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Sarcopenia

Decoding Sarcopenia: Advances in Research and Management: Dive into the evolving landscape of sarcopenia research. From cutting-edge studies on its impact on cancer patients to innovative management strategies, gain insights into combating this muscle-wasting condition.

SARC-Calf using calf circumference adjusted for BMI predicts six-months readmission and mortality in hospitalized patients: a secondary analysis of a cohort study.

Sarcopenia is a prevalent condition associated with worse clinical outcomes in hospitalized patients. The SARC-Calf is an accurate instrument for its screening; however, it includes the calf circumference (CC) measure as a criterion, which is influenced by adiposity. An adjustment...
🗓️ 2024-10-18
📰 Publication: American Journal Of Clinical Nutrition
Read MoreSARC-Calf using calf circumference adjusted for BMI predicts six-months readmission and mortality in hospitalized patients: a secondary analysis of a cohort study.

Body composition derangements in lung cancer patients treated with first-line pembrolizumab: A multicentre observational study.

While immune checkpoint inhibitors (ICIs) are increasingly reshaping the therapeutic landscape of non-small-cell lung cancer (NSCLC), only a limited proportion of patients achieve a relevant and long-lasting benefit with these treatments, calling for the identification of clinical and, ideally modifiable,...
🗓️ 2024-10-22
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBody composition derangements in lung cancer patients treated with first-line pembrolizumab: A multicentre observational study.

LRRK2 Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease.

While the gradually aggravated motor and non-motor disorders of Parkinson's disease (PD) lead to progressive disability and frequent falling, skeletal muscle impairment may contribute to this condition. The leucine-rich repeat kinase2 (LRRK2) is a common disease-causing gene in PD. Little...
🗓️ 2024-09-23
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLRRK2 Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease.

Evaluation of quadriceps muscle cross-sectional area using an ultrasonic diagnostic equipment with a wide field of view.

Skeletal muscle index measurement via dual-energy X-ray absorptiometry or bioelectrical impedance analysis is used to evaluate muscle mass when diagnosing sarcopenia. However, inherent challenges exist with these methods. We previously focused on muscle mass evaluation in the quadriceps femoris by...
🗓️ 2024-09-24
📰 Publication: Plos One
Read MoreEvaluation of quadriceps muscle cross-sectional area using an ultrasonic diagnostic equipment with a wide field of view.

Hepatic signal transducer and activator of transcription-3 signalling drives early-stage pancreatic cancer cachexia via suppressed ketogenesis.

Patients with pancreatic ductal adenocarcinoma (PDAC) often suffer from cachexia, a wasting syndrome that significantly reduces both quality of life and survival. Although advanced cachexia is associated with inflammatory signalling and elevated muscle catabolism, the early events driving wasting are...
🗓️ 2024-04-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHepatic signal transducer and activator of transcription-3 signalling drives early-stage pancreatic cancer cachexia via suppressed ketogenesis.

Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series.

Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most commonly selected measures or their...
🗓️ 2024-05-13
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBody weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series.

Effect of Bimagrumab on body composition: a systematic review and meta-analysis.

Sarcopenia, a condition marked by progressive muscle mass and function decline, presents significant challenges in aging populations and those with chronic illnesses. Current standard treatments such as dietary interventions and exercise programs are often unsustainable. There is increasing interest in...
🗓️ 2024-09-09
📰 Publication: Aging Clinical And Experimental Research
Read MoreEffect of Bimagrumab on body composition: a systematic review and meta-analysis.

Unacylated Ghrelin Protects Against Age-Related Loss of Muscle Mass and Contractile Dysfunction in Skeletal Muscle.

Sarcopenia, the progressive loss of muscle mass and function, universally affects older adults and is closely associated with frailty and reduced quality of life. Despite the inevitable consequences of sarcopenia and its relevance to healthspan, no pharmacological therapies are currently...
🗓️ 2024-09-02
📰 Publication: Aging Cell
Read MoreUnacylated Ghrelin Protects Against Age-Related Loss of Muscle Mass and Contractile Dysfunction in Skeletal Muscle.

