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Frailty

Explore the breadth of frailty research, from evaluating multimodal interventions in co-morbid conditions like Type 2 Diabetes Mellitus to understanding the role of nutrition and exercise in mitigating frailty. Gain insights into the complex interplay between frailty, sarcopenia, and chronic diseases, and discover innovative strategies to improve outcomes for the elderly.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia

Osteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study.

Osteosarcopenia is suggested to be on the causal pathway to frailty; however, data on this topic is scarce, and it is unclear if osteosarcopenia is associated with frailty risk. To investigate if osteosarcopenia is associated with frailty risk in community-dwelling...

๐Ÿ—“๏ธ 2025-05-02
๐Ÿ“ฐ Publication: Archives Of Gerontology And Geriatrics
Read MoreOsteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study.

Severe Dietary Energy Restriction for Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomised Controlled Trial.

Compensated cirrhosis due to metabolic dysfunction-associated steatotic liver disease (CC-MASLD) increases morbidity and mortality risk but has no aetiology-specific treatment. We investigated the safety and efficacy signals of severe energy restriction. In this randomised controlled trial, adults with CC-MASLD and...

๐Ÿ—“๏ธ 2025-06-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSevere Dietary Energy Restriction for Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomised Controlled Trial.

Prevalence, Characteristics, and Prognostic Associations of Cachexia Diagnosed Using Asian Working Group for Cachexia 2023 Criteria in Older Adults With Heart Failure.

Few studies have examined the characteristics of heart failure (HF) patients with cachexia using the Asian Working Group for Cachexia (AWGC) 2023 criteria. This study assessed the characteristics and clinical impact of cachexia in older adults with HF. Results of...

๐Ÿ—“๏ธ 2025-04-18
๐Ÿ“ฐ Publication: Circulation Journal
Read MorePrevalence, Characteristics, and Prognostic Associations of Cachexia Diagnosed Using Asian Working Group for Cachexia 2023 Criteria in Older Adults With Heart Failure.

Comprehensive Evaluation of Frailty and Sarcopenia Markers to Predict Survival in Glioblastoma Patients.

Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Patients with GBM are particularly susceptible to moderate-to-high frail. Frailty status has been associated with the outcome of many types of cancer, including GBM, although there is still...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreComprehensive Evaluation of Frailty and Sarcopenia Markers to Predict Survival in Glioblastoma Patients.

Prediction Models for Risk of Cardiorespiratory Morbidity/Mortality and Fracture Among Young Adults With Cerebral Palsy.

There is a dearth of screening tools for cardiorespiratory disease and fracture risk, such as risk prediction models, for adults with cerebral palsy (CP). There is heterogeneity of pathophysiology related to the severity of CP and aging, such that a...

๐Ÿ—“๏ธ 2025-02-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePrediction Models for Risk of Cardiorespiratory Morbidity/Mortality and Fracture Among Young Adults With Cerebral Palsy.

Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in Englandย (MET-PREVENT): a double-blind, randomised, placebo-controlled trial.

Metformin has effects on multiple biological systems relevant to ageing and has been posited as a candidate therapy for sarcopenia and physical frailty. We aimed to test the efficacy and safety of metformin, a candidate geroprotector, to improve physical performance...

๐Ÿ—“๏ธ 2025-03-24
Read MoreMetformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in Englandย (MET-PREVENT): a double-blind, randomised, placebo-controlled trial.

Neuroimaging Findings in Nondemented Frail Individuals: A Systematic Review.

Frailty is a chronic condition characterised by the progressive decline of multiple physiological functions. There is a critical need to investigate neuroimaging findings in nondemented frail individuals to better understand the underlying mechanisms and implications of frailty on brain health....

๐Ÿ—“๏ธ 2025-02-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNeuroimaging Findings in Nondemented Frail Individuals: A Systematic Review.

Exploring the mediating roles of depression and cognitive function in the association between sarcopenia and frailty: A Cox survival analysis approach.

Despite earlier research indicating a potential link between the development of sarcopenia and an elevated risk of frailty, the lack of comprehensive prospective data on the correlation between sarcopenia and frailty incidence leaves open the question of whether depression and...

๐Ÿ—“๏ธ 2024-12-17
๐Ÿ“ฐ Publication: Journal Of Advanced Research
Read MoreExploring the mediating roles of depression and cognitive function in the association between sarcopenia and frailty: A Cox survival analysis approach.

