Myostatin

The Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI-ฮฑ and Controls Myogenic Differentiation.

<p><b>BACKGROUND</b></p><p>Muscle RING finger (MuRF) proteins are striated muscle-specific E3 ubiquitin ligases essential for muscle homeostasis. Whereas MuRF1 is well known for its role in muscle atrophy, MuRF2 and MuRF3 contribute to microtubule stabilization, influencing muscle differentiation and function. Their cooperative...

๐Ÿ—“๏ธ 2025-01-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI-ฮฑ and Controls Myogenic Differentiation.

Silencing Myostatin Using In Vivo Self-Assembled siRNA Protects Against Cancer- and Dexamethasone-Induced Muscle Atrophy.

Maintaining skeletal muscle mass is crucial for health, as muscle atrophy caused by drugs, cancer, or aging poses serious risks. However, there are few effective pharmacological interventions targeting muscle atrophy, highlighting the need for new therapeutic strategies. In this study,...

๐Ÿ—“๏ธ 2025-10-03
๐Ÿ“ฐ Publication: Advanced Healthcare Materials
Read MoreSilencing Myostatin Using In Vivo Self-Assembled siRNA Protects Against Cancer- and Dexamethasone-Induced Muscle Atrophy.

Therapeutic advances in sarcopenia management: From traditional interventions to personalized medicine.

Sarcopenia, a progressive decline in skeletal muscle mass and function, has emerged as a critical geriatric syndrome affecting 10-40% of older adults, contributing to increased disability and mortality. This comprehensive review evaluates evidence-based strategies for sarcopenia management, from established interventions...

๐Ÿ—“๏ธ 2025-06-11
๐Ÿ“ฐ Publication: Clinical Nutrition
Read MoreTherapeutic advances in sarcopenia management: From traditional interventions to personalized medicine.

Adipokines and Myokines as Markers of Malnutrition and Sarcopenia in Patients Receiving Kidney Replacement Therapy: An Observational, Cross-Sectional Study.

Chronic kidney disease (CKD) is linked to an elevated risk of malnutrition and sarcopenia, contributing to the intricate network of CKD-related metabolic disorders. Adipokines and myokines are markers and effectors of sarcopenia and nutritional status. The aim of this study...

๐Ÿ—“๏ธ 2024-07-31
Read MoreAdipokines and Myokines as Markers of Malnutrition and Sarcopenia in Patients Receiving Kidney Replacement Therapy: An Observational, Cross-Sectional Study.

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