Publication: Journal Of Clinical Investigation

Adipose_tissue / Brain / cachexia / Cancer-associated_cachexia / chemotherapy / Drug_therapy / Food / liver / muscles / neoplasms / Nutrients / therapeutics / tissues

Cachexia

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia.

In cancer cachexia, the presence of a tumor triggers systemic metabolic disruption that leads to involuntary body weight loss and accelerated mortality in affected patients. Here, we conducted transcriptomic and epigenomic profiling of the liver in various weight-stable cancer and...

🗓️ 2025-07-18

📰 Publication: Cell

Cancer-associated_cachexia / Cell_biology / Circadian_clocks / Genes / Genomics / Hepatocytes / liver / Muscular_atrophy / neoplasms / tissues

Cachexia

Thymic Microenvironment Remodeling in Cancer Cachexia as a Determinant of Checkpoint Inhibitor Efficacy and Toxicity.

The discovery of immune checkpoints links autoimmunity and cancer, with thymus atrophy reportedly causing autoimmune multiorgan inflammation. The impact of cancer cachexia on thymic involution and its clinical significance remains unclear. This study aimed to investigate this effect and its...

🗓️ 2025-08-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autoantibodies / Cancer-associated_cachexia / CELLS / Fibroblasts / Genes / Immune_checkpoint_inhibitors / neoplasms / Sarcopenia / SERUM / Stem_cells / therapeutics / Thymocytes / Thymus_gland / tissues

Muscle

Oral apigenin prevents obesity-related muscular atrophy, but not obesity itself, in middle-aged rats fed a high-calorie diet.

Obesity constitutes a growing global health concern, affecting individuals during the aging process. Flavonoids that increase tissue NAD+ levels, such as apigenin (Api), are proposed for the treatment of obesity and age-related diseases. Thus, this study aimed to provide initial preclinical...

🗓️ 2025-07-12

📰 Publication: Biomedicine & Pharmacotherapy

Aged / Apigenin / Diet / Drug_therapy / muscles / Muscular_atrophy / Obesity / Pharmaceutical_vehicles / Research / Sarcopenia / therapeutics / tissues

Cancer Cachexia

The role of body composition in the development of diabetes mellitus among childhood cancer survivors, and novel intervention strategies to mitigate diabetes risk.

The growing population of childhood cancer survivors (CCSs) experiences a large burden of comorbidities, including a markedly increased risk of diabetes mellitus. Among CCSs, prediabetes and diabetes are important risk factors for subsequent cardiovascular disease, which is a leading cause...

🗓️ 2025-07-15

📰 Publication: Cancer

Adipose_tissue / Body_composition / Cancer_survivors / Diabetes_mellitus / Monitoring,_ambulatory / Muscle,_skeletal / muscles / neoplasms / Obesity / Sarcopenia / therapeutics / tissues

Muscle

Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia.

Although the decline in muscle mass, function and increased visceral obesity are attracting substantial attention in the ageing society, approved treatment modalities for sarcopenia/sarcopenic obesity (SO) remain limited. Elucidating effects and mechanisms of adipose tissue and lipids on skeletal muscle...

🗓️ 2025-01-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Athletes / cachexia / CELLS / Insulin / Lipid_droplets / Muscle_cells / Muscle,_skeletal / muscles / Obesity / Organelle_biogenesis / Oxidative_stress / Sarcopenia / Stress,_physiological / therapeutics / tissues

Muscle

Integrating Body Composition and Nutritional Indices: A Novel Prognostic Tool for Survival in Pancreatic Cancer.

Sarcopenia and malnutrition have been independently associated with a poorer prognosis in pancreatic ductal adenocarcinoma (PDAC), but their combined association with patient outcomes is not fully understood. This study aimed to systematically evaluate the synergistic effects of body composition parameters...

🗓️ 2025-08-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Body_composition / cachexia / Muscle,_skeletal / muscles / Pancreatic_neoplasms / Prognosis / Sarcopenia / Sex / tissues

Muscle

Scutellarein attenuates cancer cachexia-induced muscle atrophy via targeted inhibition of the JAK/STAT pathway.