Association of food group with the changes in sarcopenia parameters over 1 year in older outpatients in a frailty clinic.

This study investigated the relationship between food group and the changes in sarcopenia parameters in 1 year among older outpatients. A prospective cohort study conducted between July 2017 and April 2021 included patients aged ≥ 65 years attending a frailty clinic. Food group consumption...
🗓️ 2024-09-10
📰 Publication: European Geriatric Medicine
Read MoreAssociation of food group with the changes in sarcopenia parameters over 1 year in older outpatients in a frailty clinic.

Sarcopenia in Children Post Liver Transplant: Development of a Home-Based Video Program to Support Muscle Strength and Function-A Pre-Post Controlled Pilot Study.

Sarcopenia is common in children after liver transplantation (LTx). Resistance training (RT) may be effective in combating sarcopenia. The purpose of the study was to test the feasibility and impact of a 12-week RT program on skeletal muscle mass (SMM),...
🗓️ 2024-09-01
📰 Publication: Clinical Transplantation
Read MoreSarcopenia in Children Post Liver Transplant: Development of a Home-Based Video Program to Support Muscle Strength and Function-A Pre-Post Controlled Pilot Study.

Inflamm-ageing: How cytokines and nutrition shape the trajectory of ageing.

Population ageing is increasing in prevalence in most developed countries. Ageing is the decline of functional properties at the cellular, tissue, and organ level. Biochemical changes that occur in all organisms that experience biological ageing are referred to as the...
🗓️ 2024-09-02
📰 Publication: Cytokine & Growth Factor Reviews
Read MoreInflamm-ageing: How cytokines and nutrition shape the trajectory of ageing.

Sex difference, proteostasis and mitochondrial function impact stroke-related sarcopenia-A systematic review and meta-analysis.

The prevalence of stroke-related sarcopenia has been noted; however, epidemiological data and interventions that increase or reduce the incidence of stroke-related sarcopenia remain lacking. Studies on stroke-related sarcopenia were included in association or interventional analyses. All analyses were performed using...
🗓️ 2024-08-30
📰 Publication: Ageing Research Reviews
Read MoreSex difference, proteostasis and mitochondrial function impact stroke-related sarcopenia-A systematic review and meta-analysis.

Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis.

Sarcopenia, a prevalent condition, significantly impacts the prognosis of patients with decompensated cirrhosis (DC). Serum fibroblast growth factor 21 (FGF21) levels are significantly higher in DC patients with sarcopenia. Satellite cells (SCs) play a role in aging- and cancer-induced sarcopenia....
🗓️ 2024-08-30
📰 Publication: Redox Biology
Read MoreLiver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis.

SARCOPENIA DEFINITION

Sarcopenia is a condition which focuses on muscle loss. Loss of muscle mass and function, especially muscle strength and gait speed, associated with aging occurs in sarcopenia. Sarcopenia, cachexia, and malnutrition are considered as the main causes of muscle wasting and affect millions of elderly people and patients. Moreover, muscle atrophy can develop independently from diseases and age through disuse of the muscles. For a better classification and common language in medical science for ‘muscle wasting disease’ there is a proposal to combine the concepts of muscle wasting, sarcopenia, frailty, and cachexia by disease aetiology and disease progression. Patients with muscle atrophy show decreased muscle strength and therefore reduced quality of life, which is caused by a lower activity and increased exercise intolerance.

Despite a large number of studies, the understanding of the development of muscle wasting and the involved pathways remains very limited and more research is needed. Although many researchers and pharmaceutical companies have tried to find therapies for muscle atrophy, including cachexia and sarcopenia, no solution has been established until now.

REFERENCES

Rosenberg IH. Sarcopenia: origins and clinical relevance. Clin Geriatr Med 2011;27:337–339.

Anker SD, Coats AJ, Morley JE, Rosano G, Bernabei R, von Haehling S, Kalantar-Zadeh K. Muscle wasting disease: a proposal for a new disease classification. J Cachexia Sarcopenia Muscle 2014;5:1–3

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