EXERCISE

Lean body mass and the cardiorespiratory phenotype: An ethnic-specific relationship in Hans Chinese women and men.

Lean body mass (LBM) and the functional capacity of cardiovascular (CV) and respiratory systems constitute a female-specific relationship in European-American individuals. Whether this recent finding be extrapolated to the world's largest ethnic group, that is, Hans Chinese (HC, a population...

🗓️ 2024-04-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLean body mass and the cardiorespiratory phenotype: An ethnic-specific relationship in Hans Chinese women and men.

Free essential amino acid feeding improves endurance during resistance training via DRP1-dependent mitochondrial remodelling.

Loss of muscle strength and endurance with aging or in various conditions negatively affects quality of life. Resistance exercise training (RET) is the most powerful means to improve muscle mass and strength, but it does not generally lead to improvements...

🗓️ 2024-06-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreFree essential amino acid feeding improves endurance during resistance training via DRP1-dependent mitochondrial remodelling.

Sarcopenia is independently associated with poor preoperative physical fitness in patients undergoing colorectal cancer surgery.

Accurate preoperative risk assessment for major colorectal cancer (CRC) surgery remains challenging. Body composition (BC) and cardiopulmonary exercise testing (CPET) can be used to evaluate risk. The relationship between BC and CPET in patients undergoing curative CRC surgery is unclear....

🗓️ 2024-06-26
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenia is independently associated with poor preoperative physical fitness in patients undergoing colorectal cancer surgery.

Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series.

Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most commonly selected measures or their...

🗓️ 2024-05-13
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBody weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series.

The impact of mobility limitations on geriatric rehabilitation outcomes: Positive effects of resistance exercise training (RESORT).

Regaining walking ability is a key target in geriatric rehabilitation. This study evaluated the prevalence of walking ability at (pre-)admission and related clinical characteristics in a cohort of geriatric rehabilitation inpatients; in inpatients without walking ability, feasibility and effectiveness of...

🗓️ 2024-09-05
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe impact of mobility limitations on geriatric rehabilitation outcomes: Positive effects of resistance exercise training (RESORT).

Sarcopenia interventions in long-term care facilities targeting sedentary behaviour and physical inactivity: A systematic review.

Sedentary behaviour and physical inactivity are independent risk factors for sarcopenia for long-term care facility residents. Understanding the components, mechanisms and context of interventions that target change in these risk factors can help optimize sarcopenia management approaches. This study aimed...

🗓️ 2024-09-18
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenia interventions in long-term care facilities targeting sedentary behaviour and physical inactivity: A systematic review.

Ponsegromab for the Treatment of Cancer Cachexia.

Cachexia is a common complication of cancer and is associated with an increased risk of death. The level of growth differentiation factor 15 (GDF-15), a circulating cytokine, is elevated in cancer cachexia. In a small, open-label, phase 1b study involving...

🗓️ 2024-09-14
📰 Publication: New England Journal Of Medicine
Read MorePonsegromab for the Treatment of Cancer Cachexia.

Defining and Addressing Research Priorities in Cancer Cachexia through Transdisciplinary Collaboration.

For many patients, the cancer continuum includes a syndrome known as cancer-associated cachexia (CAC), which encompasses the unintended loss of body weight and muscle mass, and is often associated with fat loss, decreased appetite, lower tolerance and poorer response to...

🗓️ 2024-06-27
Read MoreDefining and Addressing Research Priorities in Cancer Cachexia through Transdisciplinary Collaboration.

Effect of resistance training on physical function during chemotherapy in colon cancer.

The decline of physical function during chemotherapy predicts poor quality of life and premature death. It is unknown if resistance training prevents physical function decline during chemotherapy in colon cancer survivors. This multicenter trial randomly assigned 181 colon cancer survivors...

🗓️ 2024-07-16
Read MoreEffect of resistance training on physical function during chemotherapy in colon cancer.

Mitochondrial Quantity and Quality in Age-Related Sarcopenia.

Sarcopenia, the age-associated decline in skeletal muscle mass and strength, is a condition with a complex pathophysiology. Among the factors underlying the development of sarcopenia are the progressive demise of motor neurons, the transition from fast to slow myosin isoform...

🗓️ 2024-02-08
📰 Publication: International Journal Of Molecular Sciences
Read MoreMitochondrial Quantity and Quality in Age-Related Sarcopenia.

Exercise and nutrition interventions for renal cachexia.

Renal cachexia is a deleterious condition characterized by weight loss, muscle wasting and loss of physical function, quality of life, and increased mortality. Multimodal treatment strategies utilizing exercise and nutrition interventions have been recently suggested although the evidence base is...

🗓️ 2024-02-22
📰 Publication: Current Opinion In Clinical Nutrition And Metabolic Care
Read MoreExercise and nutrition interventions for renal cachexia.

Sarcopenia of Ageing: Does a Healthier Lifestyle Matter in Reversing the Trajectory? A Brief Narrative Review and a Call for Action in Saudi Arabia.

The concept of health span is an emerging topic in recent years, with a truly palpable relevance to public health. With ageing comes a loss of skeletal muscle mass, strength, and performance, which is termed as sarcopenia. Sarcopenia is a...

🗓️ 2024-01-15
Read MoreSarcopenia of Ageing: Does a Healthier Lifestyle Matter in Reversing the Trajectory? A Brief Narrative Review and a Call for Action in Saudi Arabia.

Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers.

Options for treatment of incurable cancer remain scarce and are largely focused on limited therapeutic mechanisms. A new approach specific to advanced cancers is needed to identify new and effective treatments. Morbidity in advanced cancer is driven by functional decline...

🗓️ 2024-01-14
Read MoreHarnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers.

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