Assessing Association Between Circulating Bilirubin Levels and the Risk of Frailty: An Observational and Mendelian Randomization Study.

Bilirubin is a by-product of haemoglobin breakdown and has been reported to be a potent antioxidant recently. While elevated levels of bilirubin have been linked to a reduced risk of various diseases, their role remains unknown in frailty. This study...

๐Ÿ—“๏ธ 2024-11-25
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssessing Association Between Circulating Bilirubin Levels and the Risk of Frailty: An Observational and Mendelian Randomization Study.

New horizons in hospital-associated deconditioning: a global condition of body and mind.

Hospital-associated deconditioning is a broad term, which refers non-specifically to declines in any function of the body secondary to hospitalisation. Older people, particularly those living with frailty, are known to be at greatest risk. It has historically been most commonly...

๐Ÿ—“๏ธ 2024-11-01
๐Ÿ“ฐ Publication: Age And Ageing
Read MoreNew horizons in hospital-associated deconditioning: a global condition of body and mind.

Efficacy of empagliflozin in heart failure with preserved ejection fraction according to frailty status in EMPEROR-Preserved.

Frailty is a severe, common co-morbidity associated with heart failure (HF) with preserved ejection fraction (HFpEF). The impact of frailty on HFpEF outcomes may affect treatment choices in HFpEF. The impact of frailty on HFpEF patients and any impact on...

๐Ÿ—“๏ธ 2023-12-29
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEfficacy of empagliflozin in heart failure with preserved ejection fraction according to frailty status in EMPEROR-Preserved.

An Evaluation of Multimodal Interventions for Co-morbid Frailty and Type 2 Diabetes Mellitus

This study investigates multimodal interventions for older adults with frailty and Type 2 Diabetes Mellitus (T2DM), focusing on the effects of physical, nutritional, and educational strategies on improving functional performance. Involving 843 individuals aged 70+, findings highlight improved mobility, especially gait speed, linked to adherence and baseline health. Published in 'Age and Ageing', the research by Alvarez-Bustos A, Laosa O, Marzetti E, et al., emphasizes tailored interventions' importance for T2DM and frailty in the elderly.

๐Ÿ—“๏ธ January 2024
๐Ÿ“ฐ Publication: Age and Ageing
Read MoreAn Evaluation of Multimodal Interventions for Co-morbid Frailty and Type 2 Diabetes Mellitus

Leucine-enriched Protein Supplementation for the Pre-frail: What Are the Benefits?

It is known that one in five adults with pre-frailty progresses to frailty over a 3-year period. Low protein and energy intake, increased prevalence of multimorbidity, and a sedentary lifestyle are well-characterised drivers of sarcopenia. Consequently, they act as catalysts of older adultsโ€™ transition to frailty. In this vein, stimulating increased muscle protein synthesis through regular physical exercise and protein-enriched diet consumption is pivotal for pre-frail older adults. Current U.S. Food and Nutrition Board guidelines recommend a dietary allowance of 0.8 g/kg of protein per day for older adults. However, this amount may be insufficient for those with pre-frailty due to their low-grade inflammation, multimorbidity, and increased susceptibility to anabolic resistance.

This study aimed to examine the impact of leucine-enriched protein supplementation with or without exercise on 1) physical function, 2) body composition, and 3) systemic inflammation in pre-frail older adults with a daily protein consumption of โ‰ค1 g/kg.

Read MoreLeucine-enriched Protein Supplementation for the Pre-frail: What Are the Benefits?

Are immunosenescence and mitochondrial dysfunction hallmarks of frailty?

The development of frailty has been attributed to a number of biological mechanisms, including immunosenescence and mitochondrial dysfunction. Impairments in immune cell mitochondria have been proposed to both cause and interact with immunosenescence, hypothetically leading to ageing-related increases in sterile inflammation, commonly known as โ€˜inflammagingโ€™. However, despite the convincing evidence supporting these suggestions, claims regarding the effects of immunosenescence on clinical outcomes such as frailty have recently been challenged.

The aim of this article was to examine the association between immunosenescence, mitochondrial dysfunction, and frailty syndrome in community-dwelling frail and non-frail older adults.

๐Ÿ“ฐ Publication: ells 2022
Read MoreAre immunosenescence and mitochondrial dysfunction hallmarks of frailty?

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