SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

All Ageing Cachexia Cancer Cachexia Clinical Trials Exercise Frailty From the literature Guidelines Muscle Nutrition Other SCWD Events Sarcopenia

Muscle

Nanoparticle-Driven Skeletal Muscle Repair and Regeneration Through Macrophage-Muscle Stem Cell Interaction.

Macrophages are key innate immune cells in the muscle environment of sarcopenia patients, significantly influencing muscle stem cell (MuSC) proliferation and differentiation. However, prolonged activation of macrophages can hinder muscle recovery. In this study, it synthesizes lipoic acid-modified gold nanoparticles...

📰 Journal: Small

🗓️ Mar 23, 2025
Cell_communication / CELLS / Macrophages / Microscopy,_electron,_scanning_transmission / Muscle,_skeletal / muscles / Nanoparticles / Sarcopenia / Stem_cells / therapeutics

Sarcopenia

Looking Towards More Comprehensive Management of Interstitial Lung Disease.

📰 Journal: Respirology

🗓️ Mar 22, 2025
Lung / Lung_diseases / Lung_diseases,_interstitial

Nutrition

Sarcopenic obesity and the risk of atrial fibrillation in non-diabetic older adults: A prospective cohort study.

Evidence of an association between sarcopenic obesity (SO) and the risk of long-term atrial fibrillation (AF) is lacking, and the underlying involvement of insulin resistance (IR) and inflammation is not clear. This community-based prospective cohort study evaluated sarcopenia, obesity, and...

📰 Journal: Clinical Nutrition

🗓️ Mar 18, 2025
Atrial_fibrillation / C-reactive_protein / Cohort_studies / Enteral_nutrition / Obesity / Parenteral_nutrition / Sarcopenia

Muscle

Temporalis muscle thickness correlates with premorbid frailty in patients resuscitated from cardiac arrest.

Frailty is associated with mortality and functional outcome after cardiac arrest. Temporalis muscle thickness (TMT) is a measure of sarcopenia, which represents one dimension of frailty. We assessed the correlation between TMT, measured on head computed tomography (CT), and Clinical...

📰 Journal: Resuscitation

🗓️ Mar 18, 2025
Frailty / Heart_arrest / muscles / Resuscitation / Sarcopenia

Sarcopenia

Butyrate (short-chain fatty acid) alleviates lipopolysaccharide-binding proteins and improves physical function in knee osteoarthritis patients.

Knee-osteoarthritis (OA) is often associated with increased intestinal permeability, potentially causing sarcopenia, and mobility issues. Current treatments are ineffective. The objective of this study was to investigate if butyrate improves sarcopenia and physical function in knee-OA patients, and if improvements...

📰 Journal: International Journal Of Biological Macromolecules

🗓️ Mar 17, 2025
Bacterial_load / Carrier_proteins / Fatty_acids / Fatty_acids,_volatile / Lipopolysaccharides / Osteoarthritis / Osteoarthritis,_knee / therapeutics / Walking / Walking_speed

Muscle

Causal relationships of circulating amino acids with sarcopenia-related traits: A bidirectional Mendelian randomization study.

Recent studies have indicated a correlation between certain Amino acids (AAs) and sarcopenia. However, the exact causal relationship among these associations is still unclear. This study aims to elucidate the causal relationships between 20 types of AAs and the phenotypic...

📰 Journal: Clinical Nutrition

🗓️ Mar 16, 2025
Amino_acids / Enteral_nutrition / muscles / Parenteral_nutrition / Polymorphism,_single_nucleotide / Random_allocation / Research / Sarcopenia

Nutrition

Efficacy of nutrient supplements in managing malnutrition and sarcopenia in Chronic Obstructive Pulmonary Disease (COPD) patients: a protocol for systematic review and meta-analysis.

COPD patients suffering from malnutrition or sarcopenia often incur higher healthcare costs and experience adverse clinical outcomes. Despite this, the effectiveness of nutrient supplements in this population remains uncertain. Two reviewers will independently search seven databases-PubMed, Embase, Web of Science,...

🗓️ Mar 15, 2025
Bias / Food / Lung_diseases / Lung_diseases,_obstructive / Malnutrition / Nutrients / Pulmonary_disease,_chronic_obstructive / Sarcopenia

Cachexia

Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series.

In patients receiving anti-cancer treatment, cachexia results in poorer oncological outcomes. However, there is limited understanding and no systematic review of oncological endpoints in cancer cachexia (CC) trials. This review examines oncological endpoints in CC clinical trials. An electronic literature...