Cancer cachexia is a multifaceted metabolic syndrome characterized by severe loss of skeletal muscle and adipose tissue, diminishing both quality of life and survival in cancer patients. Despite its prevalence, effective treatments for cancer cachexia remain limited. The JAK/STAT signaling...

🗓️ 2025-07-03

📰 Publication: Journal Of Advanced Research

cachexia / Cancer-associated_cachexia / CELLS / Muscle_cells / Muscle,_skeletal / muscles / Muscular_atrophy / neoplasms / therapeutics / tissues

Muscle

Ageing Signatures and Disturbed Muscle Regeneration in Muscle Proteome of Inclusion Body Myositis.

Inclusion body myositis (IBM) is the most common acquired myopathy in adults over the age of 50 years, characterised by inflammatory and degenerative features that lead to progressive muscle weakness and physical disability for lack of effective therapies. The complex interplay...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Inclusion_bodies / muscles / Myoblasts / Myogenin / Myositis / Myositis,_inclusion_body / Pathology / Proteome / Proteomics / Sarcopenia / therapeutics / tissues

Muscle

Androgen Deprivation Therapy-Induced Muscle Loss and Fat Gain Predict Cardiovascular Events in Prostate Cancer Patients.

Androgen deprivation therapy (ADT) increases the risk of adverse cardiovascular events in patients with prostate cancer. ADT can induce body composition change; however, the association between body composition change and cardiovascular outcomes remains unclear. This study aimed to determine the...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Androgens / Body_composition / cachexia / Cardiovascular_diseases / muscles / neoplasms / Prostate / Prostatic_neoplasms / Sarcopenia / Subcutaneous_fat / therapeutics / tissues

Muscle

Myosteatosis as a New Risk Factor of Surgical Complications in Kidney Transplant Recipients: A Retrospective Study.

Computed tomography (CT) scan-defined myosteatosis is a common feature in ESKD patients receiving kidney transplantation (KT) and is associated with mortality after KT. We aimed to explore the impact of myosteatosis and other CT scan based morphometric data on the...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / cachexia / Kidney / muscles / Postoperative_complications / Retrospective_studies / Risk_factors / Sarcopenia / Skin / tissues / Transplants

Muscle

INFLAMMATION IN CANCER CACHEXIA: STILL THE CENTRAL TENET OR JUST ANOTHER PLAYER?

Cancer cachexia, a multifactorial syndrome characterised by body weight loss, muscle and adipose tissue wasting, affects cancer patients. Over time, the definition of cachexia has been modified, including inflammation as one of the main causal factors. Evidences have suggested that...

🗓️ 2025-04-18

📰 Publication: American Journal Of Physiology-Cell Physiology

cachexia / Cancer-associated_cachexia / Homeostasis / muscles / neoplasms / tissues

Cachexia

Low Visceral Adipose Tissue Predicts the Outcome of Neoadjuvant Chemotherapy for Colorectal Liver Metastases: A Multicentre Real-World Study.

Visceral obesity (VO), associated with excessive visceral adipose tissue (VAT), has been extensively studied in cancer. However, whether low VAT can predict the prognosis of colorectal liver metastases (CRLM) undergoing neoadjuvant chemotherapy (NAC) remains unknown. This multicentre real-world cohort study...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / chemotherapy / Colorectal_neoplasms / Drug_therapy / liver / Neoplasm_metastasis / Sarcopenia / tissues

Exercise

Body Composition and Intradialytic Exercise in Kidney Disease: A Combined Analysis of the PEDAL and CYCLE-HD Randomised Controlled Trials.

Haemodialysis patients are at high risk of myopenic obesity, necessitating effective nutritional status monitoring and intervention strategies. This combined analysis of two clinical trials (PEDAL trial and CYCLE-HD study) aimed to (i) determine the clinical utility of body mass index...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Body_composition / cachexia / Classification / Kidney / Kidney_diseases / Nutritional_status / Obesity / Overweight / Renal_replacement_therapy / Sarcopenia / tissues

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